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Molecules ; 17(9): 11229-41, 2012 Sep 20.
Article in English | MEDLINE | ID: mdl-22996346

ABSTRACT

Bioassay-guided fractionation of hexane extracts of Gymnosperma glutinosum (Asteraceae) leaves, collected in North Mexico, afforded the known compounds hentriacontane (1) and (+)-13S,14R,15-trihydroxy-ent-labd-7-ene (2), as well as the new ent-labdane diterpene (-)-13S,14R,15-trihydroxy-7-oxo-ent-labd-8(9)-ene (3). In addition, D-glycero-D-galactoheptitol (4) was isolated from the methanolic extract of this plant. Their structures were established on the basis of high-field 1D- and 2D NMR methods supported by HR-MS data. The cytotoxic activity was determined by using the in vitro L5178Y-R lymphoma murine model. Hentriacontane (1) and the new ent-labdane 3 showed weak cytotoxicity, whereas the ent-labdane 2 showed significant (p < 0.05) and concentration dependent cytotoxicity (up to 78%) against L5178Y-R cells at concentrations ranging from 7.8 to 250 µg/mL.


Subject(s)
Antineoplastic Agents/isolation & purification , Antineoplastic Agents/pharmacology , Cycadopsida/chemistry , Diterpenes/isolation & purification , Diterpenes/pharmacology , Plant Leaves/chemistry , Animals , Antineoplastic Agents/chemistry , Cell Line, Tumor , Diterpenes/chemistry , Drug Discovery , Drug Screening Assays, Antitumor , Hydrocarbons/chemistry , Hydrocarbons/isolation & purification , Hydrocarbons/pharmacology , Lymphoma/drug therapy , Mice , Plant Extracts/chemistry , Plant Extracts/pharmacology
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