ABSTRACT
OBJECTIVE: Our primary outcome was to determine the feasibility of patients with post-traumatic headache (PTH) keeping a daily headache diary and using sumatriptan as directed. Secondary outcomes include determining if sumatriptan is effective in aborting PTH and whether headache resolution is dependent on PTH phenotype. BACKGROUND: PTH is prevalent and persistent after traumatic brain injury, yet there have been few studies evaluating the effects of pharmacological treatments in individuals with PTH. METHODS: This is a single-arm, prospective, non-randomized phase 2 clinical trial registered at Clinicaltrials.gov (NCT01854385) and conducted from 2013 to 2017. Data analysis was completed in 2022. Of the 299 participants screened, 40 were enrolled in the study. Participants kept a headache diary documenting headache characteristics and severity. Headache characteristics were used to determine PTH phenotypes of migraine-like, probable migraine-like, or non-migraine-like. Participants reported whether sumatriptan was used for their headache, their response to the medication, if a second dose was taken, and their response to the second dose. RESULTS: A total of 15 participants out of the 40 enrolled (mean [SD] age, 41.9 [14.2] years, and 53% [21/40] male), met the criteria for the use of sumatriptan, and completed all assessments. Average headache diary compliance rate for the final month of the study was 80% (372/465). While sumatriptan was used for only 19% (122/654) of all reported headaches, 72% (88/122) of those headaches resolved within 2 h of taking the medication. Resolution of headaches with sumatriptan was not significantly different among headache phenotypes (migraine-like: 22/38 [58%], probable migraine-like: 24/29 [83%], non-migraine-like: 6/15 [40%]; p = 0.154). CONCLUSIONS: A daily headache diary is feasible for tracking headache symptoms. Preliminary results also suggest that sumatriptan, a migraine-specific medication, may be beneficial for the treatment of PTH of different clinical phenotypes. Future studies, such as a phase 3 clinical trial with a larger sample size, are needed to better understand the efficacy of sumatriptan in the treatment of PTH.
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Importance: Chronic pain after traumatic brain injury (TBI) is prevalent and associated with poor outcomes. By providing multidisciplinary care through expert consultation, a collaborative care (CC) treatment approach may reduce pain interference. Objective: To compare CC with usual care (UC) in decreasing pain interference. Design, Setting, and Participants: This randomized clinical trial was conducted from July 2018 through April 2021 at 2 hospital-based academic rehabilitation medicine clinics in Seattle, Washington. Participants included adults with mild-to-severe TBI (at least 6 months before enrollment) and chronic pain. Data analysis was performed from March 30, 2022, to August 30, 2023. Intervention: The CC intervention (called TBI Care) included up to 12 in-person or telephone visits over 16 weeks with a care manager (CM) who provided person-centered cognitive behavioral treatment. The CM met weekly with members of the expert team to review participants and discuss recommendations to optimize treatment. Main Outcomes and Measures: The primary outcome was pain interference on the Brief Pain Inventory at treatment conclusion (4 months after randomization). Secondary outcomes included pain interference at 8 months; pain severity; symptoms of depression, anxiety, and sleep disturbance; pain-related emergency department visits; community participation; and participant satisfaction. Linear mixed-effects regression was used for analysis. Results: A total of 1379 individuals were screened for eligibility, and 158 were randomized (79 to CC and 79 to UC). The participants were mostly women (92 participants [58%]) with a mean (SD) age of 46.8 (13.2) years and a mean (SD) of 15.3 (3.0) years of education. TBI occurred a mean (SD) of 4.0 (5.9) years (median [IQR], 1.9 [0.8-4.5] years) before enrollment. All TBI severities were included, and of 149 participants for whom TBI severity was known, the majority (97 participants [65%]) had mild TBI. In the CC group, 71 participants (90%) completed at least 11 sessions, and, at 4 months, this group had significantly lower pain interference scores compared with the UC group (mean [SD], 3.46 [2.17] vs 5.03 [2.28]). This difference was maintained at 8 months after randomization, with mean (SD) TBI care pain interference scores of 3.61 (2.22) for CC vs 4.68 (2.51) for UC. At 4 months, there was significantly lower pain severity in the CC group vs UC group (mean [SD] score, 3.63 [1.95] vs 4.90 [1.96]), as well as symptoms of depression (mean [SD] score, 8.07 [5.34] vs 11.31 [6.37]) and anxiety (mean [SD], 6.20 [5.17] vs 9.58 [6.00]). Satisfaction with pain treatment (mean [SD] score, 2.99 [1.23] vs 2.52 [1.25]), clinical care (mean [SD] score, 3.28 [1.00] vs 2.84 [1.26]), and overall health care (mean [SD] score, 3.25 [0.88] vs 2.82 [1.00]) were significantly higher in the CC group vs the UC group; global impression of change was significantly lower in the CC group vs the UC group (mean [SD] score, 2.74 [1.02] vs 3.47 [1.26]) (lower scores denote a better impression of change). Conclusions and Relevance: In this randomized clinical trial of CC compared with UC for patients with TBI, CC was effective at reducing pain interference and was sustained at 8-month follow-up. Further research is needed to examine the implementation and cost-effectiveness of CC for TBI in other health care settings. Trial Registration: ClinicalTrials.gov Identifier: NCT03523923.
Subject(s)
Brain Injuries, Traumatic , Chronic Pain , Humans , Brain Injuries, Traumatic/complications , Brain Injuries, Traumatic/therapy , Female , Male , Chronic Pain/therapy , Chronic Pain/etiology , Middle Aged , Adult , Pain Management/methods , Washington , Patient Care Team , Pain Measurement , Cognitive Behavioral Therapy/methodsABSTRACT
A new species of Anisaspis Simon, 1892, Anisaspis awa sp. nov., is described from Volcán Chiles, Carchi, Ecuador, constituting the first record of Anisaspis from Ecuador.
ABSTRACT
Comprehensive methods for evaluating safety are needed to objectively assess the full risk profile of a medication. The confidence of the prescribing provider in the safety and effectiveness of pharmaceuticals is extremely important. Pharmacovigilance is a key component of drug safety regulatory processes and is paramount for ensuring the safety profile of medications used to treat patients. All participants in the healthcare system, including healthcare providers and consumers, should understand and meaningfully engage in the pharmacovigilance process; healthcare providers should integrate pharmacovigilance into everyday practice, inviting feedback from patients. This narrative review aims to give an overview of the main topics underlying pharmacovigilance and drug safety in pharmaceutical research phase after the authorization of a drug in the United States. The US Food and Drug Administration guidance and post-approval regulatory actions are considered from an industry perspective. Plain language summary: Regulatory processes that ensure the safety of drugs is monitored Government agencies regulate the safe use of medicinal products. By determining and enforcing pharmacovigilance, the monitoring of drugs for potential risks, they safeguard the welfare of consumers of medicines. Comprehensive, documented methods for evaluating the safety of a drug during its development and its subsequent use allow identification of any risks associated with the drug's use throughout its lifetime. The comprehensive identification of safety issues associated with a drug is improved when all parties involved in the development and use of drugs participate in the pharmacovigilance process. For example, clinicians should regularly ask their patients if they are experiencing any issues with their treatment, and patients should be encouraged to report problems they encounter with a particular medication to their healthcare provider. This narrative review provides an overview of the main topics underlying pharmacovigilance and drug safety after approval of a drug in the United States. Guidelines and actions from the US Food and Drug Administration are considered from an industry perspective.
ABSTRACT
BACKGROUND: Erenumab is a human anti-calcitonin gene-related peptide receptor monoclonal antibody approved for migraine prevention. We sought to further assess the temporal patterns of response to erenumab in patients with chronic migraine (CM), specifically the onset and sustainability of monthly migraine day (MMD) response. METHODS: This is a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled study of erenumab for migraine prevention in patients with CM (≥15 headache days/month, including ≥8 migraine days/month). Onset and sustainability were assessed according to MMD reduction from baseline, with the following response categories: responders (≥50% reduction), partial responders (≥30% and <50%), or nonresponders (<30%). RESULTS: Among the erenumab 140 mg group (n = 187), 54.0% (101/187) achieved a response at any month during the study with a median time to onset of monthly response of 1 month. This improvement was maintained in most patients with continued treatment. An initial response was achieved at Month 1 by 28.3% (53/187) of patients; 69.8% (37/53) of whom maintained a response at Months 2 and 3. Although many patients responded early, some patients required longer treatment to achieve a response; 79.4% (27/34) of initial partial responders and 21.0% (21/100) of initial nonresponders subsequently achieved a response. Similar findings were observed for the erenumab 70mg group (n = 188). CONCLUSION: A majority of erenumab-treated patients with CM who achieved an initial response at Month 1 sustained this benefit. Many patients responded later with continued treatment. Our data support recommendations to assess outcomes after ≥3 months of preventive treatment with erenumab in CM.
Subject(s)
Antibodies, Monoclonal, Humanized/pharmacology , Calcitonin Gene-Related Peptide Receptor Antagonists/pharmacology , Migraine Disorders/drug therapy , Outcome Assessment, Health Care , Adult , Antibodies, Monoclonal, Humanized/administration & dosage , Calcitonin Gene-Related Peptide Receptor Antagonists/administration & dosage , Chronic Disease , Double-Blind Method , Female , Humans , Male , Middle Aged , Time FactorsABSTRACT
OBJECTIVE: To review the pharmacokinetics of major classes of migraine preventives and the clinical implications of drug-drug interactions (DDIs) with the use of these therapies in migraine management. BACKGROUND: Preventive treatments for migraine are recommended for a large proportion of patients with frequent migraine attacks. These patients often exhibit a number of comorbidities, which may lead to the introduction of multiple concomitant therapies. Potential DDIs must be considered when using polytherapy to avoid increased risk of adverse events (AEs) or inadequate treatment of comorbid conditions. METHODS: A literature search was performed to identify pharmacokinetic properties and potential DDIs of beta-blockers, antiepileptic drugs, antidepressants, calcium channel blockers, gepants, and monoclonal antibody therapies targeting the calcitonin gene-related peptide pathway with medications that may be used for comorbid conditions. RESULTS: Most DDIs occur through alterations in cytochrome P450 isoenzyme activity and may be complicated by genetic polymorphism for metabolic enzymes. Additionally, drug metabolism may be altered by grapefruit juice ingestion and smoking. The use of migraine preventive therapies may exacerbate symptoms of comorbid conditions or increase the risk of AEs associated with comorbid conditions as a result of DDIs. CONCLUSIONS: DDIs are important to consider in patients with migraine who use multiple medications. The development of migraine-specific evidence-based preventive treatments allows for tailored clinical management that reduces the risk of DDIs and associated AEs in patients with comorbidities.
Subject(s)
Migraine Disorders/drug therapy , Adrenergic beta-Antagonists/pharmacokinetics , Antibodies, Monoclonal/pharmacokinetics , Anticonvulsants/pharmacokinetics , Antidepressive Agents/pharmacokinetics , Calcitonin Gene-Related Peptide , Calcitonin Gene-Related Peptide Receptor Antagonists/pharmacokinetics , Calcium Channel Blockers/pharmacokinetics , Comorbidity , Drug Interactions , Humans , Migraine Disorders/epidemiologyABSTRACT
INTRODUCTION: Migraine is associated with considerable disability for patients not adequately managed with current standards of care. New acute therapies may offer relief for this population of patients; however, population size and associated potential costs of new therapies are unclear. In this study, a conceptual framework was developed to estimate anticipated use of new acute therapies. METHODS: Targeted literature review (TLR) was conducted to identify factors affecting access to migraine-specific acute therapies, and characteristics of individuals who would be eligible for new acute therapies. Findings from the TLR were combined to create a framework for estimating the size of the eligible patient population. This framework was used to calculate two estimates of the eligible patient population by applying parameters (i) identified in the TLR and (ii) from a recent budget-impact analysis (BIA). RESULTS: The primary factors affecting access to migraine-specific acute therapies identified in the TLR were consulting a healthcare professional for headache, receiving a migraine diagnosis, and receiving a prescription for migraine-specific treatment. Characteristics of individuals likely to use new acute therapies reflected in the TLR were contraindication to triptans, or failure to respond to/tolerate at least two oral triptans. Application of the framework suggested that 15-25% of individuals with migraine would be eligible for new acute therapies. CONCLUSION: A limited number of patients currently use migraine-specific acute therapies. Among such patients, a significant proportion do not have adequate symptom control. Accordingly, a minority of individuals with migraine may be expected to use new acute therapies. The framework developed in this study is intended to facilitate estimating the eligible patient population in assessments of costs of new acute therapies. Such assessments should also consider recommendations that patients have access to multiple types of acute therapies, which may yield savings from reduced medication-overuse headache (MOH), progression to chronic migraine, and urgent-care costs.
Subject(s)
Migraine Disorders , Headache , Humans , Migraine Disorders/drug therapy , Migraine Disorders/epidemiology , Tryptamines/therapeutic use , United States/epidemiologyABSTRACT
The family Theraphosidae is the most speciose in the infraorder Mygalomorphae Pocock, 1892 with over one thousand described species (World Spider Catalog 2021). The taxonomy of the group has been subjected to considerable attention in modern times, with a focus on delineation based predominantly on genital organ and stridulatory organ morphology which has shown promise, both alongside molecular methods (where possible) and as a stand-alone line of evidence, in stabilising the group (e.g. Hamilton et al. 2016; Fabiano-da-Silva et al. 2020; see also Sherwood 2020). The predominant reference to the family is as Theraphosidae Thorell, 1870 with almost as many references to Theraphosidae Thorell, 1869. This non-congruence of dates is because Tord Tamerlan Teodor Thorell (1830-1901) had his important work On European Spiders published in two parts during its publication by the Royal Society of Upsala in its journal Nova Acta Regiae Societatis Scientiarum Upsaliensis. The first half (pages 1-108 and the supplement I-XIII) was published in 1869 whereas pages 109-242 (despite being dated on the cover page as 1869) were published in 1870 (see Roewer 1942; Bonnet 1945; World Spider Catalog 2021). In the second part, the secretary of the society notes: "L'auteur avait proposé comme titre du présent mémoire: Remarks on Synonyms of European Spiders, preceded by some observations on Zoological Nomenclature and a Review of the European Genera of Spiders; mais, la partie, insérée dans le Tome VII, étant seule présentée à la Société des Sciences le 13 Fevr. 1869, il a été nécessaii'e d'y conformer le titre." [= The author proposed as the title of this memoir: Remarks on Synonyms of European Spiders, preceded by some observations on Zoological Nomenclature and a Review of the European Genera of Spiders; but, the part, inserted in Volume VII, being the only one presented to the Société des Sciences on 13 Feb. 1869, it was necessary to conform the title to it.].
Subject(s)
Spiders , Animals , Authorship , Genitalia , Spiders/classification , Spiders/physiologyABSTRACT
The family Theraphosidae is the most speciose in the infraorder Mygalomorphae Pocock, 1892 with over one thousand described species (World Spider Catalog 2021). The taxonomy of the group has been subjected to considerable attention in modern times, with a focus on delineation based predominantly on genital organ and stridulatory organ morphology which has shown promise, both alongside molecular methods (where possible) and as a stand-alone line of evidence, in stabilising the group (e.g. Hamilton et al. 2016; Fabiano-da-Silva et al. 2020; see also Sherwood 2020). The predominant reference to the family is as Theraphosidae Thorell, 1870 with almost as many references to Theraphosidae Thorell, 1869. This non-congruence of dates is because Tord Tamerlan Teodor Thorell (1830–1901) had his important work On European Spiders published in two parts during its publication by the Royal Society of Upsala in its journal Nova Acta Regiae Societatis Scientiarum Upsaliensis. The first half (pages 1–108 and the supplement I–XIII) was published in 1869 whereas pages 109–242 (despite being dated on the cover page as 1869) were published in 1870 (see Roewer 1942; Bonnet 1945; World Spider Catalog 2021). In the second part, the secretary of the society notes: “L’auteur avait proposé comme titre du présent mémoire: Remarks on Synonyms of European Spiders, preceded by some observations on Zoological Nomenclature and a Review of the European Genera of Spiders; mais, la partie, insérée dans le Tome VII, étant seule présentée à la Société des Sciences le 13 Fevr. 1869, il a été nécessaii’e d’y conformer le titre.” [= The author proposed as the title of this memoir: Remarks on Synonyms of European Spiders, preceded by some observations on Zoological Nomenclature and a Review of the European Genera of Spiders; but, the part, inserted in Volume VII, being the only one presented to the Société des Sciences on 13 Feb. 1869, it was necessary to conform the title to it.].
ABSTRACT
Two species of the genus Diplura C. L. Koch, 1850, described from the Brazilian Amazon region: Diplura nigra (F. O. Pickard-Cambridge, 1896) and Diplura sanguinea (F. O. Pickard-Cambridge, 1896), are redescribed based on the examination of types and abundant new Amazonian material. The males of D. nigra and D. sanguinea are described for the first time, ecological data is presented and, for the first time, the female spermathecae are illustrated. New distributional data for these species is presented from the Amazonian region. We also give a short summary of species placements within Diplura based on the dorsal colour of the opisthosoma.
ABSTRACT
A new species of CymbiapophysaGabriel & Sherwood, 2020, C. magnasp. nov. is described from Colombia. Proshapalopus marimbaiPerafán & Valencia-Cuéllar, 2018 is transferred to Cymbiapophysa from ProshapalopusMello-Leitão, 1923, based on male palpal bulb and tibial apophysis morphology, female spermathecal morphology, comparative labial cuspule counts in both sexes, and biogeography, creating the new combination Cymbiapophysa marimbaicomb. nov. Aspects of some structures of the male palpal bulb are also discussed.
ABSTRACT
Cyrtopholis Simon 1892 is a spider genus from the Caribbean islands characterized by the presence of stridulatory setae on trochanter of palps and legs I. Franganillo Balboa described eight species of Cyrtopholis Simon 1892 from Cuba between 1926-1936. The type-material is deposited in the Instituto de Ecología y Sistematica do Ministerio de Ciencias, Tecnologia e Meio Ambiente, La Habana, Cuba. Four species are redescribed here: Cyrtopholis plumosa Franganillo, 1931, Cyrtopholis major Franganillo, 1926, Cyrtopholis unispina Franganillo, 1926 and Cyrtopholis gibbosa Franganillo, 1936. Cyrtopholis ischnoculoformis Franganillo, 1926 is based on a juvenile specimen without stridulatory setae, and it is therefore considered here as species inquirenda. The type-material of two other species were not located: Cyrtopholis anacanta Franganillo, 1935 and Cyrtopholis obsoleta (Franganillo, 1935), and are considered to be lost. These two species are here considered as species inquirenda, since the original descriptions do not permit identification. Cyrtopholis respina Franganillo 1935 is considered a nomen dubium, due to the lack of a formal description and a doubtful citation.
Subject(s)
Spiders , Animal Distribution , AnimalsABSTRACT
BACKGROUND: Headache after traumatic brain injury (TBI) is frequent and persistent over the first year after injury. Providers may need to focus on different symptom presentations depending on their patient's TBI severity. OBJECTIVE: We evaluated headache symptoms in patients with moderate-to-severe TBI compared to patients with mild TBI and examined our data from two perspectives: (1) from providers who treat individuals after TBI and manage multiple postinjury symptoms including headache, and (2) from headache specialists who see individuals after TBI to manage headache. DESIGN: Prospective enrollment of individuals after TBI with telephone follow-up at 1-year postinjury. SETTING: Enrollment from hospital and then community followup. PARTICIPANTS: Three hundred forty-six individuals with moderate-to-severe TBI were enrolled during acute inpatient rehabilitation across seven TBI Model System Centers. One hundred eighty-nine individuals with mild TBI were enrolled within 1 week of injury at a single center. INTERVENTION: None. MAIN OUTCOME MEASUREMENTS: Headache frequency, headache type, pain intensity, Headache Impact Test-6 (HIT-6), and depressive symptoms measured 1 year after injury. RESULTS: Headache prevalence is high in both TBI groups. TBI providers are more likely to evaluate and treat headache from individuals sustaining a mild TBI versus moderate-to-severe TBI. Patients with mild TBI are most likely to report tension-type headache followed by migraine-type headache. The migraine-type headache has higher impact (HIT-6) and greater pain intensity. Headache specialists may encounter patients with moderate-to-severe TBI who report more frequent headache and higher average pain scores compared to patients with mild TBI. The severity of TBI was unrelated to depressive symptoms 1 year after injury, but patients with headache were significantly more likely to have higher scores. CONCLUSIONS: TBI providers versus headache specialists should be aware of differences in patient symptom presentation to their respective clinics. Ongoing assessment of headache and depression over time is important following TBI of any severity.
Subject(s)
Brain Concussion , Brain Injuries, Traumatic , Brain Injuries , Brain Injuries, Traumatic/complications , Brain Injuries, Traumatic/diagnosis , Headache/diagnosis , Headache/epidemiology , Headache/etiology , Humans , Prospective StudiesABSTRACT
OBJECTIVES: The primary outcome of this study was to assess the efficacy and safety of preventive treatment with amitriptyline on headache frequency and severity after mild traumatic brain injury (mTBI). BACKGROUND: Despite the fact that headache is the most common and persistent physical symptom after TBI, there has been little research on the longitudinal course or pharmacologic treatment of this disorder. Of those who have headache after injury, about 60% continue to complain of headache at 3 months post injury, with higher levels of disability than those without headache. There have been no prospective, randomized, controlled trials of a pharmacologic agent for headache after TBI. Additionally, a brain-injured population may be more susceptible to side effects of medication. DESIGN: This is a single-center phase II trial of amitriptyline to prevent persistent headache after an mTBI. Medication dose was gradually increased from 10 to 50 mg daily. RESULTS: Fifty participants were enrolled and 33 who completed the 90-day assessment were included in the final analysis. In order to detect a possible cognitive impact of the study drug, 24 participants were randomly assigned to start amitriptyline immediately after study enrollment and 26 were assigned to start 30 days after enrollment. Forty-nine percent (18/37) of those assigned to take medication took none throughout the study period, with less compliance in younger participants with mean ages of 32.7 in those who did not take any medication, 33.4 who were less than 80% compliant, and 42.3 who were compliant (P = .013). Compliance in keeping a daily headache diary was low, with 29/50 participants (58%) meeting daily entry completion, and only 10 participants maintaining 100% diary completion. No differences were found between those who started medication immediately vs at day 30 in headache frequency or severity. CONCLUSIONS: While headache is the most common symptom following mTBI, current evidence does not support a specific treatment. No differences were noted in headache frequency compared to our prior study. However, the current sample had significantly lower headache severity (15% vs 36% with pain rating of 6 or above, P = .015) compared to our prior study. Our current study was not able to determine whether there is any benefit for the use of amitriptyline as a headache preventive because of difficulty with study recruitment and compliance. The challenges with recruitment and retention in the mTBI population were instructive, and future research in this area will need to identify strategies to improve recruitment, diary compliance, and medication adherence in this population.
Subject(s)
Amitriptyline/pharmacology , Analgesics, Non-Narcotic/pharmacology , Brain Concussion/complications , Outcome Assessment, Health Care , Post-Traumatic Headache/prevention & control , Adolescent , Adult , Amitriptyline/administration & dosage , Analgesics, Non-Narcotic/administration & dosage , Feasibility Studies , Female , Glasgow Coma Scale , Humans , Male , Middle Aged , Post-Traumatic Headache/etiology , Prospective Studies , Severity of Illness Index , Treatment Failure , Young AdultABSTRACT
The taxonomic history of Bumba Pérez-Miles, Bonaldo & Miglio, 2014 is mainly based on the inclusion of the new species. Bumba have been characterized by the type IV urticating setae present, retrolateral process on male palpal tibia, palpal bulb resting in a ventral distal excavation of palpal tibia, metatarsus I passes between the two branches of tibial apophysis when flexed, presence of spiniform setae on prolateral and retrolateral sides of maxillae and coxae I-IV. In this paper we include the row of teeth (denticulate row) in the median region of the inferior prolateral keel in all male palps. This structure range from a residual tooth to a ridge of up to five teeth. Both, the denticulate row and the retrolateral process on male palpal tibia in males could be considered as putative synapomorphies for Bumba. Here, Homoeomma humile Vellard, 1924 is transferred to Bumba and redescribed, while the female is described for the first time. Bumba cabocla (Pérez-Miles, 2000) is synonymyzed with B. horrida (Schmidt, 1994). Bumba pulcherrimaklaasi (Schmidt, 1991) is transferred to Cyclosternum Ausserer, 1871. Four new species are described and illustrated: Bumba tapajos sp. nov. from state of Pará, Bumba cuiaba sp. nov. and Bumba rondonia sp. nov., both from states of Rondônia and Mato Grosso, respectively, and Bumba mineiros sp. nov. from Paraguay and the Brazilian states of Goiás, Mato Grosso and Mato Grosso do Sul. Diagnosis of B. horrida and B. lennoni are extended and figures of this species are presented.
ABSTRACT
Cyrtopholis Simon 1892 is a spider genus from the Caribbean islands characterized by the presence of stridulatory setae on trochanter of palps and legs I. Franganillo Balboa described eight species of Cyrtopholis Simon 1892 from Cuba between 1926–1936. The type-material is deposited in the Instituto de Ecología y Sistematica do Ministerio de Ciencias, Tecnologia e Meio Ambiente, La Habana, Cuba. Four species are redescribed here: Cyrtopholis plumosa Franganillo, 1931, Cyrtopholis major Franganillo, 1926, Cyrtopholis unispina Franganillo, 1926 and Cyrtopholis gibbosa Franganillo, 1936. Cyrtopholis ischnoculoformis Franganillo, 1926 is based on a juvenile specimen without stridulatory setae, and it is therefore considered here as species inquirenda. The type-material of two other species were not located: Cyrtopholis anacanta Franganillo, 1935 and Cyrtopholis obsoleta (Franganillo, 1935), and are considered to be lost. These two species are here considered as species inquirenda, since the original descriptions do not permit identification. Cyrtopholis respina Franganillo 1935 is considered a nomen dubium, due to the lack of a formal description and a doubtful citation.
ABSTRACT
The taxonomic history of Bumba Pérez-Miles, Bonaldo & Miglio, 2014 is mainly based on the inclusion of the new species. Bumba have been characterized by the type IV urticating setae present, retrolateral process on male palpal tibia, palpal bulb resting in a ventral distal excavation of palpal tibia, metatarsus I passes between the two branches of tibial apophysis when flexed, presence of spiniform setae on prolateral and retrolateral sides of maxillae and coxae I-IV. In this paper we include the row of teeth (denticulate row) in the median region of the inferior prolateral keel in all male palps. This structure range from a residual tooth to a ridge of up to five teeth. Both, the denticulate row and the retrolateral process on male palpal tibia in males could be considered as putative synapomorphies for Bumba. Here, Homoeomma humile Vellard, 1924 is transferred to Bumba and redescribed, while the female is described for the first time. Bumba cabocla (Pérez-Miles, 2000) is synonymyzed with B. horrida (Schmidt, 1994). Bumba pulcherrimaklaasi (Schmidt, 1991) is transferred to Cyclosternum Ausserer, 1871. Four new species are described and illustrated: Bumba tapajos sp. nov. from state of Pará, Bumba cuiaba sp. nov. and Bumba rondonia sp. nov., both from states of Rondônia and Mato Grosso, respectively, and Bumba mineiros sp. nov. from Paraguay and the Brazilian states of Goiás, Mato Grosso and Mato Grosso do Sul. Diagnosis of B. horrida and B. lennoni are extended and figures of this species are presented.
ABSTRACT
Cyrtopholis Simon 1892 is a spider genus from the Caribbean islands characterized by the presence of stridulatory setae on trochanter of palps and legs I. Franganillo Balboa described eight species of Cyrtopholis Simon 1892 from Cuba between 1926–1936. The type-material is deposited in the Instituto de Ecología y Sistematica do Ministerio de Ciencias, Tecnologia e Meio Ambiente, La Habana, Cuba. Four species are redescribed here: Cyrtopholis plumosa Franganillo, 1931, Cyrtopholis major Franganillo, 1926, Cyrtopholis unispina Franganillo, 1926 and Cyrtopholis gibbosa Franganillo, 1936. Cyrtopholis ischnoculoformis Franganillo, 1926 is based on a juvenile specimen without stridulatory setae, and it is therefore considered here as species inquirenda. The type-material of two other species were not located: Cyrtopholis anacanta Franganillo, 1935 and Cyrtopholis obsoleta (Franganillo, 1935), and are considered to be lost. These two species are here considered as species inquirenda, since the original descriptions do not permit identification. Cyrtopholis respina Franganillo 1935 is considered a nomen dubium, due to the lack of a formal description and a doubtful citation.
ABSTRACT
Migraine is a common headache disorder for which women are likely to seek care. This primary headache disorder, which often may be debilitating, has a higher prevalence in women than in men that is likely related to times of hormonal changes throughout the reproductive life cycle, such as menarche, pregnancy, postpartum period, lactation, perimenopause, and menopause, as well as to external hormonal changes associated with the use of oral contraceptives and hormone therapy. The obstetrician-gynecologist is well positioned to recognize and treat migraine and to recognize a potential relationship between estrogen fluctuation and migraine exacerbation. Migraine frequency is likely to decrease during pregnancy, but migraine often recurs during breastfeeding. Because headache does occur during these reproductive events, a careful evaluation and possible medication change may be necessary. Women also have unique risks for secondary headache during pregnancy, particularly pregnant women with a history of migraine. Therefore, a large portion of this monograph is devoted to evaluation, management, and drug safety in pregnant or breastfeeding women.