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1.
Article in English | MEDLINE | ID: mdl-35148218

ABSTRACT

BACKGROUND AND OBJECTIVE: Ophthalmologic telemedicine has emerged during the COVID-19 pandemic. The objective of this study is to assess the accuracy and reproducibility of a smartphone-based home vision monitoring system (Sightbook) and to compare it with existing clinical standards. PATIENTS AND METHODS: Near Snellen visual acuity (VA) was measured with Sightbook and compared with conventional measurements for distance and near VA at an academic medical center ophthalmology clinic in 200 patients with a variety of different specified preexisting ocular conditions. Measurements of contrast sensitivity were also compared by using an existing commercially available chart system in 15 normal patients and 15 patients with age-related macular degeneration. RESULTS: Sightbook VA tests were reproducible (SD = ±0.054 logMAR), and correlation with standard VA methods was significant (R > 0.87 and P < .001). Sightbook contrast sensitivity measurements were reproducible (SD/mean ratio, 0.02 to 0.04), yielding results similar to those of standard tests (R2 > 0.87 and P < .001). CONCLUSIONS: Smartphone-based VA and contrast sensitivity are highly correlated with standard charts and may be useful in augmenting limited inoffice care. [Ophthalmic Surg Lasers Imaging Retina. 2022;53:79-84.].


Subject(s)
COVID-19 , Smartphone , Humans , Pandemics , Reproducibility of Results , SARS-CoV-2
2.
Retina ; 39(2): 303-313, 2019 Feb.
Article in English | MEDLINE | ID: mdl-29160779

ABSTRACT

PURPOSE: To investigate the outcomes of intravitreal aflibercept in refractory pigment epithelial detachment (PED) with or without subretinal fluid (SRF) in patients with neovascular age-related macular degeneration. METHODS: A prospective, nonrandomized, interventional case series involved 40 patients with persistent vascularized PED previously treated with at least 3 injections of intravitreal bevacizumab or ranibizumab. Intravitreal aflibercept was administered as 3 initial loading doses every 4 weeks, followed by pro re nata retreatment every 8 weeks over 48 weeks. Pigment epithelial detachment was classified into solid-, hollow-, or mixed-type according to the reflective properties visualized using optical coherence tomography. The mean changes in best-corrected visual acuity, central subfield thickness, and the volumes of SRF and PED were analyzed. RESULTS: The PED volume (baseline: 0.43 ± 0.55 mm) significantly reduced to 0.23 ± 0.32 mm at Week 8 (P = 0.003) and increased to 0.36 ± 0.41 mm at Week 48 (P = 0.345). The SRF volume (baseline: 0.52 ± 0.64 mm) significantly reduced to 0.24 ± 0.43 mm at Week 48 (P = 0.021). The mean baseline best-corrected visual acuity was 20/75 (47.5 letters); it showed no significant difference at Week 48 (+4.4 letters; P = 0.125). The baseline central subfield thickness was 323.2 ± 92.3 µm; it significantly reduced to 281.2 ± 90.7 µm at Week 48 (P = 0.001). In solid-type PEDs, there were poorer improvements in central subfield thickness, best-corrected visual acuity, and the volumes of the SRF and PED, with newly developed intraretinal cysts. CONCLUSION: Intravitreal aflibercept in treatment-resistant neovascular age-related macular degeneration led to significant reduction in PED and SRF volume, central subfield thickness, and best-corrected visual acuity preserved, over 12 months. However, solid-type PED showed less improvement than hollow- or mixed-type PED.


Subject(s)
Macular Degeneration/complications , Receptors, Vascular Endothelial Growth Factor/administration & dosage , Recombinant Fusion Proteins/administration & dosage , Retinal Detachment/drug therapy , Retinal Pigment Epithelium/pathology , Subretinal Fluid/diagnostic imaging , Tomography, Optical Coherence/methods , Visual Acuity , Aged , Female , Follow-Up Studies , Humans , Intravitreal Injections , Macular Degeneration/diagnosis , Macular Degeneration/drug therapy , Male , Prospective Studies , Retinal Detachment/diagnosis , Retinal Detachment/etiology , Treatment Outcome , Vascular Endothelial Growth Factor A/antagonists & inhibitors
3.
Retina ; 38(6): 1220-1230, 2018 Jun.
Article in English | MEDLINE | ID: mdl-28613215

ABSTRACT

PURPOSE: To investigate the correlation between preoperative en face spectral domain optical coherence tomography findings of the photoreceptor layer with restoration of foveal microstructure and visual acuity in repaired macular holes. METHODS: Medical records of 106 patients with surgically closed macular holes were retrospectively reviewed. Preoperative OCT slabs of the external limiting membrane (ELM) and ellipsoid zone (EZ) were generated using embedded tools. All patients were classified into two groups according to the presence of preoperative retinal pigment epithelium protrusion seen as hyperreflective spots in EZ slab. Visual acuity, homogenous reflectivity, and glial proliferation in the ELM and EZ slabs were followed for 12 months. RESULTS: Baseline hyperreflective spots in the EZ slab was observed in 51 (48.1%) eyes. Postoperative homogenous reflectivity and glial proliferation were related to the presence of baseline hyperreflective spots. Vision improvement was significantly greater in the absence of hyperreflective spots group from 9 months after the operation. In logistic regression analysis, the area of hyperreflective spots was significantly associated with foveal homogenous reflectivity at 12 months (P = 0.004). CONCLUSION: Preoperative hyperreflective spots in en face EZ slab might be indicative of functional and anatomical restoration after macular hole surgery.


Subject(s)
Fovea Centralis/pathology , Retinal Perforations/physiopathology , Retinal Perforations/surgery , Retinal Pigment Epithelium/pathology , Tomography, Optical Coherence/methods , Visual Acuity/physiology , Adult , Aged , Female , Fovea Centralis/diagnostic imaging , Humans , Male , Middle Aged , Photoreceptor Cells, Vertebrate , Prognosis , Retinal Pigment Epithelium/diagnostic imaging , Retrospective Studies
4.
Korean J Ophthalmol ; 31(3): 209-216, 2017 Jun.
Article in English | MEDLINE | ID: mdl-28471106

ABSTRACT

PURPOSE: To assess the effectiveness and safety of intravitreal ranibizumab compared with bevacizumab for the treatment of macular edema associated with branch retinal vein occlusion (BRVO). METHODS: This was a retrospective study of 80 eyes with macular edema associated with BRVO. Patients received either 0.5 mg of ranibizumab (n = 24) or 1.25 mg of bevacizumab (n = 56) intravitreally. Both groups received three initial monthly injections followed by as-needed injections. The best-corrected visual acuity, central subfield thickness, mean number of injections, and retreatment rate were evaluated monthly for 6 months after the initial injection. RESULTS: The best-corrected visual acuity significantly improved from logarithm of the minimal angle of resolution (logMAR) 0.55 ± 0.26 at baseline to 0.24 ± 0.26 at 6 months in the ranibizumab group (p < 0.001) and from logMAR 0.58 ± 0.21 at baseline to 0.29 ± 0.25 at 6 months in the bevacizumab group (p < 0.001), which is not a statistically significant difference (p = 0.770). The mean reduction in central subfield thickness at 6 months was 236 ± 164 µm in the ranibizumab group (p < 0.001) and 219 ± 161 µm in the bevacizumab group (p < 0.001), which is not also a statistically significant difference (p = 0.698). The mean numbers of ranibizumab and bevacizumab injections were 3.25 ± 0.53 and 3.30 ± 0.53, respectively (p = 0.602). In addition, after the three initial monthly injections, the retreatment rates for ranibizumab and bevacizumab injections were 20.8% and 26.7%, respectively (p = 0.573). CONCLUSIONS: Both ranibizumab and bevacizumab were effective for the treatment of BRVO and produced similar visual and anatomic outcomes. In addition, the mean number of injections and the retreatment rates were not significantly different between the groups.


Subject(s)
Bevacizumab/administration & dosage , Macular Edema/drug therapy , Ranibizumab/administration & dosage , Retinal Vein Occlusion/complications , Visual Acuity , Angiogenesis Inhibitors/administration & dosage , Dose-Response Relationship, Drug , Female , Fluorescein Angiography , Follow-Up Studies , Fundus Oculi , Humans , Intravitreal Injections , Macula Lutea/pathology , Macular Edema/diagnosis , Macular Edema/etiology , Male , Middle Aged , Retinal Vein Occlusion/diagnosis , Retinal Vein Occlusion/drug therapy , Retrospective Studies , Time Factors , Tomography, Optical Coherence , Treatment Outcome
5.
Ocul Immunol Inflamm ; 25(sup1): S24-S30, 2017.
Article in English | MEDLINE | ID: mdl-27541384

ABSTRACT

PURPOSE: To identify the characteristics and causes of uveitis in Seoul, South Korea. METHODS: We performed a retrospective medical record review of 602 patients diagnosed with uveitis at seven tertiary ophthalmology centers between January and December 2013. RESULTS: The most common type of uveitis was anterior uveitis (n = 281), followed by posterior uveitis (n = 152), panuveitis (n = 126), and intermediate uveitis (n = 43). Among patients with an identified cause (n = 252), 149 and 103 had non-infectious and infectious uveitis, respectively, and ankylosing spondylitis (n = 53), Behcet disease (n = 43), and endophthalmitis (n = 25) were common identified causes of uveitis. CONCLUSIONS: Anterior uveitis was the most common type of uveitis, and the incidence of infectious uveitis was relatively high in Seoul. Ankylosing spondylitis and Behcet disease were the most common systemic diseases causing uveitis in this sample.


Subject(s)
Ophthalmology/statistics & numerical data , Tertiary Care Centers/statistics & numerical data , Uveitis/epidemiology , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Retrospective Studies , Seoul/epidemiology , Sex Distribution , Uveitis/diagnosis , Uveitis/etiology , Young Adult
6.
Retina ; 37(1): 80-87, 2017 Jan.
Article in English | MEDLINE | ID: mdl-28005719

ABSTRACT

PURPOSE: To evaluate functional and anatomical retinal recovery according to patient age using spectral domain optical coherence tomography in eyes with surgically closed macular holes. METHODS: We retrospectively studied 83 eyes with anatomically closed idiopathic macular holes after surgery confirmed by spectral domain optical coherence tomography. Patients were divided into four subgroups based on age (Group 1: ≤ 60, Group 2: 61-65, Group 3: 66-70, Group 4: > 70). Best-corrected visual acuity and reconstruction of the external limiting membrane and ellipsoid zone after surgery were documented for 12 months. RESULTS: Mean patient age was 64.5 ± 9.8 years (range 44-81). Mean visual improvement in logMAR units (ETDRS letter score) at 12 months was worse in older age subgroups (Group 1: 0.4 ± 0.3 [20], Group 2: 0.4 ± 0.3 [20], Group 3: 0.2 ± 0.3 [10], Group 4: 0.1 ± 0.3 [5], P = 0.001). When age was more than 65 years, total number of eyes with restored retinal microstructure after surgery was lower (22 eyes, 53.7%; 32 eyes, 76.2%; P = 0.018) and time (months) to structural recovery was longer (10.2, 7.1, P < 0.001) than age under 65 years. Visual improvement corresponded to recovery of the outer retinal layers. In multivariate analysis, patients of older age (odds ratio, 0.91; 95% CI, 0.89-0.93) had less visual improvement at month 12. CONCLUSION: Poor visual outcomes and delayed microstructural recovery occurred in older subjects after anatomically closed macular hole surgery. Older age may be indicative of poor clinical outcome in repaired macular holes.


Subject(s)
Retinal Perforations/surgery , Adult , Age Factors , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Multivariate Analysis , Prognosis , Retinal Perforations/pathology , Retinal Perforations/physiopathology , Retrospective Studies , Tomography, Optical Coherence , Visual Acuity/physiology , Vitrectomy/methods
7.
Korean J Ophthalmol ; 30(5): 360-368, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27729756

ABSTRACT

PURPOSE: To describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus (HIV) infection. METHODS: A total of 45 eyes from 39 patients with ocular syphilis confirmed by serologic tests were reviewed retrospectively. The included cases were all non-HIV-infected patients presenting with intraocular inflammation from 2002 to 2014 at Kyung Hee University Hospital. Medical records of 45 eyes were analyzed and included best-corrected visual acuity and ophthalmologic examination findings of the anterior and posterior segments to determine the focus of inflammation. Optical coherence tomography and fluorescein angiography findings as well as both medical and surgical management were also analyzed. RESULTS: The mean patient age was 61.0 years (range, 37 to 89 years). Bilateral ocular involvement occurred in 6 patients (15.4%), and diagnoses at presentation were most frequently related to posterior uveitis (38%), followed by panuveitis (29%) and optic neuritis (11%). Isolated interstitial keratitis and intermediate uveitis were uncommon (4%, both). Twenty-eight eyes (62.2%) were treated with penicillin, and 11 eyes (24.4%) underwent surgical treatment. The mean baseline best corrected visual acuity was 0.79 ± 0.59 (mean ± standard deviation, logarithm of the minimum angle of resolution) and significantly improved to 0.60 ± 0.63 at the final follow-up after treatment (p = 0.019). Mean visual improvement was significantly greater in the penicillin-treated group (p = 0.001). Visual impairment at the final visit occurred in 11 eyes (24.4%). Among the visual impairment group, 10 eyes (90.1%) had posterior segment-involving uveitis. CONCLUSIONS: Visual outcomes of treated, non-HIV-related ocular syphilis were favorable regardless of time to presentation. Posterior segment-involving uveitis at presentation was associated with poor visual outcome.


Subject(s)
Eye Infections, Bacterial/diagnosis , Syphilis/diagnosis , Adult , Aged , Aged, 80 and over , Eye Infections, Bacterial/epidemiology , Female , Fluorescein Angiography , Humans , Incidence , Male , Middle Aged , Republic of Korea/epidemiology , Retrospective Studies , Syphilis/epidemiology , Tomography, Optical Coherence , Visual Acuity
8.
Indian J Ophthalmol ; 64(6): 427-33, 2016 Jun.
Article in English | MEDLINE | ID: mdl-27488150

ABSTRACT

PURPOSE: The study aimed to investigate the quantitative changes of retinal pigment epithelial (RPE) atrophy during a 24-month follow-up period of anti-vascular endothelial growth factor (VEGF) for exudative age-related macular degeneration (AMD). MATERIALS AND METHODS: This is a retrospective study. Sixty-five eyes of 62 consecutive patients with naοve exudative AMD who had received treatment with anti-VEGF therapy and followed for more 24 months were enrolled. All patients received three initial monthly injections of anti-VEGF (ranibizumab or bevacizumab), followed by pro re nata or treat-and-extend protocol. Color fundus image, optical coherence tomography, and fundus autofluorescence were evaluated for RPE atrophy. Multiple regression analysis was performed to investigate the predictive factors found during univariate analysis to identify an association with increased RPE atrophic areas. RESULTS: The mean number of anti-VEGF treatments was 9.18. RPE atrophic area was 1.293 ± 1.298 mm 2 at baseline and enlarged to 2.394 ± 1.940 mm 2 after 24 months, which differed significantly (P = 0.001). Multiple regression analysis revealed that larger areas of RPE atrophy at month 4 and larger numbers of anti-VEGF treatments were associated with increased RPE atrophic areas. CONCLUSIONS: RPE atrophy progresses in eyes with exudative AMD during anti-VEGF treatment. Larger areas of RPE atrophy at month 4 and larger numbers of anti-VEGF injections were associated with an increased risk of progression of RPE atrophy the following treatment. These findings may be useful to clinicians using intravitreal anti-VEGF for the treatment of exudative AMD, both for selecting an appropriate treatment plan and for predicting the progression of RPE atrophy.


Subject(s)
Bevacizumab/administration & dosage , Ranibizumab/administration & dosage , Retinal Pigment Epithelium/pathology , Vascular Endothelial Growth Factor A/antagonists & inhibitors , Wet Macular Degeneration/pathology , Aged , Angiogenesis Inhibitors/administration & dosage , Atrophy , Female , Fluorescein Angiography , Follow-Up Studies , Fundus Oculi , Humans , Intravitreal Injections , Male , Retinal Pigment Epithelium/drug effects , Retrospective Studies , Time Factors , Tomography, Optical Coherence , Wet Macular Degeneration/drug therapy
9.
Am J Ophthalmol ; 170: 15-24, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27381712

ABSTRACT

OBJECTIVE: In this study, we evaluated the correlation of retinal thickness with peripheral nerve conduction and autonomic nerve function in diabetic patients. DESIGN: Cross-sectional study. METHODS: Medical records of 160 patients (mean age, 63.61 ± 12.52 years) with diabetes without diabetic retinopathy or mild nonproliferative diabetic retinopathy (NPDR) were reviewed. The mean retinal thickness of the parafoveal area and ganglion cell/inner plexiform layer (GC-IPL) thickness in 6 macular regions were measured using optical coherence tomography. Peripheral nerve conduction studies were conducted on peroneal and posterior tibial motor nerves and the sural sensory nerve. Five cardiovascular autonomic function tests were performed. We classified patients into groups by severity of peripheral neuropathy and autonomic dysfunction and analyzed the correlations with mean retinal thickness. RESULTS: The mean retinal thickness of the parafovea was 315.05 ± 12.70 µm and mean macular GC-IPL thickness was 79.89 ± 4.70 µm. Macular GC-IPL thickness showed significant correlation with peripheral nerve conduction (no peripheral neuropathy vs definite peripheral neuropathy: 82.0 ± 4.8 µm vs 75.2 ± 3.8 µm, P < .001). GC-IPL thickness decreased with severity of autonomic nerve dysfunction (no/mild dysfunction vs severe dysfunction: 81.2 ± 6.6 µm vs 77.6 ± 5.9 µm, P = .005). There was no significant correlation between the retinal thickness of the parafovea and electrodiagnostic tests. CONCLUSION: The decrease of GC-IPL thickness was positively correlated with both peripheral nerve conduction and autonomic nerve function in diabetic patients who presented with no diabetic retinopathy or mild NPDR.


Subject(s)
Diabetic Neuropathies/physiopathology , Diabetic Retinopathy/physiopathology , Neural Conduction/physiology , Peroneal Nerve/physiology , Retina/pathology , Sural Nerve/physiology , Tibial Nerve/physiology , Aged , Cross-Sectional Studies , Diabetes Mellitus, Type 2/complications , Female , Humans , Male , Middle Aged , Nerve Degeneration/physiopathology , Retina/diagnostic imaging , Retinal Neurons/pathology , Tomography, Optical Coherence
10.
Ophthalmic Surg Lasers Imaging Retina ; 47(4): 313-21, 2016 Apr 01.
Article in English | MEDLINE | ID: mdl-27065369

ABSTRACT

BACKGROUND AND OBJECTIVE: To evaluate en face spectral-domain optical coherence tomography (SD-OCT) findings of the outer retinal hard exudates in diabetic macular edema (DME). PATIENTS AND METHODS: Exploratory analyses of prospective and consecutive case series. Fifty-five eyes treated with intravitreal ranibizumab (IVR) (Lucentis; Genentech, South San Francisco, CA) for 12 months were classified according to OCT features of DME: diffuse retinal thickening (DRT), cystoid macular edema (CME), and serous retinal detachment (SRD). Area fraction of outer nuclear layer (ONL) hard exudates (HEs) was assessed from en face OCT images. RESULTS: Area fraction of ONL HEs increased from 1.45% ± 1.22% to 2.24% ± 1.31% in DRT and from 2.24% ± 1.85% to 3.25% ± 1.52% in CME. HE gain was greatest during first 3 months (DRT = 0.83%; CME = 1.25%). SRD showed no difference in HEs (P = .462). CONCLUSIONS: ONL HEs increased in DRT and CME at month 12 following IVR. Rapid gain of HEs was found during the initial loading phase of IVR.


Subject(s)
Angiogenesis Inhibitors/therapeutic use , Diabetic Retinopathy/diagnosis , Macular Edema/diagnosis , Ranibizumab/therapeutic use , Retina/pathology , Subretinal Fluid , Tomography, Optical Coherence , Aged , Diabetic Retinopathy/drug therapy , Follow-Up Studies , Humans , Intravitreal Injections , Macular Edema/drug therapy , Male , Middle Aged , Vascular Endothelial Growth Factor A/antagonists & inhibitors
12.
Graefes Arch Clin Exp Ophthalmol ; 254(6): 1099-109, 2016 Jun.
Article in English | MEDLINE | ID: mdl-27086725

ABSTRACT

PURPOSE: To investigate structural changes in the retina by histologic evaluation and in vivo spectral domain optical coherence tomography (SD-OCT) following selective retina therapy (SRT) controlled by optical feedback techniques (OFT). METHODS: SRT was applied to 12 eyes of Dutch Belted rabbits. Retinal changes were assessed based on fundus photography, fluorescein angiography (FAG), SD-OCT, light microscopy, transmission electron microscopy (TEM), and scanning electron microscopy (SEM) at each of the following time points: 1 h, and 1, 3, 7, 14 and 28 days after SRT. BrdU (5'-bromo-2'-deoxy-uridine) incorporation assay was also conducted to evaluate potential proliferation of RPE cells. RESULTS: SRT lesions at1 h after SRT were ophthalmoscopically invisible. FAG showed leakage in areas corresponding to SRT lesions, and hyperfluorescence disappeared after 7 days. SD-OCT showed that decreased reflectivity corresponding to RPE damage was restored to normal over time in SRT lesions. Histologic analysis revealed that the damage in SRT lesions was primarily limited to the retinal pigment epithelium (RPE) and the outer segments of the photoreceptors. SEM and TEM showed RPE cell migration by day 3 after SRT, and restoration of the RPE monolayer with microvilli by 1 week after SRT. At 14 and 28 days, ultrastructures of the RPE, including the microvilli and tight junctions, were completely restored. The outer segments of the photoreceptors also recovered without sequelae. Interdigitation between the RPE and photoreceptors was observed. BrdU incorporation assay revealed proliferation of RPE on day 3 after SRT, and peak proliferation was observed on day 7 after SRT. CONCLUSION: Based on multimodal imaging and histologic assessment, our findings demonstrate that SRT with OFT could selectively target the RPE without damaging the neurosensory retina. Therefore, the use of SRT with OFT opens the door to the possibility of clinical trials of well-defined invisible and nondestructive retina therapy, especially for macular disease.


Subject(s)
Laser Therapy , Lasers, Solid-State/therapeutic use , Retina/surgery , Retinal Photoreceptor Cell Outer Segment/pathology , Retinal Pigment Epithelium/pathology , Retinal Pigment Epithelium/surgery , Animals , Antimetabolites/administration & dosage , Bromodeoxyuridine/administration & dosage , Cell Proliferation , DNA Replication , Fluorescein Angiography , Microscopy, Electron, Scanning , Multimodal Imaging , Photography , Rabbits , Retina/pathology , Retinal Pigment Epithelium/diagnostic imaging , Tomography, Optical Coherence
13.
Curr Eye Res ; 41(10): 1346-1352, 2016 10.
Article in English | MEDLINE | ID: mdl-26862705

ABSTRACT

PURPOSE: To evaluate the in vivo repeatability and reproducibility of spectral-domain optical coherence tomography (SD-OCT) measurements of total retinal thickness (TRT) and retinal nerve fiber layer (RNFL) thickness in rats. METHODS: Retinal thickness was measured using an RNFL circular scan with AutoRescan and TruTracking modes in 20 eyes of Long-Evans Tokushima Otsuka rats. Three RNFL circular scan images were acquired with a brief rest between measurements to evaluate intra-session repeatability. Three additional RNFL circular scans were acquired 1 day later to evaluate intersession repeatability. Two experienced examiners independently measured TRT using automatic alignment and RNFL thickness using manual alignment according to the same procedure to evaluate inter-examiner reproducibility 1 week later. The correlation of measurements by OCT and histology was determined. RESULTS: For TRT, the intra-session and inter-session intraclass correlation coefficient (ICC) with SD-OCT was between 0.85 and 0.93. The coefficient of variance (CV) ranged from 3.9% to 4.8%. For RNFL thickness, intra-session, and inter-session ICC with SD-OCT were between 0.61 and 0.91. The inter-examiner ICC was 0.74 for TRT and 0.70 for RNFL. The CV was 4.4% for TRT and 6.0% for RNFL. OCT and histologically determined TRT and RNFL thicknesses were significantly positively related based on Pearson's correlation coefficient (TRT, r = 0.781, p < 0.001; RNFL, r = 0.517, p = 0.019). CONCLUSIONS: TRT and RNFL thickness measurements using SD-OCT in rats had high intra-session and inter-session repeatability and inter-examiner reproducibility in vivo. This method will facilitate longitudinal studies to follow disease processes over time and to evaluate therapeutic effects after experimental intervention.


Subject(s)
Tomography, Optical Coherence/methods , Animals , Male , Models, Animal , Nerve Fibers , Rats , Rats, Long-Evans , Reference Values , Reproducibility of Results , Retinal Ganglion Cells/cytology
14.
Retina ; 36(3): 588-95, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26398695

ABSTRACT

PURPOSE: To evaluate the visual and morphologic outcomes of intravitreal ranibizumab (IVR) in eyes with diabetic macular edema (DME) based on the morphologic pattern on optical coherence tomography. METHODS: A prospective and consecutive series of 55 eyes with DME was classified according to OCT features: diffuse retinal thickening (DRT), cystoid macular edema (CME), and serous retinal detachment (SRD). Patients received three consecutive monthly injections of IVR and as needed thereafter. The primary outcome was the number of treatments undertaken by DME type over 12 months. Best-corrected visual acuity, retinal thickness, and microstructural changes were also evaluated. RESULTS: The eyes were classified as DRT (n = 23), CME (16), or SRD (16). The mean number of injections over 12 months was significantly different among the groups: DRT (3.69), CME (5.33), and SRD (5.09; P = 0.028). Best-corrected visual acuity of SRD (20/60) was significantly worse than that of the other types (DRT = 20/38; CME = 20/43; P = 0.015) after 12 months. CONCLUSION: Vision gains and retinal anatomy improvement were maintained in all three types during the first year of IVR administration. Especially, DRT maintained a good response to ranibizumab in a fewer number of injections. Disruption of the photoreceptor integrity at the baseline was correlated with poorer visual outcome and occurred more frequently in SRD.


Subject(s)
Angiogenesis Inhibitors/administration & dosage , Diabetic Retinopathy/drug therapy , Macular Edema/drug therapy , Ranibizumab/administration & dosage , Retina/pathology , Visual Acuity/physiology , Adult , Aged , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 2/complications , Diabetic Retinopathy/diagnosis , Diabetic Retinopathy/physiopathology , Female , Humans , Intravitreal Injections , Macular Edema/diagnosis , Macular Edema/physiopathology , Male , Middle Aged , Prospective Studies , Tomography, Optical Coherence , Vascular Endothelial Growth Factor A/antagonists & inhibitors
16.
Retina ; 35(12): 2567-73, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26035512

ABSTRACT

PURPOSE: To study changes in choroidal thickness (CT) after high-dose systemic corticosteroid treatment using spectral domain optical coherence tomography. METHODS: The authors reviewed medical records for 64 eyes of 32 children who receiving high-dose corticosteroid therapy with chronic glomerulonephritis and no ocular disease. Choroidal thickness was measured in a prospective manner in the same subfoveal area using an enhanced depth imaging technique with spectral domain optical coherence tomography at the same time daily. The possible correlation between CT and various factors was evaluated. RESULTS: Choroidal thickness decreased significantly during methylprednisolone pulse treatment. Mean decrease in CT was 15.42 ± 8.86 µm (range, 14-30 µm). In 10 eyes of 5 children with multiple hospitalizations and pulse treatments, a temporary decrease in CT was observed with methylprednisolone pulse treatment and after recovery without methylprednisolone pulse treatment. In multiple regression analysis, the number of previous methylprednisolone pulse treatments was the only factor associated with the mean amplitude of CT decrease (P = 0.011). CONCLUSION: High-dose systemic corticosteroid treatment significantly reduces CT. The effect of reducing the CT does not last after cessation of the treatment. The relation of central serous chorioretinopathy with corticosteroid treatment may not be based on the effect of corticosteroid treatment on CT.


Subject(s)
Anti-Inflammatory Agents/adverse effects , Choroid/pathology , Glomerulonephritis/drug therapy , Glucocorticoids/adverse effects , Methylprednisolone/adverse effects , Adolescent , Adult , Child , Choroid/drug effects , Chronic Disease , Female , Fluorescein Angiography , Humans , Male , Retrospective Studies , Tomography, Optical Coherence , Visual Acuity , Young Adult
17.
Retina ; 35(9): 1828-35, 2015 Sep.
Article in English | MEDLINE | ID: mdl-25923957

ABSTRACT

PURPOSE: To evaluate the topographic changes in macular ganglion cell-inner plexiform layer (GCIPL) thickness after vitrectomy with indocyanine green-guided internal limiting membrane (ILM) peeling in eyes with idiopathic macular hole. METHODS: This is a retrospective analysis of 58 consecutive eyes with surgically closed macular hole after vitrectomy with indocyanine green-guided ILM peeling. Further, 31 eyes that had undergone vitrectomy without ILM peeling were used as the control group. The macular GCIPL thickness was measured with spectral domain optical coherence tomography before vitrectomy and at 1 month and 6 months after vitrectomy. RESULTS: The preoperative mean GCIPL thickness was 78.79 µm and mean thickness at 1 month and 6 months after surgery significantly reduced progressively to 70.93 µm and 67.64 µm (P < 0.001 and P < 0.001, respectively). The postoperative mean GCIPL thickness was significantly lower than that of the group without ILM peeling at 1 month and 6 months postoperatively (P < 0.001, P < 0.001, respectively). The GCIPL thickness in the temporal area was significantly lower than in the nasal area at 1 month and 6 months postoperatively (P < 0.001, P < 0.001, respectively). CONCLUSION: A reduction of the macular GCIPL thickness was observed after vitrectomy with indocyanine green-guided ILM peeling for idiopathic macular hole, especially in the temporal area.


Subject(s)
Coloring Agents/administration & dosage , Epiretinal Membrane/surgery , Indocyanine Green/administration & dosage , Retinal Ganglion Cells/pathology , Retinal Perforations/surgery , Vitrectomy , Aged , Epiretinal Membrane/physiopathology , Female , Humans , Male , Middle Aged , Organ Size , Retinal Neurons/pathology , Retinal Perforations/physiopathology , Retrospective Studies , Tomography, Optical Coherence , Topography, Medical , Visual Acuity/physiology
18.
JAMA Ophthalmol ; 132(6): 714-23, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24676334

ABSTRACT

IMPORTANCE: Iatrogenic occlusion of the ophthalmic artery and its branches is a rare but devastating complication of cosmetic facial filler injections. OBJECTIVE: To investigate clinical and angiographic features of iatrogenic occlusion of the ophthalmic artery and its branches caused by cosmetic facial filler injections. DESIGN, SETTING, AND PARTICIPANTS: Data from 44 patients with occlusion of the ophthalmic artery and its branches after cosmetic facial filler injections were obtained retrospectively from a national survey completed by members of the Korean Retina Society from 27 retinal centers. Clinical features were compared between patients grouped by angiographic findings and injected filler material. MAIN OUTCOMES AND MEASURES: Visual prognosis and its relationship to angiographic findings and injected filler material. RESULTS: Ophthalmic artery occlusion was classified into 6 types according to angiographic findings. Twenty-eight patients had diffuse retinal and choroidal artery occlusions (ophthalmic artery occlusion, generalized posterior ciliary artery occlusion, and central retinal artery occlusion). Sixteen patients had localized occlusions (localized posterior ciliary artery occlusion, branch retinal artery occlusion, and posterior ischemic optic neuropathy). Patients with diffuse occlusions showed worse initial and final visual acuity and less visual gain compared with those having localized occlusions. Patients receiving autologous fat injections (n = 22) had diffuse ophthalmic artery occlusions, worse visual prognosis, and a higher incidence of combined brain infarction compared with patients having hyaluronic acid injections (n = 13). CONCLUSIONS AND RELEVANCE: Clinical features of iatrogenic occlusion of the ophthalmic artery and its branches following cosmetic facial filler injections were diverse according to the location and extent of obstruction and the injected filler material. Autologous fat injections were associated with a worse visual prognosis and a higher incidence of combined cerebral infarction. Extreme caution and care should be taken during these injections, and physicians should be aware of a diverse spectrum of complications following cosmetic facial filler injections.


Subject(s)
Adipose Tissue/transplantation , Arterial Occlusive Diseases/etiology , Cosmetic Techniques/adverse effects , Iatrogenic Disease , Ophthalmic Artery/physiopathology , Retinal Artery Occlusion/etiology , Adult , Arterial Occlusive Diseases/diagnostic imaging , Cross-Sectional Studies , Face , Female , Fluorescein Angiography , Humans , Hyaluronic Acid/administration & dosage , Hyaluronic Acid/adverse effects , Incidence , Injections, Intradermal/adverse effects , Male , Middle Aged , Prognosis , Radiography , Republic of Korea , Retinal Artery Occlusion/diagnostic imaging , Retrospective Studies , Risk Assessment , Societies, Medical , Transplantation, Autologous , Young Adult
19.
Korean J Ophthalmol ; 28(1): 91-5, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24505205

ABSTRACT

We report a case of complete surgical resolution of Valsalva retinopathy that manifested as a premacular hemorrhage involving a membrane followed by a macular hole (MH) resulting from the first vitrectomy. A 20-year-old female patient was referred to our hospital due to sudden vision loss in the left eye. Her best-corrected visual acuity (BCVA) in the left eye was hand motion. Fundus photographs and optical coherence tomography (OCT) revealed a premacular hemorrhage. Nine weeks later, the BCVA in the left eye had returned to 20 / 100 and the premacular hemorrhage had completely resolved, but residual sub-internal limiting membrane deposits and a preretinal membrane were present. The preretinal membrane was removed by core vitrectomy and preretinal membrane peeling, but the foveal deposits could not be excised. Two weeks after the first vitrectomy, the deposits resolved spontaneously, but a full-thickness MH was present. Six months after a second vitrectomy with fluid-gas exchange, the BCVA in the left eye had improved to 20 / 25 and OCT showed that the MH had closed. This case illustrates the possibility of MH formation following vitrectomy for Valsalva retinopathy.


Subject(s)
Epiretinal Membrane/surgery , Postoperative Complications , Retinal Perforations/surgery , Vitrectomy/adverse effects , Epiretinal Membrane/diagnosis , Female , Humans , Retinal Perforations/diagnosis , Retinal Perforations/etiology , Tomography, Optical Coherence , Young Adult
20.
Retina ; 34(2): 385-93, 2014 Feb.
Article in English | MEDLINE | ID: mdl-23873165

ABSTRACT

PURPOSE: To investigate diurnal variations in choroidal thickness (CT) in relation to various factors in healthy Korean subjects using spectral-domain optical coherence tomography. METHODS: A prospective study was conducted on 100 healthy volunteers who each underwent measurements of CT in the same subfoveal area using an enhanced depth imaging technique with spectral-domain optical coherence tomography at 8 AM, 11 AM, 2 PM, and 5 PM. Possible correlations between the diurnal variation of CT and other factors, such as sex, axial length (AL), baseline CT (8 AM), blood pressure, and intraocular pressure, were evaluated. RESULTS: One hundred volunteers with a mean age of 30.1 years were scanned. A significant pattern of diurnal variation was observed, with a mean CT of 278.28 ± 91.78 µm at 8 AM, 271.57 ± 89.08 µm at 11 AM, 266.39 ± 86.18 µm at 2 PM, and 264.92 ± 87.10 µm at 5 PM in a right eye. Right eye and left eye had a similar trend of diurnal cycle. Based on sex, AL, and baseline CT, the pattern of diurnal variation was greater and the amplitude significantly was greater in men, AL ≤ 24 mm and baseline CT ≥ 300 µm (men vs. women: P = 0.048, AL ≤ 24 mm vs. AL > 24 mm: P = 0.036, baseline CT ≥ 300 µm vs. baseline CT < 200 µm: P = 0.002, baseline CT ≥ 300 µm vs. 200 µm ≤ baseline CT < 300 µm: P = 0.008). There were no significant correlations between the diurnal variation of CT and systolic blood pressure, diastolic blood pressure, or intraocular pressure. CONCLUSION: In men as well as in those with a shorter AL and thick baseline CT, a greater pattern of diurnal variation with significantly greater amplitude was observed.


Subject(s)
Axial Length, Eye/anatomy & histology , Choroid/anatomy & histology , Circadian Rhythm/physiology , Adult , Asian People , Blood Pressure/physiology , Female , Healthy Volunteers , Humans , Intraocular Pressure/physiology , Male , Middle Aged , Organ Size , Prospective Studies , Republic of Korea , Sex Factors , Tomography, Optical Coherence , Young Adult
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