Antioxidant and Chemopreventive Activity of Protein Hydrolysates from Raw and Germinated Flour of Legumes with Commercial Interest in Colorectal Cancer.

Legumes are a highly nutritious source of plant protein, fiber, minerals and vitamins. However, they also contain several bioactive compounds with significant potential benefits for human health. The objectives of this study were to evaluate the antioxidant, antitumor and chemopreventive activity of functional extracts from legumes using raw and germinated flours of six legume species of commercial interest. The methodology carried out consisted on the development of protein hydrolysates, assessment of their antioxidant capacity and in vitro tests on T84, HCT15 and SW480 colorectal cancer (CRC) cell lines. Our results showed a high antitumor activity of protein hydrolysate from M. sativa. Likewise, when combined with 5-Fluorouracile (5-Fu), there was a synergistic effect using extract concentrations from 50 to 175 µg/mL and 5-Fu concentrations from 1.5 to 5 µM. Similarly, the induction effect on detoxifying enzymes by the extracts of M. sativa, germinated V. faba Baraca × LVzt1 and V. narbonensis, which produced a higher induction rate than the positive control sulforaphane (10 µM), should be highlighted. Therefore, incorporating these enzymes into the diet could provide nutritional effects, as well as play an effective role in cancer chemoprevention and therapy.

Impactos da (des)territorialização nos processos de subjetivação: experiências migratórias de refugiadas venezuelanas em Bogotá / Impacts of (de)territorialization on processes of subjectivation: migratory experiences of Venezuelan refugee women in Bogotá / Impactos de la (des)territorialización en los procesos de subjetivación: experiencias migratorias de refugiadas venezolanas en Bogotá

O presente artigo visa analisar os impactos nos processos de subjetivação de mulheres venezuelanas que, em meio ao forte fluxo migratório recente, se veem diante de um processo de (des)territorialização. Propõem-se discussões sobre elementos do sofrimento ético-político, a construção identitária e a feminização da migração, a partir da produção de narrativas, tendo a categoria de gênero como analisador fundamental de tais fluxos. As entrevistas com mulheres que se encontravam em Bogotá, Colômbia, versaram sobre as memórias da Venezuela, a motivação para a saída, o trânsito na fronteira, a chegada à cidade, as dificuldades cotidianas de adaptação, e os ecos desse processo. Ao final, a escuta dessas experiências emerge como forma de enfrentamento ao silenciamento de vozes marginalizadas e de reflexão sobre as estratégias de acolhimento que têm sido adotadas na região.

This article aims to analyze the impacts on the processes of subjectivation of Venezuelan women who, amidst the strong recent migratory flow, find themselves facing a process of (de)territorialization. Discussions are proposed about elements of ethical-political suffering, identity construction and the feminization of migration, based on the production of narratives, with the gender category as a fundamental analyzer of such flows. The interviews with women who were in Bogotá, Colombia, were about the memories of Venezuela, the motivation to leave, the border traffic, the arrival in the city, the daily difficulties of adaptation, and the echoes of this process. In the end, listening to these experiences emerges as a way of confronting the silencing of marginalized voices and reflecting on the reception strategies that have been adopted in the region.

Este artículo tiene como objetivo analizar los impactos en los procesos de subjetivación de mujeres venezolanas que, en medio del fuerte flujo migratorio reciente, se enfrentan a un proceso de (des)territorialización. Se proponen discusiones sobre elementos del sufrimiento ético-político, la construcción de la identidad y la feminización de la migración, a partir de la producción de narrativas, con la categoría de género como analizador fundamental de dichos flujos. Las entrevistas con mujeres que se encontraban en Bogotá, Colombia, versaron sobre los recuerdos de Venezuela, la motivación para la salida, el tráfico fronterizo, la llegada a la ciudad, las dificultades diarias de adaptación y los ecos de este proceso. Al final, la escucha de estas experiencias surge como forma de enfrentar el silenciamiento de las voces marginadas y reflexionar sobre las estrategias de acogida que se han adoptado en la región.

Violencia sexual, un mecanismo de guerra / Sexual violence, a mechanism of war

En el artículo se reflexiona sobre las condiciones relacionales del maltrato infantil en sus diferentes manifestaciones, siendo la violencia sexual una de las cuales ha sido ampliamente utilizada en el marco del conflicto armado, así como replicada y naturalizada al interior de las construcciones familiares. Se parte de la comprensión de las relaciones familiares desde el plano humano, teniendo claro que así como protegen y nutren afectivamente a sus miembros, también los dañan y los victimizan especialmente en escenarios de conflicto. Finalmente se plantea la necesidad de migrar a nuevas estrategias de intervención psicosocial que contemplen la complejidad del conflicto armado en Colombia, la subjetividad presente en las realidades de sus actores y las necesidades de quienes pretenden ser reparados.

The article reflects on the relational conditions of child maltreatment in its different manifestations, sexual violence being one of which has been a widely used in the context of armed conflict, as well as replicated and naturalized to the interior of family constructions. Be part of the understanding of relationships familiar from the human plane, being clear that as well as protect and nourish affect their members, they also harm and victimize them especially in conflict scenarios. Finally, there is a need to migrate to new strategies of psychosocial intervention that take into account the complexity of the armed conflict in Colombia, the subjectivity present in the realities of its actors and the needs of who want to be repaired.