Subject(s)
Humans , Male , Female , Middle Aged , Herpes Zoster/diagnosis , Herpes Zoster/drug therapy , Acyclovir/therapeutic use , Paresis/complications , Prednisone/therapeutic use , Herpes Zoster/complications , Herpes Zoster/physiopathology , Herpes Zoster , Guillain-Barre Syndrome/complications , Hypesthesia/complications , Electromyography/methods , ElectromyographyABSTRACT
Aim. To report a case of sub-acute encephalopathy with all the extension study negative and with response to steroid therapy. Case report. The study involves a 22-year-old female with no relevant past history who presented symptoms of sub-acute encephalopathy consisting in behavioural disorders, generalised seizures and bradypsychia, which gradually progressed to a state of low-level consciousness. While she was in hospital all kinds of diagnostic tests were conducted, the results of which were either normal or negative; the electroencephalogram was repeatedly abnormal and detection of protein 14-3-3 in cerebrospinal fluid was positive. Empirical corticoid therapy was begun with clinical and electrophysiological improvements and the patient recovered completely without any sequelae. Conclusions. With no evidence of autoimmune thyroid disease, although non-specific autoimmunity was present, the patient was diagnosed as having non-vasculitic autoimmune meningoencephalitis (AU)
Objetivo. Presentar un caso de encefalopatía subaguda con todo el estudio de extensión negativo y con respuesta a terapia esteroidea. Caso clínico. Mujer de 22 años sin antecedentes de interés que presentó un cuadro de encefalopatía subaguda consistente en alteraciones del comportamiento, crisis generalizadas y bradipsiquia, que evolucionó progresivamente a un estado de bajo nivel de conciencia. Durante su ingreso se realizaron todo tipo de pruebas diagnósticas, que fueron normales o negativas; el electroencefalograma fue repetidamente anormal y se detectó positividad de la proteína 14-3-3 en el líquido cefalorraquídeo. Se inició corticoterapia empírica con mejoría clínica y electrofisiológica, y recuperación ad integrum sin secuelas. Conclusiones. Sin la evidencia de enfermedad autoinmune tiroidea, aunque con presencia de autoinmunidad no específica, se diagnosticó a la paciente meningoencefalitis autoinmune no vasculítica (AU)
Subject(s)
Humans , Female , Young Adult , Steroids/therapeutic use , Meningoencephalitis/drug therapy , Autoimmune Diseases/diagnosis , Antibodies, Anticardiolipin/analysis , Antiphospholipid Syndrome/diagnosis , Hashimoto Disease/diagnosis , Creutzfeldt-Jakob Syndrome/diagnosisABSTRACT
AIM: To report a case of sub-acute encephalopathy with all the extension study negative and with response to steroid therapy. CASE REPORT: The study involves a 22-year-old female with no relevant past history who presented symptoms of sub-acute encephalopathy consisting in behavioural disorders, generalised seizures and bradypsychia, which gradually progressed to a state of low-level consciousness. While she was in hospital all kinds of diagnostic tests were conducted, the results of which were either normal or negative; the electroencephalogram was repeatedly abnormal and detection of protein 14-3-3 in cerebrospinal fluid was positive. Empirical corticoid therapy was begun with clinical and electrophysiological improvements and the patient recovered completely without any sequelae. CONCLUSIONS: With no evidence of autoimmune thyroid disease, although non-specific autoimmunity was present, the patient was diagnosed as having non-vasculitic autoimmune meningoencephalitis.
