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1.
Case Rep Womens Health ; 32: e00345, 2021 Oct.
Article in English | MEDLINE | ID: mdl-34354932

ABSTRACT

INTRODUCTION: Cervical myomectomy can compromise cervical integrity and the risk of subsequent cervical incompetence is unclear. In this case report, the literature on cervical myomectomies is reviewed as well as that on the potential benefits of cervical cerclage. CASE PRESENTATION: A 30-year-old woman, nulligravida, with a 12 cm cervical leiomyoma consulted for heavy menstrual bleeding and pelvic pain. After failure of multiple medical therapies, a laparoscopic cervical myomectomy was successfully performed after pre-operative uterine artery embolization using absorbable gelatin sponges to reduce surgical blood loss. DISCUSSION: A concomitant laparoscopic cerclage was achieved in order to prevent cervical incompetence, given that the full thickness of the anterior cervix was penetrated during the myomectomy.

2.
J Minim Invasive Gynecol ; 19(1): 128-30, 2012.
Article in English | MEDLINE | ID: mdl-22196263

ABSTRACT

A 46-year-old woman had an unusual complication from uterine myoma embolization by development of extensive necrosis with subsequent uterine perforation at the location of a previous myomectomy. We suggest that a scarred uterus may be a risk factor for uterine fibroid embolization complications, such as uterine necrosis.


Subject(s)
Embolization, Therapeutic/adverse effects , Leiomyoma/therapy , Uterine Neoplasms/therapy , Uterine Perforation/etiology , Uterus/pathology , Female , Humans , Leiomyoma/surgery , Middle Aged , Necrosis/etiology , Uterine Artery , Uterine Neoplasms/surgery
3.
Contraception ; 77(6): 447-55, 2008 Jun.
Article in English | MEDLINE | ID: mdl-18477496

ABSTRACT

OBJECTIVE: The objective of this study was to evaluate the vaginal distribution of a microbicidal gel (Invisible Condom) before, during and after simulated intercourse using an artificial phallus. The gel was delivered using either a new proprietary vaginal applicator (PVA), which has multiple lateral and apical holes, or a commercial applicator (CA), which has a single apical hole. The persistence of the gel was evaluated up to 24 h after its administration. STUDY DESIGN: Nine women (five women using the PVA and four women using the CA) applied the vaginal gel once, and pelvic images were taken immediately after application. An artificial phallus was inserted and the women had 30 vaginal thrusts, then another set of images was taken while the phallus was still inside the vagina. On exit of the phallus, one more set of images was taken. Images were subsequently taken at 30 min, 2 h, 6 h and 24 h after gel application. RESULTS: Immediately after gel application, the PVA distributed the gel throughout the vaginal/cervical mucosae, while the CA delivered the gel only to the cervical area. During simulated intercourse, the phallus further pushed the gel delivered with the CA into the fornix, whereas it spread the gel delivered with the PVA more evenly throughout the mucosal surface. After simulated intercourse, both applicators gave similar gel distributions between 30 min and 6 h after application. However, at 24 h, using the PVA, only 5% of the gel persisted in the vagina, compared to 40% of the gel using the CA. DISCUSSION AND CONCLUSION: Using the new PVA, the Invisible Condom covered the vaginal/cervical mucosae before and during simulated intercourse, offering immediate protection, whereas only the cervical mucosa was covered using the CA. Forty percent of the gel persisted mostly in the upper vaginal/cervical area at 24 h following its administration with the CA, while only 5% of the gel was left using the PVA. The new applicator, with its unique design, ensures an even and immediate coating lasting throughout the first 6 h and could prevent potential microbicide vaginal toxicity at 24 h.


Subject(s)
Drug Delivery Systems , Sodium Dodecyl Sulfate/administration & dosage , Sodium Dodecyl Sulfate/pharmacokinetics , Spermatocidal Agents/administration & dosage , Spermatocidal Agents/pharmacokinetics , Vagina/metabolism , Administration, Intravaginal , Anti-Infective Agents/administration & dosage , Anti-Infective Agents/pharmacokinetics , Cervix Uteri/metabolism , Coitus/physiology , Female , Humans , Magnetic Resonance Imaging , Tissue Distribution , Vaginal Creams, Foams, and Jellies/administration & dosage , Vaginal Creams, Foams, and Jellies/pharmacokinetics
4.
Can J Cardiol ; 24(2): 145-7, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18273490

ABSTRACT

Two cases of life-threatening recurrent hemoptysis occurring 10 years after a Fontan operation are presented. Bleeding from aortopulmonary collateral vessels was responsible for this complication in both cases, and the importance of systematic selective angiography of all potential origins of such abnormal vessels, including those arising from the abdominal aorta, is highlighted. Although coil embolization of aortopulmonary collateral vessels is usually definitive, pulmonary lobectomy may be necessary. The present report demonstrates, for the first time, that rescue extracorporeal membrane oxygenation support can be used as a bridge to surgery in case of severe uncontrollable hemoptysis in such cases.


Subject(s)
Fontan Procedure/adverse effects , Hemoptysis/etiology , Adolescent , Adult , Collateral Circulation , Embolization, Therapeutic , Heart Defects, Congenital/surgery , Humans , Male , Polyvinyl Alcohol/administration & dosage , Recurrence , Retreatment , Sclerosing Solutions/administration & dosage
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