Subject(s)
Kidney Transplantation , Sarcoma, Kaposi , Skin Neoplasms , Humans , Kidney Transplantation/adverse effects , Sarcoma, Kaposi/etiology , Sarcoma, Kaposi/diagnosis , Sarcoma, Kaposi/pathology , Male , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Skin Neoplasms/etiology , Russia , Middle Aged , Adult , Female , Immunocompromised HostABSTRACT
Hailey-Hailey disease (HHD) is a rare genetic benign condition resulting in blisters predominantly on the skin folds. The inheritance is autosomal dominant with complete penetrance, but a variable expressivity in affected family members. It can be triggered by a vast variety of factors such as sweating, weight gain, infection, trauma, pregnancy, and ultraviolet radiation, but the major cause of the disease is a mutation in the ATP2C1 gene. The lesions are typically distributed symmetrically within intertriginous regions such as the retroarticular folds, axillae, inguinal, and perianal regions and presents as flaccid vesicles and blisters on erythematous skin, giving rise to erosions, fissures, and vegetations. There is no specific therapy for HHD. The therapeutic approach to HHD involves the control of exacerbating factors, secondary infections, and cutaneous inflammation. Because of the rarity of the disease, evidence of efficacy for topical or systemic therapies is mainly based on small observational studies, case reports, and clinical experience. We present a case of HHD successfully treated by photodynamic therapy (PDT) with a topical liposomal chlorin photosensitizer.
Subject(s)
Pemphigus, Benign Familial , Photochemotherapy , Humans , Pemphigus, Benign Familial/drug therapy , Pemphigus, Benign Familial/genetics , Pemphigus, Benign Familial/pathology , Blister/drug therapy , Ultraviolet Rays , Calcium-Transporting ATPases/genetics , Calcium-Transporting ATPases/therapeutic use , Photochemotherapy/methods , Photosensitizing Agents/therapeutic useABSTRACT
Platelet-rich plasma (PRP) is an autologous platelet concentrate in plasma enriched with growth factors that may stimulate tissue regeneration, collagen formation, re-epithelization, and angiogenesis. PRP is widely used as an androgenetic alopecia treatment option. The present work aims to test the efficacy of various PRP methods, including those with single-spin and double-spin centrifugation. We performed a review of articles published from 2011 to 2021 in PubMed and ScienceDirect. The studies vary in the preparation procedure, dose, number, intervals between the procedures, and the injection technique because of low standardization of PRP preparation, complicating the evaluation of the clinical efficacy of the method. Based on the conducted statistical analysis, we came to the conclusion that the double-spin PRP preparation method was superior to the single-spin technique, which may be taken into account for AGA management.
Subject(s)
HIV Infections , Herpesvirus 8, Human , Sarcoma, Kaposi , HIV Infections/complications , Humans , Russia , Sarcoma, Kaposi/diagnosisSubject(s)
Darier Disease , Darier Disease/diagnosis , Darier Disease/drug therapy , Humans , RussiaABSTRACT
Buschke-Löwenstein tumor is known to manifest not only in sexually active people and adolescents exposed to violence or drugs, but also in people who do not have any predisposing factors or bad habits. Several studies have shown that in the majority of children with anogenital warts, HPV can be transmitted asexually by hetero- inoculation or through infected objects. To our knowledge, there are currently few reports on BLT in HPV-negative patients in the literature. In our case, the patient presented early, with multiple slow growing warts, no history of alcohol intake, drug use or smoking and no HPV infection, which makes this case unique and important.
