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1.
J Trauma Acute Care Surg ; 89(4): 658-664, 2020 10.
Article in English | MEDLINE | ID: mdl-32773671

ABSTRACT

BACKGROUND: Current evaluation of rib fractures focuses almost exclusively on flail chest with little attention on bicortically displaced fractures. Chest trauma that is severe enough to cause fractures leads to worse outcomes. An association between bicortically displaced rib fractures and pulmonary outcomes would potentially change patient care in the setting of trauma. We tested the hypothesis that bicortically displaced fractures were an important clinical marker for pulmonary outcomes in patients with nonflail rib fractures. METHODS: This nine-center American Association for the Surgery of Trauma multi-institutional study analyzed adults with two or more rib fractures. Admission computerized tomography scans were independently reviewed. The location, degree of rib fractures, and pulmonary contusions were categorized. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of pneumonia, acute respiratory distress syndrome (ARDS), and tracheostomy. Analyses were performed in nonflail patients and also while controlling for flail chest to determine if bicortically displaced fractures were independently associated with outcomes. RESULTS: Of the 1,110 patients, 103 (9.3%) developed pneumonia, 78 (7.0%) required tracheostomy, and 30 (2.7%) developed ARDS. Bicortically displaced fractures were present in 277 (25%) of patients and in 206 (20.3%) of patients without flail chest. After adjusting for patient demographics, injury, and admission physiology, negative pulmonary outcomes occurred over twice as frequently in those with bicortically displaced fractures without flail chest (n = 206) when compared with those without bicortically displaced fractures-pneumonia (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.1-3.6), ARDS (OR, 2.6; 95% CI, 1.0-6.8), and tracheostomy (OR, 2.7; 95% CI, 1.4-5.2). When adjusting for the presence of flail chest, bicortically displaced fractures remained an independent predictor of pneumonia, tracheostomy, and ARDS. CONCLUSION: Patients with bicortically displaced rib fractures are more likely to develop pneumonia, ARDS, and need for tracheostomy even when controlling for flail chest. Future studies should investigate the utility of flail chest management algorithms in patients with bicortically displaced fractures. LEVEL OF EVIDENCE: Prognostic and epidemiological study, level III.


Subject(s)
Flail Chest/surgery , Pneumonia/epidemiology , Respiratory Distress Syndrome/epidemiology , Rib Fractures/surgery , Tracheostomy/statistics & numerical data , Adult , Aged , Female , Flail Chest/physiopathology , Humans , Injury Severity Score , Male , Middle Aged , Pneumonia/etiology , Respiratory Distress Syndrome/etiology , Retrospective Studies , Rib Fractures/physiopathology , Societies, Medical , Tomography, X-Ray Computed , Trauma Centers , United States
2.
Heliyon ; 6(3): e03523, 2020 Mar.
Article in English | MEDLINE | ID: mdl-32211540

ABSTRACT

OBJECTIVES: Percutaneous endoscopic gastrostomy (PEG) tubes and ventriculoperitoneal shunts (VPS) are commonly placed in neurologically impaired patients. There is concern about safety of VPS coexisting with PEG tubes due to the potential for an increased risk of infection. In this study, we assess the risk of VPS infection and the amount of time between both procedures. PATIENTS AND METHODS: Retrospective chart review of patients from our institution who had VPS and PEG tubes placed during the same hospitalization between 2014 and 2018. Our primary focus was assessing risk of VPS infection and timing of procedures in this patient population. Additionally, we assessed other factors which may contribute to VPS infection including SIRS criteria at time of VPS placement, comorbidities and other procedures performed. None of the SIRS factors were associated with VPS infection. RESULTS: 45 patients met inclusion criteria. Our VPS infection rate was found to be 7% (n = 3). These patients had 4, 16, and 36 days between procedures. 89% of our patients had PEG tube placed prior to VPS with 2 of these patients developing a VPS infection. At the time of VPS placement 42% of patients had SIRS. None of the SIRS factors were associated with VPS infection. CONCLUSION: Our VPS infection rate remained low even when they were performed during the same hospitalization as a PEG tube placement. SIRS is not associated with the development of VPS infections and is not an absolute contraindication to placing a VPS.

3.
J Emerg Med ; 57(6): 812-816, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31735656

ABSTRACT

BACKGROUND: The reported risk of delayed intracranial hemorrhage (ICH) in a trauma patient on warfarin is estimated to be between 0.6% and 6%. The risk of delayed ICH in trauma patients taking novel oral anticoagulants (NOACs) is not well-defined. OBJECTIVE: We hypothesized that there was a significant number of delayed presentations of ICH in patients on NOACs. METHODS: A retrospective review of our trauma registry was performed on geriatric patients (age older than 64 years) who were initially evaluated at our level I trauma center, had fall from standing height or less, and were anticoagulated (warfarin or NOACs), from April 2017 to March 2018. RESULTS: Seventy-seven patients met inclusion criteria. The mean age was 80 ± 7.7 years and 46% of patients were male. The admission head computed tomography scan was positive in 20.8% of patients. Positive scans were more common in patients on warfarin vs. NOACs (30% vs. 14%; p = 0.074) and had a significantly higher Injury Severity Score (median [interquartile range]: 9 [3-15] vs. 5 [1-9]; p = 0.030) and Abbreviated Injury Scale-Head score (median [interquartile range]: 1 [0-3] vs. 1 [0-2]; p = 0.035). The agreement between loss of consciousness (LOC) and ICH was 72% (κ = -0.064; p = 0.263). Fifty-one percent of patients had a repeat head CT. New ICH was diagnosed in 9.6% of patients. All of these patients were on NOACs. CONCLUSIONS: A fall from standing or less in anticoagulated geriatric patients is a significant mechanism of injury resulting in ICH. The absence of LOC does not eliminate the possibility of ICH. There is a significant risk of delayed ICH for patients on NOACs and repeat evaluations should be performed. A prospective multicenter evaluation of this finding is warranted.


Subject(s)
Accidental Falls/statistics & numerical data , Factor Xa Inhibitors/adverse effects , Intracranial Hemorrhages/etiology , Time Factors , Aged , Aged, 80 and over , Factor Xa Inhibitors/therapeutic use , Female , Geriatrics/methods , Humans , Intracranial Hemorrhages/physiopathology , Male , Prospective Studies , Retrospective Studies
4.
J Crit Care ; 50: 118-121, 2019 04.
Article in English | MEDLINE | ID: mdl-30530262

ABSTRACT

The use of Airway Pressure Release Ventilation (APRV) in patients with traumatic brain injury (TBI) remains controversial. Some believe that elevated mean airway pressures transmitted to the thorax may cause clinically significant increases in Central Venous Pressure (CVP) and intracranial pressure (ICP) from venous congestion. We perform a retrospective review from 2009 to 2015 of traumatically injured patients who were transitioned from traditional ventilator modes to APRV and also had an ICP monitor in place. Fifteen patients undergoing 19 transitions to APRV were identified. Prior to transitioning to APRV the average static and dynamic compliance was 22.9 +/- 5.6 and 16.5 +/- 4.12 mL/cm H2O. There was no statistical difference in ICP, MAP, and CPP prior to and after transition to APRV. There was a statistically significant increase in CVP, PaO2, and P:F ratio. Individually, only 4 patients had ICP values >20 in the first hour after transitioning to APRV and the rate of ICP elevations was similar between the two modes of ventilation. These data show that APRV is a viable mode of ventilation in patients with TBI who have low lung compliance. The increased CVP of this mode of ventilation did not affect ICP or hemodynamic parameters.


Subject(s)
Acute Lung Injury/complications , Brain Injuries, Traumatic/complications , Continuous Positive Airway Pressure , Intracranial Pressure/physiology , Lung Compliance/physiology , Respiratory Distress Syndrome/therapy , Adult , Aged , Continuous Positive Airway Pressure/adverse effects , Female , Hemodynamics , Humans , Male , Middle Aged , Respiratory Distress Syndrome/etiology , Retrospective Studies
5.
J Crit Care ; 47: 169-172, 2018 10.
Article in English | MEDLINE | ID: mdl-30005303

ABSTRACT

PURPOSE: Dosing regimens of quetiapine to treat delirium in critically ill patients are titrated to effect, and may utilize doses higher than previously reported. This study aimed to assess the safety of quetiapine for this indication. MATERIALS AND METHODS: A retrospective medical chart review was conducted, identifying 154 critically ill adults that were initiated on quetiapine to treat delirium and monitored for QTc prolongation. RESULTS: The median average daily dose was 150 mg (79-234) and median max dose was 225 mg (100-350). The overall range was 25-800 mg daily. The time to peak dose was 3 days (1-8). Patients with QTc prolongation were significantly older (age 54 ±â€¯11 vs 45 ±â€¯17 years (p = 0.002)) and with higher baseline QTc (454 ±â€¯33 vs 442 ±â€¯30 (p = 0.045)). Regression analysis revealed only dose as a significant factor (OR = 1.006 (1.003-1.009) (p < 0.001)). CONCLUSION: The dose of quetiapine has very little correlation with QTc and change from baseline. A small number of side effects were observed. Overall, titrating quickly to large doses of quetiapine is safe for treating delirium.


Subject(s)
Antipsychotic Agents/therapeutic use , Critical Care , Critical Illness , Delirium/drug therapy , Quetiapine Fumarate/therapeutic use , Adult , Aged , Critical Illness/psychology , Critical Illness/therapy , Delirium/psychology , Female , Humans , Male , Middle Aged , Retrospective Studies , Risk Assessment
6.
J Intensive Care Med ; 33(7): 424-429, 2018 Jul.
Article in English | MEDLINE | ID: mdl-27837045

ABSTRACT

OBJECTIVE: Stress gastropathy is a rare complication of the intensive care unit stay with high morbidity and mortality. There are data that support the concept that patients tolerating enteral nutrition have sufficient gut blood flow to obviate the need for prophylaxis; however, no robust studies exist. This study assesses the incidence of clinically significant gastrointestinal bleeding in surgical trauma intensive care unit (STICU) patients at risk of stress gastropathy secondary to mechanical ventilation receiving enteral nutrition without pharmacologic prophylaxis. DESIGN: A retrospective cohort study of records from 2008 to 2013. SETTING: Adult patients in a single-center STICU were included. PATIENTS: Patients were included if they received full enteral nutrition while on mechanical ventilation. Exclusion criteria were coagulopathy, glucocorticoid use, prior-to-admission acid-suppressive therapy use, direct trauma or surgery to the stomach, failure to tolerate goal enteral nutrition, orders to allow natural death, and deviation from the intervention. INTERVENTION: Pharmacologic stress ulcer prophylaxis was discontinued once enteral nutrition was providing full caloric requirements for patients requiring mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: A total of 200 patients were included. The median age was 42 years, 83.0% were male, and 96.0% were trauma patients. The incidence of clinically significant gastrointestinal bleeding was 0.50%, with a subset analysis of traumatic brain injury patients yielding an incidence of 0.68%. Rates of ventilator-associated pneumonia and Clostridium difficile infection were low at 1.0 case/1000 ventilator days and 0.2 events/1000 patient days, respectively. Hospital all-cause mortality was 2.0%. Cost savings of US$121/patient stay were realized. CONCLUSION: Stress gastropathy is rare in this population. Surgical and trauma patients at risk for stress gastropathy did not benefit from continued pharmacologic prophylaxis once they tolerated enteral nutrition. Pharmacologic prophylaxis may safely be discontinued in this patient population. Further investigation is warranted to determine whether continued prophylaxis after attaining enteral feeding goals is detrimental.


Subject(s)
Critical Illness/therapy , Enteral Nutrition , Gastrointestinal Hemorrhage/prevention & control , Stomach Ulcer/prevention & control , Stress, Psychological/physiopathology , Adult , Female , Gastrointestinal Hemorrhage/etiology , Histamine H2 Antagonists/therapeutic use , Humans , Intensive Care Units , Male , Middle Aged , Respiration, Artificial , Retrospective Studies , Stomach Ulcer/etiology , Stress, Psychological/complications
7.
J Trauma Acute Care Surg ; 83(6): 1023-1031, 2017 12.
Article in English | MEDLINE | ID: mdl-28715360

ABSTRACT

BACKGROUND: Subclavian and axillary artery injuries are uncommon. In addition to many open vascular repairs, endovascular techniques are used for definitive repair or vascular control of these anatomically challenging injuries. The aim of this study was to determine the relative roles of endovascular and open techniques in the management of subclavian and axillary artery injuries comparing hospital outcomes, and long-term limb viability. METHODS: A multicenter, retrospective review of patients with subclavian or axillary artery injuries from January 1, 2004, to December 31, 2014, was completed at 11 participating Western Trauma Association institutions. Statistical analysis included χ, t-tests, and Cochran-Armitage trend tests. A p value less than 0.05 was significant. RESULTS: Two hundred twenty-three patients were included; mean age was 36 years, 84% were men. An increase in computed tomography angiography and decrease in conventional angiography was observed over time (p = 0.018). There were 120 subclavian and 119 axillary artery injuries. Procedure type was associated with injury grade (p < 0.001). Open operations were performed in 135 (61%) patients, including 93% of greater than 50% circumference lacerations and 83% of vessel transections. Endovascular repairs were performed in 38 (17%) patients; most frequently for pseudoaneurysms. Fourteen (6%) patients underwent a hybrid procedure. Use of endovascular versus open procedures did not increase over the duration of the study (p = 0.248). In-hospital mortality rate was 10%. Graft or stent thrombosis occurred in 7% and graft or stent infection occurred in 3% of patients. Mean follow-up was 1.6 ± 2.4 years (n = 150). Limb salvage was achieved in 216 (97%) patients. CONCLUSION: The management of subclavian and axillary artery injuries still requires a wide variety of open exposures and procedures, especially for the control of active hemorrhage from more than 50% vessel lacerations and transections. Endovascular repairs were used most often for pseudoaneurysms. Low early complication rates and limb salvage rates of 97% were observed after open and endovascular repairs. LEVEL OF EVIDENCE: Prognostic/epidemiologic, level IV.


Subject(s)
Arm Injuries/complications , Axillary Artery/injuries , Blood Vessel Prosthesis Implantation/methods , Subclavian Artery/injuries , Thoracic Injuries/complications , Vascular System Injuries/surgery , Wounds, Penetrating/complications , Adult , Arm Injuries/diagnosis , Arm Injuries/mortality , Axillary Artery/diagnostic imaging , Axillary Artery/surgery , Computed Tomography Angiography , Endovascular Procedures/methods , Female , Follow-Up Studies , Hospital Mortality/trends , Humans , Incidence , Injury Severity Score , Male , Postoperative Complications/epidemiology , Retrospective Studies , Societies, Medical , Subclavian Artery/diagnostic imaging , Subclavian Artery/surgery , Survival Rate/trends , Thoracic Injuries/diagnosis , Thoracic Injuries/mortality , Traumatology , Treatment Outcome , United States/epidemiology , Vascular System Injuries/diagnosis , Vascular System Injuries/etiology , Wounds, Penetrating/diagnosis , Wounds, Penetrating/mortality
8.
J Trauma Acute Care Surg ; 79(6): 951-6; discussion 956, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26335774

ABSTRACT

BACKGROUND: A subset of patients explored for abdominal injury have persistent hepatic bleeding on postoperative computed tomography (CT) and/or angiography, either not identified or not manageable at initial laparotomy. To identify patients at risk for ongoing hemorrhage and guide triage to angiography, we investigated the relationship of early postoperative CT scan with outcomes in operative hepatic trauma. METHODS: This is a retrospective review of 528 patients with hepatic injury taken to laparotomy without imaging within 6 hours of arrival to six trauma centers from 2007 to 2013, coordinated through the Western Trauma Association multicenter trials group. RESULTS: A total of 528 patients were identified, with a mean age of 31 years, 82% male, and 37% blunt injury; mean (SD) Injury Severity Score (ISS) was 27 (16) and base deficit was -9 (6); in-hospital mortality was 26%. Seventy-three patients died during initial exploration. Of 455 early survivors, 123 (27%) had a postoperative contrast CT scan within 24 hours of laparotomy. CT patients had more common blunt injury, higher ISS, and lower base deficit than those who did not undergo CT. CT identified hepatic contrast extravasation or pseudoaneurysm in 10 patients (8%). Hepatic bleeding on CT was 83% sensitive and 75% specific (likelihood ratio, 3.3) for later positive angiography; negative CT finding was 96% sensitive and 83% specific (likelihood ratio, 5.7) for later negative or not performed angiography. Despite occurring in a more severely injured cohort, performance of early postoperative CT was associated with reduced mortality (odds ratio, 0.16) in multivariate analysis. Blunt mechanism was also a multivariate predictor of mortality (odds ratio, 3.0). CONCLUSION: Early postoperative CT scan after laparotomy for hepatic trauma identifies clinically relevant ongoing bleeding and is sufficiently sensitive and specific to guide triage to angiography. Contrast CT should be considered in the management algorithm for hepatic trauma, particularly in the setting of blunt injury. Further study should identify optimal patient selection criteria and CT scan timing in this population. LEVEL OF EVIDENCE: Care management/therapeutic study, level IV; epidemiologic/prognostic study, level III.


Subject(s)
Liver/diagnostic imaging , Tomography, X-Ray Computed , Triage , Adult , Angiography , Contrast Media , Female , Humans , Injury Severity Score , Laparotomy , Liver/injuries , Liver/surgery , Male , Retrospective Studies , Sensitivity and Specificity
9.
J Crit Care ; 30(1): 221.e1-5, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25306239

ABSTRACT

INTRODUCTION: Little is known about the incidence and etiology of fat embolism in pediatric patients. We sought to determine the incidence, time course, and associated factors of pulmonary fat embolism (PFE), cerebral fat embolism (CFE), and kidney fat embolism (KFE) in trauma and nontrauma pediatric patients at the time of autopsy. METHODS: Retrospectively, a convenience sample of consecutive pediatric patients (age, ≤10 years) who had undergone autopsy between 2008 and 2012 were evaluated for fat embolism. Patients who had no documented cause of death or who were hospital births and died during the same hospitalization were excluded. Formalin-fixed paraffin sections were reviewed by a forensic pathologist for evidence of fat embolism and nuclear elements. Autopsy reports were used to determine cause of death, injuries, resuscitative efforts taken, sex, height, weight, and age. RESULTS: Sixty-seven decedents were evaluated. The median age was 2.0 years (interquartile range, 0.75-4), median body mass index (BMI) was 18.0 kg/m(2) (interquartile range, 15.7-19.0 kg/m(2)), and 55% of the patients were male. Pulmonary fat embolism, CFE, and KFE were present in 30%, 15%, and 3% of all patients, respectively. The incidence of PFE was not significantly different by cause of death (trauma 33%, drowning 36%, burn 14%, medical 28%). Patients with PFE but not CFE had significantly higher age, height, weight, and BMI. Half of the PFE and 57% of the CFE occurred in patients who lived less than 1 hour after beginning of resuscitation. Seventy-one percent of patients with CFE did not have a patent foramen ovale. Multivariate regression revealed an increased odds ratio of PFE based on BMI (1.244 [95% confidence interval, 1.043-1.484], P = .015). None of the samples evaluated demonstrated nuclear elements. CONCLUSIONS: Pulmonary fat embolism, CFE, and KFE are common in pediatric trauma and medical deaths. Body mass index is independently associated with the development of PFE. Absence of nuclear elements suggests that fat embolism did not originate from intramedullary fat.


Subject(s)
Embolism, Fat , Intracranial Embolism , Kidney Diseases , Kidney/blood supply , Pulmonary Embolism , Autopsy , Body Mass Index , Body Weight , Child, Preschool , Embolism, Fat/epidemiology , Embolism, Fat/etiology , Embolism, Fat/pathology , Female , Humans , Incidence , Infant , Infant, Newborn , Intracranial Embolism/epidemiology , Intracranial Embolism/etiology , Intracranial Embolism/pathology , Kidney Diseases/epidemiology , Kidney Diseases/etiology , Male , Pulmonary Embolism/epidemiology , Pulmonary Embolism/etiology , Pulmonary Embolism/pathology , Regression Analysis , Retrospective Studies , Wounds and Injuries/complications
10.
J Crit Care ; 30(1): 196-200, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25449879

ABSTRACT

BACKGROUND: Traumatically injured patients have multiple causes for acute respiratory decompensation. We reviewed the use of computed tomography pulmonary angiography (CTPA) in critically injured patients to evaluate the results and impact on patient care. METHODS: The charts of trauma patients (age >16 years) admitted to our intensive care unit for greater than 48 hours, who underwent CTPA for acute respiratory decompensation, were reviewed to determine the results of these studies and the effect on patient care. RESULTS: We identified 188 patients who underwent CTPA for acute physiologic changes. Pertinent clinical finding were identified in 95% of studies and included atelectasis/collapse (56%), pleural effusion (18%), pneumonia (15%), and pulmonary embolus (18%). These results prompted interventions designed to improve patient outcome. The most frequent interventions were modifications of ventilator therapy (52%), antibiotic therapy (28%), mini-bronchoalveolar lavage (15%), or bronchoscopy (15%). Diagnostic agreement between chest x-ray and CTPA was poor to moderate (κ = 0.013-0.512). CONCLUSIONS: Computed tomography pulmonary angiography is valuable in the evaluation of cardiopulmonary deterioration in critically ill traumatically injured patients. Computed tomography pulmonary angiography offers the ability to identify causes of acute physiologic changes not detected using standard chest x-ray. The results of these studies provide insight into the underlying pathophysiology and offer an opportunity to direct subsequent patient care.


Subject(s)
Multiple Trauma/complications , Pleural Effusion/diagnostic imaging , Pneumonia/diagnostic imaging , Pulmonary Atelectasis/diagnostic imaging , Pulmonary Embolism/diagnostic imaging , Tomography, X-Ray Computed/methods , Adult , Aged , Critical Illness , Female , Humans , Hypoxia/etiology , Injury Severity Score , Lung Injury/diagnostic imaging , Lung Injury/etiology , Male , Middle Aged , Pleural Effusion/etiology , Pneumonia/etiology , Pulmonary Artery/diagnostic imaging , Pulmonary Atelectasis/etiology , Pulmonary Embolism/diagnosis , Pulmonary Embolism/etiology , Pulmonary Veins/diagnostic imaging , Radiography, Thoracic/methods , Respiratory Insufficiency/etiology , Retrospective Studies , Tachycardia/etiology , Thoracic Injuries/complications
11.
J Crit Care ; 29(1): 139-43, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24075300

ABSTRACT

PURPOSE: The goal of this study was to determine the impact of surgical rib fixation (SRF) in a treatment protocol for severe blunt chest trauma. MATERIALS AND METHODS: Patients with flail chest admitted between September 2009 and June 2010 to our level I trauma center who failed traditional management and underwent SRF were matched with an historical group. Outcome variables evaluated include age, injury severity score, intensive care unit length of stay (LOS), hospital LOS, ventilator days, total number of rib fractures, and total number of segmental rib fractures. RESULTS: The 2 groups were similar in age, injury severity score, intensive care unit LOS, hospital LOS, total number of rib fractures, and total segmental rib fractures. The operative group demonstrated a significant reduction in total ventilator days as compared with the nonsurgical group (4.5 [0-30] vs 16.0 [4-40]; P = .040). Patients with SRF were permanently liberated from the ventilator within a median of 1.5 days (0-8 days). CONCLUSIONS: Surgical rib fixation resulted in a significant decrease in ventilator days and may represent a novel approach to decreasing morbidity in flail chest patients when used as a rescue therapy in patients with declining pulmonary status. Larger studies are required to further identify these benefits.


Subject(s)
Flail Chest/surgery , Fracture Fixation, Internal/methods , Respiration, Artificial/methods , Rib Fractures/surgery , Wounds, Nonpenetrating/surgery , Adult , Age Factors , Aged , Female , Humans , Injury Severity Score , Intensive Care Units , Length of Stay , Male , Middle Aged , Time Factors , Trauma Centers
12.
J Crit Care ; 28(5): 804-9, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23876704

ABSTRACT

PURPOSE: This study aimed to identify predictive factors resulting in glucose values greater than 200 mg/dL in patients with trauma transitioned from an insulin infusion to a basal-bolus subcutaneous insulin regimen. MATERIALS AND METHODS: Thirty-nine patients with trauma on goal enteral nutrition in the intensive care unit receiving an insulin infusion for at least 48 hours and transitioned to a basal-bolus regimen were retrospectively identified. RESULTS: Ten patients had hyperglycemic events after transition. Hyperglycemia was significantly associated with increased age (42 [17] years vs 56 [13] years, P=.02), admission glucose (128 [39] mg/dL vs 214 [91] mg/dL, P=.015), and insulin drip rate 48 hours before transition (87 [38] units/d vs 127 [49] units/d, P=.012). There was no difference between groups with respect to injury severity, demographics, or physiologic parameters. Multiple regression analysis revealed that increased age (odds ratio [OR], 1.215 [1.000-1.477]; P=.05), increased admission blood glucose (OR, 1.053 [1.006-1.101]; P=.025), and higher insulin infusion rates 48 hours before transition (OR, 1.061 [1.009-1.116]; P=.020) predisposed patients to severe hyperglycemic episodes. CONCLUSIONS: Older patients with trauma and patients with higher blood glucose on admission are more likely to experience severe hyperglycemia when transitioned to basal-bolus glucose control. Higher insulin infusion rates at 48 hours before transition are also associated with severe hyperglycemia.


Subject(s)
Blood Glucose/analysis , Blood Glucose/drug effects , Hyperglycemia/etiology , Hypoglycemic Agents/administration & dosage , Insulin/administration & dosage , Intensive Care Units , Adult , Age Factors , Enteral Nutrition , Female , Humans , Infusions, Intravenous , Injections, Subcutaneous , Male , Middle Aged , Predictive Value of Tests , Retrospective Studies , Risk Factors , Treatment Outcome
13.
J Trauma ; 71(2): 396-9; discussion 399-400, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21825943

ABSTRACT

BACKGROUND: Timing and type of chemoprophylaxis (CP) that should be used in patients with traumatic brain injury (TBI) remains unclear. We reviewed our institutions experience with low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) in TBI. METHODS: The charts of all TBI patients with a head abbreviated injury severity score >2 (HAIS) and an intensive care unit length of stay >48 hours admitted during a 42-month period between 2006 and 2009 were reviewed. CP was initiated after intracranial hemorrhage was considered stable. We reviewed all operative notes and radiologic reports in these patients to analyze the rate of significant intracranial hemorrhagic complications, deep venous thrombosis, or pulmonary embolus. RESULTS: A total of 386 patients with TBI were identified; 158 were treated with LMWH and 171 were treated with UFH. HAIS was significantly different between the LMWH (3.8 ± 0.7) and UFH (4.1 ± 0.7) groups; the time to initiation of CP was not. The UFH group had a significantly higher rate of deep venous thrombosis and pulmonary embolus. Progression of ICH that occurred after the initiation of CP was significantly higher in the UFH-treated patients (59%) when compared with those treated with LMWH (40%). Two patients in the UFH group required craniotomy after the initiation of CP. CONCLUSION: LMWH is an effective method of CP in patients with TBI, providing a lower rate of venous thromboembolic and hemorrhagic complications when compared with UFH. A large, prospective, randomized study would better evaluate the safety and efficacy of LMWH in patients suffering blunt traumatic brain injury.


Subject(s)
Abbreviated Injury Scale , Anticoagulants/therapeutic use , Brain Injuries/complications , Enoxaparin/therapeutic use , Heparin/therapeutic use , Injury Severity Score , Pulmonary Embolism/prevention & control , Venous Thrombosis/prevention & control , Wounds, Nonpenetrating/complications , Disease Progression , Humans , Length of Stay , Pulmonary Embolism/etiology , Retrospective Studies , Venous Thrombosis/etiology
14.
Am Surg ; 76(5): 492-6, 2010 May.
Article in English | MEDLINE | ID: mdl-20506878

ABSTRACT

Chronic alcohol consumption has been linked to increased morbidity and mortality in the intensive care unit setting. The purpose of our study was to assess outcomes in trauma patients admitted to our institutional university-affiliated, Level I emergency trauma unit (ETU) with and without per cent carbohydrate-deficient transferrin (%CDT) elevations over a 12-week timeframe. Markers for alcohol consumption including %CDT, gamma glutamyl transferase, and serum osmolality were measured along with the standard trauma laboratory panel on arrival to the ETU. Intensive care unit length of stay (LOS), length of time requiring ventilator support, hospital LOS, total hospital charges as well as incidences of postoperative complications were collected on all patients with a LOS greater than or equal to 48 hours. Demographics between the groups were similar. Drinking histories were more significant in the elevated %CDT group (P = 0.0006). Patients with elevated %CDT had significantly longer ICU and hospital LOS (5.1 vs. 3.9, P = 0.01; 8.7 vs. 7.1 days, P = 0.0052) and ventilator days (2 vs. 1.5 days, P = 0.0286). Complications and hospital charges were similar between groups. Trauma patients presenting to the ETU with %CDT elevations appear to be at risk for longer ICU and hospital LOS.


Subject(s)
Alcoholism/blood , Emergency Service, Hospital , Transferrin/analogs & derivatives , Wounds and Injuries/blood , Wounds and Injuries/therapy , Adolescent , Adult , Alcoholism/complications , Alcoholism/diagnosis , Biomarkers/blood , Child , Cohort Studies , Critical Care , Female , Hospitalization , Humans , Male , Middle Aged , Pilot Projects , Predictive Value of Tests , Retrospective Studies , Transferrin/metabolism , Treatment Outcome , Wounds and Injuries/etiology , Young Adult
16.
J Trauma ; 68(2): 382-6, 2010 Feb.
Article in English | MEDLINE | ID: mdl-19935109

ABSTRACT

BACKGROUND: Evidence-based guidelines for managing nosocomial pneumonia were published in 2005. Subsequently, our surgical critical care service developed and implemented an adaptation of this guideline for use in our surgical trauma intensive care unit (STICU). This study examined outcomes for two STICU cohorts treated for pneumonia before and after guideline implementation. METHODS: A total of 130 charts were evaluated. The guideline cohort (GC) consisted of 65 patients with pneumonia managed by the surgical critical care service. These patients were prospectively identified for inclusion if they met specified clinical criteria for pneumonia diagnosis. The historical control cohort was identified retrospectively using ICD-9 coding. The primary outcome measure was ICU length of stay (LOS). Secondary outcome measures included overall LOS, mechanical ventilation days, mortality, and total cost of admission. The study was designed to have 80% power to detect a 1-day decrease in mean ICU LOS in a multivariable regression analysis. Descriptive differences were compared using two-sample t tests for continuous variables and chi for categorical variables. RESULTS: Baseline characteristics were not significantly different between cohorts. The multivariable regression analysis indicated a mean decrease of 4.6 days, 9.5 days, and 3.9 days for ICU LOS, overall LOS, and mechanical ventilation days, respectively, in the GC, with an expected mean cost reduction per admission of $23,322 (all significant at p

Subject(s)
Pneumonia, Ventilator-Associated/therapy , Practice Guidelines as Topic , Wounds and Injuries/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Cost of Illness , Female , Humans , Intensive Care Units , Length of Stay , Male , Middle Aged , Pneumonia, Ventilator-Associated/drug therapy , Pneumonia, Ventilator-Associated/economics , Regression Analysis , Retrospective Studies , Treatment Outcome , Young Adult
17.
Am Surg ; 74(12): 1146-8; discussion 1149-50, 2008 Dec.
Article in English | MEDLINE | ID: mdl-19097526

ABSTRACT

Deep venous thrombosis and pulmonary embolism frequently occur after trauma and continue to account for significant morbidity and mortality in this population. Asymptomatic pulmonary emboli are also believed to be quite common, but the incidence as well as the implications of these events is unknown. This case report describes two patients whose pulmonary emboli were found incidentally on the initial trauma workup. Very little has been written concerning this issue and in this case report we review the risk factors and clinical significance of these "incidentally discovered" pulmonary emboli.


Subject(s)
Multiple Trauma/complications , Pulmonary Embolism/diagnostic imaging , Thoracic Injuries/diagnostic imaging , Tomography, X-Ray Computed , Accidents, Traffic , Adult , Contrast Media , Humans , Incidental Findings , Male , Middle Aged , Multiple Trauma/therapy , Pulmonary Embolism/etiology , Risk Factors
18.
Am Surg ; 73(3): 239-42, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17375778

ABSTRACT

Although pseudoaneurysms after penetrating extremity trauma are well described, we describe an unusual case of residual occult aortic injury after an initial attempt at repair that was recognized on postoperative imaging. Reoperation with primary resection and end-to-end repair was accomplished successfully. Because this entity is so unusual, we review strategies to avoid and recognize its occurrence. Early imaging allows early identification of aortic pseudoaneurysms should they occur, and will preclude delayed manifestation of complications, including death. Our case illustrates the utility of such postoperative scanning. Other alternatives to primary repair or interposition grafting in management of penetrating abdominal aortic trauma, such as interventional stent grafting, are discussed.


Subject(s)
Abdominal Injuries/complications , Aorta, Abdominal/injuries , Wounds, Stab/complications , Abdominal Injuries/diagnostic imaging , Adolescent , Aorta, Abdominal/diagnostic imaging , Aorta, Abdominal/surgery , Aortography , Blood Vessel Prosthesis Implantation , Humans , Male , Tomography, X-Ray Computed , Wounds, Stab/diagnostic imaging
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