1.
Chem Asian J
; 15(4): 499-502, 2020 Feb 17.
Article
in English
| MEDLINE
| ID: mdl-31903690
ABSTRACT
Enantioselective addition of boronic acids to N-unsubstituted isatin-derived ketimines was realized using rhodium(I)/chiral diene catalysts. The reactions can be performed in the presence of catalytic amounts of a base to give adducts in high yield with high enantioselectivity. Preliminary mechanistic information including a computational model to explain the observed enantioselectivity is also provided.