1.
J Org Chem
; 84(15): 9671-9683, 2019 08 02.
Article
in English
| MEDLINE
| ID: mdl-31276419
ABSTRACT
Highly functionalized spirocyclic tetramates were prepared via a sequential Knoevenagel reaction and [1,5]-prototropic shift (T-reaction) of bicyclic tetramates. While these compounds isomerize in solution, stable analogues can be prepared via an appropriate choice of substituents. Further modification of these compounds allows for the introduction of aromatic groups, making them suitable as skeletons for application in medicinal chemistry.