ABSTRACT
BACKGROUND: Laryngeal involvement in inflammatory bowel disease is rare. Only 12 cases of laryngeal involvement in Crohn disease have been reported until now. Moreover, only one case of laryngeal manifestations in ulcerative colitis has been reported so far. MATERIALS AND METHODS: In this article, we present a patient with ulcerative colitis, who consulted our ear, nose, and throat (ENT) clinic with laryngeal complaints. Furthermore, a review of current literature was performed. RESULTS: A concise overview of this rare extraintestinal manifestation and other ENT manifestations of inflammatory bowel diseases is provided. CONCLUSIONS: Laryngeal manifestations in inflammatory bowel disease are very rare, but these manifestations should be known by the otorhinolaryngologist.
Subject(s)
Colitis, Ulcerative/complications , Laryngeal Diseases/etiology , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Colitis, Ulcerative/diagnostic imaging , Colitis, Ulcerative/drug therapy , Female , Humans , Laryngeal Diseases/diagnostic imaging , Laryngeal Diseases/drug therapy , Mesalamine/therapeutic use , Young AdultABSTRACT
Lipoid proteinosis is a rare cause of voice problems. Hoarseness is often the first clinical manifestation of this disorder and can present years before any other symptom. Therefore, it is very important as an otorhinolaryngologist to be familiar with the main characteristics of this disease. We present a case report and a review of current literature to provide a concise overview of this frequently missed diagnosis.
Subject(s)
Glottis/physiopathology , Hoarseness/etiology , Lipoid Proteinosis of Urbach and Wiethe/complications , Voice Quality , Adult , Female , Fiber Optic Technology , Glottis/pathology , Hoarseness/pathology , Hoarseness/physiopathology , Humans , Laryngoscopy , Lipoid Proteinosis of Urbach and Wiethe/genetics , Lipoid Proteinosis of Urbach and Wiethe/pathology , Lipoid Proteinosis of Urbach and Wiethe/physiopathology , PrognosisABSTRACT
OBJECTIVE: The purpose of this study is to establish normative values for the smoothed cepstral peak prominence (CPPS) and its sensitivity and specificity as a measure of dysphonia. STUDY DESIGN: Prospective cohort study. METHODS: Voice samples of running speech were obtained from 835 patients and 50 volunteers. Eight laryngologists and four speech-language pathologists performed perceptual ratings of the voice samples on the degree of dysphonia/normality using an analog scale. The mean of their perceptual ratings was used as the gold standard for the detection of the presence or absence of dysphonia. CPPS was measured using the CPPS algorithm of Hillenbrand, and the cut-off value for positivity that has the highest sensitivity and specificity for discriminating between normal and severely dysphonia voices was determined based on ROC-curve analysis. RESULTS: The cut-off value for normal for CPPS was set at 4.0 or higher, which gave a sensitivity of 92.4%, a specificity of 79%, a positive predictive value of 82.5%, and a negative predictive value of 90.8%. The area under the receiver operating characteristic (ROC) curve was 0.937 (P < 0.05). CONCLUSIONS: CPPS is a good measure of dysphonia, with the normal value of CPPS (Hillenbrand algorithm) of a running speech sample being defined as a value of 4.0 or higher.