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Protein Tyrosine Phosphatases (1)

Photoaffinity Labels (1)

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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme.

Thérien, Michel; Skorey, Kathryn; Zamboni, Robert; Li, Chun Sing; Lau, Cheuk K; LeRiche, Tammy; Linh Truong, Vouy; Waddleton, Deena; Ramachandran, Chidambaram.

Bioorg Med Chem Lett ; 14(9): 2319-22, 2004 May 03.

Article in English | MEDLINE | ID: mdl-15081032

ABSTRACT

The synthesis of a novel radioactive peptidic photoaffinity probe for the PTP-1B enzyme as well as some SAR leading to the choice of this compound as a photoaffinity probe are presented.

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Photoaffinity Labels/chemical synthesis , Protein Tyrosine Phosphatases/chemistry , Photoaffinity Labels/chemistry , Protein Tyrosine Phosphatase, Non-Receptor Type 1

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