EFFECTIVENESS OF THE APPLICATION OF THE DEVELOPED BIOPOLYMER FIBROUS MATRIX WITH CENOBONE® BIOGEL FOR THE RECONSTRUCTION OF BONE TISSUE DEFECTS OF THE JAWS.

The aim of the research was to study the framework ability of the fibrous non-woven PCL matrices we've created during the restoration of bone tissue.There were performed some spectroscopic, histological and immunohistochemical, radiological and clinical analyses of the effectiveness of microfibrous non-woven PCL polycaprolactone matrices developed by us, in the work. The obtained results of morphological studies of bone tissue in the experiment of the implantation of a fibrous matrix indicated an increase in reparative osteogenesis in the form of an increase in osteoid areas up to 34.38% (p<0.05) at an early period. The analysis of clinical data showed the effectiveness of the frame developed by us, which was confirmed by the absence of pronounced compaction of bone tissue in group III, in contrast to group II, where, on the contrary, the use of granulate based on hydroxyapatite and tricalcium phosphate has led to a significant increase in density indices of 974.53+19.74 HU p<0.05, which did not exceed 36.8% of indices of the group III 615.17+24.53 HU p<0.05.The matrix material developed by us is not only a means of delivering some other substances and materials into the damaged area, but also serves as a kind of framework for the restoration of bone tissue.

[Changes in cell adhesion molecules under the influence of surgical treatment in patients with acute thrombophlebitis of the subcutaneous veins in the lower extremities]. / Zminy volekul adheziï klityn pid vplyvom khirurhichnoho likuvannia khvorykh na hostryi tromboflebit pidshkirnykh nyzhnikh kintsivok.

The content of soluble molecules of intercellular adhesion-1 (sICAM-1) in 60 patients with an acute thrombophlebitis (TP) of the lower extremities subcutaneous veins was studied preoperatively and 7 days after the operation using method of a solid phase immunoenzymatic analysis (IEA). The sICAM-1 level before treatment in men was increased at average by 75.8% (P < 0.001), in women--by 81.5% (P < 0.001) in comparison with control group, after treatment it was lowered somewhat. The gender differences of patients for the average sICAM-1 concentration was not noted. In ascending TP sICAM-1 higher level preoperatively and its normalization on 7th day postoperatively were observed in patients, admitted to in surgical unit and operated 3-5 days after the beginning of disease. In patients, to whom conservative treatment was performed initially (anti-inflammatory and thrombolytic therapy), but its efficacy was minimal, the content of cell adhesion molecules preoperatively and before the treatment did not differ. Positive dynamic of index was revealed after the intervention. The results of investigation trust the important role of cell adhesion in pathogenesis of an acute TP of the lower extremities subcutaneous veins and perspective of application of the sICAM-1 method determination in dynamic of the patients treatment to estimate the surgical efficacy intervention.

[Investigation of quantitative and species composition and antifungal drug susceptibility of yeasts isolated from patients with generalized periodontitis complicated by candidosis]. / Vyvchennia kil'kisnoho i vydovoho skladu ta chutlyvosti do protyhrybkovykh zasobiv drizhdzhopodibnykh grybiv, vydilenykh vid patsiientiv z heneralizovanym parodontytom, uskladnenym kandydozom.

Biological properties of 68 Candida strains isolated from parodontal pockets of patients with generalized parodontitis complicated with candidosis have been investigated. It was established that 72.1 +/- 5.43% of strains belong to Candida albicans. The clinical Candida albicans isolates display high resistance to nystatin and levorin, but they are sensitive to synthetic antifungal drugs 5-fluorocytosine, fluconazol, especially to ketoconazol, itraconazole and to antifungal antibiotic amphotericin B as well.

[Species composition and antibiotic sensitivity of staphylococci isolated from patients with furunculosis]. / Vydovyi sklad i chutlyvist' do antybiotykiv stafilokokkiv, vydilenykh vid patsiientiv z furunkul'ozom.

Biological properties and sensitivity to modern antibacterial drugs 54 strains of staphylococci isolated under furunculosis have been studied with the aim to optimize this disease treatment. Staphylococcus aureus was revealed with frequency 35.2 +/- 6.50%, S. epidermidis (31.5 +/- 6.32%), S. warneri (16.7 +/- 5.08%), S. hominis (7.4 +/- 3.56%), S. haemolyticus and S. saprophyticus (3.7 +/- 2.57%) as well as S. lentus (1.9 +/- 1.86%) were identified among coagulase-negative staphylococci. Methycillin-resistant staphylococci were isolated from 25.92% of patients with furunculosis. High level of resistance of furunculosis agents to erythromycin, clarythromycine, cephtriaxon, pephloxacyne, tetracycline, doxycycline, levomycetine and phosphomycine has been registered. Basing on the study of isolates antibioticograms, cephasoline is recommended as the selected drug under furunculosis, and tobramycin as the reserve antibiotic. Autovaccine was also made for the patients treatment.

[The level of total immunoglobulin E in the blood serum of rheumatism patients]. / Riven' zahal'noho imunohlobulinu klasu E v syrovattsi krovi khvorykh na revmatyzm.

The mean level of total IgE in the sera of patients with active rheumatism was significantly higher than during non-active phase of the disease and in healthy blood donors. The highest level of hyper-IgE-emia is observed in the continuously relapsing variant of rheumatism. Increased content of total serum IgE in active rheumatism is observed both in manifest and in latent variants of the disease. Articular and cerebral manifestations of rheumatism are not, apparently, related to the IgE level. The serum IgE may be a supplementary diagnostic criterion of rheumatic activity, especially with advance of the cardiovascular insufficiency.

[The significance of eosinophilia in diagnosing rheumatism activity]. / Znachenie éozinofilii v raspoznavanii aktivnosti revmatizma.

Increases of the level of eosinophils in patients with rheumatism depends on the character of the disease course. In patients suffering of latent rheumatism with a subminimal activity, no increased number of circulating eosinophils is observed. It was established that patients with active rheumatism showed an increased subpopulation of eosinophils characterized by low density.