ABSTRACT
Our aim was to investigate the effectiveness of navigated transcranial magnetic stimulation (nTMS) brain mapping to characterise preoperative motor impairment caused by an intradural extramedullary (IDEM) tumour and postoperative cortical functional reorganisation. Preoperative and 1-year follow-up clinical, radiological and nTMS data from a case of thoracic spinal meningioma that underwent surgical resection of the lesion were collected and compared. A 67-year-old patient presented with severe progressive thoracic myelopathy (hypertonic paraparesis, clonus, insensate urinary retention) secondary to an IDEM tumour. Initial nTMS assessment showed bilateral upper limb representation with no positive responses for both lower limbs. He underwent successful surgical resection for his IDEM (meningioma WHO grade 1). At 1-year follow-up, the patient's gait was improved and his bladder function normalised. nTMS documented positive responses for both upper and lower limbs and a decrease in the area (right side: 1.01 vs 0.39cm2; left side: 1.92 vs 0.81cm2) and volume (right side: 344.2 vs 42.4uVcm2; left side: 467.1 vs 119uVcm2) of cortical activation for both upper limbs, suggesting a functional reorganisation of the motor areas after tumour resection. nTMS motor mapping and derived metrics can characterise preoperative motor deficit and cortical plasticity during follow-up after IDEM resection.
ABSTRACT
INTRODUCTION: Traumatic brain injury (TBI) is a leading cause of death and morbidity worldwide. Evidence-based guidelines for managing severe TBI have been available for over 25 years. However, adherence to guidelines remains variable despite evidence highlighting improvement in outcomes with individual recommendations. There is limited evidence to support a superior outcome with compliance to whole sets of recommendations. The aim of this review was to determine whether adherence to TBI guidelines as a package improves outcomes in adults and paediatric patients with severe TBI. METHODS: A structured literature search was conducted using the MEDLINE®, Embase™, PubMed and CINAHL® (Cumulative Index to Nursing and Allied Health Literature) databases. Studies were considered eligible for inclusion in this review if they were quantitative studies investigating the use of TBI guidelines in relation to one or more of the following outcomes: mortality, functional outcome and length of hospital stay. RESULTS: Nine cohort studies were identified that fulfilled the inclusion criteria and answered the clinical question. A review of these papers was conducted. CONCLUSIONS: Mortality after severe TBI improves with increasing adherence to evidence-based guidelines in both adults and children. The evidence also suggests that compliance with guideline recommendations results in improved functional outcomes and reduced length of hospital stay.
Subject(s)
Brain Injuries, Traumatic , Guideline Adherence , Adult , Humans , Child , Brain Injuries, Traumatic/therapy , Cohort Studies , Length of Stay , Databases, FactualABSTRACT
INTRODUCTION: Spinal solitary fibrous tumors are rare entities, particularly when considered in a dumbbell-shaped form. CASE DESCRIPTION: The authors report on a 23-year-old female patient with dorsalgia and a D11-D12 dumbbell-shaped lesion on MRI, and highly vascularized on angiography. After a biopsy-based diagnosis, an integrated approach was performed with a preoperative embolization of the feeding intercostal arteries and an en bloc resection. At 3 months postoperatively, the patient had no pain or other neurologic symptoms and a complete resection was performed and documented on MRI. CONCLUSION: To our knowledge, only 3 previous reports of dumbbell-shaped spinal solitary fibrous tumors were carried-out and this is the first case, to our knowledge, treated by pre-operatory embolization. Nevertheless, this tumor should be considered among other spinal dumbbell-shaped lesions with a differential diagnosis, i.e. meningioma and schwannoma.
