[The model specification of the period without recurrences in rats after Pliss lymphosarcoma resection].

The purpose of the present study was to make an experimental model of the period without recurrences in rats after Pliss lymphosarcoma (PLS) resection. Experiments were carried out on white low-bred male rats (n=109). For the tumor transinoculation the rats received subcutaneously 0.2 ml of the aseptic 50% suspension of PLS prepared according to the standards on saline without antibiotic addition. The injections were done in the right abdomen region. The animals were classified into three groups. Group 1 was used for control. An operation of lymphosarcoma resection was carried out on the rats from group 2 on the fifth day from the tumor inoculation. The tumor in the animals from group 3 was dissected on 12-22nd day from its inoculation. At the same time the specification of the duration of the period without recurrences was estimated in every group. According to the suggested method the Pliss lymphosarcoma resection significantly increases the life duration of operated rats that proves the efficiency of surgical interventions. The absence of intraoperative and postoperative lethality on the fifth day from the Pliss lymphosarcoma resection and 100% animal death resulting from the recurrences makes the proposed model potentially suitable for the investigation of adjuvant methods that are used in the treatment of cancer.

[Clomiphene, ovarian hyperstimulation syndrome and pregnancy].

In case of an ovarian hyperstimulation syndrome surgical treatment causes the regress of symptoms much faster than pharmacotherapy--during the resection of an ovary the concentration of estrogenes in blood is effectively reduced. Frequent use of ovulation inductors (Clomiphene Gonadotrop(h)in) is accompanied by ovarian hyperstimulation syndrome. It is characterized by the increase of sizes of ovaries; the formation of ascites and hydrothorax, by the thromboemboly of main blood vessels and etc. Clomiphene accelerates the maturation process of follicles, but contributes to the increase of concentration of oncomarker CA-125 in blood. This makes it difficult to verify the diagnosis of ovary cancer, particularly among pregnants. The case report of infertility treatment with Clomiphene is depicted. Woman became pregnant after three courses of infertility treatment, but pregnancy was complicated with cardiac and lung insufficiency; the suspicion of stage III ovarian cancer aroused. Serious threat to health of a woman resulted in prevention of pregnancy. Right side adnexectomy was conducted. Surgical treatment led to improvement and after four years the patient delivered a healthy child.

[Cytoreductive surgery and immunotherapy].

The aim of the article was to treat Pliss lymphosarcoma by means of Cytoreductive surgery to improve patient outcomes by taking into consideration the dynamics of Blood Auto-Proteolytic Activity (BAPA). In rats suffering from tumour proves to be obvious that higher the BAPA, more intensive is the process of invasive growth of tumour. Therefore, the performance of cytoreductive surgery is more reasonable when BAPA is at its minimal level, i. e. either at the early stage of tumour, though this may sound as a paradox. Removal of the tumour at the maximal level of BAPA will favour rapid development of a recurrent tumour. This can be explained by the fact that the remained cells tend to be more serious threat when BAPA level appears to be high.