ABSTRACT
BACKGROUND: Cardiovascular disease (CVD) is one of the most important causes of death in developing countries. The current study evaluates the serum 25-hydroxyvitamin D (25OHD), phosphate and calcium levels in patients with angiographically-defined coronary artery disease (CAD) and healthy subjects in a sample population in northeastern Iran. METHODS: There were 566 subjects aged between 20-80 years out of whom283 subjects with CAD were divided into two study groups based on their angiogram results; those withâ¯>â¯50% stenosis of one or more coronary arteries and those withâ¯≤â¯50% stenosis. Serum 25OHD levels and anthropometric parameters were measured for all subjects. RESULTS: There were approximately 53% (nâ¯=â¯303) males and 47% (nâ¯=â¯269) females in the population sample. We found that crude serum 25OHD concentrations were significantly higher in both the Angio- (21.6⯱â¯11.8â¯ng/ml) and Angio+ (21.3⯱â¯10.2â¯ng/ml) groups compared to the control subjects (16.4⯱â¯9.5â¯ng/ml) (Pâ¯<â¯0.001). CONCLUSION: The findings show that 25OHD state could be a risk factor for CAD, although this would need to be explored further, taking the potential confounding effects of diet into account in future studies.