ABSTRACT
BACKGROUND: Stress urinary incontinence (SUI) causes both physical and psychological problems to women and their partners. Recently, vaginal radiofrequency (RF) application, as well as the administration of non-crosslinked hyaluronic acid (NCLHA) together with calcium hydroxyapatite (CaHA), has attracted attention for SUI treatment. The current, comparative study evaluated the efficacy and safety of these technologies acting separately and in a combined treatment. METHODS: Sixty women with mild to moderate SUI, aged between 46 and 76 years (mean age 63.2) were divided into three groups intended for different treatments: group I, RF vaginal treatment only, group II, NCLHA plus CaHA periurethral injection only, group III, combined treatment including a single periurethral injection of NCLHA plus CaHA followed by four vaginal applications of RF at intervals of 3-5 days. The clinical effects of the treatments were evaluated by ICIQ-LUTSqol (Polish version) and UDI-6. RESULTS: The obtained results suggest that the symptoms of SUI and the quality of life of the patients improved significantly in each group after the therapies compared to the pre-treatment levels and were more persistent in the third HA + RF group compared to the HA or the RF group.
ABSTRACT
OBJECTIVES: Increased estrogen activity and prolactin hypersecretion is a hormonal reason for Benign Breast Diseases. DESIGN: To evaluate hormonal disorders in women with gross breast cysts. MATERIAL AND METHODS: 30 women with gross breast cysts (over 10 mm in diameter) have been investigated. Cytohormonal vaginal swabs and serum levels of prolactin, estradiol and gonadotropins were evaluated. RESULTS: Normal prolactin levels were found in 96.7% of cases, but in 8 women with recurrent breast cysts after repeated FNA-biopsies prolactin secretion stimulated by metoclopramide was significantly increased. Low progesterone activity in all women and low estrogen activity in 65.3% were shown. Absolute high estrogen activity was diagnosed only in 8.7% women with gross breast cysts. CONCLUSIONS: Nearly all patients with gross breast cysts have normal prolactin and low progesterone levels. High estrogen levels appear very seldom and in most cases these patients are hypoestrogenic.
Subject(s)
Estradiol/blood , Fibrocystic Breast Disease/blood , Gonadotropins, Pituitary/blood , Prolactin/blood , Adult , Biomarkers/blood , Female , Fibrocystic Breast Disease/physiopathology , Humans , Immunoenzyme Techniques , Middle Aged , Time FactorsABSTRACT
OBJECTIVES: The most common and generally accepted methods of breast cysts treatment are fine needle aspiration or surgical excision. None of these methods allow to avoid or decrease number of recurrences. Regarding hormonal disturbances as a main reason for breast cysts also conservative treatment should be given. DESIGN: To evaluate whether adjuvant pharmacologic therapy is effective in breast cysts recurrence prevention. MATERIAL AND METHODS: 30 women (35-54 yrs) were treated with fine needle aspiration and afterwards with bromocriptine, estrogen-progestogens and progestogens. RESULTS: The authors shows that breast cysts recurrence is approximately 10 fold decreased in group with adjuvant therapy with bromocriptine, estrogen-progestogens and progestogens than in group treated with fine needle aspiration only.