Effects of wrist tendon vibration and eye movements on manual aiming.

In the present study, we investigated whether visual information mediates a proprioceptive illusion effect induced by muscle tendon vibration in manual aiming. Visual information was gradually degraded from a situation in which the targets were present and participants (n = 20; 22.3 ± 2.7 years) were permitted to make saccadic eye movements to designated target positions, to a condition in which the targets were not visible and participants were required to perform cyclical aiming while fixating a point between the two target positions. Local tendon vibration applied to the right wrist extensor muscles induced an illusory reduction of 15% in hand movement amplitude. This effect was greater in the fixation than in the saccade condition. Both anticipatory control and proprioceptive feedback are proposed to contribute to the observed effects. The primary saccade amplitude was also reduced by almost 4% when muscle tendon vibration was locally applied to the wrist. These results confirm a tight link between eye movements and manual perception and action. Moreover, the impact of the proprioceptive illusion on the ocular system indicates that the interaction between systems is bidirectional.

Manual aiming in healthy aging: does proprioceptive acuity make the difference?

The present study examines whether non-active older adults are more dependent on visual information when executing aiming movements and whether age-related declines in proprioception play a mediating role herein. Young (N = 40) and older adults (N = 38) were divided into physically active and non-active subgroups based on self-reported sports participation levels. In experiment 1, participants executed wrist-aiming movements with and without visual feedback. In experiment 2, passive proprioceptive acuity was assessed using wrist motion detection and position matching tests. Results showed similar aiming accuracy across age groups both with and without visual feedback, but older adults exhibited longer movement times, prolonged homing-in phase, and made more corrective submovements. Passive proprioceptive acuity was significantly affected by physical activity level and age, with participants in the active group scoring better than their non-active peers. However, these declines did not predict performance changes on the aiming task. Taken together, our observations suggest that decline in proprioceptive acuity did not predict performance changes on the aiming task and older adults were able to compensate for their decreased motion and position sense when allowed sufficient time. In line with these observations, we proposed that older adults are able to compensate for their decline in proprioception by increasing their reliance on predictive models.

Factors underlying age-related changes in discrete aiming.

Age has a clear impact on one's ability to make accurate goal-directed aiming movements. Older adults seem to plan slower and shorter-ranged initial pulses towards the target, and rely more on sensory feedback to ensure endpoint accuracy. Despite the fact that these age-related changes in manual aiming have been observed consistently, the underlying mechanism remains speculative. In an attempt to isolate four commonly suggested underlying factors, young and older adults were instructed to make discrete aiming movements under varying speed and accuracy constraints. Results showed that older adults were physically able to produce fast primary submovements and that they demonstrated similar movement-programming capacities as young adults. On the other hand, considerable evidence was found supporting a decreased visual feedback-processing efficiency and the implementation of a play-it-safe strategy in older age. In conclusion, a combination of the latter two factors seems to underlie the age-related changes in manual aiming behaviour.

Unraveling the relationship between trait negative affectivity and habitual symptom reporting.

OBJECTIVE: In two studies, we aimed at further elucidating the relationship between trait negative affectivity (NA) and habitual symptom reporting (HSR) by relating these variables to measures of executive function, trait questionnaires, and effects of emotion induction. METHODS: Healthy female participants (N = 75) were selected on their scores for trait NA and for the Checklist for Symptoms in Daily Life. Three groups were compared: (1) low NA-low HSR; (2) high NA-low HSR; and (3) high NA-high HSR (low NA-high HSR did not occur). In study 1, participants underwent a Parametric Go/No-go Task and a Stroop Color-Word test, and trait questionnaires measured alexithymia and absorption. Forty-five participants (N = 15 in each group) were further engaged in study 2 to induce state NA using an affective picture paradigm. RESULTS: Impaired inhibition on the Stroop and Go/No go Task characterized high trait NA, but not high HSR, whereas alexithymia and absorption were elevated in HSR, regardless of trait NA. Negative picture viewing induced elevated state NA in all groups, but only high HSR also reported more bodily symptoms. This effect was moderated, but not mediated by state NA. CONCLUSION: High trait NA is a vulnerability factor but not a sufficient condition to develop HSR. Deficient inhibition is related to the broad trait of NA, whereas the moderating effect of state NA on symptom reporting is specific for high HSR. Understanding processes related to alexithymia and absorption may specifically help to explain elevated HSR.

The impact of age and physical activity level on manual aiming performance.

Older adults traditionally adapt their discrete aiming movements, thereby traveling a larger proportion of the movement under closed-loop control. As the beneficial impact of a physically active lifestyle in older age has been described for several aspects of motor control, we compared the aiming performance of young controls to active and sedentary older adults. To additionally determine the contribution of visual feedback, aiming movements were executed with and without saccades. Results showed only sedentary older adults adopted the typical movement changes, highlighting the impact of a physically active lifestyle on manual aiming in older age. In an attempt to reveal the mechanism underlying the movement changes, evidence for an age-related decline in force control was found, which in turn resulted in an adapted aiming strategy. Finally, prohibiting saccades did not affect older adults' performance to a greater extent, suggesting they do not rely more on visual feedback than young controls.

Both age and physical activity level impact on eye-hand coordination.

Aging impacts on our ability to perform goal-directed aiming movements. Older adults generally make slower and shorter initial impulses towards the end target, and therefore require more time for corrections in the final movement stage. Recent studies however suggest that a physically active lifestyle may attenuate these age-related changes. Also, it remains unclear whether eye-movement control exhibits a similar pattern of adaptation in older adults. Therefore, the first aim of this study was to describe how age and physical activity level impact eye-hand coordination during discrete manual aiming. Young and older participants were divided into physically active and sedentary subgroups, and performed discrete aiming movements while hand and eye movements were recorded. Secondly, to determine whether older adults depend more on vision during aiming, the task was repeated without visual feedback. The results revealed that the typical age-related hand movement adaptations were not only observed in older, but also in sedentary young participants. Older and sedentary young participants also spent more hand movement time after the eyes fixated the end target. This finding does not necessarily reflect an augmented reliance on vision, as all groups showed similar aiming errors when visual feedback was removed. In conclusion, both age and physical activity level clearly impacted eye-hand coordination during discrete manual aiming. This adapted coordination pattern seems to be caused by other factors than an increased reliance on vision.

Hemispheric asymmetries in goal-directed hand movements are independent of hand preference.

Asymmetries in the kinematics and neural substrates of voluntary right and left eye-hand coordinated movements have been accredited to differential hemispheric specialization. An alternative explanation for between-hand movement differences could result from hand preference related effects. To test both assumptions, an experiment was conducted with left- and right-handers performing goal-directed movements with either hand paced by a metronome. Spatiotemporal accuracy was comparable between hands, whereas hand peak velocity was reached earlier when moving with the left compared to the right hand. The underlying brain activation patterns showed that both left- and right-handers activated more areas involved in visuomotor attention and saccadic control when using their left compared to the right hand. Altogether, these results confirm a unique perceptuomotor processing specialization of the left brain/right hand system that is independent of hand preference.

The costs of taking it slowly: fast and slow movement timing in older age.

We investigated adult age-differences in timing control of fast vs. slow repetitive movements using a dual-task approach. Twenty-two young (M = 24.23 yr) and 22 older adults (M = 66.64 yr) performed three cognitive tasks differing in working memory load and response production demands and they tapped series of 550-ms or 2100-ms target intervals. Single-task timing was comparable in both groups. Dual-task timing was characterized by shortening of produced intervals and increases in drift and variability. Dual-task costs for both cognitive and timing performances were pronounced at slower tapping tempos, an effect exacerbated in older adults. Our findings implicate attention and working memory processes as critical components of slow movement timing and sources of specific challenges thereof for older adults.

Hemispheric asymmetries in eye-hand coordination.

Manual asymmetries in limb kinematics and eye-hand coordination have usually been attributed to differences in online processing capabilities between the left and the right cerebral hemisphere. In the present fMRI experiment, we examined in right handers the brain areas involved in eye-hand coordination with either the left or the right hand. Although temporal and spatial accuracy was equal for left- and right-hand movements, manual asymmetries were found in behavioral and neurophysiologic data, suggesting an asymmetric mode of control for left vs. right eye-hand coordination. For left eye-hand coordination, peak velocity and saccade completion occurred earlier than for the contralateral movements, suggesting that there was more time needed for homing-in on the target. When using the right hand, there was more activation in occipital areas. This might indicate a more intense visual processing or visualization of the target locations. When using the left hand, there was more activation in sensorimotor areas, frontal areas and cerebellum. This might point toward more processing effort. Left-hand movements may be considered as more difficult than right-hand movements by right-handed participants. Alternatively and more likely, these findings might reflect a difference in attention or resources attributed to different aspects of the tasks because of the different functional specializations of both hand/hemisphere systems.

Online movement control in multiple sclerosis patients with tremor: effects of tendon vibration.

Patients with intention tremor due to multiple sclerosis (MS) exhibit an increased reliance on visual feedback in the sensorimotor control of slow goal-directed movements. In the present study, the use of proprioceptive information was investigated in MS patients with intention tremor compared to MS patients without tremor and healthy controls. Tendon vibration was applied to the wrist extensor muscles during a memory-guided slow wrist step-tracking task to investigate the use of muscle spindle afferent information in online movement control. A significant reduction of movement amplitude was induced by tendon vibration in all three groups, but the effect was found to be smaller in MS patients with tremor (28%) than in subjects without tremor (50%). Vibration also induced an increase of overall tremor amplitude in the MS tremor group; however, its effect on movement amplitude was not directly related to (changes in) tremor severity. The results suggest that the decreased online use of proprioceptive information in MS patients with tremor reflects an adaptation over time to cope with a tremor-related noisy background. Abnormalities in proprioceptive processing may explain why MS patients with tremor show an increased reliance on visual feedback for online motor control.

The type of visual information mediates eye and hand movement bias when aiming to a Müller-Lyer illusion.

Aiming bias typically influences perception but action towards the illusory stimulus is often unaffected. Recent studies, however, have shown that the type of information available is a predictor for the expression of action bias. In the present cyclical aiming experiment, the type of information (retinal and extra-retinal) was manipulated in order to investigate the differential contributions of different cues on both eye and hand movements. The results showed that a Müller-Lyer illusion caused very similar perturbation effects on hand and eye-movement amplitudes and this bias was mediated by the type of information available on-line. Interestingly, the impact of the illusion on goal-directed movement was smaller, when information about the figure but not the hand was provided for on-line control. Saccadic information did not influence the size of the effect of a Müller-Lyer illusion on hand movements. Furthermore, the illusions did not alter the eye-hand coordination pattern. The timing of saccade termination was strongly linked to hand movement kinematics. The present results are not consistent with current dichotomous models of perception and action or movement planning and on-line control. Rather, they suggest that the type of information available for movement planning mediates the size of the illusory effects. Overall, it has been demonstrated that movement planning and control processes are versatile operations, which have the ability to adapt to the type of information available.

Relationship between multiple sclerosis intention tremor severity and lesion load in the brainstem.

Intention tremor due to multiple sclerosis is clinically similar to cerebellar tremor. This study investigated, in 14 multiple sclerosis patients, the relationship between intention tremor severity and the lesion load in different infratentorial regions. Tremor amplitude was quantified during step-tracking tasks. The lesion load was measured on magnetic resonance images using an automated segmentation method. Intention tremor amplitude was significantly related to lesion load in the brainstem but not in the cerebellum. Specifically, tremor amplitude correlated with the lesion load in the contralateral pons, and patients with more severe tremor in both arms had a greater lesion load bilaterally in the pons. These results support the view that multiple sclerosis intention tremor is related to dysfunction of cerebellar inflow and/or outflow pathways.

Interaction between eye and hand movements in multiple sclerosis patients with intention tremor.

Deficient eye and hand movements are present in patients with multiple sclerosis. In the present study, eye and hand movements were simultaneously measured during visually guided wrist step-tracking tasks in 16 patients with intention tremor and 15 healthy controls. The coupling between eye and hand movements was analyzed during simultaneous eye-hand tracking, and interactions were studied by comparing the coordinated eye-hand condition with isolated eye- or hand-tracking conditions. Despite movement abnormalities, the onset of eye and hand movements was highly correlated and an invariant coupling between the saccadic completion time and hand peak velocity was found, suggesting that the temporal coupling was very much preserved. The differences between the experimental tracking conditions suggest that, in MS patients with intention tremor, the ocular system influenced the hand movements. Intention tremor amplitude was reduced when there was no preceding saccadic eye movement, whereas conversely, eye movements were not affected by different hand tremor severity.

Effects of vision and arm position on amplitude of arm postural tremor in patients with multiple sclerosis.

OBJECTIVES: To quantify the effects of vision and arm position on arm postural tremor, comparisons were made between flexed and extended arm positions performed with the eyes open and closed. DESIGN: Case-control study. SETTING: National multiple sclerosis (MS) center in Belgium. PARTICIPANTS: Sixteen patients (32 arms) with MS who had intention tremor and 16 healthy controls (32 arms). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: The amplitude of postural tremor was assessed by a magnetic position sensor attached to the index finger. RESULTS: The amplitude of postural tremor was not influenced by changes in visual condition or different arm positions. Both healthy controls and MS patients made more directional changes in the flexed, compared with the extended arm position. CONCLUSIONS: The amplitude of the arm postural tremor in MS is independent of vision and arm position. Selecting 1 arm position is sufficient to assess postural tremor amplitude.

The control of sequential aiming movements: the influence of practice and manual asymmetries on the one-target advantage.

The present experiment was conducted to explore the effect of practice on the one-target advantage in manual aiming, as well as asymmetries in intermanual transfer of training. Reaction and movement times for the first movement were longer in the 2-target than in the 1-target task, regardless of the amount of practice, hand preference and practice hand. When two movements were required, peak velocity was lower and, proportionally, more time was spent after peak velocity. Our kinematic results suggest that the one-target advantage is related to both predefined strategies as well as movement implementation processes during execution. Therefore, an integration of advance planning and on-line explanations for the one-target advantage is suggested. Regarding manual asymmetries, right-handers showed more transfer of training from the left to the right hand than vice versa. Left-handers exhibited a reversed pattern of asymmetric transfer of training to right-handers, but they were more disadvantaged using their non-dominant hand. These latter two findings have implications for models of manual asymmetry and upper limb control.

The one-target advantage: advanced preparation or online processing?

The one-target advantage refers to a shorter movement time for one- target aiming movements, in comparison to aiming attempts followed by a second movement. Theoretical explanations of the one-target advantage vary in the extent to which they attribute this phenomenon to prior planning or to online control mechanisms. In this research, we attempted to gain insight into the control of sequential aiming movements by manipulating the availability of online feedback during this first or second movement component. When the participants vision was occluded during the first movement (Experiment 1) or during the second movement (Experiment 2), their performance was affected, showing that vision was important for online control of the movement sequence. A one-target advantage was found when the second movement was in the same direction as the first, but not when it was reversed with respect to the home button. Both prior planning and online control processes contribute to the one-target advantage. The degree to which these processes are important for limb control depends on the specific task demands