Multi-point calorimeter using distributed fiber Bragg gratings for small field dosimetry in radiotherapy.

BACKGROUND: The interest of using fiber Bragg gratings (FBGs) dosimeters in radiotherapy (RT) lies in their (i) microliter detection volume, (ii) customizable spatial resolution, (iii) multi-point dose measurement, (iv) real-time data acquisition and (v) insensitivity to Cherenkov light. These characteristics could prove very useful for characterizing dose distributions of small and nonstandard fields with high spatial resolution. PURPOSE: We developed a multi-point FBGs dosimeter customized for small field RT dosimetry with a spatial resolution of ∼ $\sim$ 1 mm. METHODS: The 3 cm-long multi-point dosimeter is made by embedding a 80 µ m $\umu{\rm {m}}$ silica fiber containing an array of thirty (30) co-located ∼ $\sim$ 1 mm-long fs-written FBGs inside a plastic cylinder with an UV curing optical adhesive. With its higher thermal expansion coefficient, the plastic cylinder increases the sensitivity of the dosimeter by stretching the fiber containing the FBGs when the temperature rises slightly due to radiation energy deposition. Irradiations (2000 MU at 600 MU/min) were performed with a Varian TrueBeam linear accelerator. RESULTS: The dose profile of a 2  × $ \times$ 2 cm 2 $^{2}$ 6 MV beam was measured with a mean relative difference of 1.8% (excluding the penumbra region). The measured output factors for a 6 MV beam are in general agreement with the expected values within the experimental uncertainty (except for the 2  × $\,\times $ 2 cm 2 $^{2}$ field). The detector response to different energy of photon and electron beams is within 5% of the mean response ( 0.068 ± 0.002 $0.068\pm 0.002$  pm/Gy). The calorimeter's post-irradiation thermal decay is in agreement with the theory. CONCLUSIONS: An energy-independent small field calorimeter that allows dose profile and output factor measurements for RT using FBGs was developed, which, to our knowledge, has never been done before. This type of detector could prove really useful for small field dosimetry, but also potentially for MRI-LINAC since FBGs are insensitive to magnetic fields and for FLASH since FBGs have been used to measure doses up to 100 kGy.

Tumor Shape-Specific Brachytherapy Implants by 3D-Printing, Precision Radioactivity Painting, and Biomedical Imaging.

In brachytherapy (BT), or internal radiation therapy, cancer is treated by radioactive implants. For instance, episcleral plaques (EPs) for the treatment of uveal melanoma, are designed according to generic population approximations. However, more personalized implants can enhance treatment precision through better adjustment of dose profiles to the contours of cancerous tissues. An original approach integrating biomedical imaging, 3D printing, radioactivity painting, and biomedical imaging, is developed as a workflow for the development of tumor shape-specific BT implants. First, computer-aided design plans of EP are prepared according to guidelines prescribed by the Collaborative Ocular Melanoma Study protocol. Polyetheretherketone (PEEK), a high-performance polymer suitable for permanent implants, is used to 3D-print plaques and the geometrical accuracy of the printed design is evaluated by imaging. The possibility to modulate the dose distribution in a tridimensional manner is demonstrated by painting the inner surfaces of the EPs with radioactive 103Pd, followed by dose profile measurements. The possibility to modulate dose distributions generated by these 3D-printed plaques through radioactivity painting is therefore confirmed. Ex vivo surgical tests on human eyeballs are performed as an assessment of manipulation ease. Overall, this work provides a solution for the fabrication of tumor-specific radioactive implants requiring higher dose precision.

Real-Time Temperature Correction of Medical Range Fiber Bragg Gratings Dosimeters.

The interest in fiber Bragg gratings dosimeters for radiotherapy dosimetry lies in their (i) submillimeter size, (ii) multi-points dose measurements, and (iii) customizable spatial resolution. However, since the radiation measurement relies on the thermal expansion of the surrounding polymer coating, such sensors are strongly temperature dependent, which needs to be accounted for; otherwise, the errors on measurements can be higher than the measurements themselves. In this paper, we test and compare four techniques for temperature compensation: two types of dual grating techniques using different coatings, a pre-irradiation and post-irradiation temperature drift technique, which is used for calorimetry, and finally, we developed a real-time interpolated temperature gradient for the multi-points dosimetry technique. We show that, over these four tested techniques, the last one outperforms the others and allows for real-time temperature correction when an array of 13 fiber Bragg gratings spatially extending over the irradiation zone is used. For a 20 Gy irradiation, this technique reduces the measurement errors from 200% to about 10%, making it suitable for a radiotherapy dose range. Temperature correction for medical low-dose range dosimetry is a first in our field and is essential for clinical FBG dosimetry applications.

Medical Range Radiation Dosimeter Based on Polymer-Embedded Fiber Bragg Gratings.

Fiber Bragg gratings (FBGs) are valuable dosimeters for doses up to 100 kilograys (kGy), but have hardly been used for the low-dose range of a few grays (Gy) required in medical radiation dosimetry. We report that embedding a doped silica fiber FBG in a polymer material allows a minimum detectable dose of 0.3 Gy for γ-radiation. Comparing the detector response for different doped silica fibers with various core doping, we obtain an independent response, in opposition to what is reported for high-dose range. We hypothesized that the sensor detection is based on the radio-induced thermal expansion of the surrounding polymer. Hence, we used a simple physical model based on the thermal and mechanical properties of the surrounding polymer and obtained good accordance between measured and calculated values for different compositions and thicknesses. We report that over the 4 embedding polymers tested, polyether ether ketone and polypropylene have respectively the lowest (0.056 pm/Gy) and largest sensitivity (0.087 pm/Gy). Such FBG-based dosimeters have the potential to be distributed along the fiber to allow multipoint detection while having a sub-millimeter size that could prove very useful for low-dose applications, in particular for radiotherapy dosimetry.

100-W-level single-mode ytterbium-free erbium fiber laser.

We report on an ytterbium-free, erbium-doped single-mode all-fiber laser reaching a record output power of 107 W at 1598 nm, with a slope efficiency of 38.6% according to the absorbed pump power at 981 nm. The erbium-doped gain fiber, co-doped with cerium, aluminum, and phosphorus, was fabricated in-house with adjusted doping concentrations to reduce erbium ions clustering, thereby increasing efficiency while keeping the numerical aperture low to ensure a single-mode laser operation. The addition of cerium co-dopant in the core glass of an erbium system is used for the first time, to the best of our knowledge, in order to adjust the fiber's numerical aperture without increasing the erbium concentration. Numerical modeling, validated by the experimental results, demonstrates that adding aluminum and phosphorus at high concentration mitigates erbium ions clustering, with an estimated erbium paired ions of only 5.0% in the reported gain fiber.

CaMKIIα Expression Defines Two Functionally Distinct Populations of Granule Cells Involved in Different Types of Odor Behavior.

Granule cells (GCs) in the olfactory bulb (OB) play an important role in odor information processing. Although they have been classified into various neurochemical subtypes, the functional roles of these subtypes remain unknown. We used in vivo two-photon Ca2+ imaging combined with cell-type-specific identification of GCs in the mouse OB to examine whether functionally distinct GC subtypes exist in the bulbar network. We showed that half of GCs express Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα+) and that these neurons are preferentially activated by olfactory stimulation. The higher activity of CaMKIIα+ neurons is due to the weaker inhibitory input that they receive compared to their CaMKIIα-immunonegative (CaMKIIα-) counterparts. In line with these functional data, immunohistochemical analyses showed that 75%-90% of GCs expressing the immediate early gene cFos are CaMKIIα+ in naive animals and in mice that have been exposed to a novel odor and go/no-go operant conditioning, or that have been subjected to long-term associative memory and spontaneous habituation/dishabituation odor discrimination tasks. On the other hand, a perceptual learning task resulted in increased activation of CaMKIIα- cells. Pharmacogenetic inhibition of CaMKIIα+ GCs revealed that this subtype is involved in habituation/dishabituation and go/no-go odor discrimination, but not in perceptual learning. In contrast, pharmacogenetic inhibition of GCs in a subtype-independent manner affected perceptual learning. Our results indicate that functionally distinct populations of GCs exist in the OB and that they play distinct roles during different odor tasks.