[Paramecium test for toxic substances in the blood of humans exposed to conditions simulating weightlessness]. / Parametsiinyi test na toksicheskie veshchestva v krovi cheloveka, nakhodiashchegosia v usloviiakh, modeliruiushchikh nevesomost'.

The Paramecium test was for the first time used to measure the build-up of toxic substances in the healthy man exposed to simulated weightlessness. The most distinct changes were seen on bed rest days 3 and 7-8 in all test subjects (41 subjects). After bed rest day 8 the parameter reached a plateau, the toxicity level stopped to increase, but the Paramecium test time remained shorter than normal. It can therefore be suggested that the prognosis of any disease that may develop in this situation will be worse. In view of this it is important to improve the prophylaxis and treatment of endogenous and exogenous intoxications during space flight and to provide active detoxication based on the purification of biological fluids by sorption.

[Experience in the use of standard perfusion packings for hemosorption]. / Opyt ispol'zovaniia standartnoi perfuzionnoi nasadki dlia provedeniia gemosorbtsii.

A fixture for locking the perfusion packing to all types of the standard bottles with non-threaded neck is proposed. It consists of a metal ring, a yoke and two stop screws. The fixture has been clinically tested in the course of 45 hemosorption procedures.

[Changes in several indicators of blood rheology in experiments simulating weightlessness]. / Izmenenie nekotorykh reologicheskikh pokazatelei krovi v eksperimentakh, modeliruiushchikh nevesomost'.

Changes in blood rheological parameters of 21 male volunteers, aged 25-37 years, were studied. The test subjects were subdivided into three groups. Nine subjects of Group 1 were exposed to head-down tilting (-8 degrees) for 14 days, six subjects of Group 2 were exposed to 7-day continuous immersion, and six subjects of Group 3 to intermittent immersion. During head-down tilting the apparent viscosity and hematocrit and then caisson viscosity increased. By day 7 the coefficient of red blood cell aggregation decreased significantly. These changes persisted till the end of the tilt study. The above rheological parameters returned to normal three days after the exposure. During continuous immersion the apparent viscosity showed the largest changes. Other specific changes included a moderate decrease of hematocrit, lack of significant changes in the yield limit of blood and a tendency towards an increase in the erythrocyte aggregation coefficient. Three days after the exposure the blood viscosity was much higher than before the study. During intermittent immersion rheological changes were induced by the first 36-hour exposure when shifts in blood viscosity and other parameters were most significant. It should be noted that following this exposure 72 hours of normal motor activity did not result in the normalization of the above rheological parameters.