The immunomodulatory nutritional intervention NR100157 reduced CD4+ T-cell decline and immune activation: a 1-year multicenter randomized controlled double-blind trial in HIV-infected persons not receiving antiretroviral therapy (The BITE Study).

BACKGROUND: The immunomodulatory nutritional product NR100157 was developed for human immunodeficiency virus (HIV)-infected individuals. We hypothesized that targeting the compromised gastrointestinal tract of HIV-infected individuals would result in systemic immunological benefits. METHODS: In a multicenter, randomized, controlled, double-blind trial, 340 HIV-1-positive adults not on antiretroviral therapy, with CD4(+) T-cell counts <800/µL, were given either NR100157 or an isocaloric and isonitrogenous control for 52 weeks. Primary outcome was CD4(+) T-cell count. Secondary outcomes included plasma viral load (pVL), safety, and tolerability. In a pilot study (n = 20), levels of CD4(+)CD25(+) and CD8(+)CD38(+) activation were measured (n = 20). The trial is registered at the Dutch Trial Register (NTR886) and ISRCTN81868024. RESULTS: At 52 weeks, CD4(+) T-cell decline showed a 40-cell/µL difference (P = .03) in the intention-to-treat population in favor of the immunomodulatory NR100157 (control vs active, -68 ± 15 vs -28 ± 16 cells/µL/year). The change in pVL from baseline was similar between groups (P = .81). In the pilot study, the percentage of CD4(+)CD25(+) was lower in the active group (P < .05) and correlated with changes in CD4(+) T-cell count (r = -0.55, P < .05). The percentage of CD8(+)CD38(+) levels was unaffected. CONCLUSIONS: The specific immunonutritional product NR100157 significantly reduces CD4(+) decline in HIV-1-infected individuals, and this is associated with decreased levels of CD4(+)CD25(+). (This nutritional intervention is likely to affect local gut integrity and gut-associated lymphoid tissue homeostasis, which in turn translates positively to systemic effects.) Clinical Trials Registration. ISRCTN81868024.

Drunk in public, drunk in private: the relationship between college students, drinking environments and alcohol consumption.

This study examines environmental differences in public (bars) and private (parties) drinking settings among of-age (21 and up years of age) and underage (18-20 years of age) college students attending college near the US/Mexico border. A random telephone survey of graduate and undergraduate students attending two large public universities in the southwestern United States was conducted during the 2000-2003 academic years. A university-based social science research laboratory conducted the telephone interviews with respondents who reported an occasion in the past 28 days where alcohol was being consumed (N = 4,964). The data were analyzed using ordinary least squares multiple regression. The results suggests that drinking settings contributed to the amount of alcohol consumed by respondents. Additionally, environmental factors contributing to drinking vary by setting. In general, having many people intoxicated at an event, BYOB parties, playing drinking games, and having illicit drugs available contribute to heavier drinking.

Traumatísmo craneoencefálico por accidente con vehículos de dos ruedas / Head injury and accident by two wheels vehicles

En los EE.UU., el traumatísmo craneoencefálico (TCE) es la principal causa mortis entre individuos de 10 a 44 años y constituye por más del 50 por ciento de los órbitos por trauma alcanzado, por lo tanto, una importante parcela económicamente activa de la población. El uso de vehículos de dos ruedas, sea como medio de transporte, recreación o para la práctica de deportes, no está exento de accidentes, siendo el TCE relevante consecuencia de esa práctica y la principal causa de muerte e invalidez. Se realizó un estudio prospectivo de 20 pacientes atendidos en el Hospital Universitario Vírgen de la Arrixaca, Murcia, España, con diagnóstico de TCE por caída de vehículo de dos ruedas, en el período de enero a junio de 2002, utilizando un protocolo patrón, el cual fue rellenado por el autor o por el equipo del hospital. En nuestra muestra, hubo una nítida predominancia del sexo masculino (95 por ciento de los casos), siendo el grupo más afectado el de los jóvenes de 11 a 20 años, con el 65 por ciento de los casos. Hubo 17 accidentes por motocicleta y tres por bicicleta. En el primer grupo, siete (41,2 por ciento) usaban casco y entre los usuarios de bicicleta, dos (67 por ciento). En todo el muestreo, el uso de casco fue relatado por el 45 por ciento de los pacientes. La tomografía computarizada (TC) fue el método de elección para la evaluación de esos pacientes, pues es un método rápido que tiene la posibilidad de reconocer a los pacientes que necesitan intervención quirúrgica. En cuanto a las lesiones encontradas en las imágenes por TAC, el 85 por ciento del muestreo evidenció la presencia de lesiones intracraneales, siendo el hematoma subdural la más frecuente, seguido de la hemorragia subaracnoidea, la contusión cerebral y el edema cerebral. El tratamiento instituído fue conservador en la mayoría de los casos, siendo en apenas 5 pacientes (25 por ciento) necesaria la cirugía. El tiempo medio de internación fue significativamente más alto en los pacientes sometidos a tratamiento quirúrgico en relación al grupo sometido a tratamiento conservador (26,6 días y 15,3 días, respectivamente). La mortalidad fue de 10 por ciento (2 pacientes). La atención en el lugar del accidente es de importancia fundamental para reducir el número de óbitos y secuelas después del traumatísmo en general y el TEC en particular.

Youth escaping limits on drinking: binging in Mexico.

AIMS: In Tijuana, Mexico, a loosely enforced age-18 law and inexpensive drinks have given rise to a nightclub district frequented by thousands of young Southern Californians each weekend night. Surveys were designed to characterize the extent of the cross-border binge-drinking traffic and to support and evaluate the community's response. DESIGN: Over 1 year, two anonymous and voluntary breath-test surveys were done. Drivers and pedestrians were pulled randomly from the stream of northbound border crossers and recruited to participate. SETTING: Surveys occurred between 12 a.m. and 4 a.m. on randomly selected Wednesdays, Fridays, and Saturdays. Participants were recruited within the Port of Entry building. PARTICIPANTS: Of the 5849 border crossers recruited, 87.4% participated in the survey. MEASUREMENTS: Information was obtained through a standardized verbal interview. All participants were asked to take an alcohol breath test. FINDINGS: On weekend nights, more than 6500 people cross back into the United States between 12 a.m. and 4 a.m. after drinking or visiting a bar or restaurant. Pedestrians represent the highest concentration of drinkers, with more than 30% having BACs of 0.08 or greater. Most of these pedestrians return to parked vehicles on the US side and drive or ride home. CONCLUSIONS: The flow of young binge drinkers at the Tijuana border is substantial and translates into a significant public health problem for the region as crossers use their vehicles to drive home. There are many such binge-drinking locales. However, the border is unique in that it is amenable to scientific estimations of the problem with relatively high precision.

Defining binge drinking quantities through resulting BACs.

Binge drinking as a researchable construct has generally been defined as 5 or more drinks on one occasion. However, no study has been conducted to determine if the binge concept that implies "excessive drunkenness" is being optimally captured within that level. Random interviews with breath tests of drinkers returning from visiting bars in Tijuana provide both blood alcohol concentration (BAC) measurements and the self-reported number of drinks consumed. Results indicate that currently used definitions of binge drinking predict relatively low BACs and may not be capturing the "excessive drunkenness" quality of the term. Consumption duration may explain the lower BACs.

A survey of the San Diego-Tijuana cross-border binging. Methods and analysis.

On a typical weekend night between 12:00 a.m. and 4:00 a.m., about 4 thousand Americans 25 or younger cross back into the United States from a night in Tijuana, Mexico, clubs. More than 40% of the drinkers return the next morning with an illegal blood-alcohol concentration (.08 or higher). To study this phenomenon and to provide data with which to evaluate the community effort in San Diego County, a border research effort involving two separate surveys of individuals entering and leaving Mexico was established in June 1997. This article briefly reviews past roadside survey studies and reports on the survey methods developed to conduct these surveys and the procedure required to analyze the data collected.

Health care cost containment: how Pittsburgh is addressing the challenge.

Rapidly escalating health care costs have the public and private sectors searching for methods to provide health care benefits in a more efficient manner. Efforts have also been underway at the community level with the development of health care coalitions created to build consensus toward a fair solution for all parties affected. With the assistance of the Robert Wood Johnson Foundation and many local co-sponsors, the Pittsburgh Program for Affordable Health Care (PPAHC) was organized to address health care cost containment issues in the greater Pittsburgh area. One of the means by which PPAHC chose to achieve this was through the development of a Model Utilization Management Program. This is a document containing community-sanctioned administrative and clinical standards for utilization review which take into consideration the needs and concerns of providers, purchasers, and consumers, and which have a goal of reducing medically unnecessary inpatient hospitalization while concurrently maintaining quality of and access to care. This article describes both the process and the product of PPAHC's efforts toward health care cost containment in Pittsburgh, specifically focusing on its utilization management component.