Ultra-broadband frequency shifting of laser pulses in a square multicore chalcogenide fiber.

The process of Raman frequency shifting of out-of-phase laser pulses in fibers with a square configuration of weakly coupled cores having two or more zero dispersion wavelengths has been studied. The use of out-of-phase distributions in multicore fibers makes it possible to increase pulse energies by orders of magnitude in comparison with the case of single-core fibers. Conditions for the stability of out-of-phase laser pulses are determined and confirmed by numerical simulations. A configuration of chalcogenide multicore fiber with three zero dispersion wavelengths is proposed, allowing ultra-broadband frequency shifting of laser pulses up to 6.2 µm with an energy efficiency of more than 25%.

Stable few-cycle out-of-phase solitons in a rectangular multi-core fiber.

Stable out-of-phase soliton-like distributions of the wave field with few-cycle durations are found in fibers consisting of a rectangular lattice of weakly coupled cores. The stability of found distributions for durations larger than the critical value is shown analytically and numerically. Numerical simulation shows that the radiation of linear dispersive waves rather quickly transforms shorter pulses to the found solution with critical duration.

Laser pulse cutoff at nonlinear reflection due to Raman backscattering in plasma.

A method for generating subrelativistic laser pulses with a sharp leading edge is proposed, which is based on Raman backscattering of an intense short pump pulse by a counter-propagating long low-frequency pulse propagating in a thin plasma layer. A thin plasma layer serves both to attenuate parasitic effects and to effectively reflect the central part of the pump pulse when the field amplitude exceeds the threshold value. A prepulse with a lower field amplitude passes through the plasma almost without scattering. This method works for subrelativistic laser pulses with durations up to 100 fs. The contrast of the leading edge of the laser pulse is determined by the seed pulse amplitude.

Coherent amplification of high-power laser radiation in multicore fibers from a rectangular array of cores.

The coherent propagation and amplification of high-power laser radiation in a multicore fiber consisting of a square array of weakly bound cores are studied. Exact stable analytical solutions are found for the out-of-phase mode, which describes the coherent propagation of wave beams in such fibers. The analytical results are confirmed by direct numerical simulation of the wave equation. The stability conditions of the out-of-phase mode in the active medium are found.

Coherent propagation and amplification of intense laser pulses in hexagonal multicore fibers.

Propagation and amplification of intense coherent laser pulses in a multicore fiber of 24 weakly coupled cores arranged in the form of seven close-packed hexagons were studied. Exact stable analytical solutions are found for the out-of-phase mode, which describes the coherent propagation of wave beams and temporal soliton solutions in such fibers. Their stability is demonstrated. The analytical results are confirmed by the direct numerical simulation of the wave equation.

Improved tolerability of neratinib in patients with HER2-positive early-stage breast cancer: the CONTROL trial.

BACKGROUND: Neratinib is an irreversible pan-HER tyrosine kinase inhibitor approved for extended adjuvant treatment in early-stage HER2-positive breast cancer based on the phase III ExteNET study. In that trial, in which no antidiarrheal prophylaxis was mandated, grade 3 diarrhea was observed in 40% of patients and 17% discontinued due to diarrhea. The international, open-label, sequential-cohort, phase II CONTROL study is investigating several strategies to improve tolerability. PATIENTS AND METHODS: Patients who completed trastuzumab-based adjuvant therapy received neratinib 240 mg/day for 1 year plus loperamide prophylaxis (days 1-28 or 1-56). Sequential cohorts evaluated additional budesonide or colestipol prophylaxis (days 1-28) and neratinib dose escalation (DE; ongoing). The primary end point was the incidence of grade ≥3 diarrhea. RESULTS: Final data for loperamide (L; n = 137), budesonide + loperamide (BL; n = 64), colestipol + loperamide (CL; n = 136), and colestipol + as-needed loperamide (CL-PRN; n = 104) cohorts, and interim data for DE (n = 60; completed ≥six cycles or discontinued; median duration 11 months) are available. No grade 4 diarrhea was observed. Grade 3 diarrhea rates were lower than ExteNET in all cohorts and lowest in DE (L 31%, BL 28%, CL 21%, CL-PRN 32%, DE 15%). Median number of grade 3 diarrhea episodes was one; median duration per grade 3 episode was 1.0-2.0 days across cohorts. Most grade 3 diarrhea and diarrhea-related discontinuations occurred in month 1. Diarrhea-related discontinuations were lowest in DE (L 20%, BL 8%, CL 4%, CL-PRN 8%, DE 3%). Decreases in health-related quality of life did not cross the clinically important threshold. CONCLUSIONS: Neratinib tolerability was improved with preemptive prophylaxis or DE, which reduced the rate, severity, and duration of neratinib-associated grade ≥3 diarrhea compared with ExteNET. Lower diarrhea-related treatment discontinuations in multiple cohorts indicate that proactive management can allow patients to stay on neratinib for the recommended time period. CLINICALTRIALS.GOV: NCT02400476.

Laser pulse compression up to few-cycle durations in multicore fiber.

A mechanism for self-compression of laser pulses in a multicore fiber on the basis of nonlinear combining of radiation from many cores, surrounding the central core in a ring and its trapping into the central core in a chirp-free and pedestal-free soliton-like pulse, is proposed. It is shown that the compression ratio is weakly dependent on the energy and the number of cores in the fiber and approximately equal to 6 with an almost 100% energy efficiency. The compression ratio can be increased to 40 with an efficiency of more than 50% by using additional compression of longer pulses with approximately the same energy. The possibility of a 38-fold compression of a laser pulse to a duration of 15 fs with a pulse energy of 4 nJ in the fiber with realistic parameters was demonstrated numerically.

High-energy femtosecond pulse shaping, compression, and contrast enhancement using multicore fiber.

Nonlinear spatiotemporal dynamics of femtosecond pulses in a hexagonal seven-core silica fiber pumped by a sub-µJ 370 fs Er:fiber chirped pulse amplification (CPA) system were studied. Nonlinear pulse shaping and compression in the central core and pedestal coupling to the outer cores were directly measured by frequency-resolved optical gating. Further compression of the pulses spectrally broadened in the multicore fiber down to 53 fs was demonstrated. Two orders of magnitude contrast enhancement of the pulses after compression was observed.

Acoustically induced transparency in optically dense resonance medium.

It is shown that mechanical vibration (acoustical oscillation) of a solid medium along the propagation of multifrequency laser radiation enables one to control the resonant absorption. There exists an optimal spectral structure of the incident field dependent on vibration amplitude as well as the number and intensity of the frequency components that provides the full resonant transparency. A mechanism of the transparency is discussed. Transparency of this kind is shown to appear also via adiabatic modulation of the atomic transition frequency by an external microwave field.

Arginine uptake is attenuated through modulation of cationic amino-acid transporter-1, in uremic rats.

Endothelial cell dysfunction (ECD) is a common feature of chronic renal failure (CRF). Defective nitric oxide (NO) generation due to decreased endothelial NO synthase (eNOS) activity is a crucial parameter characterizing ECD. L-arginine is the sole precursor for NO biosynthesis. Among several transporters that mediate L-arginine uptake, cationic amino-acid transporter-1 (CAT-1) acts as the specific arginine transporter for eNOS. Our hypothesis implies that CAT-1 is a major determinant of eNOS activity in CRF. We studied glomerular and aortic arginine uptake, CAT-1, and CAT-2 messenger ribonucleic acid (mRNA) expression, and CAT-1 protein in: (a) rats 6 weeks following 5/6 nephrectomy (CRF), (b) sham-operated animals, and (c) rats with CRF treated orally with either atorvastatin or arginine in drinking water (modalities which have been shown to enhance eNOS activity and improve endothelial function). Both glomerular and aortic arginine transport were significantly decreased in CRF. Treatment with either arginine or atorvastatin abolished the decrease in arginine uptake in CRF rats. Using reverse transcriptase-polymerase chain reaction and Northern blotting, we found a significant increase in glomerular and aortic CAT-1 mRNA expression in CRF. Western blotting revealed that CAT-1 protein was decreased in CRF, but remained intact following arginine and atorvastatin administration. Renal and systemic arginine uptake is attenuated in CRF, through modulation of CAT-1 protein. These findings provide a possible novel mechanism to eNOS inactivation and endothelial dysfunction in uremia.

Electromagnetically induced transparency in ensembles of classical oscillators.

We develop a classical model of the parametric effect of electromagnetically induced transparency (EIT) within the line of resonance absorption of an electromagnetic wave in the medium--an effect initially discovered for a quantum three-level system. On the basis of this model, the EIT effect for electromagnetic waves at frequencies of the electron-cyclotron resonance in a cold plasma is considered. Similar to the analogous quantum scheme, the EIT window in the classical model is characterized by group deceleration of the reference electron-cyclotron wave.

Immediate provisional restorations to aid in gingival healing and optimal contours for implant patients.

A procedure for making an impression at stage I implant surgery is described, and the sequential laboratory procedures for fabricating a custom provisional restoration are presented. The provisional restoration is delivered at the uncovering of the implant, providing a template for the tissue healing with desired contours. This procedure facilitates the fabrication of implant restorations with optimal gingival contours and esthetics.

Hygroscopic fine mode particle deposition on electronic circuits and resulting degradation of circuit performance: an experimental study.

A portion of electronic equipment failures is a consequence of particle deposition on electronic circuits in normal indoor environments. Deposited hygroscopic particles reduce the electrical isolation (EI) between conductors. In laboratory experiments, we investigated the mechanisms, locations, and effects of particle deposition on electronic circuits with surface mounted chips (SMCs) and also on small television sets. One set of electronics was exposed for 281 h to an unusually high concentration of artificially-generated ammonium sulfate particles while a second set (experimental controls) was exposed to normal indoor particles. The particle mass concentration in the high-exposure chamber was 500 times higher than normal. Television reliability was observed and the changes in EI between adjacent legs of SMCs were measured. The experiments demonstrate the strong influence of electrostatic forces on the locations and rates of particle deposition. Although televisions did not fail after exposure to concentrated aerosols, the EI between adjacent legs of the SMCs was, in many cases, greatly diminished. Relative humidity had a very strong influence on the magnitude of EI. A qualitative explanation of the mechanisms of particle deposition and circuit degradation is proposed, including the role of fibers. Finally, a potential method to reduce particle deposition on electronic components is discussed.

Effectiveness of smokeless ashtrays.

Most environmental tobacco smoke (ETS) issues from the tips of smoldering cigarettes between puffs. Smokeless ashtrays are designed to reduce ETS exposure by removing particulate and/or gas-phase contaminants from this plume. This paper describes an experimental investigation of the effectiveness of four smokeless ashtrays: two commercial devices and two prototypes constructed by the authors. In the basic experimental protocol, one or more cigarettes was permitted to smolder in a room. Particulate or gas-phase pollutant concentrations were measured in the room air over time. Device effectiveness was determined by comparing pollutant concentrations with the device in use to those obtained with no control device. A lung deposition model was applied to further interpret device effectiveness for particle removal. The commercial ashtrays were found to be substantially ineffective in removing ETS particles because of the use of low-quality filter media and/or the failure to draw the smoke through the filter. A prototype ashtray using HEPA filter material achieved better than 90% particle removal efficiency. Gas-phase pollutant removal was tested for only one prototype smokeless ashtray, which employed filters containing activated carbon and activated alumina. Removal efficiencies for the 18 gas-phase compounds measured (above the detection limit) were in the range of 70 to 95%.

High retroperitoneal lymphocele: unusual clinical presentation and diagnosis by ultrasonography.

A case of a mid lumbar lymphocele secondary to retroperitoneal lymphadenectomy for testicular carcinoma is described. The clinical picture was unusual and confusing in that the symptoms were gastrointestinal in nature. Ultrasound provided the diagnosis and guidance for aspiration. Although the most common operative source of lymphocele formation appears to be the pelvic lymphatics similar collections may arise from para-aortic and renal hilar dissections and produce unusual manifestations. Ultrasound is of established value in such cases.

Comparison of serum and prostatic levels of tobramycin.

Tobramycin sulfate, an aminoglycoside antibiotic, has been shown to be effective in the treatment of complicated urinary tract infections. Because of this, a study was undertaken to determine the penetrance of tobramycin into the prostate gland. It was found that the drug is concentrated at inhibitory levels in the prostate gland after the routinely recommended administration and should be useful in the treatment of bacterial prostatic infection.