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BMC Psychiatry ; 22(1): 277, 2022 04 20.
Article in English | MEDLINE | ID: mdl-35443629

ABSTRACT

OBJECTIVE: The objective of the study is to explore the long-term effectiveness and tolerability of metoclopramide in the treatment of CIH. METHOD: This study is a retrospective, observational cohort study of patients prescribed metoclopramide for CIH at the South London & Maudsley (SLaM) NHS Foundation Trust. RESULTS: Of the 96 patients identified, 14 patients were eligible for inclusion in our study. Five patients continued treatment with a mean duration of 27 months (SD = 17.8), and one patient continued until transfer with a duration of 3 months. Eight patients discontinued treatment after a mean duration of 8 months. CONCLUSION: Metoclopramide may be an effective and tolerated drug in CIH, but more data is required to establish its place in the pharmacotherapy of this condition.


Subject(s)
Antipsychotic Agents , Clozapine , Schizophrenia , Sialorrhea , Antipsychotic Agents/adverse effects , Clozapine/adverse effects , Humans , Metoclopramide/adverse effects , Retrospective Studies , Schizophrenia/drug therapy , Sialorrhea/chemically induced , Sialorrhea/drug therapy
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