ABSTRACT
BACKGROUND: Migrant farmworkers are prone to several psychosocial stressors. OBJECTIVE: To investigate the effect of perceived psychosocial factors on pesticide exposure among seasonal migrant Hispanic farmworkers in North Carolina, USA. METHODS: A cross-sectional interview survey of 187 seasonal migrant farmworkers of Mexican descent, identified from labor camps located in rural counties in North Carolina, was conducted using nonprobability purposive sampling approach. Multivariable ordinal logistic regression analysis was used to determine the relationship between perceived control over the harmful effects of pesticide exposure, lack of social support, and the impact of anxiety on perception of pesticide exposure. RESULTS: More than 20% (n=39) of farmworkers reported frequent or constant contact with pesticides while working in the fields. More than 68% of farmworkers reported they believe they have control over avoiding harmful effects of pesticide exposure; the odds of pesticide exposure were 55% lower in this group (adjusted OR: 0.45; 95% CI: 0.22-0.91). No significant relationship was observed between farmworkers perception of lack of social support and presence of anxiety with odds of on-field pesticide exposure. CONCLUSION: The study results suggest that perception of control is an important predictor of reduced pesticide exposure among seasonal migrant farmworkers.
Subject(s)
Agriculture , Occupational Exposure/adverse effects , Pesticides/adverse effects , Stress, Psychological/ethnology , Transients and Migrants/psychology , Adolescent , Adult , Cross-Sectional Studies , Humans , Internal-External Control , Male , Mexico/epidemiology , Middle Aged , North Carolina/epidemiology , Perception , Risk Factors , Rural Population , Social Support , Stress, Psychological/etiology , Workforce , Young AdultABSTRACT
The effects of the peptide fasciculin (FAS), a potent inhibitor of acetylcholinesterase (AChE) have been examined, following unilateral microinfusion, on tissue levels of monoamines in the rat substantia nigra and concomitant circling behaviour. Although FAS inhibited 87% of total AChE, the levels of dopamine and its metabolites remained unchanged. Furthermore, the treatment induced modest contraversive rotation which was markedly enhanced in the presence of a systemic challenge with apomorphine. This behavioural effect of FAS was partially reversed by systemically administered atropine. Any possible interaction of FAS with nigral dopamine systems was further investigated by testing the peptide in animals that five days earlier had undergone a 6-hydroxydopamine (6-OHDA) lesion of the SN such that dopamine and AChE were significantly but not completely reduced. In a majority of these animals, FAS treatment caused a reversal of the lesion induced ipsiversive rotation, ie restored contraversive rotation. It is concluded that in the SN, FAS can have biochemical and behavioural actions independent of local dopamine systems and linked to cholinergic transmission. In addition, treatment with FAS in the substantia nigra also reveals the possible existence of at least two distinct pools of AChE with, respectively, non-cholinergic and cholinergic actions.