Subject(s)
Dasatinib , Desensitization, Immunologic , Drug Hypersensitivity , Hypersensitivity, Immediate , Humans , Dasatinib/adverse effects , Dasatinib/administration & dosage , Desensitization, Immunologic/methods , Drug Hypersensitivity/diagnosis , Drug Hypersensitivity/immunology , Drug Hypersensitivity/therapy , Drug Hypersensitivity/etiology , Hypersensitivity, Immediate/immunology , Hypersensitivity, Immediate/etiology , Administration, Oral , Female , Protein Kinase Inhibitors/adverse effects , Protein Kinase Inhibitors/administration & dosage , Male , Middle Aged , Antineoplastic Agents/adverse effects , Antineoplastic Agents/administration & dosage , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunologySubject(s)
Asthma , Bronchial Spasm , Child , Humans , Emergency Service, Hospital , Respiratory SoundsSubject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Asthma/therapy , Bronchial Spasm/therapy , Emergency Service, Hospital , Respiratory Sounds , Recurrence , Retrospective StudiesSubject(s)
Humans , Male , Female , Adolescent , Young Adult , Adult , Middle Aged , Aged , Aged, 80 and over , Anti-Asthmatic Agents/therapeutic use , Antibodies, Monoclonal, Humanized/therapeutic use , Pulmonary Eosinophilia/drug therapy , Asthma/drug therapy , Severity of Illness Index , Treatment Outcome , Retrospective StudiesSubject(s)
Egg Hypersensitivity , Food Hypersensitivity , Milk Hypersensitivity , Allergens , HumansABSTRACT
Summary: Background. We assessed differences in allergic sensitization and clinical characteristics in a foreign-born population. Methods. Prospective, observational, descriptive study of patients aged > 12 years who were seen at the Department of Allergy, La Paz Hospital (Madrid, Spain), between January 2017 and December 2018. Patients were classified by geographical origin and ethnicity. Results. We included 150 patients (110 female) with a mean age of 38.38 years. Mean time to onset of respiratory symptoms after immigration was 8.47 years. Significant differences were observed between ethnic groups (p = 0.007). The most frequent sensitization was to grass pollen (75.2%), which was more common in South American patients (p = 0.005). We found that 59% of patients were sensitized to Cupressus and Olea pollen (higher in Asian patients, p = 0.032 and p = 0.049). Conclusions. Allergic sensitization in the foreign-born population was similar to that of the autochthonous population although differences between the groups were identified.
Subject(s)
Allergens , Hypersensitivity , Adult , Asian People , Humans , Hypersensitivity/diagnosis , Hypersensitivity/epidemiology , Pollen/immunology , Prospective StudiesSubject(s)
Angioedemas, Hereditary/complications , Factor XII Deficiency/complications , Hemorrhage/etiology , Hemorrhage/prevention & control , Heparin, Low-Molecular-Weight/therapeutic use , Pregnancy Complications , Tranexamic Acid/therapeutic use , Angioedemas, Hereditary/etiology , Drug Therapy, Combination , Female , Heparin, Low-Molecular-Weight/administration & dosage , Humans , Pregnancy , Tranexamic Acid/administration & dosageSubject(s)
Acute Generalized Exanthematous Pustulosis , Antimalarials , Malaria, Falciparum , Malaria , Acute Generalized Exanthematous Pustulosis/diagnosis , Acute Generalized Exanthematous Pustulosis/drug therapy , Acute Generalized Exanthematous Pustulosis/etiology , Antimalarials/therapeutic use , Atovaquone/adverse effects , Drug Combinations , Humans , Malaria/drug therapy , Malaria, Falciparum/drug therapy , Proguanil/adverse effectsABSTRACT
Summary: Clindamycin is widely used in the prophylaxis and treatment of infections due to its broad spectrum of antimicrobial activity. Hypersensitivity to clindamycin seems to be not very common (less than 1% of drug-allergic reactions) and it mostly appears as delayed T-cell mediated. For the diagnosis, skin testing is considered to be highly sensitive and rather safe, but cutaneous and systemic reactions have been described. Provocation test is considered the gold standard. However, it includes the possibility of severe reactions. We reported two cases of delayed allergic reaction to clindamycin, confirmed with a positive lymphocyte transformation test, showing this in vitro test like a promising diagnostic method because of its usefulness and safety.