ABSTRACT
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Subject(s)
Female , Adult , Humans , Adenoma, Sweat Gland/diagnosis , Vulva/pathology , Erythema Nodosum/diagnosis , Diagnosis, DifferentialSubject(s)
Antihypertensive Agents/adverse effects , Drug Eruptions/etiology , Enalapril/adverse effects , Lichenoid Eruptions/chemically induced , Lichenoid Eruptions/pathology , Antihypertensive Agents/therapeutic use , Biopsy, Needle , Drug Eruptions/pathology , Enalapril/therapeutic use , Female , Follow-Up Studies , Humans , Hypertension/diagnosis , Hypertension/drug therapy , Immunohistochemistry , Middle Aged , Risk Assessment , Severity of Illness IndexABSTRACT
Malignant neoplasm from natural killer (NK) cells are characterized by their positivity for CD56 and absence of monoclonal TCR gene rearrangement. We present the case of a 54-year-old man with a fungous mass in his left flank whose histological examination was consistent with cutaneous extranasal T/NK cell lymphoma. We review the literature and also discuss the prognosis and treatment of this variety of lymphoma.
Subject(s)
Killer Cells, Natural/pathology , Lymphoma, T-Cell, Cutaneous/pathology , Neoplasm Invasiveness/pathology , Skin Neoplasms/pathology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy, Needle , CD56 Antigen/immunology , Combined Modality Therapy , Disease Progression , Follow-Up Studies , Humans , Immunohistochemistry , Lymphoma, T-Cell, Cutaneous/physiopathology , Lymphoma, T-Cell, Cutaneous/therapy , Male , Middle Aged , Neoplasm Staging , Radiotherapy, Adjuvant , Risk Assessment , Skin Neoplasms/physiopathology , Skin Neoplasms/therapyABSTRACT
A major controversy in the treatment of melanoma is the width of the surgical margin necessary for complete excision. We have reviewed the case histories of 1125 patients at the Melanoma Unit of the Dermatology Department of the San Cecilio Clinical Hospital in Granada from 1988 to 2000. The first aim was to verify whether there is a statistically significant correlation between occupied margins and other prognosis factors. We also analyse the situation after re-excising the scar from the previous extirpation with a minimum margin of 1 cm.
Subject(s)
Melanoma/surgery , Neoplasm Recurrence, Local/surgery , Reoperation/statistics & numerical data , Skin Neoplasms/surgery , Humans , Medical Records , Melanoma/epidemiology , Melanoma/pathology , Mohs Surgery , Neoplasm Recurrence, Local/epidemiology , Neoplasm Recurrence, Local/pathology , Retrospective Studies , Skin Neoplasms/epidemiology , Skin Neoplasms/pathology , Spain/epidemiologyABSTRACT
In 1947, Ota described a malformative syndrome associating a vascular component (nevus flammeus) with melanocytic or epidermic nevi, which he named phakomatosis pigmentovascularis (PPV). We will discuss the case of a 10-year-old boy presenting giant nevus flammeus, nevus spillus, asymmetry in the development of both lower limbs, characteristic of PPV, together with interventricular communication and Lisch nodules, representative of Von Recklinghausen's disease. We believe that this case can be classified as PPV type IIb, associated with Lisch nodules and rarely described in Caucasian individuals.
Subject(s)
Iris Neoplasms/diagnosis , Neurocutaneous Syndromes/diagnosis , Neurofibromatosis 1/diagnosis , Nevus, Pigmented/diagnosis , Port-Wine Stain/diagnosis , Skin Neoplasms/diagnosis , Child , Humans , MaleABSTRACT
El linfangiosarcoma es una neoplasia vascular maligna poco frecuente. Aparece en extremidades con linfedema crónico, generalmente en los brazos de mujeres sometidas a mastectomía radical con vaciamiento axilar. Se presenta el caso de una paciente mujer de 71 años a la que se le realizó una mastectomía radical con vaciamiento axilar por un carcinoma de mama. Posteriormente se detectó un linfedema crónico en el brazo derecho, con una gran placa con áreas ulceradas de fácil sangrado y nódulos eritemato-violáceos. Las lesiones fueron diagnosticadas de linfangiosarcoma. Se comentan algunos aspectos de la evolución del cuadro y sus posibilidades terapéuticas (AU)
Subject(s)
Aged , Female , Humans , Mastectomy, Radical/adverse effects , Lymphangiosarcoma/diagnosis , Lymphangiosarcoma/etiology , Carcinoma/surgery , Breast Neoplasms/surgeryABSTRACT
La queratodermia palmoplantar punctata de Buschke-Fisher-Brauer es una genodermatosis autosómica dominante que se caracteriza por la presencia de pápulas queratósicas con depresión central localizadas en las palmas de las manos y las plantas de los pies. Presentamos el caso de un varón de 52 años afectado de esta queratodermia desde hace 21 años y cuyas características clínicas, histológicas y terapéuticas se describen revisando las bases genéticas de las queratodermias que han permitido mejorar el conocimiento de las mismas (AU)
Subject(s)
Male , Middle Aged , Humans , Keratoderma, Palmoplantar/drug therapy , Keratoderma, Palmoplantar/genetics , Keratolytic Agents/therapeutic useABSTRACT
Presentamos el caso de una mujer de 42 años que consultó por presentar lesiones papulosas amarillentas de consistencia blanda en el hueco poplíteo del miembro inferior izquierdo que le causaban una sensación molesta. Tras el examen histopatológico de 2 piezas diferentes se apreció la coexistencia de lipoma y nevo cutáneo lipomatoso superficial (AU)
Subject(s)
Adult , Female , Humans , Lipoma/surgery , Lipoma/complications , Nevus/surgery , Nevus/complications , Hamartoma/surgery , Hamartoma/complications , Adipose Tissue/surgery , Adipose Tissue/physiopathology , Diagnosis, Differential , Focal Dermal Hypoplasia/diagnosisABSTRACT
La paniculitis eosinofílica se caracteriza por una infiltración prominente de eosinófilos en el tejido celular subcutáneo. Ha sido descrita en pacientes con una gran variedad de cuadros clínicos.Presentamos el caso de una mujer de 40 años de edad con nódulos en el muslo derecho cuya biopsia fue informada de paniculitis eosinofílica (AU)
Subject(s)
Adult , Female , Humans , Panniculitis/pathology , Eosinophilia/pathology , Panniculitis/drug therapy , Eosinophilia/drug therapy , Triamcinolone Acetonide/therapeutic use , Glucocorticoids/therapeutic useABSTRACT
Clásicamente ha existido gran controversia entre el psoriasis pustuloso generalizado del embarazo y el impetigo herpetiforme. Presentamos el caso de una mujer de 34 años que en su segunda gestación desarrolla un cuadro compatible con psoriasis pustuloso generalizado del embarazo. Comentamos su evolución, características diferenciales y las diferentes opciones terapéuticas disponibles (AU)
Subject(s)
Adult , Pregnancy , Female , Humans , Psoriasis/diagnosis , Pregnancy Complications/diagnosis , Psoriasis/drug therapy , Pregnancy Complications/drug therapy , Prednisone/therapeutic use , Impetigo/diagnosis , Diagnosis, Differential , Glucocorticoids/therapeutic useABSTRACT
Los trasplantes suponen un método efectivo para tratar patologías que afectan a un órgano de forma irreversible (riñón, médula, médula ósea, pulmón, hígado, corazón...) y para las que hoy en día no existe tratamiento. La utilización de fármacos inmunosupresores y antiinfecciosos motiva la aparición de patologías con afectación de la piel. La porfiria es una de estas entidades que por su carácter adquirido o hereditario es capaz de manifestarse tras la administración continua de cierta medicación. Presentamos el caso de un enfermo con trasplante pulmonar que desarrolló posteriormente la aparición de una porfiria cutánea tardía, posiblemente como consecuencia de la polimedicación a la que fue sometido (AU)
Subject(s)
Adult , Male , Humans , Porphyria Cutanea Tarda/chemically induced , Immunosuppressive Agents/adverse effects , Sodium Bicarbonate/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Lung Transplantation , Immunosuppressive Agents/therapeutic use , Time Factors , Porphyrins/metabolismABSTRACT
El Mycobacterium marinum es un microorganismo que produce infecciones cutáneas y de partes blandas, dando origen al denominado "Granuloma de las piscinas". La infección se produce por inoculación del microorganismo en la piel erosionada expuesta al agua contaminada de piscinas y acuarios. Se presenta el caso de un paciente con lesiones nodulares en el dorso de una mano producidas por Mycobacterium marinum. Se comenta la fuente incierta del microorganismo, las dificultades diagnósticas de este caso y las distintas modalidades terapéuticas (AU)
Subject(s)
Male , Middle Aged , Humans , Mycobacterium marinum , Skin Diseases, Infectious/pathology , Hand/microbiology , Mycobacterium Infections, Nontuberculous/pathology , Skin Diseases, Infectious/microbiology , Skin Diseases, Infectious/drug therapy , Trimethoprim/therapeutic use , Sulfamethoxazole/therapeutic use , Anti-Infective Agents/therapeutic use , Mycobacterium Infections, Nontuberculous/drug therapySubject(s)
Melanoma/secondary , Skin Neoplasms/pathology , Skin Transplantation , Aged , Antigens, Neoplasm , Dermatologic Surgical Procedures , Humans , Male , Melanoma/pathology , Melanoma/surgery , Melanoma-Specific Antigens , Neoplasm Proteins/analysis , S100 Proteins/analysis , Skin/chemistry , Skin/pathology , Skin Neoplasms/surgeryABSTRACT
Congenital erosions and vesicles that heal with reticulate scarring comprise a new entity first described in 1985 in 3 girls aged 3, 5 and 6 years. Two years later, an 8-year-old boy in whom the skin lesions were accompanied by neurological disorders was described, as in one of the patients described in the 1985 study. In 1990, similar findings were reported in a neonate, and recently the 7th case has been reported in the American literature. We describe an 8-month-old infant born with cutaneous lesions that subsequently formed reticulate scars peculiar to this clinical entity, which is characterized by variable clinical and histological expression.
Subject(s)
Cicatrix/etiology , Skin Diseases, Vesiculobullous/congenital , Adipose Tissue/pathology , Blister/congenital , Blister/pathology , Cicatrix/pathology , Follow-Up Studies , Humans , Hypopigmentation/etiology , Hypopigmentation/pathology , Infant , Male , Sclerosis , Skin Diseases, Vesiculobullous/pathology , Skin Ulcer/congenital , Skin Ulcer/pathology , Wound HealingABSTRACT
A description of 93 cases of angiokeratoma [Mibelli (3 cases), Fordyce (13 cases), circumscriptum naeviformis (12 cases) and solitary (65 cases)], confirmed histologically and observed during the last 30 years (1955-1985) in the Department of Medicine and Surgery of the School of Medicine of the University of Granada is presented. We carry out a detailed histological and ultrastructural study.
