ABSTRACT
Type 2 diabetes mellitus (T2DM) is a risk factor for patients with impaired renal function. The onset of T2DM-induced diabetic kidney disease (DKD) is frequently sub-clinical, potentially culminating in end-stage renal disease. In the current study the factors influencing DKD in elderly patients diagnosed with T2DM were determined. A retrospective cohort study was conducted involving patients ≥60 years of age with T2DM from June 2019 to December 2022. The Cockcroft-Gault formula was used to estimate the glomerular filtration rate. The clinical information and biochemical indicators of patients with an estimated glomerular filtration rate (eGFR)â <â 90 mL/min/1.73m2 were collected. Patients were grouped based on a 3-year eGFR declineâ <â 15% andâ ≥â 15%. The differences between the two groups were compared and the factors influencing the 3-year eGFR declineâ ≥â 15% were analyzed. A total of 242 patients were included, including 154 in the group with a 3-year eGFR declineâ <â 15% and 88 in the group with a three-year eGFR declineâ ≥â 15%. Univariate logistic regression analysis showed that smoking cigarettes, and triglycerides (TG) and high-density lipoprotein levels were related to a 3-year eGFR declineâ ≥â 15% (Pâ =â .039, Pâ <â .001, and Pâ =â .011, respectively). Multivariate logistic regression analysis showed that the TG level was independently related to a 3-year eGFR declineâ ≥â 15% (Pâ =â .004; ORâ =â 2.316). There was a significant linear relationship between the eGFR decline and TG level (Pâ =â .002). Patients with a TG concentrationâ >â 1.7 mmol/L had a more apparent decrease in the eGFR (Pâ <â .05). For elderly patients with T2DM and an eGFRâ <â 90 mL/min/1.73m2, the TG level may be an important risk factor for deteriorating renal function that warrants actively intervention.