Deterministic All-Optical Continuous-Variable Quantum Telecloning.

Quantum telecloning, a pivotal multiuser quantum communication protocol in the realm of quantum information science, facilitates the copy of a quantum state across M distinct locations through teleportation technique. In the continuous-variable regime, the implementation of quantum telecloning necessitates the distribution of multipartite entanglement among the sender and M receiver parties. Following this, the sender carries out optic-electro conversion and transmits information via classical channel to M spatially separated receivers simultaneously. To successfully reconstruct the input state, electro-optic conversion needs to be employed by each receiver. However, due to these conversions, the bandwidth of the optical mode in this process is largely constrained. In this Letter, we present an all-optical version of the 1→2 continuous-variable quantum telecloning scheme, wherein both optic-electro and electro-optic conversions are replaced by optical components. Our scheme allows the two receivers to achieve input state reconstruction solely by utilizing beam splitters, significantly simplifying its complexity. We experimentally demonstrate all-optical 1→2 quantum telecloning of coherent state and achieve the fidelities of 58.6%±1.0% and 58.6%±1.1% for two clones, exceeding the corresponding classical limits (51.9%±0.5% and 51.9%±0.6%). Our results establish a platform for constructing a flexible all-optical multiuser quantum network and promote the field of all-optical quantum information processing.

Application of pocket-first technique for implantation of totally implantable venous access ports.

BACKGROUND: While vascular puncture is always performed before making port pocket in the implantation of totally implantable venous access ports (TIVAP), some surgeons preferred to make port pocket first. This study seeks to verify the safety and feasibility for the pocket-first technique. METHODS: The study retrospectively reviewed 447 patients who undergone TIVAP implantation from July 2017 to November 2022. All the patients were divided into two groups based on vascular puncture first or making port pocket first. The general information, operation information and post-operative complications were reviewed and analyzed. RESULTS: All the operations were performed successfully. No difference was observed in the sex, age, height, weight, BMI, port location and total complication rate between the two groups. The operation time of the Puncture Group and the Pocket Group were 46.9 ± 22.4 min and 33.8 ± 13.6 min ( P<0.00001 ). In the patients of SCV approach, the operation time between the two groups were 37.4 ± 14.8 min and 33.5 ± 10.9 min ( P<0.05 ). Multivariate analysis showed the variable BMI and first procedure were independent prognostic factors for operation time. In the cases using SCV/AxV approach the variable first procedure was the only independent prognostic factor for operation time (P = 0.002). CONCLUSIONS: The pocket-first technique can be considered as a safe, feasible and convenient technique for TIVAP implantation. The time consuming is significantly shortened compared with the puncture-first technique and this advantage may be more obvious when using SCV/AxV approach.

Deterministic All-Optical Quantum Teleportation of Four Degrees of Freedom.

Quantum teleportation, disembodied transfer of the unknown quantum state between two locations, has been experimentally demonstrated for both discrete and continuous variable states in one degree of freedom (DOF). Generally, multiple DOFs are needed to fully characterize a quantum state. Therefore, to implement intact quantum teleportation, multiple DOFs of quantum state should be teleported simultaneously. Recently, teleporting a single photon encoded in two DOFs has been experimentally demonstrated in discrete variable regime. However, the teleportation of more than two DOFs remains unexplored. Here, by utilizing continuous variable hyperentanglement in four DOFs (azimuthal and radial indexes of Laguerre-Gaussian mode, frequency, and polarization), we experimentally demonstrate deterministic all-optical quantum teleportation of four DOFs. Moreover, we experimentally construct 24 parallel teleportation channels. Our results pave the way for deterministically implementing multiple-DOF quantum communication protocols.

Orbital Angular Momentum Multiplexed Deterministic All-Optical Quantum Erasure-Correcting Code.

Quantum erasure-correcting code, which corrects the erasure in the transmission of quantum information, is an important protocol in quantum information. In the continuous variable regime, the feed-forward technique is needed for realizing quantum erasure-correcting code. This feed-forward technique involves optic-electro and electro-optic conversions, limiting the bandwidth of quantum erasure-correcting code. Moreover, in the previous continuous variable quantum erasure-correcting code, only two modes are protected against erasure, limiting the applications of quantum erasure-correcting code in high-capacity quantum information processing. In this Letter, by utilizing the orbital angular momentum (OAM) multiplexed entanglement in the encoding part and replacing the feed-forward technique with OAM mode-matched phase-sensitive amplifier in the decoding part, we experimentally demonstrate a scheme of OAM multiplexed deterministic all-optical quantum erasure-correcting code. We experimentally demonstrate that four orthogonal modes can be simultaneously protected against one arbitrary erasure. Our results provide an all-optical platform to implement quantum erasure-correcting code and may have potential applications in implementing all-optical fault-tolerant quantum information processing.

Case Report: Complete pathological remission of human chorionic gonadotrophin-producing gallbladder carcinoma with multiple liver metastases after treatment with chemotherapy plus an immune checkpoint inhibitor.

Background: Gallbladder carcinoma (GBC) producing human chorionic gonadotrophin (HCG) is an extremely rare and highly invasive tumor with a poor prognosis. This unfavorable clinical outcome is partly due to the aggressive nature of the tumor and its insensitivity to chemotherapy. Case presentation: We herein report a case of primary GBC producing HCG with liver metastases in a 58-year-old woman. The patient presented with a markedly elevated ß-HCG level and a mass in the gallbladder with multiple liver metastases. A definitive diagnosis was obtained after a needle biopsy of the liver metastases, showing poorly differentiated carcinoma with large-scale necrosis and strong positivity of immunostaining for HCG in tumor cells. The patient received chemotherapy (gemcitabine plus capecitabine) combined with carrellizumab, an immune checkpoint inhibitor (ICI). Pathological complete response was achieved after eight courses of combined therapy, which was confirmed by pathological analysis of resected specimens. After surgery, two courses of chemotherapy plus ICIs were adopted again. Complete response remained for approximately 1 year up to the present. Tumor tissue was collected to perform immunostaining of PD-L1, whole-exome sequencing, and RNA-seq. Low-TMB (1.51 mut/Mb), MSS, and high PD-L1 expression (TPS ≥ 50%) were observed in the tumor. Besides, the dominant types of infiltrating immune cells were macrophage and CD4+ T cells. Compared to other gallbladder adenocarcinoma without HCG, the proportion of M1 macrophage was at a higher level and the gene sets of MYC targets v1 and PI3K/AKT/mTOR signaling were highly expressed in our case. To the best of our knowledge, this is the first case report of complete remission of HCG-producing gallbladder carcinoma with liver metastases after chemotherapy combined with an immune checkpoint inhibitor. Furthermore, this is also the first report that described the tumor genetic feature and tumor immune microenvironment atlas of HCG-producing GBC. Conclusion: chemotherapy plus an immune checkpoint inhibitor may provide a potentially curative option for gallbladder carcinoma with HCG production.

Experimental measurement of quadrature squeezing in quadripartite entanglement.

Multipartite entanglement is one of the most fundamental and important resources for quantum information processing in both discrete variable and continuous variable (CV) regimes. For its applications in the CV regime, such as the realization of quantum teleportation networks and quantum dense coding, the quadrature squeezing of multipartite entanglement plays a significant role. Here, we report the first, to the best of our knowledge, experimental measurement of the quadrature squeezing in the quadripartite entanglement generated by the two-beam pumped cascaded four-wave mixing process in a 85 R b vapor cell. Moreover, we find that the quadrature squeezing is nonexistent in each pair of beams, but exists in the whole quadripartite entanglement. Our results may find potential applications in building a multi-user quantum secret sharing network.

All-Optical Entanglement Swapping.

Entanglement swapping, which is a core component of quantum network and an important platform for testing the foundation of quantum mechanics, can enable the entangling of two independent particles without direct interaction both in discrete variable and continuous variable systems. Conventionally, the realization of entanglement swapping relies on the Bell-state measurement. In particular, for entanglement swapping in continuous variable regime, such Bell-state measurement involves the optic-electro and electro-optic conversion, which limits the applications of the entanglement swapping for constructing broadband quantum network. In this Letter, we propose and demonstrate a measurement-free all-optical entanglement swapping. In our scheme, a high-gain parametric amplifier based on the four-wave mixing process is exploited to realize the function of Bell-state measurement without detection, which avoids the introduction of the optic-electro and electro-optic conversion. Our results provide an all-optical paradigm for implementing entanglement swapping and pave the way to construct a measurement-free all-optical broadband quantum network.

Phase manipulated two-mode entangled state from a phase-sensitive amplifier.

The phase manipulation of the two-mode entangled state, which can flexibly control the combination of quadrature components on demand, is important for continuous variable (CV) quantum information and quantum metrology. Here, we experimentally demonstrate the phase manipulation of entangled state by using a phase-sensitive amplifier (PSA) based on four-wave mixing (FWM) process. The entanglement with different phase space squeezing orientations can be generated by directly changing the phase of the PSA. Our scheme is concise and can be expanded to generate multi-parties entangled states on demand. Our results here pave the way to realize a phase-coded quantum key distribution protocol and squeezing-enhanced Raman spectroscopy.

Orbital Angular Momentum Multiplexed Quantum Dense Coding.

To beat the channel capacity limit of conventional quantum dense coding (QDC) with fixed quantum resources, we experimentally implement the orbital angular momentum (OAM) multiplexed QDC (MQDC) in a continuous variable system based on a four-wave mixing process. First, we experimentally demonstrate that the Einstein-Podolsky-Rosen entanglement source coded on OAM modes can be used in a single channel to realize the QDC scheme. Then, we implement the OAM MQDC scheme by using the Einstein-Podolsky-Rosen entanglement source coded on OAM superposition modes. In the end, we make an explicit comparison of channel capacities for four different schemes and find that the channel capacity of the OAM MQDC scheme is substantially enhanced compared to the conventional QDC scheme without multiplexing. The channel capacity of our OAM MQDC scheme can be further improved by increasing the squeezing parameter and the number of multiplexed OAM modes in the channel. Our results open an avenue to construct high-capacity quantum communication networks.

Multidimensional four-wave mixing signals detected by quantum squeezed light.

Four-wave mixing (FWM) of optical fields has been extensively used in quantum information processing, sensing, and memories. It also forms a basis for nonlinear spectroscopies such as transient grating, stimulated Raman, and photon echo where phase matching is used to select desired components of the third-order response of matter. Here we report an experimental study of the two-dimensional quantum noise intensity difference spectra of a pair of squeezed beams generated by FWM in hot Rb vapor. The measurement reveals details of the [Formula: see text] susceptibility dressed by the strong pump field which induces an AC Stark shift, with higher spectral resolution compared to classical measurements of probe and conjugate beam intensities. We demonstrate how quantum correlations of squeezed light can be utilized as a spectroscopic tool which unlike their classical counterparts are robust to external noise.

Experimental Demonstration of a Multifunctional All-Optical Quantum State Transfer Machine.

Quantum information protocol with quantum resources shows a great advantage in substantially improving security, fidelity, and capacity of information processing. Various quantum information protocols with diverse functionalities have been proposed and implemented. However, in general, the present quantum information system can only carry out a single information protocol or deal with a single communication task, which limits its practical application in the future. Therefore, it is essential to develop a multifunctional platform compatible with multiple different quantum information protocols. In this Letter, by utilizing an all-optical platform consisting of a gain-tunable parametric amplifier, a beam splitter, and an entanglement source, we experimentally realize the partially disembodied quantum state transfer protocol, which links the all-optical quantum teleportation protocol and the optimal 1→N coherent state cloning protocol. As a result, these three protocols, which have different physical essences and functionalities, are implemented in a single all-optical machine. In particular, we demonstrate that the partially disembodied quantum state transfer protocol can enhance the state transfer fidelity compared with all-optical quantum teleportation under the same strength of entanglement. Our all-optical quantum state transfer machine paves a way to implement the multifunctional quantum information system.

All-Optical Optimal N-to-M Quantum Cloning of Coherent States.

The laws of quantum mechanics forbid the perfect copying of an unknown quantum state, known as the no-cloning theorem. In spite of this, approximate cloning with imperfect fidelity is possible, which opens up the field of quantum cloning. In general, quantum cloning can be divided into discrete variable and continuous variable (CV) categories. In the CV regime, all-optical implementation of the optimal N→M quantum cloning has been proposed in two original parallel works, which involves a parametric amplifier and a set of beam splitters and thus avoids the optic-electro and electro-optic conversions in the current CV quantum cloning technologies. However, such original proposal of all-optical CV optimal N→M quantum cloning scheme has never been experimentally implemented. Here, we show that optimal N→M quantum cloning of coherent states can be realized by utilizing a parametric amplifier based on four-wave mixing process in a hot atomic vapor and a set of beam splitters. In particular, we realize 1→M, 2→M, and 4→M quantum cloning. We find that the fidelity of N→M quantum cloning increases with the decrease of clone number M and the increase of original replica number N. The best cloning fidelity achieved in our experiment is about 93.3% ±1.0% in the 4→5 case. Our results may find potential applications in realizing all-optical high-fidelity quantum state transfer and all-optical high-compatibility eavesdropping attack in quantum communication networks.

Characterization of quantum squeezing generated from the phase-sensitive and phase-insensitive amplifiers in the ultra-low average input photon number regime.

We give the general expressions of intensity-difference squeezing (IDS) generated from two types of optical parametric amplifiers [i.e. phase-sensitive amplifier (PSA) and phase-insensitive amplifier (PIA)] based on the four-wave mixing process, which clearly shows the IDS transition between the ultra-low average input photon number regime and the ultra-high average input photon number regime. We find that both the IDS of the PSA and the IDS of the PIA get enhanced with the decrease of the average input photon number especially in the ultra-low average input photon number regime. This result is substantially different from the result in the ultra-high average input photon number regime where the IDS does not vary with the average input photon number. Moreover, under the same intensity gain, we find that the optimal IDS of the PSA is better than the IDS of the PIA in the ultra-low average input photon number regime. Our theoretical work predicts the presence of strong quantum correlation in the ultra-low average input photon number regime, which may have potential applications for probing photon-sensitive biological samples.

Orbital angular momentum multiplexed deterministic all-optical quantum teleportation.

Quantum teleportation is one of the most essential protocol in quantum information. In addition to increasing the scale of teleportation distance, improving its information transmission capacity is also vital importance for its practical applications. Recently, the orbital angular momentum (OAM) of light has attracted wide attention as an important degree of freedom for realizing multiplexing to increase information transmission capacity. Here we show that by utilizing the OAM multiplexed continuous variable entanglement, 9 OAM multiplexed channels of parallel all-optical quantum teleportation can be deterministically established in experiment. More importantly, our parallel all-optical quantum teleportation scheme can teleport OAM-superposition-mode coded coherent state, which demonstrates the teleportation of more than one optical mode with fidelity beating the classical limit and thus ensures the increase of information transmission capacity. Our results open the avenue for deterministically implementing parallel quantum communication protocols and provide a promising paradigm for constructing high-capacity all-optical quantum communication networks.

Reconfigurable Hexapartite Entanglement by Spatially Multiplexed Four-Wave Mixing Processes.

Multipartite entanglement serves as a vital resource for quantum information processing. Generally, its generation requires complex beam splitting processes which limit scalability. A promising trend is to integrate multiple nonlinear processes into a single device via frequency or time multiplexing. The generated states in these schemes are useful for quantum computation. However, they are confined in one or two beams and hard to be spatially separated for applications in quantum communication. Here, we experimentally demonstrate a scheme to generate spatially separated hexapartite entangled states by means of spatially multiplexing seven concurrent four-wave mixing processes. In addition, we show that the entanglement structure characterized by subsystem entanglement distribution can be modified by appropriately shaping the pump characteristics. Such reconfigurability of the entanglement structure gives the possibility to target a desired multipartite entangled state for a specific quantum communication protocol. Our results here provide a new platform for generating large scale spatially separated reconfigurable multipartite entangled beams.

Experimental characterization of multiple quantum correlated beams in two-beam pumped cascaded four-wave mixing process.

We experimentally explore the relationships between the number of multiple quantum correlated beams generated by two-beam pumped cascaded four-wave mixing (CFWM) process and the system parameters, such as the angle between the two pump beams, one-photon detuning and two-photon detuning. We find that all of three system parameters can influence the number of multiple quantum correlated beams. Under the optimal system parameters, we can observe the emission of up to 14 quantum correlated beams with the intensity-difference squeezing of -6.29 ± 0.20 dB (-7.93 ± 0.64 dB after accounting for losses) from such CFWM scheme. Our results may find potential applications in building multi-user quantum network and multi-parameter quantum metrology.

Interference-Induced Quantum Squeezing Enhancement in a Two-beam Phase-Sensitive Amplifier.

We experimentally demonstrate a method for realizing quantum squeezing enhancement which is induced by the interference in a two-beam phase-sensitive amplifier (PSA) based on a four-wave mixing process. Compared to the normal phase-insensitive amplifier with an intensity-difference squeezing (IDS) of 8.97±0.24 dB or 8.76±0.26 dB, the IDS of our two-beam PSA is enhanced to 10.13±0.21 dB under the same experimental situation. Furthermore, we study how various parameters influence the quantum squeezing enhancement of the PSA. These results clearly show that the physical mechanism inducing the IDS enhancement of the two-beam PSA is its intrinsic interference nature. Our results may find potential applications in improving the fidelity of quantum information processing and the precision of quantum metrology.

Construction and analysis of lncRNA-associated ceRNA network identified potential prognostic biomarker in gastric cancer.

BACKGROUND: Long non-coding RNAs (lncRNAs) are defined as non-coding RNA (ncRNA) with transcripts longer than 200 nucleotides with tissue specificity. Recently it has been found participate in cancer tumorigenesis and progression via transcriptional regulation, post-transcriptional regulation and epigenetic gene regulation. Competitive endogenous RNA (ceRNA) hypothesis assume that lncRNAs compete the target RNA by sponging the common miRNA response elements (MREs) to complete the post-transcriptional regulation. To explore the function and mechanisms of lncRNAs as ceRNAs in gastric cancer (GC), this study performed a genome-wide analysis. METHODS: The lncRNAs, mRNAs and microRNAs (miRNAs) profiles of 375 GC samples and 32 normal samples were obtained from The Cancer Genome Atlas (TCGA) Stomach Adenocarcinoma (STAD) datasets. The data was standardized with a cross match in the miRBase (a database at http://www.mirbase.org/), which made 365 samples as the analysis objects. We identify differentially expressed RNAs (DERNAs), including differentially expressed mRNAs (DEmRNAs), differentially expressed miRNAs (DEmiRNAs) and differentially expressed lncRNAs (DElncRNAs) by applying edge R package with thresholds of |log2FC| >2 and false discovery rate (FDR) <0.01. The potential RNAs for the gastric ceRNA network were screened out from the DERNAs based on "ceRNA hypothesis". The further construction of the network and analysis of its topological properties were performed by Cytoscape. Gene oncology (GO) function enrichment was analyzed by BINGO plugin of Cytoscape. Survival analysis was estimated according to Kaplan-Meier curve analysis. RESULTS: The constructed gastric ceRNA network involved 61 mRNAs, 44 lncRNAs and 22 miRNAs. Five lncRNAs out of the DElncRNAs, namely MIR100HG, MAGI2-AS3, AC080038.1, AC010478.1 and MEF2C-AS1, were found mostly involved in the network. The lncRNA AL139147 were detected negatively correlated with overall survival (log-rank, P<0.05). CONCLUSIONS: In conclusion, our study identified promising lncRNAs, which might be potential diagnostic biomarker and therapeutic targets and contribute to further understanding of the ceRNA pathogenesis in GC and guide for further investigation.