[Advances in diagnosis and therapy of breast cancer between the 20th and the 21st centuries]. / L'evoluzione della diagnostica e della terapia chirurgica del carcinoma mammario tra XX e XXI secolo.

During the last two decades several new data have been acquired about tumor biology and therapy. Breast cancer is one of the more common cancers occurring, determining life threatening and depression in affected females. By the way a great interest has been developed during the time attempting to reach the earliest diagnosis and the more conservative treatment. However, breast cancer is now considered as a disease which meet the interests of several specialists (oncologists, surgeons, radiologists, and so), all dedicated to reduce the consequences of such pathology. The aim of this review is the resume of the progresses made in the last century about breast cancer knowledge.

[Expression of epithelial oncoproteins in large intestine neoplasms]. / Espressione di oncoproteine epiteliali in neoformazioni del grosso intestino.

The high incidence of the colorectal cancer in the industrialized countries has drawn the interest of the scientific community to detect and investigate its morphologic precursors. Growth factors and oncoproteins could be useful to investigate the morphologic and biologic evolution of precancerous lesions of the large bowel. Therefore the Authors report the results obtained from 30 selected patients with hyperplastic and adenomatous polyps, and different histotypes of colorectal cancer, investigated using the EGF-r and p62 protein expression. The results show the potential usefulness of such markers to evaluate the biology of intestinal tumors.