Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 17 de 17
Filter
1.
BMC Nurs ; 22(1): 380, 2023 Oct 13.
Article in English | MEDLINE | ID: mdl-37833707

ABSTRACT

BACKGROUND: Smart device overdependence adversely affects the overall development of preschool children. This study aimed to provide an emotion coaching group programme to mothers raising preschool children who are overly dependent on smart devices and to confirm the programme's effectiveness. METHODS: This concurrent embedded mixed methods study used a non-equivalent control group pre-post design to verify the quantitative effect of the programme, and a descriptive research design to verify the qualitative effect. The study collected data from June 2019 to March 2021 from 51 (25 experimental, 26 control) mothers raising children aged 3-6 years in South Korea. The quantitative study examined the effects of an eight-session programme, conducted once a week for two hours, on mothers' emotional intelligence, parenting behaviour, and their children's attachment stability and smart device overdependence using a non-equivalent control group pre-post design. The analysis used a generalized estimate equation. For qualitative research, focus group interviews were used as a descriptive research design method, and content analysis was used for analysis. RESULTS: Quantitatively, the results showed significant differences between the experimental and control groups in terms of changes in maternal emotional intelligence (χ2 = 14.99, p = .001), maternal positive parenting behaviour (χ2 = 9.32, p = .009), children's unstable attachment to their mothers (χ2 = 9.49, p = .009), and children's overdependence on smart devices (χ2 = 14.48, p = .001). Qualitatively, the study derived five themes for the experiences of mothers who participated in the programme: "hope for desirable parenting without emotional difficulties," "feelings touched by reflection," "warm but authoritative parenting," "children who became responsible by gaining psychological stability," and "changed view of my home." CONCLUSIONS: The emotion coaching group programme was effective in improving the emotional intelligence and parenting behaviour of mothers raising preschool children. The programme also improved preschool children's attachment stability to their mothers and overdependence on smart devices. The programme can be useful in community practice, and the present study can be used as evidence for education and research related to device overdependence.

2.
PLoS One ; 18(4): e0284340, 2023.
Article in English | MEDLINE | ID: mdl-37053218

ABSTRACT

BACKGROUND: Unmarried mothers who raise their children alone in South Korea experience various difficulties in maintaining their health. Improving the health of unmarried mothers, who are socioeconomically vulnerable, is important not only for them but also for the healthy growth and development of their children. We aimed to implement a natural wellness group program using an interactive real-time video platform for unmarried mothers and to verify its effects. METHODS: This quasi-experimental study utilized a sequential explanatory mixed-methods design. The participants were unmarried mothers raising children aged 0-6 years. The quantitative data collection occurred from August to November 2021. For the qualitative data collection, semi-structured interviews were conducted with seven participants from the experimental group. The experimental group received eight 90-minute weekly online sessions, whereas the control group received no intervention. The outcome variables were physical and mental health, depression, anxiety, self-esteem, and parenting stress. RESULTS: A total of 42 unmarried mothers (21 experimental, 21 control) participated. The Wilcoxon signed-rank test revealed significant post-intervention differences in mental health, depression, and self-esteem in the experimental group. Moreover, a generalized estimating equation analysis revealed significant differences in self-esteem levels between the experimental and control groups. Four themes identified through qualitative analysis revealed that the natural wellness group program using interactive real-time video not only increased mothers' vitality and relaxation but also improved depression and anxiety, and had a positive effect on parenting stress. CONCLUSIONS: Natural wellness group programs using interactive real-time videos can help improve the psychological health of unmarried mothers with young children, a group that tends to be socially and psychologically marginalized.


Subject(s)
Depression , Illegitimacy , Female , Child , Humans , Child, Preschool , Mothers/psychology , Anxiety , Mental Health , Parenting/psychology
3.
Issues Ment Health Nurs ; 44(3): 180-193, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36920274

ABSTRACT

This study evaluates positive psychotherapy's effects on the well-being and psychiatric symptoms of people with psychosis. A systematic search was conducted using 10 electronic databases according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A meta-analysis was performed using the R 4.2.0 program to estimate the effect size. Seventeen studies were included in the systematic review and 14 in meta-analysis. Positive psychotherapy for people with psychosis had significant effects on subjective and psychological well-being and psychiatric symptoms. Further, country, age, and session were significant moderators. Thus, positive psychotherapy improves the well-being and psychiatric symptoms of people with psychosis.


Subject(s)
Psychotic Disorders , Humans , Psychotic Disorders/therapy , Psychotherapy
4.
BMC Womens Health ; 22(1): 274, 2022 07 05.
Article in English | MEDLINE | ID: mdl-35790953

ABSTRACT

BACKGROUND: Birth outside of marriage has been gradually increasing in Korea. However, social perception of unmarried mothers is still negative, and a number of them are not accepted by their family. Therefore, the Korean government has implemented a policy to provide financial aid and communal residence to unmarried mothers who cannot raise children with their family, or afford residence. Unmarried young mothers who rely on this government policy have low economic independence and social adaptation skills. Additionally, they have a high chance of encountering numerous challenges in raising children due to their living conditions in residential facilities and social prejudice. This study was conducted to gain an in-depth understanding of the lived experience of unmarried mothers raising children in residential facilities. METHODS: Data were collected through in-depth interviews with nine unmarried mothers living in residential facilities with their children. An interpretative phenomenological analysis was conducted to analyze the data. RESULTS: The findings revealed that unmarried mothers struggled with various difficulties given the limitations of living in the facility, but attempted to navigate their uncertain future with the determination to be good mothers. Three main themes and eight sub-themes emerged: (1) adaptation to the identity of "unmarried mother", (2) willingly undertaking the heavy burden of childrearing, (3) indispensable but insufficient supports from facilities. Participants had childrearing responsibilities, and tried to be good mothers for their children while struggling to adapt to their new identities. However, their self-doubt as a "good mother" and the absence of the child's father made them feel sorry for their child. Their daily experiences raising children and simultaneously preparing for their own independence were exhausting. The supports from the facilities were helpful but unsatisfactory and led to various psychosocial difficulties such as anxiety, depression, fear, guilty, and anger in unmarried mothers. CONCLUSIONS: Besides information and resources for parenting and independence, active approaches are needed to improve the psychological stability of unmarried mothers raising their children in facilities, and sustain a long-term socioeconomic support system. Thoughtful services tailored to mothers and children are also needed, instead of standardized services.


Subject(s)
Parenting , Single Person , Child , Female , Humans , Mothers/psychology , Parenting/psychology , Qualitative Research , Residential Facilities
5.
BMC Public Health ; 22(1): 752, 2022 04 14.
Article in English | MEDLINE | ID: mdl-35421976

ABSTRACT

BACKGROUND: As smart device overdependence among preschoolers could adversely affect their overall development, it is essential to understand the related factors of such overdependence. Mothers have a large influence on preschoolers; however,, the relationship between mothers' emotional intelligence, negative parenting behaviour, preschoolers' attachment instability, and smart device overdependence remain unclear. This study aims to develop and test a structural model to explain smart device overdependence among preschoolers. METHODS: The study collects and analyses data from January to May 2021 from 283 mothers raising children aged 3-6 years in South Korea. Questionnaires regarding mothers' emotional intelligence and negative parenting behaviour, as well as preschoolers' attachment instability and smart device overdependence, were used to collect data. The data were analysed by SPSS23.0 and AMOS 23.0 software and a structural equation model was constructed; p ≤ 0.05 was taken as significant. RESULTS: Mothers' emotional intelligence had a direct negative relationship with mothers' negative parenting behaviour (ß = - 0.44) and an indirect negative relationship with preschoolers' attachment instability (ß = - 0.25) and preschoolers' smart device overdependence (ß = - 0.24). Mothers' negative parenting behaviour had a direct positive relationship with preschoolers' attachment instability (ß = 0.56) and both direct and indirect positive relationships with preschoolers' smart device overdependence (ß = 0.55). Preschoolers' attachment instability had a direct positive relationship with preschoolers's smart device overdependence (ß = 0.46). CONCLUSIONS: Mothers' emotional intelligence, negative parenting behaviour, and preschoolers' attachment instability are associated with preschoolers' vulnerability to smart device overdependence. These results are shown that more attention is needed to these variables in order to reduce preschoolers' overdependence on smart devices. Additionally, we propose to develop and provide interventions based on these results.


Subject(s)
Mothers , Parenting , Child , Emotional Intelligence , Female , Humans , Mother-Child Relations , Mothers/psychology , Republic of Korea , Surveys and Questionnaires
6.
J Psychosoc Nurs Ment Health Serv ; 60(3): 40-47, 2022 Mar.
Article in English | MEDLINE | ID: mdl-34590984

ABSTRACT

Smartphone overdependence (SO) in mothers of preschoolers (MPs) reduces the parenting capacity of MPs. The current study aimed to identify associated factors of SO in MPs through a systematic review and meta-analysis conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using 10 electronic databases. A total of 18 studies met the inclusion criteria. It was confirmed that SO in MPs is a coping strategy used to manage stress during childrearing. Parenting stress, depression, unemployment, and low household income were identified as risk factors that increased SO in MPs. Protective factors that reduced SO in MPs included resilience and parental intelligence. Findings emphasize the need to assess risk factors to prevent SO in MPs. It is suggested that programs to prevent SO in MPs be developed based on results of this study. [Journal of Psychosocial Nursing and Mental Health Services, 60(3), 40-47.].


Subject(s)
Mothers , Smartphone , Female , Humans , Parenting , Parents
7.
J Psychosoc Nurs Ment Health Serv ; 60(3): 31-39, 2022 Mar.
Article in English | MEDLINE | ID: mdl-34432589

ABSTRACT

Self-concept affects the overall process of pregnancy, childbirth, and parenting among adolescent mothers. The current systematic review explores intervention studies on the enhancement of self-concept among adolescent mothers, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. English and Korean literature published within the past 10 years was searched and five articles met the inclusion criteria. To improve self-concept among adolescent mothers, especially self-esteem, it was deemed necessary to strengthen a balanced capacity of physiological, psychological, sociocultural, and developmental aspects, based on a comprehensive assessment. To provide effective intervention, it was essential to reflect the cultural characteristics of adolescent mothers' native countries. Lectures were confirmed as a representative method of enhancing self-concept and participatory learning methods, such as group discussions, group activities, practical skills training, and supervision, were considered effective for enhancing self-esteem by strengthening not only knowledge but also the motivation of adolescent mothers. [Journal of Psychosocial Nursing and Mental Health Services, 60(3), 31-39.].


Subject(s)
Adolescent Mothers , Parenting , Adolescent , Female , Humans , Pregnancy , Self Concept
8.
Article in English | MEDLINE | ID: mdl-34444433

ABSTRACT

Unmarried mothers living in residential facilities (UMLFs) in Korea face complex and challenging physical, psychological, and socioeconomic issues. This study developed a physical and mental health promotion program using urban forests for UMLFs based on the transtheoretical model and evidence. We utilized an intervention mapping approach (IMA) and assessed the needs of UMLFs by analyzing previous quantitative studies. Moreover, we conducted a qualitative hermeneutic phenomenological study involving nine participants. Based on the needs assessment, important and changeable determinants were identified; further, the program performance and change objectives were classified to achieve the program goals and establish the intervention strategy. We found that physical activity using forests, self-reflection using metaphors, five-sense activities, achievement activities using natural objects, building interpersonal relationships in the forest, and designing future plans, are desirable methods for improving the health of UMLFs. The IMA was deemed appropriate for the systematic development of health promotion programs for UMLFs through clear links among change objectives, theoretical methods, and practice strategies. These results should be applied to future intervention studies.


Subject(s)
Illegitimacy , Transtheoretical Model , Forests , Health Promotion , Humans , Residential Facilities
9.
Arch Psychiatr Nurs ; 35(3): 243-249, 2021 06.
Article in English | MEDLINE | ID: mdl-33966787

ABSTRACT

INTRODUCTION: Older adults with schizophrenia experience aging-related challenges and chronic psychiatric difficulties. However, their uniqueness is understudied. Aim This study explored three life stories to illuminate schizophrenia's trajectory. METHOD: A narrative inquiry method was used to elicit rich narratives in chronic patients' lives. Two men and one woman suffering from chronic schizophrenia for more than 20 years were engaged in conversation three times. RESULTS: The analysis revealed one main theme expressing their fundamental perspective on their lives: "moving forward despite adversity." Three subthemes emerged: living with the mental disorder, giving and receiving support, and adaptation to old age. They reflected on their interpersonal relationships, failures, and successes in the context of the challenges of schizophrenia. They indicated adapting to schizophrenia, exchanging social support with loved ones, and meeting aging-related challenges with confidence. They were hopeful about brighter personal futures than their pasts. DISCUSSION: Family and community supports were very important; self-acceptance positively influenced their successful community living. IMPLICATIONS FOR PRACTICE: For effective long-term treatment of older adults with schizophrenia, mental health policies should focus on meeting the social needs of patients and families and reorient programs away from the medical model limited to symptom reduction.


Subject(s)
Schizophrenia , Aged , Female , Humans , Interpersonal Relations , Male , Narration , Republic of Korea , Social Support
10.
J Korean Acad Nurs ; 50(3): 349-368, 2020 Jun.
Article in Korean | MEDLINE | ID: mdl-32632070

ABSTRACT

PURPOSE: This study aimed to identify parental factors associated with smartphone overuse in preschoolers. METHODS: A systematic review was conducted according to PRISMA guidelines. Relevant studies published in peer-reviewed journals from 2009 to June 2019 were identified through systematic search in 10 electronic databases (PubMed, CINAHL, Cochrane Central, EMBASE, Web of Science, NDSL, KISS, KMbase, KoreaMed, and RISS). Standardized effect sizes were calculated to quantify the associations of parental factors with smartphone overuse in preschoolers using meta-analysis. RESULTS: A total of 30 cross-sectional studies involving 7,943 participants met the inclusion criteria. The following were negatively correlated with smartphone overuse in preschoolers: mother's parenting self-efficacy (r=-.35), mother-child attachment (r=-.28), mother's positive parenting behavior (r=-.28), mother's positive parenting attitude (r=-.25), and father's parenting involvement (r=-.15). Further, maternal factors such as smartphone addiction tendency (r=.41), parenting stress (r=.40), negative parenting behavior (r=.35), negative parenting attitude (r=.14), smartphone usage time (r=.26), employment status (r=.18), and age (r=.12) were positively correlated with smartphone overuse in preschoolers. CONCLUSION: Several parental factors influence smartphone overuse in preschoolers. These findings emphasize the need to assess and enhance the parental factors identified in this study to prevent smartphone overuse in preschoolers. Accordingly, we recommend the development of preventive interventions to strengthen parent-related protective factors and mitigate risk factors.


Subject(s)
Behavior, Addictive/pathology , Parenting , Child , Cross-Sectional Studies , Humans , Mother-Child Relations , Smartphone , Stress, Psychological
11.
J Psychosoc Nurs Ment Health Serv ; 58(6): 18-29, 2020 Jun 01.
Article in English | MEDLINE | ID: mdl-32286663

ABSTRACT

Children living in foster care group homes are more likely to have physical, mental, and social health problems due to parental abuse, neglect, and family breakdown. The purpose of the current study was to develop and apply the urban forest-based health promotion program on children living in group homes in Korea to investigate its effects on perceived health, psychological health, and connectedness to nature. Eight children (mean age = 12.13 [SD = 1.25] years) from three group homes participated in the study. The intervention was conducted individually for each group home once per week for 8 weeks. Quantitative and qualitative data were collected and analyzed. Participants showed significant improvement in restoration. Six themes were identified that reflect participants' experience and the effectiveness of the urban forest-based health promotion program. This program may be considered a possible intervention to promote children's psychosocial health and connectedness to nature. Continuous efforts are needed to further examine the program's effectiveness. [Journal of Psychosocial Nursing and Mental Health Services, 58(6), 18-29.].


Subject(s)
Child Health/statistics & numerical data , Forests , Group Homes , Health Promotion , Mental Health , Nature , Child , Female , Humans , Male , Self Report , Surveys and Questionnaires
12.
Child Health Nurs Res ; 26(2): 238-253, 2020 Apr.
Article in Korean | MEDLINE | ID: mdl-35004468

ABSTRACT

PURPOSE: The purpose of this study was to explore the structure of variables in studies related to unmarried mothers (UMs) based on Neuman's systems model, and the stressors and stress responses of UMs. METHODS: Whittemore and Knafl's methodology for integrative reviews was applied. The literature was searched using five electronic databases (KISS, KMbase, KoreaMed, NDSL, and RISS) and a total of 99 variables were collected from 15 studies published between 2009 and 2019. RESULTS: The main stressors for UMs were a sense of loss and burden caused by childbirth and childrearing. The main stress responses were parenting stress and depression, respectively. Within the basic structure of variables related to UMs, self-esteem played a crucial role by helping UMs adapt to their situation. Meanwhile, social support of UMs was significantly correlated with parenting stress, depression, and self-esteem. CONCLUSION: In order to understand UMs' stress, is necessary to explore their sense of loss, burden, and self-esteem. Furthermore, it is important to assess the level of parenting stress and depression of UMs and to provide effective interventions to alleviate these stressors. The results of this study provide useful knowledge that can be applied to nursing assessment and interventions for stress management in UMs.

13.
Article in English | MEDLINE | ID: mdl-31547249

ABSTRACT

This study developed the Children's Vitality-Relaxation Scale (CVRS) by revising the adult version of the Restoration Outcome Scale (ROS). The CVRS was translated and culturally adapted into Korean, and its reliability and validity were evaluated in a cross-sectional, descriptive design study. Data collected from 181 elementary school students in grades 4‒6 were used to test the validity and reliability of the CVRS. Exploratory factor analysis, Pearson's correlation, known-groups comparison, and Cronbach's alpha were used for analysis. The factor analysis indicated a two-factor structure, and all factor loadings were above 0.40. The CVRS was a seven-point Likert scale consisting of eight items, which were classified as "vitality" (four items) and "relaxation" (four items). The external construct validity with the PANAS, PSS, and SRI was acceptable. In the known-groups comparison, the CVRS score was significantly higher for boys than for girls, and the CVRS score for high-income students was higher than low-income students. The Cronbach's α for the scale was 0.84 and ranged from 0.72-0.87 for the subscales. Results showed that the CVRS is a valid and reliable scale with acceptable psychometric characteristics in Korean children. The scale can be used to measure children's affect in various settings.


Subject(s)
Psychometrics/standards , Relaxation/psychology , Reproducibility of Results , Students/psychology , Students/statistics & numerical data , Translations , Child , Cross-Sectional Studies , Factor Analysis, Statistical , Female , Humans , Male , Republic of Korea , Surveys and Questionnaires
14.
Child Health Nurs Res ; 25(3): 273-289, 2019 Jul.
Article in English | MEDLINE | ID: mdl-35004420

ABSTRACT

PURPOSE: The purpose of this study was to review the literature on intervention studies for abused children and adolescent in residential facilities in South Korea (ACARF-K). The goal was to understand the problems they experience, to evaluate the content and effectiveness of interventions applied to them, and to develop evidence-based nursing intervention programs. METHODS: We used four electronic databases to search for relevant articles. 18 studies according to Whittemore and Knafl's integrative review method to synthesize the literature. RESULTS: The ACARF-K experienced problems in biophysical, psychological, and sociocultural domains related to attachment impairment. Effective intervention strategies were building trust through empathy and fulfillment of needs, encouraging ACARF-K to express themselves and helping them to clarify emotions in an unthreatening environment, and improving their self-concept through activities in which they experienced achievement. CONCLUSION: Interventions are needed to help restore attachment damage among ACARF-K. The interventions in this study utilized emotional, cognitive, relational, and behavioral therapeutic tools to improve their psychological and social capacities. Future intervention programs for ACARF-K should include these key elements.

15.
Chem Biodivers ; 1(3): 530-7, 2004 Mar.
Article in English | MEDLINE | ID: mdl-17191867

ABSTRACT

In the light of the steady increase of infections related to vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA), the medicinal plant Magnolia officinalis was subjected to bioassay-directed fractionation, which led to the isolation of the known neolignans piperitylmagnolol (1), magnolol (2), and honokiol (3) from the MeOH extract. In broth-microdilution assays, 1-3 exhibited antibacterial activities against VRE and MRSA at minimum-inhibitory concentrations (MIC) in the range of 6.25-25 microg/ml, compound 1 being the most-potent antibiotic. The ratio of MBC/MIC (MBC = minimum bactericidal concentration) was < or = 2 for all compounds. The kinetics of the antibacterial action of 1 and 3 were studied by means of time-kill assays; both compounds were bactericidal against VRE and MRSA, their actions being time dependent, or both time and concentration dependent. Magnolol (2) was acetylated to magnolol monoacetate (4) and magnolol diacetate (5) (partial or full masking of the phenolic OH functions). The cytotoxic properties of 1-5 against human OVCAR-3 (ovarian adenocarcinoma), HepG2 (hepatocellular carcinoma), and HeLa (cervical epitheloid carcinoma) cell lines were evaluated. The CD50 values for compounds 1-3 were in the range of 3.3-13.3 microg/ml, derivatives 4 and 5 being much less potent. This study indicates that piperitylmagnolol (= 3-[(1S,6S)-6-isopropyl-3-methylcyclohex-2-enyl]-5,5'-di(prop-2-enyl)[1,1'-biphenyl]-2,2'-diol; 1) possesses both significant anti-VRE activity and moderate cytotoxicity against the above cancer cell lines.


Subject(s)
Anti-Infective Agents/isolation & purification , Anti-Infective Agents/toxicity , Cytotoxins/isolation & purification , Cytotoxins/toxicity , Lignans/isolation & purification , Lignans/toxicity , Magnolia/chemistry , Cell Line, Tumor , HeLa Cells , Humans , Magnolia/toxicity , Microbial Sensitivity Tests , Plant Extracts/isolation & purification , Plant Extracts/toxicity , Staphylococcus aureus/drug effects , Staphylococcus aureus/growth & development , Vancomycin Resistance/drug effects
16.
J Nat Prod ; 66(9): 1175-80, 2003 Sep.
Article in English | MEDLINE | ID: mdl-14510592

ABSTRACT

Bioassay-directed fractionation of Saussurea lappa led to the isolation of a novel lappadilactone (1) and seven sesquiterpene lactones (2-8) as cytotoxic principles against selected human cancer cell lines. Lappadilactone (1), dehydrocostuslactone (2), and costunolide (5) exhibited the most potent cytotoxicity with CD50 values in the range 1.6-3.5 microg/mL in dose- and time-dependent manners. The cytotoxicities were not specific and showed similar activities against HepG2, OVCAR-3 and HeLa cell lines. The structure-activity relationship showed that the alpha-methylene-gamma-lactone moiety is necessary for cytotoxicity, and activity is reduced with the presence of a hydroxyl group. In addition, seven noncytotoxic compounds (9-15) were also isolated, including two novel sesquiterpenes, a guaianolide-type with a C17 skeleton, lappalone (13), and 1beta,6alpha-dihydroxycostic acid ethyl ester (14). The structures of the new compounds were elucidated from spectroscopic and/or X-ray data interpretations. Some representative compounds were also tested for antibacterial activity; however, only marginal activities were observed. Therefore, compounds 1-8 are potential cytotoxic agents but without significant antibacterial effect.


Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Drugs, Chinese Herbal/isolation & purification , Lactones/isolation & purification , Plants, Medicinal/chemistry , Saussurea/chemistry , Sesquiterpenes/isolation & purification , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/pharmacology , Carcinoma, Hepatocellular , Crystallography, X-Ray , Drug Screening Assays, Antitumor , Drugs, Chinese Herbal/chemistry , Drugs, Chinese Herbal/pharmacology , Female , HeLa Cells/drug effects , Humans , Lactones/chemistry , Lactones/pharmacology , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Ovarian Neoplasms , Plant Roots/chemistry , Sesquiterpenes/chemistry , Sesquiterpenes/pharmacology , Structure-Activity Relationship , Tumor Cells, Cultured/drug effects
17.
J Nat Prod ; 65(12): 1857-62, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12502328

ABSTRACT

Bioassay-directed fractionation of extract of Arnebia euchroma led to the isolation of alkannin (1), shikonin (2), and their derivatives (3-8) as the active principles against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The stereochemistry of alpha-methylbutyryl alkannin (8) is revealed for the first time, and the antimicrobial activity of 8 was compared with its corresponding diastereomer (9). The derivatives 3-9 showed stronger anti-MRSA activity [minimum inhibitory concentrations (MICs) ranged from 1.56 to 3.13 microg/mL] than alkannin or shikonin (MIC = 6.25 microg/mL). Anti-MRSA activity of derivatives was bactericidal with minimum bactericidal concentration (MBC)/MIC < or = 2. In a time-kill assay, the bactericidal activity against MRSA was achieved as rapidly as 2 h. The derivatives 3-9 were also active against vancomycin-resistant Enterococcus faecium (F935) and vancomycin-resistant Enterococcus faecalis (CKU-17) with MICs similar to those with MRSA. Aromatic ester derivatives were also synthesized for antimicrobial activity comparison. None of these compounds were active against Gram-negative bacteria tested. Their cytotoxicity was also evaluated on selected cancer cell lines, and they expressed their activity in the range 0.6-5.4 microg/mL (CD(50)). Our results indicate that the ester derivatives of alkannin are potential candidates of anti-MRSA and anti-VRE agents with antitumor activity.


Subject(s)
Anti-Bacterial Agents/isolation & purification , Boraginaceae/chemistry , Naphthoquinones/isolation & purification , Plants, Medicinal/chemistry , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Carcinoma, Hepatocellular , China , Drug Screening Assays, Antitumor , Electron Spin Resonance Spectroscopy , Enterococcus faecalis/drug effects , Female , HeLa Cells/drug effects , Humans , Methicillin Resistance , Microbial Sensitivity Tests , Molecular Structure , Naphthoquinones/chemistry , Naphthoquinones/pharmacology , Nuclear Magnetic Resonance, Biomolecular , Ovarian Neoplasms , Plant Bark/chemistry , Staphylococcus aureus/drug effects , Stereoisomerism , Tumor Cells, Cultured/drug effects , Vancomycin/pharmacology
SELECTION OF CITATIONS
SEARCH DETAIL
...