Remnant cholesterol and all-cause mortality risk: findings from the National Health and Nutrition Examination Survey, 2003-2015.

Aims: Cholesterol carried in triglyceride-rich lipoproteins, also called remnant cholesterol, is increasingly acknowledged as an important causal risk factor for atherosclerosis. Elevated remnant cholesterol, marked by elevated plasma triglycerides, is associated causally with an increased risk of atherosclerotic cardiovascular disease. However, the association with all-cause mortality and cause-specific mortality is inconclusive. This study aimed to test the hypothesis that remnant cholesterol levels and plasma triglycerides are associated with increased all-cause mortality and mortality from cardiovascular disease, cancer, and other causes. Methods and results: Using a contemporary population-based cohort, 7,962 individuals from the National Health and Nutrition Examination Survey (NHANES) aged over 40 years at baseline in 2003-2015 were included. During up to 109.2 (± 1.44) months of follow-up, 1,323 individuals died: 385 individuals died from cardiovascular disease, 290 from cancer, 80 from cerebrovascular disease, and 568 from other causes. Compared with the middle tertile remnant cholesterol level, multivariable-adjusted mortality hazard ratios were 1.20 (95% confidence interval 1.02-1.40) for all-cause mortality. For the highest tertile remnant cholesterol level, multivariable-adjusted mortality hazard ratios were 1.21 (95% confidence interval 1.05,1.40). Our conclusions remained stable in subgroup analyses. Exploratory analysis of the cause of death subcategories showed corresponding hazard ratios of 1.25 (1.13-1.38) for Non-cardiovascular and Non-cerebrovascular Death for lower remnant cholesterol individuals, 1.47 (1.01-2.15) for cancer death for lower remnant cholesterol (RC) individuals, and 1.80 (1.36-2.38) for cancer death for higher RC individuals. Conclusion: RC levels were associated with U-shaped all-cause mortality. RC was associated with mortality from non-cardiovascular, non-cerebrovascular, and cancer, but not from cardiovascular causes. This novel finding should be confirmed in other cohorts.

Development of alginate hydrogel/gum Arabic/gelatin based composite capsules and their application as oral delivery carriers for antioxidant.

We have designed microcapsules-immobilized composite capsules and evaluated the oral delivery efficacy. The composite capsules were developed by encapsulating Perinereis aibuhitensis extract (PaE), a model substance possessing antioxidant activity, loaded gum Arabic/gelatin microcapsules in calcium alginate (CA) hydrogel (PaE:CA/GA/GE-CCs). In vitro antioxidant assay showed the obtained composite capsules were able to protect PaE from gastric acid, since O2- scavenging rate of encapsulated PaE was about 1.8 folds as that of free PaE after 5 h incubation in simulated gastrointestinal fluid. Moreover, in vivo study showed that after the treatment of oral administration for 30 days, the mice of PaE:CA/GA/GE-CCs group suffered significantly lower oxidative stress level than those of other groups, illustrated as higher SOD and catalase activity, as well as lower malondialdehyde content in liver cells. The results demonstrated the composite capsules could concentrate PaE in small intestine, and enhance the absorption efficiency and in vivo efficacy.

Multifunctional chitosan/dopamine/diatom-biosilica composite beads for rapid blood coagulation.

Uncontrollable bleeding is the main cause of death in wars and accidents. The development of emergency material for rapid hemostatic can effectively reduce bleeding-related death. The commercial hemostatic materials available in the market are difficult to meet requirements of rapid hemostasis, good biocompatibility, low cost and ease of use. In this study, we developed chitosan/dopamine/diatom-biosilica composite beads (CDDs) for rapid hemostasis with good biocompatibility. CDDs were prepared by combining chitosan with diatom-biosilica (DB) using dopamine as bio-glue. The porous internal structure of CDDs led to rapid and large amount of water absorption, which contributed to the rapid hemostasis (83 s, 22% of the control group). The hemolytic rate of CDDs was less than 5% and cell viability was above 80%, confirming its good biocompatibility. All the above results indicated that CDDs had potential to develop into safe and non-toxic hemostatic material.

[Fluorescent Dissolved Organic Matter and Its Correlation with Water Quality in a Urban River: A Case Study of the Lujiang River in Beilun, Ningbo].

Excitation-emission matrix fluorescence spectroscopy combined with fluorescence regional integration (FRI) analysis were adopted to analyze the water samples collected from the Lujiang River, which flows through the rapidly urbanizing areas of Beilun, Ningbo, in order to illuminate the composition and characteristics of the spatial distribution of fluorescent dissolved organic matter (FDOM), and further to explain its correlation with water quality in the urban river. The results showed that FDOM was composed of tyrosine-like, tryptophan-like, soluble microbial by-product-like, fulvic-like, and humic-like materials, and FDOM was dominated by protein-like components, accounting for 83.8% of the total fluorescence intensity, while humic-like components accounted for much less. The concentrations of the water quality parameters, such as total nitrogen, total phosphorus, and metals, were linearly correlated with the total fluorescence intensity of all components, indicating that FDOM was significantly related to the removal and transformation of nitrogen and phosphorus. The distribution of FDOM in different areas has the following characteristics:FDOM was low and not distinctly influenced by human activities in the upstream, while in the downstream, FDOM was high and showed the characteristics typical of that in urbanized rivers. Therefore, anthropogenic activities can greatly influence river water quality and the concentration and composition of FDOM.

[Characteristics of Dissolved Organic Matter (DOM) and Relationship with Dissolved Heavy Metals in a Peri-urban and an Urban River].

Dissolved organic matter (DOM) is ubiquitous in the aquatic environment, playing an important role in the fate of heavy metals in aquatic systems. In this study, we characterized the DOM and heavy metals and their distribution in a peri-urban river and an urban river in Ningbo city. In addition, the relationship between DOM and dissolved heavy metals was also determined. Results showed that higher DOC, CDOM, and FDOM concentrations were found in the river with the higher urbanization level. Four fluorescence peaks were identified in the excitation-emission matrix (EEM) of DOM, including fulvic acid-like fluorescence peaks A and C and protein-like fluorescence peaks B and T. The higher fluorescence intensities of peak B and T were found in the urban river, and similar trends were also found for the degree of humification and aromaticity of DOM. Similarly, concentrations of heavy metals, such as As, Cu, and Mn, were significantly higher in the urban river. Moreover, DOM had significant positive correlations with Cu, Cr, Mn, As, Zn, and Pb in the urban river, while DOM only exhibited significant positive correlations with Mn, Pb, and Cu in the peri-urban river. In conclusion, urbanization level influenced the characteristics and concentrations of CDOM in rivers which were closely related to the distribution of heavy metals.