Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases.

Background: Summer and spring eruptions on the elbows are a variant of polymorphous light eruption described on clinical and histopathological grounds; however, to our knowledge, they have not been confirmed by photobiological studies. Objective: Based on photobiological studies, this study aimed to demonstrate the involvement of ultraviolet-A (UVA) radiation in this variant of polymorphous light eruption occurring exclusively on the elbows. Methods: A series of five patients with polymorphous light eruption lesions on the elbows were included in our study. All patients underwent phototesting and photoprovocation of the skin lesions after exposure to a UVA light source [Philips UVA HPA lamp (400 W)]. All patients underwent punch biopsy and histopathological and immunohistochemical studies with anti-CD123. Results: In all the cases, UVA irradiation caused the appearance of skin lesions on the elbows with characteristic polymorphous light eruption. Histological data showed edema in the superficial dermis and a perivascular lymphocytic infiltrate compatible with polymorphous light eruption. Immunohistochemical staining for CD1-23 showed negative results. Conclusions: For the first time, photobiological photoprovocation studies demonstrated that repeated exposure to UVA radiation leads to the generation of skin lesions on the elbows, which are clinically and histologically consistent with summer and spring eruptions, confirming that elbow rash is a variant of polymorphous light eruption.

Crohn's disease and Sweet's syndrome: A debut together.

The association of Sweet's syndrome and Crohn's disease is unusual, with less than 50 reported cases. We report a case in which these entities debut together.

Crohn’s disease and Sweet’s syndrome: a debut together / Debut conjunto de enfermedad de Crohn y síndrome de Sweet

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Chronology of metastasis in cutaneous melanoma: growth rate model.

In humans, it is not possible to obtain experimental evidence of when a cancer begins to metastasize. The purpose of this study was to estimate the time of onset of metastatic dissemination in cutaneous melanoma using a model based on its growth rate (GR). The critical time of onset of metastatic dissemination below which no cases of fatal melanomas were seen may be described with a potential function in which this time is inversely proportional to the GR. The critical time of development beyond which a melanoma may metastasize presents great variation. This time was just 1 month for those melanomas with a fast GR, whereas it was over 5 years for those with a very slow GR. Quantitatively, the fastest-growing melanomas began metastasizing with a greater thickness than the slowest-growing melanomas. A correlation exists between the critical time of onset of metastatic potential and the GR of the melanoma. These results may well have relevance to the understanding of mechanisms of tumor dissemination and for the design of future studies on melanomas, irrespective of whether they are basic studies on biomolecular mechamisms or clinical studies.

Erosive pustular dermatosis of the scalp: a successful treatment with photodynamic therapy.

Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disease of unknown aetiology that usually occurs in the elderly. It is characterized by sterile pustules, chronic crusted erosions, cicatricial alopecia, and skin atrophy. The histopathology is nonspecific, and its pathophysiology remains undetermined, with various types of local trauma possibly acting as the triggering factor. We describe a case of EPDS in a 75-year-old female in whom there was a marked response to photodynamic therapy with methyl 5-aminolaevulinic acid.

Successful treatment of perforating granuloma annulare with 0.1% tacrolimus ointment.

Perforating granuloma annulare (PGA) is a rare subtype of granuloma annulare (GA) named in 1971 by Owens and Freeman. It is characterized by necrobiotic areas surrounded by histiocytes and lymphocytes with transepidermal elimination. Many treatments for PGA have been used, often with unsatisfactory results. Tacrolimus in its topical formulation has been established as a safe and effective alternative to topical corticosteroids because of its mild side effects and its minimal systemic absorption. Topical tacrolimus has been approved for the treatment of atopic dermatitis; moreover, ample data exist which demonstrate the usefulness of tacrolimus for the specific treatment of other inflammatory diseases. We report a 70-year-old diabetic woman with PGA, in whom the ulceration due to PGA responded to 0.1% topical tacrolimus.

Keratosis lichenoides chronica: response to photodynamic therapy.

Keratosis lichenoides chronica (KLC) is a rare, acquired disorder of keratinization of unknown aetiology. The disease has a chronic and progressive course and is characterized by a poor response to almost all topical treatments and most systemic regimens. We report the first case of KLC in which there was a marked response in localized areas to photodynamic therapy (PDT) with methyl 5-aminolaevulinic acid (ALA).

Lepra en el tercer milenio. A propósito de cuatro casos en Málaga, dos autóctonos y dos importados / Leprosy in the third millenium. Four cases in Malaga, two autochthonous and two imported

Aunque los focos históricos de infección leprosa en nuestro país están controlados y prácticamente inactivos, se siguen diagnosticando algunos casosautóctonos aislados. Además, la existencia en los últimos años de una elevada inmigración procedente de zonas endémicas, hace cada vez más posiblela llegada de casos importados.Presentamos 4 pacientes, tres varones y una mujer, de 28, 30, 46 y 81 años de edad, afectos de lepra, dos de tipo lepromatoso, una borderline lepromatosay otra indeterminada. Dos casos eran autóctonos de Málaga y dos importados de Bolivia y Brasil, con diferencias en edad y actividad laboralentre ambos tipos de pacientes. Se destaca un caso de lepra lepromatosa florida en un paciente malagueño de edad avanzada que no se diagnosticóhasta que fue remitido a nuestro hospital por otro problema de salud

Although historical leprosy focus in our country are under control and show low activity, new cases from time to time are energing. In addition, the highimmigration in the last few years from endemic areas provide facilitates the arrival of imported cases.We report four cases of leprosy, three males and a female, 28, 30, 46 and 81-year-old, two with the lepromatous type, one borderline lepromatous andan undetermined one. Two patients are from Malaga and the other two come from Colombia and Brazil, with some differences in age and activityamong both types of patients. It is remarkable one case of lepromatous leprosy in an old patient from Malaga undiagnosed since he was seen at emergencyarea of our hospital for other health problem