ABSTRACT
BACKGROUND: Sedentary behavior (SB) is deeply ingrained in the daily lives of community-dwelling older adults with type 2 diabetes mellitus (T2DM). However, the specific underlying mechanisms of the determinants associated with SB remain elusive. We aimed to explore the determinants of SB based on the behavior change wheel framework as well as a literature review. METHODS: This cross-sectional study recruited 489 community-dwelling older adults with T2DM in Jinan City, Shandong Province, China. Convenience sampling was used to select participants from relevant communities. This study used the Measure of Older Adults' Sedentary Time-T2DM, the Abbreviated-Neighborhood Environment Walkability Scale, the Social Support Rating Scale, the Lubben Social Network Scale 6, the Subjective Social Norms Questionnaire for Sedentary Behavior, the Functional Activities Questionnaire, the Numerical Rating Scale, the Short Physical Performance Battery, and the Montreal Cognitive Assessment Text to assess the levels of and the determinants of SB. Descriptive statistical analysis and path analysis were conducted to analyze and interpret the data. RESULTS: Pain, cognitive function, social isolation, and social support had direct and indirect effects on SB in community-dwelling older adults with T2DM (total effects: ß = 0.426, ß = -0.171, ß = -0.209, and ß = -0.128, respectively), and physical function, walking environment, and social function had direct effects on patients' SB (total effects: ß = -0.180, ß = -0.163, and ß = 0.127, respectively). All the above pathways were statistically significant (P < 0.05). The path analysis showed that the model had acceptable fit indices: RMSEA = 0.014, χ 2/df = 1.100, GFI = 0.999, AGFI = 0.980, NFI = 0.997, RFI = 0.954, IFI = 1.000, TLI = 0.996, CFI = 1.000. CONCLUSION: Capability (physical function, pain, and cognitive function), opportunity (social isolation, walking environment, and social support), and motivation (social function) were effective predictors of SB in community-dwelling older adults with T2DM. Deeper knowledge regarding these associations may help healthcare providers design targeted intervention strategies to decrease levels of SB in this specific population.
Subject(s)
Diabetes Mellitus, Type 2 , Independent Living , Sedentary Behavior , Humans , Diabetes Mellitus, Type 2/psychology , Diabetes Mellitus, Type 2/epidemiology , Aged , Male , Female , Cross-Sectional Studies , Independent Living/psychology , Social Support , China/epidemiology , Middle Aged , Social Isolation/psychology , Surveys and Questionnaires , Aged, 80 and overABSTRACT
Ethanol (alcohol) is a risk factor that contributes to non-communicable diseases. Chronic abuse of ethanol is toxic to both the heart and overall health, and even results in death. Ethanol and its byproduct acetaldehyde can harm the cardiovascular system by impairing mitochondrial function, causing oxidative damage, and reducing contractile proteins. Endothelial cells are essential components of the cardiovascular system, are highly susceptible to ethanol, either through direct or indirect exposure. Thus, protection against endothelial injury is of great importance for persons who chronic abuse of ethanol. In this study, an in vitro model of endothelial injury was created using ethanol. The findings revealed that a concentration of 20.0 mM of ethanol reduced cell viability and Bcl-2 expression, while increasing cell apoptosis, intracellular reactive oxygen species (ROS) levels, mitochondrial depolarization, and the expression of Bax and cleaved-caspase-3 in endothelial cells. Further study showed that ethanol promoted nuclear translocation of nuclear factor kappa B (NF-κB), increased the secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1ß, IL-6 in the culture medium, and inhibited nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling pathway. The aforementioned findings suggest that ethanol has a harmful impact on endothelial cells. Nevertheless, the application of epigallocatechin-3-gallate (EGCG) to the cells can effectively mitigate the detrimental effects of ethanol on endothelial cells. In conclusion, EGCG alleviates ethanol-induced endothelial injury partly through alteration of NF-κB translocation and activation of the Nrf2 signaling pathway. Therefore, EGCG holds great potential in safeguarding individuals who chronically abuse ethanol from endothelial dysfunction.
Subject(s)
Catechin , Ethanol , NF-E2-Related Factor 2 , NF-kappa B , Signal Transduction , Ethanol/toxicity , NF-E2-Related Factor 2/metabolism , Catechin/analogs & derivatives , Catechin/pharmacology , Catechin/therapeutic use , NF-kappa B/metabolism , Humans , Signal Transduction/drug effects , Apoptosis/drug effects , Human Umbilical Vein Endothelial Cells/drug effects , Human Umbilical Vein Endothelial Cells/metabolism , Reactive Oxygen Species/metabolism , Cell Survival/drug effects , Endothelial Cells/drug effects , Endothelial Cells/metabolism , Proto-Oncogene Proteins c-bcl-2/metabolismABSTRACT
The early strength of magnesium phosphate cement (MPC) decreases sharply in severe cold environments ≤-10 °C, with the 2 h compressive strength falling to 3.5 MPa at-20 °C. Therefore, it cannot be used as a repair material for emergency repair construction in such environments. In this study, MPC is adapted for use in such cold environments by replacing part of the dead-burned magnesia (M) in the mixture with a small amount of light-burned magnesia (LBM) and introducing dilute phosphoric acid (PA) solution as the mixing water. The heat released by the highly active acid-base reaction of PA and LBM stimulates an MPC reaction. Moreover, the early strength of the MPC significantly improves with the increase in the Mg2+ concentration and the initial reaction temperature of the MPC paste, which enables MPC hardening in severe cold environments. Although the morphology of the reaction products of the MPC is poor and the grain plumpness and size of the struvite crystals are remarkably reduced, the early strength of MPC prepared in the severe cold environment is close to that of MPC prepared under normal temperature. Furthermore, the increases in the early reaction temperature and early strength of magnesium phosphate cement concrete (MPCC) are significantly improved when the PA concentration in the mixing water and the LBM/M ratio are 10% and 4-6% at -10 °C and 20% and 6-8% at -20 °C, respectively. Moreover, self-curing of MPCC can be realized even at -20 °C, at which temperature the 2 h and 24 h compressive strength of MPCC reach 36 MPa and 45 MPa, respectively.