ABSTRACT
Invasive breast cancer (BC) is infrequent among women aged ≤40 years, however, the disease outlook in these younger patients is generally worse than among older women. The present study aimed to compare socio-demographic, clinical and pathological characteristics, and their association with long-term survival, between two random cohorts of young (≤40 years) and older (50-69 years) Brazilian patients with BC. The cohort comprised of 738 randomly selected women who were diagnosed with BC at Barretos Cancer Hospital, Pio XII Foundation (Barretos, Brazil) between January 1985 and December 2002; the patients included young women (n=376) and older women (n=362). The current analysis suggested that BC in young women is associated with numerous pathological features of aggressiveness. Second cancer and bilateral BC were independent predictors of a poor outcome in the younger group. Furthermore, C-erB-2 was positively correlated with poor outcome in the older group, whereas estrogen receptor status and TNM stage were associated with disease prognosis in both groups. The overall survival rates of the two age groups were similar except when analyzed according the treatment period (1997-2002). Although patients aged ≤40 years harbored tumors with more aggressive clinicopathological characteristics, these characteristics were not independent predictors of overall survival. The present study indicates that medical advances associated with prevention of breast cancer may improve screening programs, which may therefore increase early diagnosis and subsequently lower mortality rates.
ABSTRACT
Como o objetivo de avaliar os critérios cito-morfológicos na sugestäo diagnóstica de papiloma, foram estudados 67 casos de descarga papilar. Esses diagnósticos foram correlacionados como os achados histopatológicos, a fim de se interpretar as formaçöes papiliferas encontradas em citologia, essa correlaçäo foi possível em 36 casos (53,7 por cento): lesöes benignas foram encontradas em 15 (41,7 por cento); diagnóstico confirmativo de papiloma foi relatado em 10(27,8 por cento) e carcinomas diagnosticados em 11 (30,5 por cento. As características polêmicas das formaçöes papiliferas de mama puderam ser comprovadas neste estudo, onde o método citológico näo concludente para reconhecer neoplasias malignas em 30,5 por cento dos casos. Trinta e um casos näo mostraram exames histopatológicos, a revisäo dos protnuários destas pacientes referiam lesöes benignas e seguimento clínico livre de neoplasia