ABSTRACT
Polyfepan, a sorbent, included in the complex of therapeutic measures for the patients with exacerbations of chronic enterocolitis, has considerably reduced the terms necessary to arrest the major symptoms of the condition vs. the reference group. The effect was the most manifest when the sorbent was combined with polyenzyme drugs. Laboratory tests and rat experiments have helped validate polyfepan action as the agent binding microorganisms and their toxins on its surface and fixing the enzyme vector at the site of the pathologic process.
Subject(s)
Bacterial Infections/drug therapy , Enterocolitis/drug therapy , Enterotoxins/antagonists & inhibitors , Lignin/therapeutic use , Adsorption , Adult , Antitoxins , Chronic Disease , Female , Humans , Male , Middle AgedABSTRACT
Experimental rats were subjected to an extreme action: 3-hour immobilization with simultaneous electrostimulation. A complete healing of erosion-ulcerous defects of the gastroduodenal mucosa was recorded in rats given diets with an increased (by 4 g) protein content (group I), on day 5. The mucosal affections in the rats receiving a standard ration still persisted. The content of creatine-phosphate in the gastric wall tissue, decreased under the extreme action, was rapidly recovered in group I rats, no changes in the proper fluorescence level of reduced NADH and flavoproteins were noted. In group II rats both parameters returned to normal only on day 5. Blood serum ceruloplasmin (CP) activity increased during first 3 days with a similar rate in both animal groups. However, in the following 2 days CP activity in group I rats became completely normal, while that in group II animals was still rising. The results of the study have shown that the diet with increased protein content stimulates epithelization of the gastroduodenal mucosa due to the improvement of the bioenergy processes in the gastroduodenal area, and to intensified adaptation potentialities of the body.