Feasibility and Safety of Mesocolon Excision with Medical Imaging: A Systematic Review and Meta-Analysis.

The development of new technologies based on electronic intelligent images is a very active research and promotion of new technologies in recent years. This article mainly summarizes the basic concept, development, and technology of electronic intelligent imaging technology, as well as the research, promotion, and application of electronic intelligent imaging technology in clinical treatment. It especially emphasizes the practicality and application of electronic intelligent imaging technology in the current clinical operation process and conducts a meta-analysis of the current mesorectal excision, so as to provide more scientific and professional guidance for clinical surgery. The results of the meta-analysis showed that 3291 documents were initially obtained and duplicate documents were deleted by searching for keywords in mesocolon excision. We excluded 2399 subjects and articles whose interventions did not meet the inclusion criteria of this study after reading the title and abstract. Then, we obtained 892 papers that may meet the inclusion criteria through preliminary screening. We further optimized the search strategy based on selection criteria and data integrity filtering principles and finally determined 111 references. 100 articles that did not meet the requirements were excluded, and 11 articles were finally included for meta-analysis. Medical imaging can effectively improve the therapeutic effect of mesocolon excision and reduce the occurrence of complications. Therefore, it is very important to combine medical intelligent images for preoperative evaluation, and the development of the combination of surgical treatment and medical images should not be underestimated in the future.

Ganoderic Acid A Enhances Tumor Suppression Function of Oxaliplatin via Inducing the Cytotoxicity of T Cells.

BACKGROUND: Various natural products have been demonstrated for their anti-tumor activities. As a natural triterpenoid, the effects of ganoderic acid A on oxaliplatin chemotherapy for cancer treatment remain unclear. METHODS: A xenograft mouse model of colon cancer was constructed using the HT-29 cells. Ganoderic acid A was intravenously administered with or without oxaliplatin. The CCK-8 method was performed to assess cell viability. Flow cytometry was used to determine cell apoptosis and subtyping of T cells. Cytotoxicity of the T cells was assayed using a lymphocyte-tumor co-culture system in vitro. RESULTS: Ganoderic acid A enhanced tumor suppression of oxaliplatin in the xenograft model, while single administration showed no obvious anti-tumor effect. Ganoderic acid A didn't affect cell proliferation and apoptosis of HT-29 cells treated by oxaliplatin in vitro. Additionally, ganoderic acid A co-administered with oxaliplatin didn't impact T cell subtyping in the xenograft model. Cytotoxicity of T cells in co-administered mice was remarkably enhanced compared with oxaliplatin-treated mice. CONCLUSION: Our findings reveal that ganoderic acid A synergistically enhances tumor suppression of oxaliplatin possibly via increasing the cytotoxicity of T cells.

Postoperative complications observed with robotic versus laparoscopic surgery for the treatment of rectal cancer: An updated meta-analysis of recently published studies.

BACKGROUND: This is an updated meta-analysis comparing the postoperative complications observed with robotic versus laparoscopic surgery (LS) for the treatment of rectal cancer. METHODS: Cochrane central, MEDLNE (Medical Literature Analysis and Retrieval System Online), EMBASE (Excerpta Medica dataBASE), Google Scholar, Web of Science and http://www.ClinicalTrials.gov were searched for studies (published after the year 2015), comparing robotic versus LS for the treatment of rectal cancer. The postoperative outcomes were considered as the endpoints in this analysis. RevMan 5.4 was used to carry out the statistical analysis. Risk ratio (RR) with 95% confidence intervals (CI) were used to represent the results following data analysis. RESULTS: A total number of 22,744 participants were included in this study whereby 9178 participants were assigned to the robotic surgery and 13,566 participants were assigned to the LS group. The time period of patients' enrollment varied from years 2007 to 2017. Our results showed that overall complications (RR: 0.91, 95% CI: 0.71-1.17; P = .45), wound complications (RR: 0.81, 95% CI: 0.64-1.04; P = .09), anastomotic leak (RR: 1.12, 95% CI: 0.88-1.42; P = .37), anastomotic bleeding (RR: 0.88, 95% CI: 0.29-2.64; P = .82), stoma-related complications (RR: 0.88, 95% CI: 0.24-3.21; P = .85), intra-abdominal abscess (RR: 0.53. 95% CI: 0.22-1.31; P = .17), urinary tract infection (RR: 0.94, 95% CI: 0.53-1.66; P = .83), enterocolitis (RR: 1.35, 95% CI: 0.38-4.71; P = .64), reoperation (RR: 0.85, 95% CI: 0.46-1.54; P = .58), and mortality (RR: 0.75, 95% CI: 0.34-1.62; P = .46) were not significantly different between robotic-assisted versus LS for rectal cancer. Postoperative ileus (RR: 1.21, 95% CI: 0.81-1.81; P = .34), readmission (RR: 1.17, 95% CI: 0.75-1.83; P = .48), and urinary retention (RR: 0.51, 95% CI: 0.21-1.23; P = .14) were also similarly manifested. CONCLUSIONS: In this updated meta-analysis, both robotic and laparoscopic surgeries were equally effective for the treatment of rectal cancer. Similar postoperative complications were observed. However, our analysis was restricted only to postoperative outcomes, parameters such as duration of surgery were not taken into consideration.

Removal characteristics of heavy metal ions in rainwater runoff by bioretention cell modified with biochar.

As a form of pollution source control and a low-impact development measure, bioretention is a convenient, economical, and effective method for the removal of heavy metals from stormwater runoff, which can adapt to the randomness and uncontrollability of non-point source pollution. However, few studies have assessed the performance of bioretention in the simultaneous removal of multiple heavy metals and the impact of heavy metal migration on the bioretention life cycle. In this study, the removal rates of various heavy metals: copper (Cu), zinc (Zn), lead (Pb), and cadmium (Cd), were enhanced using a biochar modified bioretention cell, as compared to the traditional sandy soil bioretention process. Following treatment with the biochar modified bioretention cell, the average concentrations of Cu, Zn, Pb, and Cd were 55%, 61%, 19.66%, and 36.43% lower than the traditional sandy soil bioretention effluent, respectively. These results show that biochar significantly improves the removal of heavy metals by the bioretention process, especially Cu and Zn. This study also evaluated the effect of biochar on the inhibition of heavy metal migration in the filler material, by sampling and analysing the filler and retained water at different filler depths, then repeating the filler leaching experiment after simulated rainfall. The content of heavy metals at a filler depth of 45 cm in the traditional sandy soil bioretention system, was significantly higher than in the biochar modified bioretention system, showing that biochar plays an important role in the inhibition of heavy metal migration.

Purification effect of bioretention with improved filler on runoff pollution under low temperature conditions.

In recent years, there have been a number of studies on bioretention during hot summer, with only few studies reported during low-temperature winters. The application of bioretention in cold areas still lacks effective guidance. In this study, runoff simulation experiments were conducted to explore the influence of wood chips filler and water treatment residue on the removal of runoff pollutants under different packing gradations and low temperature conditions. Under low temperature, nitrate nitrogen removal rate of wood chips filler decreased from 70% to 90% in autumn to -23%- 35% in winter, the total nitrogen removal rate decreased from 75 to 90% in autumn to 20%-50% in winter, the removal rate of ammonia nitrogen and total phosphorus exceeded 70% during the entire experiment. Water treatment residue filler maintained a high ammonia nitrogen and total phosphorus removal rate during the experiment, with the total phosphorus removal rate above 90% and ammonia nitrogen removal rate above 80%. The bioretention effluent concentration of nitrate and total nitrogen was higher than 7.3 mg/L and 8.5 mg/L, respectively, most of the time. However, at low temperature, the COD removal rate of the two fillers was 25%-50%, which was very poor. Therefore, wood chips filler was observed to be better suited for the removal of nitrate and total nitrogen from the runoff, while water treatment residue had a better effect on the removal of ammonia nitrogen and total phosphorus in winter. Thus, for the application of bioretention in northern China, appropriate fillers should be selected considering the water quality characteristics of the area.

Thermodynamic Analysis of a Hybrid Trigenerative Compressed Air Energy Storage System with Solar Thermal Energy.

The comprehensive utilization technology of combined cooling, heating and power (CCHP) systems is the leading edge of renewable and sustainable energy research. In this paper, we propose a novel CCHP system based on a hybrid trigenerative compressed air energy storage system (HT-CAES), which can meet various forms of energy demand. A comprehensive thermodynamic model of the HT-CAES has been carried out, and a thermodynamic performance analysis with energy and exergy methods has been done. Furthermore, a sensitivity analysis and assessment capacity for CHP is investigated by the critical parameters effected on the performance of the HT-CAES. The results indicate that round-trip efficiency, electricity storage efficiency, and exergy efficiency can reach 73%, 53.6%, and 50.6%, respectively. Therefore, the system proposed in this paper has high efficiency and flexibility to jointly supply multiple energy to meet demands, so it has broad prospects in regions with abundant solar energy resource.

miR-190b promotes colorectal cancer progression through targeting forkhead box protein P2.

microRNA-190b (miR-190b) is abnormally expressed in multiple types of cancer, however, its role in colorectal cancer (CRC) is largely unknown. In the present study, it was demonstrated that miR-190b expression was upregulated in CRC cell lines compared with the normal epithelial colon cell line. Knockdown of miR-190b decreased proliferation, colony formation and invasion, and increased apoptosis of CRC cells. Furthermore, forkhead box protein P2 (FOXP2) was predicted as a target of miR-190b and further validated by luciferase activity reporter assay and western blotting. Rescue experiments showed that knockdown of FOXP2 reversed the inhibitory effects of miR-190b inhibitor on the behavior of the CRC cell lines. Taken together, the present study demonstrated the oncogenic role of miR-190b in CRC through regulation of FOXP2 expression.

Protein signatures for classification and prognosis of gastric cancer a signaling pathway-based approach.

Current methods have limited accuracy in predicting survival and stratifying patients with gastric cancer for appropriate treatment. We sought to identify protein signatures of gastric cancer for classification and prognostication. The Protein Pathway Array (initial study) and Western blot (confirmation) were used to assess the protein expression in a total of 199 fresh frozen gastric samples. There were 56 paired samples divided into a training set (n = 37) and a validation set (n = 19) for the identification of differentially expressed proteins between tumor and normal tissues. There were 56 tumor samples used to identify proteins correlating with tumor and nodal staging. All 93 tumor samples were used to identify candidate proteins for predicting survival. We confirmed the survival prediction of the candidate proteins by using an additional cohort of gastric cancer samples (n = 50). There were 22 proteins differentially expressed between normal and tumor tissues. Nine proteins were selected to build the predictor to classify normal and tumor samples. Ten proteins were differentially expressed among different T stages and four of these were associated with invasive behavior. An additional four proteins were associated with lymph node metastasis. Two proteins were identified as independent risk factors for overall survival. This study indicated that some dysregulated signaling proteins could be selected as useful biomarkers for tumor classification and predicting outcome in gastric cancer patients.