ABSTRACT
A 33-year-old Indonesian woman presented for follow-up after a recent history of papillary thyroid carcinoma treated with total thyroidectomy and radioiodine therapy. A 131I whole-body scintigraphy showed an elongated iodine accumulation in the right hemithorax. On suspicion of pulmonary metastasis, further diagnostics with 124I PET/CT showed thickening of the bronchial wall and retention of secretion in a middle lobe bronchus. Bronchoscopy and histology allowed a diagnosis of stenosing anthracofibrosis with chronic inflammatory changes.
Subject(s)
Bronchi/diagnostic imaging , Carcinoma/radiotherapy , Iodine Radioisotopes/adverse effects , Radiopharmaceuticals/adverse effects , Thyroid Neoplasms/radiotherapy , Adult , Bronchi/pathology , Carcinoma, Papillary , False Positive Reactions , Female , Fibrosis/diagnostic imaging , Humans , Iodine Radioisotopes/therapeutic use , Multimodal Imaging , Positron-Emission Tomography , Radiopharmaceuticals/therapeutic use , Thyroid Cancer, Papillary , Thyroid Neoplasms/pathology , Tomography, X-Ray ComputedABSTRACT
A precise estimate of thyroid volume is necessary for making adequate therapeutic decisions and planning, as well as for monitoring therapy response. The goal of this study was to compare the precision of different volumetry methods. Thyroid-shaped phantoms were subjected to volumetry via 2-D and 3-D ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI). The 3-D US scans were performed using sensor navigation and mechanical sweeping methods. Volumetry calculation ensued with the conventional ellipsoid model and the manual tracing method. The study confirmed the superiority of manual tracing with CT and MRI volumetry of the thyroid, but extended this knowledge also to the superiority of the 3-D US method, regardless of whether sensor navigation or mechanical sweeping is used. A novel aspect was successful use of the same universally applicable cross-imaging software for all modalities.
Subject(s)
Algorithms , Image Interpretation, Computer-Assisted/methods , Imaging, Three-Dimensional/methods , Multimodal Imaging/instrumentation , Multimodal Imaging/methods , Phantoms, Imaging , Thyroid Gland/anatomy & histology , Humans , Image Enhancement/methods , Magnetic Resonance Imaging/instrumentation , Magnetic Resonance Imaging/methods , Organ Size/physiology , Reproducibility of Results , Sensitivity and Specificity , Thyroid Gland/diagnostic imaging , Tomography, X-Ray Computed/instrumentation , Tomography, X-Ray Computed/methods , Ultrasonography/instrumentation , Ultrasonography/methodsABSTRACT
We report the draft genome sequence of Bacillus anthracis UR-1, isolated from a fatal case of injectional anthrax in a German heroin user. Analysis of the genome sequence of strain UR-1 may aid in describing phylogenetic relationships between virulent heroin-associated isolates of B. anthracis isolated in the United Kingdom, Germany, and other European countries.
Subject(s)
Bacillus anthracis/genetics , DNA, Bacterial/chemistry , DNA, Bacterial/genetics , Genome, Bacterial , Sequence Analysis, DNA , Anthrax/microbiology , Bacillus anthracis/isolation & purification , Germany , Heroin/administration & dosage , Molecular Sequence Data , Substance Abuse, Intravenous/complicationsABSTRACT
Bacillus anthracis BF-1 was isolated from a cow in Bavaria (Germany) that had succumbed to anthrax. Here, we report the draft genome sequence of this strain, which belongs to the European B2 subclade of B. anthracis. The closest phylogenetic neighbor of strain BF-1 is a strain isolated from cattle in France.
Subject(s)
Anthrax/veterinary , Bacillus anthracis/classification , Bacillus anthracis/genetics , Cattle Diseases/microbiology , Genome, Bacterial , Animals , Anthrax/epidemiology , Anthrax/microbiology , Cattle , Cattle Diseases/epidemiology , Germany/epidemiology , Molecular Sequence DataABSTRACT
The shear modulus of the vocal fold is an essential parameter required to enhance our understanding of how the vocal fold operates, to develop mathematical models of phonatation, and to provide benchmarks to quantify the effectiveness of surgical procedures. The authors announced the successful deployment of an instrument to measure vocal fold elasticity in vivo last year, and now present the data taken from eight patients in vivo. The shear modulus was measured at the mid-membranous point, in a transverse direction with respect to the axis drawn between the anterior commissure and vocal process. The range of mean shear modulus results is 701-2,225 Pa, with a mean value of 1,371 Pa.