Effect of Posterior Tibial Slope on Knee Kinematics After Bicruciate-Retaining Total Knee Arthroplasty.

Background: Following total knee arthroplasty (TKA), normal knee kinematics are rarely replicated. Retention of both cruciate ligaments (bicruciate retaining TKA) has helped this. Postoperative posterior tibial slope (PPTS) may further affect ligament tension and kinematics. The objective of this study is to determine how changes between the preoperative posterior tibial slope (PTS) and PPTS affect knee kinematics. Methods: Twenty bicruciate retaining TKAs were performed using standard instrumentation. Fluoroscopic kinematic data were obtained during gait and a single knee bend. Differences (Δ) between radiographic measurements of preoperative and PPTS were correlated with in-vivo knee kinematics. Patients were separated into 2 groups based on their Δ values. Group I consisted of Δ values less than 0.7, indicating either a similar PPTS compared to preoperative PTS or a slightly flatter PPTS. Group II consisted of Δ values above 0.7, indicating a steepened PPTS. Results: Preoperative PTS values ranged from -0.5° to 11.2°, with an average of 5.0° ± 3.4°. PPTS values ranged from 3.0° to 12.1°, with an average of 7.1° ± 3.1°. Weight-bearing range of motion (WBROM) measured from 94° to 139°, and femorotibial axial rotation ranged from -2.9° to 17.3°. A t-test revealed average values for WBROM in Group IT (Δ < 0.7) to be significantly greater than those for Group IIT (Δ > 0.7) (P = .01). Conclusions: These findings indicate that either a PPTS approximating the preoperative PTS or a slightly flattened PPTS in comparison (Δ < 0.7) is associated with WBROM greater than 130°. Values for axial rotation and anterior sliding were not significantly associated with changes to the PTS.

3D preoperative predictions of in vivo hip stability and edge loading for neutral and lipped liners.

Hip dislocation is one of the leading causes of failure and revision surgery for total hip arthroplasty. To reduce dislocation rates, lipped liners have been designed with an elevated portion of the rim, to increase jump distance and maintain greater contact area. While it has been documented that lipped liners help reduce dislocation, the objective of this study is to investigate whether lipped liners also help reduce smaller instances of hip micromotion, separation, and edge loading. This study uses an advanced three-dimensional preoperative planning tool to analyze 10 patients, each implanted with both a neutral and lipped liner. Patients within the simulation performed stance phase of gait, and each cup was implanted with the rotation center aligned with the preoperative acetabulum center as well as shifted medially by 2, 4, 6, 8, and 10 mm, yielding 120 total simulations. Specific postoperative outcomes-of-interest included specified component offset, resultant in vivo hip forces, hip separation, and contact area to evaluate edge loading. The planner predicted a reduction in hip separation and an increase in articulating contact area for when using a lipped liner compared to a neutral liner. Additionally, regardless of liner type, increases in hip separation corresponded to decreases in contact area, therefore resulting in edge loading of the liner. Together, this indicates that improper component alignment and offsets may lead to an increase in hip separation and edge loading, but the use of a lipped liner may provide improved stability and resistance to this micromotion.

Determination of optimal component positioning in THA using 3D preoperative planning.

Advancements in three-dimensional (3D) preoperative planning tools can offer surgeons and design engineers detailed feedback and additional opportunities for clinical advancements. The objective of this study is to use a 3D total hip arthroplasty preoperative planning tool to compare femoral component alignment for three different stem systems. The planning tool in this study used morphology data of femoral bones gathered from a CT database, seven from postoperative patients and 63 from statistical shape models (SSMs), to suggest specific implant sizes and optimal placements in 3D to match each specific bone model. Retrospective validations of predicted stem size and femoral version were first performed by comparing planner-chosen and surgeon-implanted stem sizes and version angles for the seven postoperative patients. Next, the alignment of three different stem systems was evaluated using bone models generated from SSMs, with a quantitative focus on component head positioning. In the validation study, the planner accurately selected stem size and orientation compared to the surgeon for all assessed subjects. In the stem evaluation, the three stem systems yielded different accuracies in component placement, with the newest stem system demonstrating the closest restoration of anatomical head center location. It is evident that new stem designs may have the potential for increased accuracy over their predecessors, demonstrating that new stem designs can offer improved intraoperative and postoperative alignment potential. The 3D preoperative planning tools can provide novel and reliable data to both surgeons and design engineers, which can ultimately improve clinical outcomes and future implant designs.

Alignment and mechanics evaluation for a compaction broach stem versus a blade style proximal press fit stem using 3-Dimensional planning.

Three-dimensional (3D) preoperative planning tools can be used to help plan and compare component alignment scenarios for different total hip arthroplasty systems to ultimately improve postoperative outcomes and patient satisfaction. The objective of this study is to use 3D preoperative planning tools based on patient-specific bone models to compare two different stem designs, specifically a compaction broach stem and a proximal press fit stem. The planner uses patient-specific proximal femoral bone morphology to suggest a specific implant size and placement. The planner then allows for preoperative predictions of component head positioning, stem fit within the canal, and potential cortical bone reaming that must be done, as well as postoperative predictions of stability and mechanics. The stems were evaluated to determine the accuracy of stem placement, the theoretical volumetric bone removal/reaming required to achieve a desired fit, and the associated postoperative mechanics. This study demonstrated that there was a difference in component alignment and predicted postoperative mechanics between a compaction broach stem and a press fit stem, with the compaction broach stem allowing for more accurate alignment with less required bone removal, resulting in improved postoperative stability and mechanics. This study also demonstrated that much of the stem misalignment for both systems occurred in the anterior/posterior direction. Overall, 3D preoperative planning offers significant benefits and novel intraoperative insight, and the industry should continue to enhance their THA preoperative planning tools.

Can Asymmetry in Total Knee Arthroplasty Design Lead to More Normal-Like Postoperative Kinematics? A Multi-Implant Evaluation.

BACKGROUND: Few studies have evaluated the effects of symmetrical versus asymmetrical implant designs, more specifically the femoral condyles, trochlear groove, joint line, and bearing surfaces. The objective of this study was to investigate multiple posterior cruciate-retaining (PCR) total knee arthroplasty (TKA) designs influencing factors related to TKA asymmetry, and to investigate whether asymmetry can improve postoperative knee kinematics. METHODS: In vivo tibio-femoral kinematics for 99 subjects was evaluated in this retrospective study. Overall, 10 subjects had a nonimplanted, normal knee, and 89 subjects had 1 of 3 PCR TKAs with varying degrees of asymmetry within their femoral and tibial components (PCR #1 = 30, PCR #2 = 29, PCR #3 = 30). All TKAs were implanted by the same surgeon and were analyzed using fluoroscopy during a deep knee bend. RESULTS: At full extension, all 3 PCR TKAs experienced a more posteriorized position of the femoral condyles compared to the normal knee, with the 2 asymmetrical PCR TKAs experiencing more anteriorization compared to the third, symmetrical PCR TKA. Both the normal knee and the PCR TKA with greatest amount of asymmetry experienced statistically more posterior femoral rollback of the lateral condyle than the other 2 PCR TKAs. The PCR TKA with greater asymmetry also experienced statistically greater range of motion than the other 2 PCR TKAs. CONCLUSIONS: With increasing flexion, the design with the most asymmetry also experienced the most posterior femoral rollback, axial rotation, and greatest range of motion. The results in this study seem to suggest that the inclusion of asymmetry in a TKA could be beneficial for achieving more normal-like kinematics and greater weight-bearing knee flexion.

In Vivo Weight-Bearing Kinematics for Constrained Versus Traditional Bicruciate Stabilized Total Knee Arthroplasty Cohorts Compared to the Normal Knee.

BACKGROUND: Constrained inserts in total knee arthroplasty (TKA) may offer additional stability, but can this insert type allow unrestricted movements or will the extra conformity cause kinematic conflict with the cam-post mechanism in deeper flexion? The objective of this study was to evaluate the weight-bearing kinematics of both traditional and constrained bicruciate stabilized (BCS) TKA inserts to determine if the rollback induced by the cam-post mechanism will work in unison with the constrained polyethylene insert. METHODS: This study used previously published 3-dimensional model fitting techniques to compare weight-bearing flexion and femoro-tibial condylar motion patterns for 20 patients who had a traditional insert, 20 patients who had a constrained insert, and 10 previously published nonimplanted knees, all performing a deep knee bend activity while under fluoroscopic surveillance. RESULTS: The results from this study indicate that subjects having a bicruciate stabilized TKA experienced similar postoperative kinematics for both constrained and unconstrained insert options, comparable to normal knees. CONCLUSIONS: Subjects in this study having either a constrained or traditional insert experienced progressive rollback of both condyles, with the lateral condyle rolling more posterior than the medial condyle, leading to axial rotation. Although less in magnitude, these results were comparable to the normal knee in pattern, indicating that kinematic conflict did not occur for subjects having a constrained insert.

Improved accuracy of implant placement with an imageless handheld robotic system compared to conventional instrumentation in patients undergoing total knee arthroplasty: a prospective randomized controlled trial using CT-based assessment of radiological outcomes.

PURPOSE: Image-free handheld robotic-assisted total knee arthroplasty (RATKA) has shown to achieve desired limb alignment compared to conventional jig-based instrumented total knee arthroplasty (CTKA). The aim of this prospective randomized controlled trial (RCT) was to evaluate the accuracy of a semi-autonomous imageless handheld RATKA compared to CTKA in order to achieve the perioperative planned target alignment of the knee postoperatively. METHODS: Fifty-two patients with knee osteoarthritis were randomized in 1:1 ratio to undergo unilateral CTKA or an imageless handheld RATKA. A full-length lower limb CT-scan was obtained pre- and 6-week postoperative. The primary outcomes were radiologic measurements of achieved target hip-knee-ankle axis (HKA-axis) and implant component position including varus and external rotation and flexion of the femur component, and posterior tibial slope. The proportion of outliers in above radiographic outcomes, defined as > 3° deviation in postoperative CT measurements as compared to perioperative planned target, were also noted. Knee phenotypes were compared with use of the Coronal Plane Alignment of the Knee (CPAK) classification. RESULTS: Baseline conditions were comparable between both groups. The overall proportion and percentage of outliers (n = 38, 24.4% vs n = 9, 5.8%) was statistically significant (p < 0.001) in favor of RATKA. The achieved varus-valgus of the femoral component (varus 1.3° ± 1.7° vs valgus - 0.1° ± 1.9°, p < 0.05) with statistically significant less outliers (0% vs 88.5%, p < 0.01), the achieved HKA-axis (varus 0.4° ± 2.1° vs valgus - 1.2° ± 2.1°, p < 0.05) and the posterior tibial slope (1.4° ± 1.1° vs 3.2° ± 1.8°, p < 0.05) were more accurate with RATKA. The most common postoperative CPAK categories were type II (50% CTKA vs 61.5% RATKA), type I (3.8% CTKA vs 23.1% RATKA) and type V (26.9% CTKA vs 15.4% RATKA). CPAK classification III was only found in CTKA (19.2%). Type VI, VII, VIII, and IX were rare in both populations. CONCLUSIONS: The present trial demonstrates that an imageless handheld RATKA system can be used to accurately perioperatively plan the desired individual component implant positions with less alignment outliers whilst aiming for a constitutional alignment. LEVEL OF EVIDENCE: I.

Advancements in total knee arthroplasty kinematics: 3D implant computer aided design model creation through X-ray or fluoroscopic images.

BACKGROUND: 3D-to-2D fluoroscopic registration is a popular and important step for analyzing total-knee-arthroplasty weight-bearing kinematics. Unfortunately, in vivo analyses using these techniques cannot be completed if the associated computer-aided design implant models are not available. This study introduces a novel method that enables the accessible computation of knee replacement patients' kinematics from fluoroscopy, achieved through the reconstruction of 3-dimensional knee component models using a limited set of 2-dimensional X-ray or fluoroscopic images. METHODS: The proposed non-rigid morphing algorithm, based on the coherent point drift algorithm, scales and transforms the shape of the template model to fit with the silhouette of the corresponding fluoroscopic images without changing the structure of the knee implant. While a greater number of fluoroscopic images can lead to higher accuracy, our study utilizes only 4 images. FINDINGS: The morphed models show excellent results in comparison with known models with a 0.52 mm average root-mean-square error and a 2.82 mm largest source error for 17 tested knee models of various implant types. The proposed algorithm also enables direct output of patient kinematics using fluoroscopy, with an average error of only 0.54 ± 0.42 mm for femorotibial contact and 0.86 ± 0.34 degrees for axial rotation. INTERPRETATION: A novel methodology was introduced to overcome common 3-dimentional to 2-dimensional registration limitations by recreating entire families of 3 dimensional models from a limited number of fluoroscopic images for both cruciate-retaining and posterior-stabilized knee replacement implants. Our algorithm has demonstrated high levels of accuracy with multiple potential extended applications.

Anatomic vs Dome Patella: Is There a Difference Between Fixed- vs Mobile-Bearing Posterior-Stabilized Total Knee Arthroplasties?

BACKGROUND: It has been hypothesized that the patella, working in conjunction with both medial and lateral femoral condyles, can influence kinematic parameters such as posterior femoral rollback and axial rotation. The objective of this study is to determine the in vivo kinematics of subjects implanted with a fixed-bearing (FB) or mobile-bearing (MB) posterior-stabilized (PS) total knee arthroplasty (TKA), with a specific focus on evaluating the impact that Anatomic and Medialized Dome patellar components have on tibiofemoral kinematic patterns. METHODS: Tibiofemoral kinematics were assessed for 40 subjects; 20 with an anatomic patella and 20 with a dome patella. Within these groups, 10 subjects received an FB PS TKA and 10 subjects received an MB PS TKA. All subjects were analyzed using fluoroscopy while performing a deep knee bend activity. Kinematics were collected during specific intervals to determine similarities and differences in regard to patella and bearing type. RESULTS: The greatest variation in kinematics was detected between the 2 Anatomic patellar groups. Specifically, the MB-Anatomic subjects experienced greater translation of the lateral condyle, the highest magnitude of axial rotation, and the highest range of motion compared to the FB-Anatomic subjects. Subjects with a Dome Patella displayed much variability among the average kinematics, with all parameters between FB and MB cohorts being similar. CONCLUSION: The findings in this study suggest that subjects with an Anatomic patellar component could have more normal kinematic patterns with an MB PS TKA as opposed to an FB PS TKA, while subjects with a Dome patella could achieve similar kinematics regardless of TKA type.

Effects of the Medial Plateau Bearing Insert Conformity on Mid-Flexion Paradoxical Motion in a Posterior-Stabilized Total Knee Arthroplasty Design.

BACKGROUND: One of the most common kinematic abnormalities reported for posterior-stabilized (PS) total knee arthroplasty (TKA) design is paradoxical anterior sliding during early and mid-flexion. PS TKAs have been designed such that the cam-post mechanism does not engage until later in flexion, making these implants vulnerable to anterior sliding during early and mid-flexion. The objective of this study is to investigate the biomechanical effect of increasing bearing conformity on a PS TKA. METHODS: Using a validated computational model of the knee joint, the sagittal conformity of the medial plateau of a PS TKA design was altered. Three scenarios were created and evaluated for mechanics: (1) baseline conformity, (2) increased conformity, and (3) decreased conformity. RESULTS: From full extension to approximately 70° of knee flexion, the medial condyle demonstrated minimal anterior sliding for the increased medial conformity design but revealed anterior sliding of 2 and 4 mm for the baseline and decreased conformity designs, respectively. After cam-post engagement, the medial condyle consistently rolled back for all 3 designs. The lateral condyle experienced consistent rollback throughout the entire flexion range for all 3 designs. However, femorotibial contact force was higher for the increased conformity design, peaking at 3.13 times body weight (×BW) compared to 3.0 × BW contact force for other 2 designs. CONCLUSION: Increasing medial conformity of the bearing insert appears to reduce mid-flexion sliding for PS TKA designs, although this comes at the expense of increased femorotibial forces. This could be due to kinematic conflicts that may be introduced with highly constraining designs.

Effects of Posterior Tibial Slope on a Posterior Cruciate Retaining Total Knee Arthroplasty Kinematics and Kinetics.

BACKGROUND: It has been hypothesized that increasing posterior tibial slope can influence condylar rollback and play a role in increasing knee flexion. However, the effects of tibial slope on knee kinematics are not well studied. The objective of this study is to assess the effects of tibial slope on femorotibial kinematics and kinetics for a posterior cruciate retaining total knee arthroplasty design. METHODS: A validated forward solution model of the knee was implemented to predict the femorotibial biomechanics of a posterior cruciate retaining total knee arthroplasty with varied posterior slopes of 0°-8° at 2° intervals. All analyses were conducted on a weight-bearing deep knee bend activity. RESULTS: Increasing the tibial slope shifted the femoral component posteriorly at full extension but decreased the overall femoral rollback throughout flexion. With no tibial slope, the lateral condyle contacted the polyethylene 6 mm posterior of the midline, but as the slope increased to 8°, the femur shifted an extra 5 mm, to 11 mm posterior of the tibial midline. Similar shifts were observed for the medial condyle, ranging from 7 mm posterior to 13 mm posterior, respectively. Increasing posterior slope decreased the posterior cruciate ligament tension and femorotibial contact force. CONCLUSION: The results of this study revealed that, although increasing the tibial slope shifted the femur posteriorly at full extension and maximum flexion, it reduced the amount of femoral rollback. Despite the lack of rollback, a more posterior location of condyles suggests lower chances of bearing impingement of the posterior femur and may explain why increasing slope may lead to higher knee flexion.

In Vivo Knee Kinematics: How Important Are the Roles of Femoral Geometry and the Cruciate Ligaments?

BACKGROUND: While posterior cruciate-retaining (PCR) implants are a more common total knee arthroplasty (TKA) design, newer bicruciate-retaining (BCR) TKAs are now being considered as an option for many patients, especially those that are younger. While PCR TKAs remove the ACL, the BCR TKA designs keep both cruciate ligaments intact, as it is believed that the resection of the ACL greatly affects the overall kinematic patterns of TKA designs. The objectives of this study are to assess the in vivo kinematics for subjects implanted with either a PCR or BCR TKA and to compare the in vivo kinematic patterns to the normal knee during flexion. These objectives were achieved with an emphasis on understanding the roles of the cruciate ligaments, as well as the role of changes in femoral geometry of nonimplanted anatomical femurs vs implanted subjects having a metal femoral component. METHODS: Tibiofemoral kinematics of 50 subjects having a PCR (40 subjects) or BCR (10 subjects) TKA were analyzed using fluoroscopy while performing a deep knee bend activity. The kinematics were compared to previously published normal knee data (10 subjects). Kinematics were determined during specific intervals of flexion where the ACL or PCL was most dominant. RESULTS: In early flexion, subjects having a BCR TKA experienced more normal-like kinematic patterns, possibly attributed to the ACL. In mid-flexion, both TKA groups exhibited variable kinematic patterns, which could be due to the transitional cruciate ligament function period. In deeper flexion, both TKA functioned more similar to the normal knee, leading to the assumption that the PCL was properly balanced and functioning in the TKA groups. Interestingly, during late flexion (after 90°), the kinematic patterns for all three groups appeared to be statistically similar. CONCLUSION: Subjects having a PCR TKA experienced greater weight-bearing flexion than the BCR TKA group. Subjects having a BCR TKA exhibited a more normal-like kinematic pattern in early and late flexion. The normal knee subjects achieved greater lateral condyle rollback and axial rotation compared to the TKA groups.

Can an OA Knee Brace Effectively Offload the Medial Condyle? An In Vivo Fluoroscopic Study.

BACKGROUND: Previous studies evaluating the effectiveness of OA offloading knee braces focused on qualitative results. The objective of this study was to analyze the effectiveness of an off-loading knee brace with respect to in vivo three-dimensional knee kinematics to quantitatively measure the changes in medial joint space and relative bone alignment when wearing the brace. METHODS: Twenty subjects diagnosed with medial compartmental joint space narrowing and varus deformity due to OA were recruited. During fluoroscopic surveillance, subjects performed normal gait on a treadmill with and without the brace. Images were sequenced at heel-strike and mid-stance during the weight-bearing portion of gait. 3D-to-2D image registration was performed on each subject using 3D bone models derived from CT segmentation and 3D ultrasound scans. RESULTS: Medial joint space was to increase when the brace was applied in all subjects (1.6 ± 0.7 mm at heel-strike, 1.6 ± 0.8 mm at mid-stance) and was statistically significant (P < .001). It was also found that sixteen of the twenty subjects experienced a medial joint space increase of more than 1.0 mm during heel-strike while thirteen of twenty experienced this change at mid-stance. While wearing the brace, over half of the subjects experienced a valgus correction to their alignment. CONCLUSIONS: All subjects in this study experienced a positive change in the medial joint space when wearing the offloading knee brace. In addition, many subjects also saw joint space values representative of previously documented, nonosteoarthritic subjects and valgus changes in bone alignment more akin to the normal knee.

Development of a hip joint mathematical model to assess implanted and non-implanted hips under various conditions.

While total hip arthroplasty does generally improve patient quality of life, current systems can still yield atypical forces, premature component wear, and abnormal kinematics compared to native joints. Specifically, common complications include instability, separation, sliding, and edge loading within the hip joint. Unfortunately, evaluating potential solutions to these issues can be costly and time-consuming. Fortunately, mathematical modeling is an accurate and efficient tool that can be used to evaluate potential solutions. A forward dynamics mathematical model of the hip allows users to virtually insert a hip implant into a theoretical patient and observe the predicted postoperative mechanics. The objective of this study is therefore to develop, validate, and use a fully functional forward solution mathematical model that allows for a comparison between various hip implant designs and a determination of factors leading to in vivo hip separation, instability, and edge loading. The model presented herein has been validated kinetically against telemetric data and kinematically against fluoroscopic data. It was determined through this research that shifting of the joint rotation center during total hip arthroplasty has the potential to yield postoperative instability, and surgical errors can exacerbate these outcomes. However, the relationships between subject-specific joint shifting and hip instability are extremely complex, and therefore it becomes essential for surgeons to focus on implanting components as accurately as possible to minimize these risks.

A Validated Forward Solution Dynamics Mathematical Model of the Knee Joint: Can It Be an Effective Alternative for Implant Evaluation?

BACKGROUND: Mathematical modeling is among the most common computational tools for assessing total knee arthroplasty (TKA) mechanics of different implant designs and surgical alignments. The main objective of this study is to describe and validate a forward solution mathematical of the knee joint to investigate the effects of TKA design and surgical conditions on TKA outcomes. METHODS: A 12-degree of freedom mathematical model of the human knee was developed. This model includes the whole lower extremity of the human body and comprises major muscles and ligaments at the knee joint. The muscle forces are computed using a proportional-integral-derivative controller, and the joint forces are calculated using a contact detection algorithm. The model was validated using telemetric implants and fluoroscopy, and the sensitivity analyses were performed to determine how sensitive the model is to both implant design, which was analyzed by varying medial conformity of the polyethylene, and surgical alignment, which was analyzed by varying the posterior tibial tilt. RESULTS: The model predicted the tibiofemoral joint forces with an average accuracy of 0.14× body weight (BW), 0.13× BW, and 0.17× BW root-mean-square errors for lateral, medial, and total tibiofemoral contact forces. With fluoroscopy, the kinematics were validated with an average accuracy of 0.44 mm, 0.62 mm, and 0.77 root-mean-square errors for lateral anteroposterior position, medial anteroposterior position, and axial rotation, respectively. Increasing medial conformity resulted in reducing the paradoxical anterior sliding midflexion. Furthermore, increasing posterior tibial slopes shifted the femoral contact point more posterior on the bearing and reduced the tension in the posterior cruciate ligament. CONCLUSION: A forward solution dynamics model of the knee joint was developed and validated using telemetry devices and fluoroscopy data. The results of this study suggest that a validated mathematical model can be used to predict the effects of component design and surgical conditions on TKA outcomes.

In Vivo Knee Kinematics for a Cruciate Sacrificing Total Knee Arthroplasty Having Both a Symmetrical Femoral and Tibial Component.

BACKGROUND: Early total knee arthroplasty (TKA) designs were symmetrical, but lead to complications due to over-constraint leading to loosening and poor flexion. Next-generation TKAs have been designed to include asymmetry, pertaining to the trochlear groove, femoral condylar shapes, and/or the tibial component. More recently, an advanced posterior cruciate sacrificing (PCS) TKA was designed to include both a symmetrical femoral component with a patented V-shaped trochlear groove and a symmetrical tibial component with an ultracongruent insert, in an attempt to reduce inventory costs. Because previous PCS TKA designs produced variable results, the objective of this study is to determine and evaluate the in vivo kinematics for subjects implanted with this symmetrical TKA. METHODS: Twenty-one subjects, implanted with symmetrical PCS fixed-bearing TKA, were asked to perform a weight-bearing deep knee bend (DKB) while under fluoroscopic surveillance. A 3-dimensional to 2-dimensional registration technique was used to determine each subject's anteroposterior translation of lateral and medial femoral condyles as well as tibiofemoral axial rotation and their weight-bearing knee flexion. RESULTS: During the DKB, the average active maximum weight-bearing flexion was 111.7° ± 13.3°. On average, from full extension to maximum knee flexion, subjects experienced -2.5 ± 2.0 mm of posterior femoral rollback of the lateral condyle and 2.5 ± 2.2 mm of medial condyle motion in the anterior direction. This medial condyle motion was consistent for the majority of the subjects, with the lateral condyle exhibiting rollback from 0° to 60° of flexion and then experienced an average anterior motion of 0.3 mm from 60° to 90° of knee flexion. On average, the subjects in this study experienced 6.6°± 3.3° of axial rotation, with most of the rotation occurring in early flexion, averaging 4.9°. CONCLUSION: Although subjects in this study were implanted with a symmetrical PCS TKA, they did experience femoral rollback of the lateral condyle and a normal-like pattern of axial rotation, although less in magnitude than the normal knee. The normal axial rotation pattern occurred because the lateral condyle rolled in the posterior direction, while the medial condyle moved in the anterior direction. Interestingly, the magnitude of posterior femoral rollback and axial rotation for subjects in this study was similar in magnitude reported in previous studies pertaining to asymmetrical TKA designs. It is proposed that more patients be analyzed having this TKA implanted by other surgeons.

In Vivo Determination and Comparison of Total Hip Arthroplasty Kinematics for Normal, Preoperative Degenerative, and Postoperative Implanted Hips.

BACKGROUND: The study objective is to analyze subjects having a normal hip and compare in vivo kinematics to subjects before and after receiving a total hip arthroplasty. METHODS: Twenty subjects, 10 with a normal hip and 10 with a preoperative, degenerative hip were analyzed performing normal walking on level ground while under fluoroscopic surveillance. Seven preoperative subjects returned after receiving a total hip arthroplasty using the anterior surgical approach by a single surgeon. Using 3-dimensional to 2-dimensional registration techniques, joint models were overlayed on fluoroscopic images to obtain transformation matrices in the image space. From these images, displacements of the femoral head and acetabulum centers were computed, as well as changes in contact patches between the 2 surfaces throughout the gait cycle. RESULTS: Implanted hips experienced the least amount of separation, compression, and overall sliding throughout the entire gait cycle, but they did show signs of edge loading contact patterns. Conversely, the degenerative hips experienced the most compression, sliding, and separation, with the maximum amount of sliding being 6.9 mm. The normal group ranged in the middle, with the maximum amount of sliding being 1.75 mm. CONCLUSION: Current analysis revealed trends that degenerative hips experience more abnormal hip kinematics that leads to higher articulating surface forces and stresses within the acetabulum. None of the implanted hips experienced hip separation.

Self-perspective leads to increased activation of pain processing brain regions in fibromyalgia.

BACKGROUND: Dysfunction of central nervous pain processing is assumed to play a key role in primary fibromyalgia (FM) syndrome. This pilot study examined differences of pain processing associated with adopting different interpersonal perspectives. METHODS: Eleven FM patients and 11 healthy controls (HC) were scanned with functional magnetic resonance imaging. Participants were trained to take either a self-perspective or another person's perspective when viewing the visual stimuli. Stimuli showed body parts in painful situations of varying intensity (low, medium, and high) and visually similar but neutral situations. RESULTS: Patients with FM showed a higher increase in blood oxygen level dependent (BOLD) response, particularly in the supplementary motor area (SMA). All pain-related regions of interest (anterior insula, somatosensory cortices, anterior cingulate cortex, and SMA) showed stronger modulation of BOLD responses in FM patients in the self-perspective. In contrast to pain processing regions, perspective-related regions (e.g. temporoparietal junction) did not differ between FM and HC. CONCLUSIONS: The stronger response of all four pain processing cerebral regions during self-perspective is discussed in the light of disturbed bottom-up processing. Furthermore, the results confirm earlier reports of augmented pain processing in FM, and provide evidence for sensitization of central nervous pain processing.

Political science. When contact changes minds: an experiment on transmission of support for gay equality.

Can a single conversation change minds on divisive social issues, such as same-sex marriage? A randomized placebo-controlled trial assessed whether gay (n = 22) or straight (n = 19) messengers were effective at encouraging voters (n = 972) to support same-sex marriage and whether attitude change persisted and spread to others in voters' social networks. The results, measured by an unrelated panel survey, show that both gay and straight canvassers produced large effects initially, but only gay canvassers' effects persisted in 3-week, 6-week, and 9-month follow-ups. We also find strong evidence of within-household transmission of opinion change, but only in the wake of conversations with gay canvassers. Contact with gay canvassers further caused substantial change in the ratings of gay men and lesbians more generally. These large, persistent, and contagious effects were confirmed by a follow-up experiment. Contact with minorities coupled with discussion of issues pertinent to them is capable of producing a cascade of opinion change.

Confirmation of long-term in vivo bearing mobility in eight rotating-platform TKAs.

BACKGROUND: Posterior-stabilized rotating-platform prostheses for TKAs were designed to improve contact mechanics at the femoral-polyethylene (PE) interface. Short-term followup studies have shown that the PE bearings rotate with respect to the tibia but might not necessarily track with the femur. It is important to know how kinematics in these designs change owing to long-term in vivo use. QUESTIONS/PURPOSES: We asked whether there is a significant change in the in vivo kinematic performance of a posterior-stabilized rotating-platform prosthesis at as much as 10 years postoperative. We specifically examined (1) relative femoral component-PE bearing and relative PE bearing-tibial tray motion; (2) relative AP motion of the femoral condyles with respect to the tibial tray; and (3) relative femorotibial condylar translations. METHODS: In vivo three-dimensional kinematics were evaluated for eight patients at 3 months, 15 months, 5 years, and 10 years after TKA with primary implantation of a posterior-stabilized rotating-platform prosthesis. Each patient performed deep knee bend activity, and three-dimensional kinematics were reconstructed from multiple fluoroscopic images using a three-dimensional to two-dimensional registration technique. Once complete, relative component axial rotation patterns, medial and lateral condyle motions throughout flexion, and the presence of femoral condylar lift-off were analyzed. RESULTS: Overall, tibial bearing rotation was maintained at 10 years postoperatively. There was no statistical difference between postoperative periods for any kinematic parameter except for femoral component-PE bearing axial rotation, which was reduced at the 10-year evaluation versus other assessment periods (p = 0.0006). The lack of statistical difference between postoperative evaluation periods indicates sustained overall implant kinematic performance. CONCLUSIONS: Our study showed that PE bearing-tibial tray mobility was maintained and that femoral component-PE bearing rotation was reduced at the 10-year followup. This suggests that the overall kinematic performance of this mobile-bearing implant is not negatively affected 10 years postoperatively. LEVEL OF EVIDENCE: Level III, retrospective study. See the Instructions for Authors for a complete description of levels of evidence.