Lack of association between month of birth and risk of developing type 1 diabetes in Brazil: a 40-year analysis.

OBJECTIVES: Seasonal environment at birth may influence diabetes incidence in later life. We sought evidence for this effect and analyzed the association between the month of birth and the risk of developing type 1 diabetes mellitus (T1DM). METHODS: This was a cohort study carried out with 814 patients diagnosed with T1DM in the region of Bauru - São Paulo State, Brazil, receiving medical care in a private Endocrinology clinic or in the public Brazilian National Health Care System, from 1981 to 2021. All live births that occurred in São Paulo State between 1974 and 2020 were classified by month of birth and were considered as the control group. RESULTS: We found no statistically significant difference (χ2=16.31, critical 19.68) between the month of birth and risk of developing T1DM, when comparing our patients with the background population of the region. There was no association between the month of birth, sex, age at diagnosis, duration of symptoms before diagnosis, self-reported color, and socioeconomic status. CONCLUSIONS: We found no association between month of birth and the risk of developing T1DM in this highly admixed South American population. Our data suggest that our population heterogeneity and geographic location may be important factors in the development of T1DM. Future prospective studies, evaluating environmental factors that may confer risk or protection to the disease, are warranted.

Avaliação do volume urinário: comparação do desempenho do equipamento de ultrassonografia portátil de bexiga Mobissom® com o equipamento de mesa / Urinary volume assessment: comparison of the performance of Mobissom® portable bladder ultrasound equipment with tabletop equipment

Este estudo teve como objetivo comparar o desempenho do equipamento de ultrassonografia portátil de bexiga Mobissom® com o equipamento de ultrassonografia de mesa para avaliar o volume de urina da bexiga. Foram analisadas 192 imagens de 16 pacientes adultos que realizaram o exame. Os volumes vesicais obtidos pelo equipamento portátil foram arquivados na forma de imagem e, posteriormente, comparados com o laudo ultrassonográfico da avaliação realizada por um aparelho ultrassonográfico de mesa. Os resultados obtidos foram comparados por meio do Teste t pareado e as diferenças foram distribuídas graficamente pelo método de Bland & Altmann. No resultado geral, não houve diferenças significativas entre os dois equipamentos. Conclui-se que o equipamento, apesar da limitação na visibilização de outros órgãos, é de fácil utilização e relevante para avaliação beira leito.

This study aimed to compare the performance of Mobissom® portable bladder ultrasound equipment with tabletop ultrasound equipment to assess bladder urine volume. 192 images of 16 adult patients who underwent the exam were analyzed. The bladder volumes obtained by the portable equipment were archived in the form of an image and, later, compared with the ultrasound report of the evaluation performed by a tabletop ultrasound device. The results obtained were compared using the paired t test and the differences were graphically distributed using the Bland & Altmann method. In the overall result, there were no significant differences between the two devices. It is concluded that the equipment, despite the limitation in the visualization of other organs, is easy to use and relevant for bedside assessment.