ABSTRACT
This paper explores the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the prognosis of glioma, and judges the relevant factors affecting the prognosis of glioma. This paper used a Cox proportional hazards model to retrospectively analyze clinical data of 81 patients with complete neuroglioma from the same neurosurgery medical team from January 2012 to November 2018, including DCE-MRI data. To determine the prognostic factors, P < 0.05 was used as the statistical standard, and the survival curve of statistically significant factors was drawn by Kaplan-Meier method. The Cox proportional hazard model analysis showed the preoperative Karnofsky Performance Status Scale (KPS) score, age, tumor pathologic grade, postoperative radiotherapy, temozolomide use, and Ki-67 expression had an impact on the prognosis of patients with neuroglioma. Multivariate analysis and DCE-MRI data showed that age, tumor grade, preoperative KPS score, postoperative radiotherapy, and Ki-67 expression were prognostic factors for patients with glioma. The older the age, the higher the pathologic grade, the higher the Ki-67 expression level, and the lower the KPS score before surgery, the worse the prognosis. Postoperative radiotherapy and appropriate temozolomide chemotherapy will help improve the prognosis of patients with neuroglioma.
Subject(s)
Antineoplastic Agents, Alkylating/therapeutic use , Brain Neoplasms/diagnostic imaging , Glioma/diagnostic imaging , Neurosurgical Procedures , Temozolomide/therapeutic use , Brain Edema/etiology , Brain Neoplasms/complications , Brain Neoplasms/pathology , Brain Neoplasms/therapy , Chemotherapy, Adjuvant , Contrast Media , Epilepsy/etiology , Female , Glioma/complications , Glioma/pathology , Glioma/therapy , Headache/etiology , Humans , Kaplan-Meier Estimate , Karnofsky Performance Status , Ki-67 Antigen/metabolism , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Grading , Preoperative Period , Prognosis , Proportional Hazards Models , Radiotherapy, Adjuvant , Tumor BurdenABSTRACT
The aim of the present study was to investigate the effects of microRNA-18a (miR-18a) on the invasiveness and metastasis of invasive meningiomas and the underlying mechanism. A total of 69 patients with meningiomas (30 patients in the invasive meningioma group and 39 patients in the non-invasive meningioma group) and 48 cases in the control group were enrolled. Samples of meningioma tissues, serum and cerebrospinal fluid were collected. Reverse transcription-quantitative polymerase chain reaction was performed to quantify the expression levels of hypoxia-inducible factor-1α (HIF-1α) mRNA and miR-18a. Western blot analysis was used to determine protein expression levels of HIF-1α. The expression levels of HIF-1α mRNA and protein in all three types of sample from the invasive meningioma group were significantly higher compared with those in the control and non-invasive meningioma groups (P<0.05), and the expression levels of HIF-1α mRNA in the serum and cerebrospinal fluid of the non-invasive meningioma group were significantly higher compared with those in the control group (P<0.05). The expression levels of miR-18a in the invasive meningioma group were significantly reduced compared with those in the control and non-invasive meningioma groups (P<0.05), whereas the levels of miR-18a in the non-invasive meningioma group were significantly lower compared with those in the control group (P<0.05). The expression of HIF-1α is significantly upregulated in patients with invasive meningiomas, possibly due to the downregulation of miR-18a expression. Therefore, miR-18a may regulate invasive meningiomas via HIF-1α.
ABSTRACT
Thermal microbubbles generally grow directly from the heater and are spherical to minimize surface tension. We demonstrate a novel type of microbubble indirectly generated from a graphene oxide-microheater. Graphene oxide's photothermal properties allowed for efficient generation of a thermal gradient field on the microscale. A series of approximately ellipsoidal microbubbles were generated on the smooth microwire based on heterogeneous nucleation. Other dynamic behaviors induced by the microheater such as constant growth, directional transport and coalescence were also investigated experimentally and theoretically. The results are not only helpful for understanding the bubble dynamics but also useful for developing novel photothermal bubble-based devices.
ABSTRACT
This study makes a claim of utilizing the photothermal effect of graphene oxide nanosheets (GONs) to effectively produce various microbubbles in an optical microfiber system at infrared optical communications band. A low power continuous-wave light at wavelength of 1527-1566 nm was launched into the microfiber to form GONs-deposition which acted as a linear heat source for creating various microbubbles. Both thermal convection flow and optical gradient force were responsible for the driving force to assemble GONs onto the microfiber. This simple optical fiber system can be used for assembling other micro/nanoscale particles and biomolecules, which has prospective applications in sensing, microfluidics, virus detection, and other biochip techniques.
