ABSTRACT
Cardiac haemodynamics have been studied radiocardiographically in 56 men at the age of 40-60 including 15 healthy persons, 24 patients with chronic coronary disease and 17 patients associating coronary disease with chronic cholecystitis. This association was shown to reduce minute heart volume thus playing the role of a factor compromising cardiac blood circulation in such patients. Neuroreflex influence on the coronary arteries and autoimmune damage of myocardium due to similarity of myocardial and gallbladder antigenic determinants may be probable mechanisms of such an effect.
Subject(s)
Cholecystitis/physiopathology , Heart/physiopathology , Myocardial Ischemia/physiopathology , Adult , Cholelithiasis/physiopathology , Chronic Disease , Hemodynamics , Humans , Male , Middle AgedABSTRACT
Complement-binding antibodies to liver tissue, gallbladder, myocardium were determined in 20 patients with chronic cholecystitis, 21 patients with persisting hepatitis and 20 patients with liver cirrhosis. The obtained findings indicate that diseases of the hepatobiliary system may be accompanied by autoimmune involvement of the myocardium.
Subject(s)
Biliary Tract Diseases/immunology , Liver Diseases/immunology , Antibodies/blood , Antibody Formation/immunology , Chronic Disease , Complement Fixation Tests , Gallbladder/immunology , Humans , Liver/immunology , Myocardium/immunologyABSTRACT
A study is presented of 58 patients with chronic cholecystitis associated with chronic ischemic heart disease. Single sublingual use of phenigidin was followed by ultrasonic examination and revealed elimination of signs of spasm of the sphincter apparatus of the biliary tract and improvement of evacuation of bile from the gallbladder. Peroral use of phenigidin (10-20 mg three times daily before meals for 2-3 weeks) was accompanied by a positive dynamics of clinical manifestations of chronic cholecystitis and chronic ischemic heart disease. Average indices of tolerance to physical loads (bicycle ergometric [correction of veloergometric] data) did not change essentially as a result of treatment.
Subject(s)
Cholecystitis/drug therapy , Coronary Disease/drug therapy , Nifedipine/therapeutic use , Administration, Sublingual , Biliary Tract/pathology , Cholecystitis/diagnosis , Chronic Disease , Coronary Disease/diagnosis , Drug Evaluation , Exercise Test , Humans , Physical Endurance/drug effects , UltrasonographyABSTRACT
Ultrasonic scanning of the gallbladder was realized in 234 patients with ischemic heart disease and results of 924 autopsy findings in those who died of myocardial infarction. A high incidence of concomitant cholelithiasis was found in patients with ischemic heart disease as compared with the general population. The data obtained by ultrasound examination were close to the results of autopsy findings.
Subject(s)
Cholelithiasis/epidemiology , Coronary Disease/epidemiology , Adult , Age Factors , Cholelithiasis/diagnosis , Cholelithiasis/pathology , Coronary Disease/diagnosis , Coronary Disease/pathology , Female , Gallbladder/pathology , Humans , Male , Middle Aged , Myocardial Infarction/epidemiology , Myocardial Infarction/mortality , Sex Factors , Ukraine/epidemiology , UltrasonographySubject(s)
Cholecystitis/drug therapy , Coronary Disease/drug therapy , Papaverine/administration & dosage , Parasympatholytics/administration & dosage , Adult , Aged , Cholecystitis/complications , Cholecystitis/physiopathology , Chronic Disease , Coronary Disease/complications , Coronary Disease/physiopathology , Drug Therapy, Combination , Female , Gallbladder/drug effects , Gallbladder/physiopathology , Humans , Liver/drug effects , Liver/physiopathology , Male , Middle AgedSubject(s)
Cholelithiasis/diagnosis , Myocardial Infarction/diagnosis , Female , Humans , Male , Middle Aged , SyndromeSubject(s)
Duodenal Ulcer/physiopathology , Liver/physiopathology , Adult , Humans , Liver Diseases/etiology , Male , Middle AgedSubject(s)
Biliary Dyskinesia/diagnostic imaging , Cholelithiasis/complications , Common Bile Duct/diagnostic imaging , Duodenal Ulcer/complications , Gallbladder Diseases/diagnostic imaging , Liver Cirrhosis/complications , Adult , Biliary Dyskinesia/etiology , Common Bile Duct Diseases/etiology , Gallbladder Diseases/etiology , Humans , Male , Middle Aged , Radionuclide ImagingSubject(s)
Cholelithiasis/diagnosis , Duodenal Ulcer/diagnosis , Adult , Female , Humans , Male , Middle Aged , UltrasonographySubject(s)
Ulcer/etiology , Acute Disease , Chronic Disease , Humans , Peptic Ulcer/etiology , Peptic Ulcer/therapy , Ulcer/therapyABSTRACT
Histochemistry, cario- and zytometry methods showed that the activators of gastric secretion (histamine and pentagastrine) exerted opposite effects upon functional state of hypothalamo-neurohypophyseal secretory system in the guinea-pigs. Histamine (4 mg/kg) activated the system and induced the development of gastric mucosa defects. Pentagastrine (5, 12, 15, 25, and 60 mcg/kg) decreased the activity of the system. No gastric mucosa or duodenum defects developed after pentagastrine administration.