1.
J Org Chem
; 86(15): 10166-10176, 2021 Aug 06.
Article
in English
| MEDLINE
| ID: mdl-34252273
ABSTRACT
A highly efficient strategy for the direct thiolation of phenols under transition metal-free and solvent-free conditions has been developed. These reactions are operationally simple with employing air (molecular oxygen) as an ideal oxidant and can selectively provide mono- and dithiolation products in good to excellent yields under basic conditions. The reaction tolerates a broad range of aryl thiols and arenes and is especially applicable for large-scale synthesis.