ABSTRACT
Angiosarcoma (AS) is a malignant mesenchymal neoplasm of endothelial origin with a predominantly lymphatic immunophenotype, which accounts for less than 1% of all sarcomas. Cutaneous AS of the scalp is associated with high rates of local recurrence and a poor prognosis. Histologically, poorly differentiated AS often comprises solid epithelioid cells, although rare variants involving spindle cells have been reported; diagnosis requires immunohistochemical analysis using vascular cell markers. We report on a cutaneous spindle-cell AS of the scalp in a female patient; key features included spontaneous regression after biopsy, local recurrence 2 years later, and aberrant nuclear staining for S100 protein in an area of the tumor not expressing CD34 or D2-40. Tumor cells exhibited positivity for vascular markers CD31, CD34, D2-40, ERG and FLI-1 and were negative for myoid markers (αSMA and desmin), epithelial (EMA and cytokeratin AE1/AE3) and melanocyte markers (HMB45 and melan-A). Cutaneous spindle-cell AS of the scalp is a rare variant with a poor prognosis. Diagnosis of spindle-cell AS was confirmed by immunohistochemical analysis using CD31, CD34, ERG, FLI-1, podoplanin (D2-40), and claudin-5. Although a number of authors have noted aberrant expression of cytokeratins, CD30, CD117 and neuroendocrine markers (synaptophysin and chromogranin A) in AS, intense positive nuclear staining for S100 protein in neoplastic cells has not hitherto been observed. This article reports on a spindle-cell AS of the scalp notable for aberrant expression of S100, spontaneous regression and recurrence 2 years later at the same site and displaying identical histological and immunohistochemical features.
Subject(s)
Hemangiosarcoma/pathology , Neoplasm Regression, Spontaneous/pathology , S100 Proteins/biosynthesis , Scalp/pathology , Skin Neoplasms/pathology , Aged, 80 and over , Biomarkers, Tumor/analysis , Female , Humans , Neoplasm Recurrence, Local/pathology , S100 Proteins/analysisABSTRACT
Objetivos. El leiomiosarcoma de vesícula seminal es un tumor poco frecuente, por lo que existen pocos datos en relación con el tratamiento óptimo, así como el beneficio que aporta el tratamiento adyuvante. Métodos y resultados. Describimos un caso de leiomiosarcoma de vesícula seminal en un paciente de 65 años de edad. Conclusión. Los leiomiosarcomas son tumores malignos con mal pronóstico, y la exéresis quirúrgica completa es el tratamiento de elección(AU)
Aims. Leiomyosarcoma of the seminal vesicle is extremely rare and very little information is available on how best it should be treated. The advantage of adjuvant therapy treatment is unclear. Methods and results. We report a case of leiomyosarcoma arising from the seminal vesicle in a 65-year-old man. Conclusion. Leiomyosarcoma is a malignant neoplasm with a poor prognosis and radical surgical excision is the treatment of choice(AU)
Subject(s)
Humans , Male , Middle Aged , Leiomyosarcoma/diagnosis , Leiomyosarcoma/pathology , Leiomyosarcoma/surgery , Prognosis , Leiomyosarcoma , Seminal Vesicles/pathology , Chemotherapy, Adjuvant/methods , Radiotherapy, AdjuvantABSTRACT
Los carcinomas verrugosos de vagina son neoplasias poco frecuentes, con un crecimiento lento, localmente invasivo, que no suelen metastatizar y con unas características macro y microscópicas específicas. Describimos un caso de carcinoma verrugoso de cúpula vaginal en paciente postmenopáusica histerectomizada 4 años antes por prolapso uterino grado IV, discutiéndose su diagnóstico diferencial y tratamiento. El carcinoma verrugoso de vagina es un tumor poco frecuente que plantea el diagnóstico diferencial con el condiloma acuminado, el carcinoma escamoso clásico y el condilomatoso, siendo el tratamiento de elección la exéresis quirúrgica completa (AU)
Verrucous carcinoma of the vagina is a rare neoplasm. This entity is a slow-growing, locally invasive but generally nonmetastasizing neoplasm, with a characteristic gross and microscopic appearance.We report a case of verrucous carcinoma of the vagina in a postmenopausal woman diagnosed 4 years after transvaginal hysterectomy for grade 4 uterine prolapse. We also discuss the differential diagnosis and treatment.Verrucous carcinoma of the vagina is a rare neoplasm. The differential diagnosis includes typical squamous cell carcinoma, warty carcinoma, and condyloma acuminatum. Surgery remains the most effective treatment (AU)
Subject(s)
Humans , Female , Aged , Carcinoma, Verrucous/complications , Carcinoma, Verrucous/diagnosis , Uterine Prolapse/complications , Uterine Prolapse/diagnosis , Uterine Prolapse/surgery , Vaginal Neoplasms/diagnosis , Vaginal Neoplasms/surgery , Carcinoma, Verrucous/physiopathology , Carcinoma, Verrucous , Uterine Prolapse/physiopathology , Uterine Prolapse , Vaginal Neoplasms , Epithelial Cells/pathology , Epithelial Cells , Epithelial Cells/ultrastructure , Diagnosis, DifferentialABSTRACT
Los tumores ováricos de células de la granulosa son neoplasias poco frecuentes, que se caracterizan por un curso clínico indolente con tendencia a presentar recurrencias tardías.Describimos un caso de tumor de células de la granulosa de patrón difuso sarcomatoide en una paciente posmenopáusica y se discuten su diagnóstico diferencial y tratamiento.Los tumores de células de la granulosa son neoplasias poco frecuentes, cuyo tratamiento de elección es quirúrgico con seguimiento prolongado debido al riesgo de recurrencias tardías. El patrón difuso sarcomatoide puede plantear dificultades diagnósticas con sarcomas y lesiones benignas como el tecoma (AU)
Granulosa-cell tumors are rare malignant neoplasms characterized by a long natural history and a tendency to recur years after the initial diagnosis.We report a case of granulosa-cell tumor with a diffuse sarcomatoid growth pattern in a postmenopausal woman and discuss the differential diagnosis and treatment of this entity.Granulosa-cell tumors are rare neoplasms. The treatment of choice is surgery with prolonged post-therapeutic follow-up due to the risk of late recurrences. Granulosa-cell tumors with a diffuse sarcomatoid pattern can be mistaken for sarcomas and benign lesions such as thecoma (AU)
Subject(s)
Humans , Female , Middle Aged , Granulosa Cell Tumor/complications , Granulosa Cell Tumor/diagnosis , Bignoniaceae/complications , Bignoniaceae/diagnosis , Magnetic Resonance Spectroscopy/standards , Immunohistochemistry/methods , Immunohistochemistry/trends , Endometriosis/complications , Endometriosis/diagnosis , Diagnosis, Differential , Sarcoma/complications , Sarcoma/diagnosis , Biomarkers/analysis , PrognosisABSTRACT
Los sarcomas del estroma endometrial son neoplasias malignas poco frecuentes originadas en el estroma endometrial, que pueden presentar varias formas de diferenciación, incluidos diferenciación muscular lisa y tipo cordones sexuales. Describimos un caso de sarcoma del estroma endometrial con diferenciación tipo cordones sexuales en una paciente posmenopáusica, y se discute su diagnóstico diferencial y tratamiento. Los sarcomas del estroma endometrial son neoplasias heterogéneas con diferenciación multipotencial y su diferenciación tipo cordones sexuales puede plantear dificultades diagnósticas (AU)
Endometrial stromal sarcomas are rare malignant neoplasms arising from the endometrial stroma. These tumors may exhibit several forms of differentiation, including smooth muscle and sex cord differentiation. We report a case of endometrial stromal sarcoma with sex cord-like differentiation in a postmenopausal woman and discuss the differential diagnosis and treatment of this entity. Endometrial stromal sarcomas are heterogeneous neoplasms with multipotential differentiation. A uterine tumor resembling an ovarian sex cord tumor may pose diagnostic difficulties
Subject(s)
Humans , Female , Aged , Sarcoma, Endometrial Stromal/diagnosis , Sex Cord-Gonadal Stromal Tumors/diagnosis , Uterine Neoplasms/pathology , Sarcoma, Endometrial Stromal/surgery , Diagnosis, DifferentialABSTRACT
OBJECTIVE: Differential diagnosis of a testicular mass includes inflammatory conditions, malignant tumors and traumatic lesions, including hematomas and hematocele. METHODS/RESULTS: We report two cases of chronic hematocele. We discuss the clinico-radiologic characteristic and differential diagnosis. CONCLUSION: Hematocele is difficult to diagnose preoperatively because its symptoms may mimic cysts or neoplasms.
Subject(s)
Hematocele/diagnosis , Testicular Neoplasms/diagnosis , Aged, 80 and over , Chronic Disease , Diagnosis, Differential , Humans , Male , Middle AgedABSTRACT
OBJECTIVE: To identify markers of response to therapy in neuroblastic tumors. STUDY DESIGN: A total of 58 patients with neuroblastic tumor (38 neuroblastomas, 13 ganglioneuroblastomas and 7 ganglioneuromas) were included in the study. TP53, BCL-2, p21Waf1/Cip1 and metallothionein were included as a biologic approach to tumor differentiation, response to therapy and prognosis. RESULTS: Patients who died of disease had the following immunophenotype: BCL-2 (9 of 10), nuclear TP53 (7 of 10) and metallothionein (7 of 10). TP-53 expression was related to clinical stage (p = 0.062) and disease outcome (p = 0.0218). All patients in whom treatment failed expressed metallothionein (3 of 3). CONCLUSION: TP53, BCL-2, p21Waf1/Cip1 and metallothionein had limited value reflecting tumor maturation (differentiation) or predicting response to therapy. Only nuclear TP53 accumulation may be relevant in patient's prognosis.
Subject(s)
Biomarkers, Tumor/metabolism , Cyclin-Dependent Kinase Inhibitor p21/metabolism , Metallothionein/metabolism , Neuroblastoma/drug therapy , Proto-Oncogene Proteins c-bcl-2/metabolism , Tumor Suppressor Protein p53/metabolism , Adolescent , Adult , Cell Differentiation , Child , Female , Ganglioneuroblastoma/diagnosis , Ganglioneuroblastoma/drug therapy , Ganglioneuroblastoma/pathology , Humans , Male , Neuroblastoma/diagnosis , Neuroblastoma/pathology , PrognosisABSTRACT
Introducción: Los quistes de inclusión epidérmica intraóseos son lesiones benignas poco frecuentes que no suelen diagnosticarse antes de la intervención quirúrgica por tratarse de lesiones poco conocidas. Material, métodos y conclusión: Describimos dos casos de quiste de inclusión epidérmica intraóseo de falange distal, realizando una descripción clínico-radiológica y discutiéndose los diagnósticos diferenciales de esta infrecuente lesión
Introduction: Intraosseous epidermoid inclusion cysts are rare benign lesions. A correct diagnosis is rarely made before operation by radiologists or surgeons primarily because of failure to recognize this entity. Patients and methods: Two cases of intraosseous epidermal cyst in distal phalanx are described. Conclusions: Clinicoradiologic aspects and differential list of diagnoses of this uncommon lesion are reviewed