ABSTRACT
Cranial irradiation of primary or metastatic lesions is frequent, historically with 3D-conformal radiation therapy and now with stereotactic radiosurgery and intensity modulation. Evolution of radiotherapy technique is concomitant to systemic treatment evolution permitting long time survival. Thus, physicians have to face underestimated toxicities on long-survivor patients and unknown toxicities from combination of cranial radiotherapy to new therapeutics as targeted therapies and immunotherapies. This article proposes to develop these toxicities, without being exhaustive, to allow a better apprehension of cranial irradiation in current context.
Subject(s)
Cranial Irradiation/adverse effects , Alopecia/etiology , Cancer Survivors , Cataract/etiology , Cognition Disorders/etiology , Cranial Irradiation/methods , Disorders of Excessive Somnolence/etiology , Dry Eye Syndromes/etiology , Epilepsy/etiology , Humans , Hypothalamic Diseases/etiology , Hypothalamo-Hypophyseal System/radiation effects , Immunotherapy/adverse effects , Meningeal Carcinomatosis/etiology , Migraine Disorders/etiology , Molecular Targeted Therapy/adverse effects , Olfaction Disorders/etiology , Radiosurgery/methods , Radiotherapy, Conformal/trends , Radiotherapy, Intensity-Modulated/trends , Syndrome , Taste Disorders , Xerostomia/etiologyABSTRACT
Outpatient anaesthesia was investigated for a two-month period by means of a questionnaire filled from the preoperative anaesthesia consultation to the surgical procedure and the discharge of the patient. 868 consultations led to schedule 260 ambulatory procedures. ENT (88 patients), paediatric surgery (73 patients) and gynaecology (63 patients) were most frequently concerned. Indications of ambulatory practice could probably be enlarged provided that recovery rooms and surgical schedules were fully adapted.
Subject(s)
Ambulatory Care/statistics & numerical data , Anesthesiology/statistics & numerical data , Gynecology , Otolaryngology , Pediatrics , Adolescent , Adult , Aged , Child , Child, Preschool , Evaluation Studies as Topic , Female , France , Humans , Infant , Male , Middle Aged , Surveys and QuestionnairesABSTRACT
Operative and post operative (two months) mortality among 1280 patients undergoing total hip replacement is studied. Mortality rate was 1%. The main cause is pulmonary embolism, then mental deterioration and anaesthesia. Use of methylmethacrylate did not cause death. Rheumatoid arthritis could increase the risk.
Subject(s)
Anesthesia, General/mortality , Hip Prosthesis/mortality , Aged , Anesthesia, General/adverse effects , Arrhythmias, Cardiac/etiology , Bacterial Infections/mortality , Dementia/mortality , Female , Heart Failure/etiology , Humans , Male , Middle Aged , Postoperative Complications/mortality , Pulmonary Edema/etiology , Pulmonary Embolism/mortality , Retrospective StudiesABSTRACT
Iso-volaemie hemodilution without preoperative blood letting was produced inpatients undergoing orthopedic surgery. Bleeding was compensated by a modified fluid gelatin-electrolyte solution until a predetermined volume was reached. Further blood-loss was compensated by blood transfusion. Clinical condition, hematocrit, coagulation and renal function were observed in the per- and post-operative period.