A study of the proteomic expression in patients with complicated parapneumonic pleural effusion.

Introduction: The present study aimed to investigate the differences in the proteomic expression between uncomplicated parapneumonic pleural effusion (UPPE) and complicated parapneumonic pleural effusion (CPPE). Material and methods: There were 10 patients with UPPE and 10 patients with CPPE. These patients were combined due to the complication of pleural effusion and further divided into group A and group B. An LC-MS analysis was conducted with the extraction of high-abundance proteins, and proteins with 1.5-fold or higher difference multiples were identified as differential proteins. Then, gene ontology (GO) and KEGG analyses were conducted on the differential proteins between the groups. Results: Compared with the UPPE group, there were 38 upregulated proteins and 29 downregulated proteins in the CPPE group. The GO analysis revealed that the CPPE group had enhanced expressions in monosaccharide biosynthesis, glucose catabolism, fructose-6-phosphate glycolysis, glucose-6-phosphate glycolysis, and NADH regeneration as well as reduced expressions in fibrinogen complexes, protein polymerization, and coagulation. Moreover, the KEGG analysis showed that the CPPE group had enhanced expressions in amino acid synthesis, the HIF-1 signalling pathway, and glycolysis/glycoisogenesis and decreased expressions in platelet activation and complement activation. Conclusions: In pleural effusion in patients with CPPE, there are enhanced expressions of proteins concerning glucose and amino acid metabolism, NADH regeneration, and HIF-1 signalling pathways together with decreased expressions of proteins concerning protein polymerization, blood coagulation, platelet activation, and complement activation.

Anti-saccades reveal impaired attention control over negative social evaluation in individuals with depressive symptoms.

Depressed individuals are excessively sensitive to negative information but blunt to positive information, which has been considered as vulnerability to depression. Here, we focused on inhibitory control over attentional bias on social evaluation in individuals with depression. We engaged individuals with and without depressive symptoms (categorized by Beck Depression Inventory-II) in a novel attention control task using positive and negative evaluative adjectives as self-referential feedback given by social others. Participants were instructed to look at sudden onset feedback targets (pro-saccade) or the mirror location of the targets (anti-saccade) when correct saccade latencies and saccade errors were collected. The two indices showed that while both groups displayed longer latencies and more errors for anti-saccade relative to pro-saccade responses depressed individuals spent more time reacting correctly and made more errors than non-depressed individuals in the anti-saccade trials and such group differences were not observed in the pro-saccade trials. Although group differences in correct anti-saccade latencies were found for both positive and negative stimuli, depressed individuals spent more time making correct anti-saccade responses to negative social feedback than to positive ones whereas non-depressed individuals featured longer correct anti-saccade latencies for positive relative to negative evaluations. Our results suggest that depressed individuals feature an impaired ability in attention control for self-referential evaluations, notably those of negative valence, shedding new light on depression-distorted self-schema and corresponding social dysfunctions.

Emotion-dependent language featuring depression.

BACKGROUND AND OBJECTIVES: Understanding language features of depression contributes to the detection of the disorder. Considering that depression is characterized by dysfunctions in emotion and individuals with depression often show emotion-dependent cognition, the present study investigated the speech features and word use of emotion-dependent narrations in patients with depression. METHODS: Forty depression patients and forty controls were required to narrate self-relevant memories under five basic human emotions (i.e., sad, angry, fearful, neutral, and happy). Recorded speech and transcribed texts were analyzed. RESULTS: Patients with depression, as compared to non-depressed individuals, talked slower and less. They also performed differently in using negative emotion, work, family, sex, biology, health, and assent words regardless of emotion manipulation. Moreover, the use of words such as first person singular pronoun, past tense, causation, achievement, family, death, psychology, impersonal pronoun, quantifier and preposition words displayed emotion-dependent differences between groups. With the involvement of emotion, linguistic indicators associated with depressive symptoms were identified and explained 71.6% variances of depression severity. LIMITATIONS: Word use was analyzed based on the dictionary which does not cover all the words spoken in the memory task, resulting in text data loss. Besides, a relatively small number of depression patients were included in the present study and therefore the results need confirmation in future research using big emotion-dependent data of speech and texts. CONCLUSIONS: Our findings suggest that consideration of different emotional contexts is an effective means to improve the accuracy of depression detection via the analysis of word use and speech features.

Depressive symptoms following traumatic brain injury are associated with resting-state functional connectivity.

BACKGROUND: To determine whether depressive symptoms in traumatic brain injury (TBI) patients were associated with altered resting-state functional connectivity (rs-fc) or voxel-based morphology in brain regions involved in emotional regulation and associated with depression. METHODS: In the present study, we examined 79 patients (57 males; age range = 17-70 years, M ± s.d. = 38 ± 16.13; BDI-II, M ± s.d. = 9.84 ± 8.67) with TBI. We used structural MRI and resting-state fMRI to examine whether there was a relationship between depression, as measured with the Beck Depression Inventory (BDI-II), and the voxel-based morphology or functional connectivity in regions previously identified as involved in emotional regulation in patients following TBI. Patients were at least 4 months post-TBI (M ± s.d. = 15.13 ± 11.67 months) and the severity of the injury included mild to severe cases [Glasgow Coma Scale (GCS), M ± s.d. = 6.87 ± 3.31]. RESULTS: Our results showed that BDI-II scores were unrelated to voxel-based morphology in the examined regions. We found a positive association between depression scores and rs-fc between limbic regions and cognitive control regions. Conversely, there was a negative association between depression scores and rs-fc between limbic and frontal regions involved in emotion regulation. CONCLUSION: These findings lead to a better understanding of the exact mechanisms that contribute to depression following TBI and better inform treatment decisions.

Disorder-specific impaired neurocognitive function in major depression and generalized anxiety disorder.

BACKGROUND: Generalized anxiety disorder (GAD) and major depressive disorder (MDD) are both highly prevalent and comorbid psychiatric disorders. Neurocognitive dysfunction has been commonly found in MDD, but the findings in GAD are inconsistent. Few studies have directly compared cognitive performance between GAD and MDD. Therefore, the present study aimed to reveal the similar and distinct cognitive impairments between both disorders. METHODS: Three non-overlapping and non-comorbid groups were enrolled in the current study including patients with GAD (n = 37), MDD (n = 107) and healthy controls (n = 74). Levels of anxiety and depression were assessed using the Hamilton Anxiety Rating Scale (HAMA) and the Hamilton Depression Rating Scale (HAMD) respectively. The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to compare the cognitive performance, including sustained attention, visual memory, executive functions and learning. RESULTS: Both MDD and GAD groups demonstrated common significant deficits in sustained attention, visual memory, working memory and learning when compared to healthy controls. Despite the similarities, the MDD group had significantly greater impairment in learning, particularly generalization, while the GAD group demonstrated more pronounced deficits in visual memory. LIMITATIONS: Patients involved were medicated and the sample size for GAD was relatively small. CONCLUSIONS: The significant differences in visual memory and learning between MDD and GAD groups might be indicators to distinguishing both disorders. These results confirm that cognitive function is of great importance as a future target for treatment in order to improve wellbeing, quality of life and functionality in both GAD and MDD.

More Exposure to Childhood Trauma Associates with Reduced Displeasure at Self-Referential Criticism.

Childhood trauma has been shown to contribute to low self-concept, potentially affecting trauma survivors' perception of social evaluations from others. However, there is little evidence for the association between traumatic experience in childhood and adult processing of evaluative verbal cues related to self. Therefore, the present study aimed to address whether and how cognitive and affective responses to self-referential praise and criticism would vary with different forms of childhood trauma. We engaged undergraduates and postgraduates in completing the Childhood Trauma Questionnaire (CTQ) and an evaluation task in which participants rated self-related praising and criticizing sentences for pleasantness and truthfulness. These ratings and CTQ scores were subjected to correlation and regression analyses. Positive correlations were found between the pleasantness ratings for criticism and the scores of the CTQ full scale (r 90 = .314, p = 0.0011) and two subscales for physical abuse (r 90 = .347, p = 0.0004) and physical neglect (r 90 = .335, p = 0.0005), indicating that higher scores in the scales were associated with reduced unpleasantness for self-related criticism. The regression analysis further revealed that 14.2% variances of emotional response to criticism could be explained by experience in physical abuse (ß = .452, p = .022) and physical neglect (ß = .387, p = .027). These findings suggest that childhood exposure to traumatic experience, particularly physical abuse and neglect, leads to attenuated emotional responses to self-referential criticism possibly via the mediation of self-concept.

Altered centromedial amygdala functional connectivity in adults is associated with childhood emotional abuse and predicts levels of depression and anxiety.

BACKGROUND: Childhood maltreatment is significantly associated with greater occurrence of mental disorders in adulthood such as depression and anxiety. As a key node of the limbic system, the amygdala is engaged in emotional processing and regulation and is dysfunctional in many psychiatric disorders. The present study aimed at exploring the association between childhood maltreatment and amygdala-based functional networks and their potential contributions to depression and anxiety. METHODS: Totally 90 Chinese healthy volunteers participated in a resting-state fMRI experiment. Levels of childhood maltreatment experience were assessed using the Childhood Trauma Questionnaire (CTQ-SF) as well as levels of depression and anxiety. Associations between CTQ-SF scores and bilateral amygdala gray matter volume and resting-state functional connectivity (RSFC) of the amygdala and selected regions of interest were analyzed using multiple regression analyses with sex and age as covariates. A subsequent moderation analysis was performed to identify whether associations were predictive of depression and anxiety levels. RESULTS: Childhood maltreatment was significantly negatively associated with RSFC between left amygdala and anterior insula. Further sub-region analyses revealed that this negative association only occurred for the left centromedial amygdala subregion, which subsequently moderated the relationship between levels of childhood emotional abuse and depression / anxiety. LIMITATIONS: No psychiatric patients were involved and specific neural associations with different childhood maltreatment subtypes need to be examined in future studies. CONCLUSION: The present findings provide evidence for altered RSFC of centromedial amygdala and the anterior insula associated with childhood maltreatment and which moderate levels of depression and anxiety in adulthood.

Insights into the Metal-CO Bond in O2M(η1-CO) (M = Cr, Mo, W, Nd, and U) Complexes.

Investigations on the structures and bonding properties of metal carbonyl compounds provide fundamental understandings on the origin of small-molecule activations. Herein, the geometry and bonding trends of a series of isovalent metal oxocarbonyl complexes O2M(η1-CO) (M = Cr, Mo, W, Nd, and U) were studied by combined matrix-isolation infrared spectroscopy and advanced quantum chemical calculations. The title complexes present red shift of C-O stretching bands in the range from 122 to 244 cm-1, indicating the difference of CO activation ability for the series of isovalent metal dioxides. Density functional theory calculations predict T-shaped structures with a C2v symmetry for all the title molecules. O2Nd(η1-CO) bears little resemblance to the other complexes in bonding characters because of the weak interactions between the NdO2 and CO moiety. For the other complexes, natural localized molecular orbital analysis reveals a gradual increase of covalent character in M-CO bonds along the metal series Cr → Mo → W→ U. Energy decomposition analysis with natural orbitals for chemical valence calculations demonstrates that the M-CO bonding patterns conform to the conventional Dewar-Chatt-Duncanson motif. The contributions from orbital interactions in total attractions increase from Cr (41.7%) to U (52.7%). The breakdown of the orbital term into pairwise interactions shows that contributions of the M ← CO σ donation decrease from Cr (59.2%) to U (28.4%), while the M → CO π* backdonation increases significantly from Cr (23.8%) to U (67.3%). The more effective overlap and the better energy matching of U 5f and U 6d valence orbitals with CO π* orbitals result in much stronger U → CO π backdonation than the other metal elements.

Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety and major depressive disorder.

Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) are highly debilitating and often co-morbid disorders. The disorders exhibit partly overlapping dysregulations on the behavioral and neurofunctional level. The determination of disorder-specific behavioral and neurofunctional dysregulations may therefore promote neuro-mechanistic and diagnostic specificity. In order to determine disorder-specific alterations in the domain of emotion-cognition interactions the present study examined emotional context-specific inhibitory control in treatment-naïve MDD (n = 37) and GAD (n = 35) patients and healthy controls (n = 35). On the behavioral level MDD but not GAD exhibited impaired inhibitory control irrespective of emotional context. On the neural level, MDD-specific attenuated recruitment of inferior/medial parietal, posterior frontal, and mid-cingulate regions during inhibitory control were found during the negative context. GAD exhibited a stronger engagement of the left dorsolateral prefrontal cortex relative to MDD. Overall the findings from the present study suggest disorder- and emotional context-specific behavioral and neurofunctional inhibitory control dysregulations in major depression and may point to a depression-specific neuropathological and diagnostic marker.

Intranasal oxytocin may help maintain romantic bonds by decreasing jealousy evoked by either imagined or real partner infidelity.

BACKGROUND: While romantic jealousy may help to maintain relationships, following partner infidelity and an irretrievable loss of trust it can also promote break-ups. The neuropeptide oxytocin can enhance the maintenance of social bonds and reduce couple conflict, although its influence on jealousy evoked by imagined or real infidelity is unclear. AIMS: This study aimed to investigate the effects of intranasal oxytocin (24 IU) on romantic jealousy in both males and females in imagined and real contexts. METHODS: Seventy heterosexual couples participated in this double-blind, placebo-controlled, between-subject design study. Jealousy was firstly quantified in the context of subjects imagining partner infidelity and secondly in a Cyberball game where their partner interacted preferentially with an opposite-sexed rival stranger to simulate partner exclusion, or rejected a neutral stranger but not the partner. RESULTS: Oxytocin primarily decreased jealousy and arousal ratings towards imagined emotional and sexual infidelity by a partner in both sexes. During the Cyberball game, while male and female subjects in both groups subsequently threw the ball least often to the rival stranger, under oxytocin they showed reduced romantic jealousy and arousal ratings for stranger players, particularly the rival one, and reported reduced negative and increased positive feelings while playing the game. CONCLUSIONS: Together, our results suggest that oxytocin can reduce the negative emotional impact of jealousy in established romantic partners evoked by imagined or real infidelity or exclusive social interactions with others. This provides further support for oxytocin promoting maintenance of relationships.

Decreased interhemispheric resting-state functional connectivity in male adolescents with conduct disorder.

Conduct disorder (CD) is a common psychiatric disorder defined by a repetitive and persistent pattern of aggressive and antisocial behaviors. Although numerous task-based and resting-state functional magnetic resonance imaging (rsfMRI) studies have emphasized the disrupted functional connectivity in CD, the CD-related alterations in functional interactions between the bilateral cerebral hemispheres are rarely investigated directly. In this study, a voxel-mirrored homotopic connectivity (VMHC) method based on rsfMRI was employed for the first time to examine the abnormalities of interhemispheric functional connectivity in patients with CD. The VMHC was compared between eighteen pure CD patients and eighteen typically developing (TD) healthy controls. In CD patients, reduced homotopic connectivity was observed relative to TDs in the middle occipital gyrus (MOG), pre- and postcentral gyrus, rolandic operculum and paracentral lobe (PCL) which were the components of visual and motor networks. Furthermore, the VMHC of the MOG and PCL was found to be negatively correlated with clinical scores in the CD group. Moreover, the regions with altered VMHC exhibited a relative good and robust ability to discriminate CD patients from TDs. This study provided a novel angle to identify the important role of interhemispheric coordination in the pathophysiology underlying CD and further indicated that the aberrant homotopic connectivity could be a potential clinical neural marker for CD diagnosis.

Intrinsic connectivity of the prefrontal cortex and striato-limbic system respectively differentiate major depressive from generalized anxiety disorder.

Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are highly prevalent and debilitating disorders. The high overlap on the symptomatic and neurobiological level led to ongoing debates about their diagnostic and neurobiological uniqueness. The present study aims to identify common and disorder-specific neuropathological mechanisms and treatment targets in MDD and GAD. To this end we combined categorical and dimensional disorder models with a fully data-driven intrinsic network-level analysis (intrinsic connectivity contrast, ICC) to resting-state fMRI data acquired in 108 individuals (n = 35 and n = 38 unmedicated patients with first-episode GAD, MDD, respectively, and n = 35 healthy controls). Convergent evidence from categorical and dimensional analyses revealed MDD-specific decreased whole-brain connectivity profiles of the medial prefrontal and dorsolateral prefrontal cortex while GAD was specifically characterized by decreased whole-brain connectivity profiles of the putamen and decreased communication of this region with the amygdala. Together, findings from the present data-driven analysis suggest that intrinsic communication of frontal regions engaged in executive functions and emotion regulation represent depression-specific neurofunctional markers and treatment targets whereas dysregulated intrinsic communication of the striato-amygdala system engaged in reinforcement-based and emotional learning processes represent GAD-specific markers.

The baby schema effect in adolescence and its difference from that in adulthood.

The baby schema effect induced by particular features of baby faces acts as an innate releasing mechanism that evokes positive emotions and instinctual behavioral responses. Our prior research in adults has revealed that this effect initially found in infancy extends into child faces. Adolescence is an important period involving development in various aspects of cognition, including face perception. Here, we investigated whether the extended baby schema effect we previously found in adult observers develops earlier-in adolescence-and how different it appears in adolescents as compared with in adults. In the current study, 76 adolescents and 77 adults were asked to judge the likeability of 148 neutral faces of infants and children (0.08-6.5 years of age) on 7-point scales. Results showed that both adolescents and adults perceived the faces of both infants and children younger than 4.6 years as more likeable relative to those of older children, indicating that the baby schema effect previously found in adulthood also occurs in adolescence. However, adolescents rated lower than adults toward the infant and child faces across all face ages, suggesting that this effect might be under development in adolescence. Overall, our findings provide new evidence for the development of face perception in adolescence and demonstrate age-related changes in innate releasing mechanisms in our protective and caretaking responses toward infants and children.

Criticism in a foreign language hurts less.

Understanding emotional resonances to social evaluations delivered in different languages may contribute to favourable social communication in today's increasingly internationalised world. The present study thus investigated the language-induced emotionality differences by presenting Chinese-English bilinguals with self-referential praising and criticising statements in both their native Chinese and foreign English languages and asking them to make their affective and cognitive judgments on the comments, namely, to rate how pleased they were by the comments and how truly the comments described their attributes. Results revealed that while criticism was rated more unpleasant than praise in both languages, the unpleasantness was reduced by the use of English as compared to Chinese. Intriguingly, no cross-language differences were found in the cognitive assessment. Our findings may shed light on facilitating affective social communication using different languages.

A dimensional approach to jealousy reveals enhanced fronto-striatal, insula and limbic responses to angry faces.

Jealousy is a complex social emotion combining the different primary emotions of anger, fear and sadness. Previous evidence has suggested the involvement of fronto-striatal dopaminergic circuitry in pathological jealousy, although little is known about overlaps with the neural representation of primary emotions involved in non-morbid jealousy and the utility of a dimensional neuroimaging approach. In the current study, 85 healthy subjects underwent fMRI during an emotional face recognition paradigm and resting state. A total of 150 faces (happy, angry, fearful, sad, neutral) were presented and subjects required to identify the expression and rate its intensity. Trait jealousy was assessed using the Multidimensional Jealousy Scale. Behavioral results showed that only intensity ratings of angry faces were positively associated with subjects' jealousy scores. During processing of angry versus neutral expression faces, subjects with elevated jealousy exhibited increased activation in the right thalamus, insula, fusiform gyrus and hippocampus, left dorsal striatum, superior parietal lobule and bilateral cerebellum and inferior frontal gyrus after controlling for trait aggression and sex. Functional connectivity between the inferior frontal gyrus and dorsal striatum was also increased. No associations with resting-state functional connectivity were found. Overall, the present study demonstrates an association between exaggerated jealousy and increased intensity ratings of angry faces as well as activity and functional connectivity of the dorsal striatal-inferior frontal circuitry. Thus, increased emotional responsivity to social threat and enhanced activity in limbic regions and dopaminergic fronto-striatal circuitry may be features of both non-morbid and pathological jealousy confirming the utility of a dimensional approach.

Personality Counts More Than Appearance for Men Making Affective Judgments of Verbal Comments.

Previous research has shown that that evaluative verbal information (praise and criticism) conveys different affective values: criticism is perceived as unpleasant while praise is generally considered pleasant. Here, using praise and criticism in Chinese, we investigated how affective value is modulated in men and women, depending on the particular attribute (personality vs. appearance) targeted by social comments. Results showed that whereas praise was rated as pleasant and criticism as unpleasant overall, criticizing personality reduced pleasantness more than criticizing appearance. In men, moreover, criticism of personality was deemed more unpleasant than criticism of appearance while personality-targeted praise was rated more pleasant than appearance-targeted praise. This effect was absent in women and consistent with men's higher arousal ratings for personality- relative to appearance-targeted comments. Our findings suggest that men are more concerned about external perception of their personality than that of their appearance whereas women's affective judgment is more balanced. These gender-specific results may have implications for topic selection in evaluative social communication.

Physical properties and field-induced metamagnetic transitions in UAu0.8Sb2.

We have successfully synthesized single crystals of UAu0.8Sb2 using a flux method and present a comprehensive study of its physical properties by measuring the magnetic susceptibility, electrical resistivity and specific heat. Evidence for at least three magnetic phases is observed in the field-temperature phase diagram of UAu0.8Sb2. In zero field, the system undergoes an antiferromagnetic transition at 71 K, and upon further cooling it passes through another antiferromagnetic phase with a ferromagnetic component, before reaching a ferromagnetic ground state. A complex magnetic field-temperature phase diagram is obtained for fields along the easy c-axis, where the antiferromagnetic order eventually becomes polarized upon applying a magnetic field.

Regional homogeneity and functional connectivity patterns in major depressive disorder, cognitive vulnerability to depression and healthy subjects.

BACKGROUND: Cognitive vulnerability to depression (CVD) is a high risk for depressive disorder. Recent studies focus on individuals with CVD to determine the neural basis of major depressive disorder (MDD) neuropathology. However, whether CVD showed specific or similar brain functional activity and connectivity patterns, compared to MDD, remain largely unknown. METHODS: Here, using resting-state functional magnetic resonance imaging in subjects with CVD, healthy controls (HC) and MDD, regional homogeneity (ReHo) and resting-state functional connectivity (R-FC) analyses were conducted to assess local synchronization and changes in functional connectivity patterns. RESULTS: Significant ReHo differences were found in right posterior lobe of cerebellum (PLC), left lingual gyrus (LG) and precuneus. Compared to HC, CVD subjects showed increased ReHo in the PLC, which was similar to the difference found between MDD and HC. Compared to MDD patients, CVD subjects showed decreased ReHo in PLC, LG, and precuneus. R-FC analyses found increased functional connections between LG and left inferior parietal lobule, posterior cingulate cortex, and dorsolateral prefrontal cortex in CVD compared to both HC and MDD. Moreover, Regional mean ReHo values were positively correlated with Center for Epidemiologic Studies Depression Scale scores. CONCLUSION: These analyses revealed that PLC and functional connections between LG and left inferior parietal lobule, posterior cingulate cortex, and dorsolateral prefrontal cortex may be a potential marker for CVD.