Constructing Organic Phosphorescent Scintillators with Enhanced Triplet Exciton Utilization Through Multi-Mode Radioluminescence for Efficient X-Ray Imaging.

The development of organic phosphorescent scintillators with high exciton utilization efficiency has attracted significant attention but remains a difficult challenge because of the inherent spin-forbidden feature of X-ray-induced triplet excitons. Herein, a design strategy is proposed to develop organic phosphorescent scintillators through thermally activated exciton release to convert stabilized spin-forbidden triplet excitons to spin-allowed singlet excitons, which enables singlet exciton-dominated multi-mode emission simultaneously from the lowest singlet, triplet, and stabilized triplet states. The resultant scintillators demonstrate a maximum photoluminescence efficiency of 65.8% and a minimum X-ray radiation detection limit of 110 nGy s-1; this allows efficient radiography imaging with a spatial resolution of ≈10.0 lp mm-1. This study advances the fundamental understanding of exciton dynamics under X-ray excitation, significantly broadening the practical use of phosphorescent materials for safety-critical industries and medical diagnostics.

Efficient metal free organic radical scintillators.

The development of high-performance metal-free organic X-ray scintillators (OXSTs), characterized by a synergistic combination of robust X-ray absorption, efficient exciton utilization, and short luminescence lifetimes, poses a considerable challenge. Here we present an effective strategy for achieving augmented X-ray scintillation through the utilization of halogenated open-shell organic radical scintillators. Our experimental results demonstrate that the synthesized scintillators exhibit strong X-ray absorption derived from halogen atoms, display efficacious X-ray stability, and theoretically achieve 100% exciton utilization efficiency with a short lifetime (∼18 ns) due to spin-allowed doublet transitions. The superior X-ray scintillation performance exhibited by these organic radicals is not only exploitable in X-ray radiography for contrast imaging of various objects but also applicable in a medical high-resolution micro-computer-tomography system for the clear visualization of fibrous veins within a bamboo stick. Our study substantiates the promise of organic radicals as prospective candidates for OXSTs, offering valuable insights and a roadmap for the development of advanced organic radical scintillators geared towards achieving high-quality X-ray radiography.

Progress of machine learning-based biosensors for the monitoring of food safety: A review.

Rapid urbanization and growing food demand caused people to be concerned about food safety. Biosensors have gained considerable attention for assessing food safety due to selectivity, and sensitivity but poor stability inherently limits their application. The emergence of machine learning (ML) has enhanced the efficiency of different sensors for food safety assessment. The ML combined with various noninvasive biosensors has been implemented efficiently to monitor food safety by considering the stability of bio-recognition molecules. This review comprehensively summarizes the application of ML-powered biosensors to investigate food safety. Initially, different detector-based biosensors using biological molecules with their advantages and disadvantages and biosensor-related various ML algorithms for food safety monitoring have been discussed. Next, the application of ML-powered biosensors to detect antibiotics, foodborne microorganisms, mycotoxins, pesticides, heavy metals, anions, and persistent organic pollutants has been highlighted for the last five years. The challenges and prospects have also been deliberated. This review provides a new prospect in developing various biosensors for multi-food contaminants powered by suitable ML algorithms to monitor in-situ food safety.

Prehypertension in male affects both semen quality and pregnancy outcomes in their first single blastocyst frozen-thawed embryo transfer cycles.

OBJECTIVE: To investigate whether prehypertension (Pre-HTN) in male affects semen quality and assisted reproductive technology (ART) outcomes. DESIGN: Retrospective cohort study. SETTING: University-affiliated reproductive medicine center in Beijing, China. PATIENTS: Clinical data were collected from 1043 couples undergoing their first single blastocyst frozen-thawed embryo transfer (FET) cycles. INTERVENTIONS: According to the blood pressure (BP, 1mmHg = 0.133 kPa) in male, including systolic blood pressure (SBP) and diastolic blood pressure (DBP), the subjects were divided into the Control group (90 ≤ SBP < 120 mmHg and 60 ≤ DBP < 80 mmHg, n = 611) and the Pre-HTN group (120 ≤ SBP < 140 mmHg and/or 80 ≤ DBP < 90 mmHg, n = 432). The association between Pre-HTN and semen quality, and ART outcomes was then evaluated. MAIN OUTCOME MEASURES: Primary outcome: live birth rate (LBR). SECONDARY OUTCOMES: semen quality, laboratory embryo outcomes, clinical pregnancy rate (CPR), biochemical pregnancy rate, miscarriage rate, and other pregnancy outcomes. RESULTS: Compared with the Control group, the Pre-HTN group showed lower total sperm motility, total sperm count, sperm progressive motility, progressive sperm count (P < .05), and higher prevalence of oligozoospermia (17.6% vs. 13.1%, P = .045), and asthenozoospermia (37.7% vs. 19.8%, P < .001). Meanwhile, compared with the Control group, the Pre-HTN group had a lower CPR (42.8% vs. 57.6%, P < .001) and a lower LBR (32.9% vs. 47.3%, P < .001). There were no differences in the remaining parameters of semen quality, laboratory embryo outcomes (except for the proportion of ICSI), and pregnancy outcomes between the two groups. Additionally, regression analysis showed that Pre-HTN in male was an independent risk factor for clinical pregnancy (adjusted OR: 0.57, 95% CI: 0.44-0.74, P < .001) and live birth (adjusted OR: 0.58, 95% CI: 0.44-0.75, P < .001). CONCLUSIONS: Pre-HTN in male not only results in lower semen quality, but also has negative consequences on the success of ART. It is an independent risk factor for clinical pregnancy and live birth in the first single blastocyst FET cycles.

Standardization and application of ARMS TaqMan real-time PCR for screening of folate metabolism genes in Han Chinese.

Folate has antioxidant properties, and low concentration in seminal plasma may be associated with increased DNA damage in sperm. Mutations of the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes, including MTHFR C677T (rs1801133), MTHFR A1298C (rs1801131), and MTRR A66G (rs1801394), can lead to decreased activity of the encoded folate metabolic enzymes, thereby affecting male reproduction. The current SNP detection methods commonly used in clinical practice have some shortcomings, such as long time-consuming, complex detection steps, or high cost. The purpose of this study was to establish a simple, time-saving, sensitive, accurate, and easy to clinical popularization method for folate metabolism gene detection. We combined ARMS-PCR with TaqMan fluorescent probe to establish an ARMS TaqMan real-time PCR detection method. According to the variation of rs1801131, rs1801133, and rs1801394, two specific primers (one wild type and one mutant) were designed. Mismatched nucleotides were introduced at the penultimate or third position to improve the specificity of the primer. Specific TaqMan probe was introduced to detect PCR products to improve the sensitivity of the method. The results showed that the sensitivity of ARMS TaqMan real-time PCR in SNP genotyping was 1 ng, and the accuracy was 100%. A total of 249 clinical samples were detected by the established method, and the correlation between three SNPs and semen quality was analyzed. We found that individuals carrying the AG + GG genotype of rs1801394 had a lower risk of abnormal semen quality. In conclusion, we developed a highly sensitive, accurate, rapid, and easy to be popularized method for detecting SNPs of rs1801394, rs1801131, and rs1801133. ARMS TaqMan real-time PCR is a reliable SNP genotyping method in folate metabolism genes.

Functionalized metal-organic frameworks with biomolecules for sensing and detection applications of food contaminants.

The increasing demand for toxin-free food, driven by the rise in fast food consumption and changing dietary habits, necessitates advanced and efficient detection methods to address the potential risks associated with contaminated food. Nanomaterial-based detection methods have shown significant promise, particularly using metal-organic frameworks (MOFs) combined with biomolecules. This review article provides an overview of recent advancements in using functionalized metal-organic frameworks (FMOFs) with biomolecules to detect various food contaminants, including heavy metals, antibiotics, pesticides, bacteria, mycotoxins and other chemical contaminants. We discuss the fundamental principles of detecting food contaminants, evaluate existing analytical techniques, and explore the development of biomacromolecule-functionalized MOF-based sensors encompassing colorimetric, optical, electrochemical, and portable variants. The review also examines sensing mechanisms, uses FMOFs as signal probes and carriers for capture probes, and assesses sensitivity. Additionally, we explore the opportunities and challenges in producing FMOFs with biomacromolecules for food contaminant assessment. Future directions include improving sensor sensitivity and specificity, developing more cost-effective production methods, and integrating these technologies into real-world food safety monitoring systems. This work aims to pave the way for innovative and reliable solutions to ensure the safety of our food supply.

Correction: Highly stable color-tunable organic long-persistent luminescence from a single-component exciplex copolymer for in vitro antibacterial.

[This corrects the article DOI: 10.1039/D4SC02839B.].

Regulating the Pore Structure of Biomass-Derived Hard Carbon for an Advanced Sodium-Ion Battery.

Biomass-derived hard carbon materials are attractive for sodium-ion batteries due to their abundance, sustainability, and cost-effectiveness. However, their widespread use is hindered by their limited specific capacity. Herein, a type of bamboo-derived hard carbon with adjustable pore structures is developed by employing a ball milling technique to modify the carbon chain length in the precursor. It is observed that the length of the carbon chain in the precursor can effectively control the rearrangement behavior of the carbon layers during the high-temperature carbonization process, resulting in diverse pore structures ranging from closed pores to open pores, which significantly impact the electrochemical properties. The optimized hard carbon with abundant closed pores exhibits a high specific capacity of 356 mAh g-1 at 20 mA g-1, surpassing that of bare hard carbon (243 mAh g-1) and hard carbon with abundant open pores (129 mAh g-1 at 20 mA g-1). However, the kinetic analysis reveals that hard carbon with open pores shows better sodium-ion diffusion kinetics, indicating that a balance between the closed and open pores should be considered. This research offers valuable insights into pore design and presents a promising approach for enhancing the performance of hard carbon anode materials derived from biomass precursors.

Highly stable color-tunable organic long-persistent luminescence from a single-component exciplex copolymer for in vitro antibacterial.

Developing exciplex-based organic long-persistent luminescence (OLPL) materials with high stability is very important but remains a formidable challenge in a single-component system. Here, we report a facile strategy to achieve highly stable OLPL in an amorphous exciplex copolymer system via through-space charge transfer (TSCT). The copolymer composed of electron donor and acceptor units can not only exhibit effective TSCT for intra/intermolecular exciplex emission but also construct a rigid environment to isolate oxygen and suppress non-radiative decay, thereby enabling stable exciplex-based OLPL emission with color-tunable feature for more than 100 h under ambient conditions. These single-component OLPL copolymers demonstrate robust antibacterial activity against Escherichia coli under visible light irradiation. These results provide a solid example to exploit highly stable exciplex-based OLPL in polymers, shedding light on how the TSCT mechanism may potentially contribute to OLPL in a single-component molecular system and broadening the scope of OLPL applications.

Investigation of heat-induced pork batter quality detection and change mechanisms using Raman spectroscopy coupled with deep learning algorithms.

Pork batter quality significantly affects its product. Herein, this study explored the use of Raman spectroscopy combined with deep learning algorithms for rapidly detecting pork batter quality and revealing the mechanisms of quality changes during heating. Results showed that heating increased ß-sheet content (from 26.38 to 41.42%) and exposed hidden hydrophobic groups, which formed aggregates through chemical bonds. Dominant hydrophobic interactions further cross-linked these aggregates, establishing a more homogeneous and denser network at 80 °C. Subsequently, convolutional neural networks (CNN), long short-term memory neural networks (LSTM), and CNN-LSTM were comparatively used to predict gel strength and whiteness in batters based on the Raman spectrum. Thereinto, CNN-LSTM provided the optimal results for gel strength (Rp = 0.9515, RPD = 3.1513) and whiteness (Rp = 0.9383, RPD = 3.0152). Therefore, this study demonstrated the potential of Raman spectroscopy combined with deep learning algorithms as non-destructive tools for predicting pork batter quality and elucidating quality change mechanisms.

Multifunctional bacterial cellulose­derived carbon hybrid aerogel for ultrabroad microwave absorption and thermal insulation.

Carbon aerogel has gained intense attention as one of the most promising microwave absorption materials. It can overcome severe electromagnetic pollution, thanks to its 3D macroscopic structure and superb conductive loss capacity. However, there is still a big challenge to endow multifunctionality to carbon aerogel while maintaining its good electromagnetic wave absorption (EWA) so as to adapt wide practical application. Herein, a novel carbon-based aerogel consisting of Cu and TiO2 nanoparticles dispersed on carbon nanofiber framework was derived from carbonized bacterial cellulose (CBC) decorated with its mother bacteria via freeze-drying, in situ growth and carbonization strategies. The synthesized carbon-based CBC/Cu/TiO2 aerogel achieved an excellent EWA performance with a broad effective absorption bandwidth (EAB) of 8.32 GHz. It is attributed to the synergistic loss mechanism from multiple scattering, conductive network loss, interfacial polarization loss and dipolar polarization relaxation. Meanwhile, the obtained aerogel also shows an excellent thermal insulation with a 3-mm-thick sample generating a temperature gradient of over 42 °C at 85 °C and a maximum radar cross-section (RCS) reduction of 23.88 dB m2 owing to the cellular structure and synergistic effects of multi-components. Therefore, this study proposes a feasible design approach for creating lightweight, effective, and multifunctional CBC-based EWA materials, which offer a new platform to develop ultrabroad electromagnetic wave absorber under the guidance of RCS simulation.

A Photoenzymatic Pathway for Gram-Scale Synthesis of 25-Hydroxyvitamin D3.

Vitamin D and its analogues play a crucial role in promoting the well-being of both humans and animals. However, the current synthesis of this vital class of nutrients heavily relies on chemical transformations, which suffer from low step- and atom-efficiency due to lengthy synthetic pathways. To enhance sustainability in the chemical industry, it is necessary to develop alternative synthetic processes. Herein, we present a photoenzymatic approach for synthesizing 25-hydroxyvitamin D3 from 7-dehydrocholesterol. In this sequential synthesis, 7-dehydrocholesterol is initially hydroxylated at the C25 C-H bond, resulting in an 85% conversion to 25-hydroxyl-7-dehydrocholesterol. Subsequently, by employing photo-irradiation using a monochromatic LED ultraviolet light source in a batch reactor and thermal isomerization, 25-hydroxyvitamin D3 is obtained in satisfactory yield. This photoenzymatic process significantly reduces the need for purification steps and allows for gram-scale synthesis of the target product. Our work offers a selective, efficient, and environmentally friendly method for synthesizing 25-OH-vitamin D3, addressing the limitations of current synthetic approaches.

CLINICOPATHOLOGIC CHANGES OF VITREOMACULAR INTERFACE IN IDIOPATHIC EPIRETINAL MEMBRANE WITH DISORGANIZATION OF RETINAL INNER LAYERS.

PURPOSE: To compare the pathological characteristics of the vitreomacular interface of the idiopathic epiretinal membrane with and without disorganization of retinal inner layers (DRIL) and to correlate with clinical data. METHODS: In this clinicopathologic study, the samples of epiretinal membrane and internal limiting membrane were extracted from DRIL(+) (19 eyes) and DRIL(-) (22 eyes) idiopathic epiretinal membrane eyes. Ultrathin series sectioning for transmission electron microscopy was observed and correlated with surgery status and prognosis. RESULTS: All idiopathic epiretinal membrane eyes presented fibrocellular membranes accompanied by vitreous collagen, glial cells, and myofibroblasts, regardless of association with DRIL. A robust signal indicative of Collagen Type VI was observed in eyes DRIL(-), whereas Collagen Type I was discovered in DRIL eyes. Cell debris and microvascular basement membrane were seen on the retinal side of DRIL eyes and a larger cell count on the vitreous side. These have more intraoperative complications and less surgery benefit. CONCLUSION: Although internal limiting membrane peeling seems important, the histopathologic findings underscore the potential for retinal injury in DRIL(+) idiopathic epiretinal membrane eyes. This suggests that further research is needed to investigate individual preoperative assessment and to modify surgical procedures.

Structural switch in acetylcholine receptors in developing muscle.

During development, motor neurons originating in the brainstem and spinal cord form elaborate synapses with skeletal muscle fibres1. These neurons release acetylcholine (ACh), which binds to nicotinic ACh receptors (AChRs) on the muscle, initiating contraction. Two types of AChR are present in developing muscle cells, and their differential expression serves as a hallmark of neuromuscular synapse maturation2-4. The structural principles underlying the switch from fetal to adult muscle receptors are unknown. Here, we present high-resolution structures of both fetal and adult muscle nicotinic AChRs, isolated from bovine skeletal muscle in developmental transition. These structures, obtained in the absence and presence of ACh, provide a structural context for understanding how fetal versus adult receptor isoforms are tuned for synapse development versus the all-or-none signalling required for high-fidelity skeletal muscle contraction. We find that ACh affinity differences are driven by binding site access, channel conductance is tuned by widespread surface electrostatics and open duration changes result from intrasubunit interactions and structural flexibility. The structures further reveal pathogenic mechanisms underlying congenital myasthenic syndromes.

Study on the Shear Strength of Loess Solidified by Guar Gum and Basalt Fiber.

Loess is widely distributed in the northwest and other regions, and its unique structural forms such as large pores and strong water sensitivity lead to its collapsibility and collapse, which can easily induce slope instability. Guar gum and basalt fiber are natural green materials. For these reasons, this study investigated the solidification of loess by combining guar gum and basalt fiber and analyzed the impact of the guar gum content, fiber length, and fiber content on the soil shearing strength. Using scanning electron microscopy (SEM), the microstructure of loess was examined, revealing the synergistic solidification mechanism of guar gum and basalt fibers. On this basis, a shear strength model was established through regression analysis with fiber length, guar gum content, and fiber content. The results indicate that adding guar gum and basalt fiber increases soil cohesion, as do fiber length, guar gum content, and fiber content. When the fiber length was 12 mm, the fiber content was 1.00%, and the guar gum content was equal to 0.50%, 0.75%, or 1.00%, the peak strength of the solidified loess increased by 82.80%, 85.90%, and 90.40%, respectively. According to the shear strength model, the predicted and test data of the shear strength of solidified loess are evenly distributed on both sides of parallel lines, indicating a good fit. These findings are theoretically significant and provide practical guidance for loess solidification engineering.

Permeability and Disintegration Characteristics of Loess Solidified by Guar Gum and Basalt Fiber.

Loess has the characteristics of loose, large pore ratio, and strong water sensitivity. Once it encounters water, its structure is damaged easily and its strength is degraded, causing a degree of subgrade settlement. The water sensitivity of loess can be evaluated by permeability and disintegration tests. This study analyzes the effects of guar gum content, basalt fiber content, and basalt fiber length on the permeability and disintegration characteristics of solidified loess. The microstructure of loess was studied through scanning electron microscopy (SEM) testing, revealing the synergistic solidification mechanism of guar gum and basalt fibers. A permeability model was established through regression analysis with guar gum content, confining pressure, basalt fiber content, and length. The research results indicate that the addition of guar gum reduces the permeability of solidified loess, the addition of fiber improves the overall strength, and the addition of guar gum and basalt fiber improves the disintegration resistance. When the guar gum content is 1.00%, the permeability coefficient and disintegration rate of solidified soil are reduced by 50.50% and 94.10%, respectively. When the guar gum content is 1.00%, the basalt fiber length is 12 mm, and the fiber content is 1.00%, the permeability of the solidified soil decreases by 31.9%, and the disintegration rate is 4.80%. The permeability model has a good fitting effect and is suitable for predicting the permeability of loess reinforced with guar gum and basalt fiber composite. This research is of vital theoretical worth and great scientific significance for guidelines on practicing loess solidification engineering.

Applications of Artificial Intelligence in Psychiatric Nursing: A Scope Review.

Rapid advances in artificial intelligence (AI) have reshaped healthcare, including psychiatric nursing, to address the limitations of traditional approaches and meet escalating mental health challenges. A scoping review analyzed 48 articles examining the application of AI in psychiatric nursing across different technologies and topics, noting trends in publications and countries involved. The articles covered different aspects of mental health using AI technologies such as machine learning and robotics, and primarily explored AI applications in mental health, specifically dementia, autism and schizophrenia. These studies highlighted the role of AI in personalized care plans, symptom monitoring and risk assessment. AI is promising, but faces challenges such as data bias and ethical concerns. Future research needs to focus on long-term studies, diverse populations, patient interaction and personalized treatments for practical integration into psychiatric nursing.

Enhancing Ablation Resistance of TaB2-Based Ultra-High Temperature Ceramics by Mixing Fine TaC Particles and Dispersed Multi-Walled Carbon Nanotubes.

Ultra-high temperature ceramics (UHTCs) have been widely applied in many fields. In order to enhance the comprehensive properties of TaB2-based UHTCs, the first collaborative use of fine TaC particles and dispersed multi-walled carbon nanotubes (MWCNTs) was employed via spark plasma sintering (SPS) at 1700 °C. The derived UHTCs exhibited an average grain size of 1.3 µm, a relative density of 98.6%, an elastic modulus of 386.3 GPa, and a nano hardness of 21.7 GPa, leading to a greatly improved oxidation resistance with a lower linear ablation rate at -3.3 × 10-2 µm/s, and a markedly reinforced ablation resistance with mass ablation rate of -1.3 × 10-3 mg/(s·cm2). The enhanced ablation resistance was attributable to the physical pinning effect, sealing effect and self-healing effect. Thus, this study provides a potential strategy for preparation of UHTCs with bettered ablation resistance and physical properties.

Effects of high-normal fasting blood glucose on ART outcomes of frozen-thawed single blastocyst transfer in women with normal BMI.

PURPOSE: This retrospective cohort study aims to investigate whether high-normal fasting blood glucose (FBG) affects assisted reproductive technology (ART) outcomes undergoing single blastocyst frozen-thawed embryo transfer (FET) cycles in women with normal body mass index (BMI). METHODS: 944 women with normal BMI and FBG levels undergoing single blastocyst FET cycles were enrolled. Based on the median of FBG (4.97 mmol/L, 1 mmol/L = 18 mg/dL), the subjects were categorized into the low-normal group (3.90 ≤ FBG ≤ 4.97 mmol/L, n = 472) and the high-normal group (4.97 < FBG < 6.10 mmol/L, n = 472). Multivariable logistic regression and receiver operating characteristic (ROC) were used to analyze the relationship between high-normal FBG and ART outcomes. PRIMARY OUTCOME: live birth rate (LBR). RESULTS: LBR was significantly lower in the high-normal group than in the low-normal group (36.8% vs. 45.1%, p = 0.010), and the miscarriage rate was considerably higher than that in the low-normal group (23.9% vs. 16.5%, p = 0.041). High-normal FBG of female was an independent predictor of live birth (adjusted OR:0.747, 95% CI: 0.541-0.963, p = 0.027) and miscarriage (adjusted OR:1.610, 95% CI: 1.018-2.547, p = 0.042). ROC analyses showed that the cut-off values of FBG (endpoints: live birth and miscarriage) were 5.07 mmol/L, and 5.01 mmol/L, respectively. CONCLUSIONS: In women with normal BMI, high-normal FBG is an independent risk factor for lower LBR and higher miscarriage rate in single blastocyst FET cycles. Attention to preconception FBG monitoring in this particular population may allow early intervention to improve ART outcomes.

Resonance-Induced Dynamic Triplet Exciton Population for Photoactivated Organic Ultralong Room Temperature Phosphorescence.

Dynamically populating triplet excitons under external stimuli is desired to develop smart optoelectronic materials, but it remains a formidable challenge. Herein, we report a resonance-induced excited state regulation strategy to dynamically modulate the triplet exciton population by introducing a self-adaptive N-C═O structure to phosphors. The developed phosphors activated under high-power ultraviolet irradiation exhibited enhanced photoactivated organic ultralong room temperature phosphorescence (PA-OURTP) with lifetimes of up to ∼500 ms. The enhanced PA-OURTP was ascribed to activated N-C═O resonance variation-induced intersystem crossing to generate excess triplet excitons. The excellent PA-OURTP performance and ultralong deactivation time under ambient conditions of the developed materials could function as a reusable recorded medium for time-sensitive information encryption through optical printing. This study provides an effective approach to dynamically regulating triplet excitons and offers valuable guidance to develop high-performance PA-OURTP materials for security printing applications.