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Hong Kong Med J ; 15(5): 394-6, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19801701

ABSTRACT

We present a case of a 17-year-old man with first-episode schizophrenia who developed olanzapine-induced hepatitis, cholestasis, and splenomegaly, all of which were reversed after ceasing olanzapine. Clinicians prescribing olanzapine should be aware of this possible hepatotoxicity. Patient education, vigilance from clinicians, and careful clinical examination can help detect this complication early.


Subject(s)
Antipsychotic Agents/adverse effects , Benzodiazepines/adverse effects , Chemical and Drug Induced Liver Injury/etiology , Adolescent , Antipsychotic Agents/therapeutic use , Benzodiazepines/therapeutic use , China , Cholestasis/chemically induced , Humans , Male , Olanzapine , Schizophrenia/drug therapy , Splenomegaly/chemically induced
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