Half-sandwich ruthenium complexes with acylhydrazone ligands: synthesis and catalytic activity in the N-alkylation of hydrazides.

Novel half-sandwich ruthenium complexes termed [(p-cymene)RuClL] were synthesized by chelating arylhydrazone ligands with [(p-cymene)RuCl2]2 and were then fully characterized using different spectroscopic and analytical techniques. The crystal structure of complex 4 indicated that the hydrazone ligands bonded to the ruthenium ion in a bidentate manner through the imine nitrogen and imidazolate oxygen, exhibiting a pseudo-octahedral geometry centered by the ruthenium atom. The as-fabricated air and moisture stable half-sandwich ruthenium complexes demonstrated excellent catalytic activity towards the N-alkylation of hydrazides under mild conditions. Under the catalysis of ruthenium complexes, acyl hydrazides were reacted with different types of alcohols in a one-pot reaction, resulting in N-alkylation hydrazides with different substituents. This catalyst exhibited characteristics such as high catalytic efficiency, broad substrate scope, and mild reaction conditions, indicating that it has great potential for industrial applications.

Cationic N,S-chelate half-sandwich iridium complexes: synthesis, characterization, anticancer and antiplasmodial activity.

A series of pyrazole-based ligands and their corresponding cationic N,S-chelate half-sandwich iridium complexes were successfully synthesized. All iridium complexes exhibited good anticancer activity against the MCF-7 and MDA-MB-231 human breast cancer cells. The cytotoxic activity of unsubstituted iridium complex 1 is greater than that of cisplatin against MCF-7 cells. In addition, the cationic half-sandwich iridium complexes are also efficient in antiplasmodial study and complex 1 displayed the best activity as its IC50 was observed to be approximately 0.11 µM against the CQS-NF54 strain. These iridium complexes generally exhibited enhanced activity against the CQS-NF54 strain in comparison with that against the CQR-K1 strain. An "IC50 speed assay" investigation against the CQS-NF54 strain indicated complexes 1-3 to be fast-acting complexes that reach their lowest IC50 values within 16 hours. All complexes were fully characterized by IR spectroscopy, NMR spectroscopy, and elemental analysis, and the structure of the iridium complex was confirmed by single-crystal X-ray diffraction.

Half-sandwich iridium complexes with hydrazone ligands: preparation, structure, and catalytic synthesis of cyanosilylethers under air.

A series of hydrazone-based N,O-chelate half-sandwich iridium complexes were synthesized through a facile route with good yields. These air- and moisture-stable iridium complexes exhibited excellent catalytic activity in the cyanosilylether synthesis under mild reaction conditions. Under the catalysis of iridium, various cyanosilylethers with different substituents were obtained through a one-pot reaction of trimethylsilyl cyanide (TMSCN) with carbonyl substrates, with good to excellent yields. The excellent catalytic efficiency, wide substrate range, and mild reaction conditions made this type of iridium catalyst have the potential for industrial applications. All the half-sandwich iridium complexes were well characterized by IR, NMR, and EA analyses. The molecular structure of iridium complex 1 was confirmed by single-crystal X-ray analysis.

Effects of Multimedia Assisted Song Integrated Teaching on College Students' English Learning Interests and Learning Outcomes.

In the process of globalization, the English language not only represents British and American culture, but it has also gradually become a language used all over the world, and it has become essential for many people to learn it as a second language. Education is the century business of a nation. At the same time, to meet the needs of E generation, I generation, and touch-screen generation students, teachers are increasingly undertaking multimedia-integrated curriculum design and instruction. Teachers are no longer knowledge providers, but they are expected to provide students with a personalized learning model and guide and support them in a timely manner. This study included a sample of business students from Guilin University of technology. A total of 216 students participated in a 16-week (3 h per week, a total of 48 h) course of experimental teaching. The research results showed that 1. multimedia assisted, song integrated English teaching affected learning interest, 2. That multimedia assisted, song integrated English teaching affected learning outcomes, and 3. That learning interest had significantly positive effects on learning outcome. Based on these results, this study contributes to improving college students' English listening, speaking, reading, and writing skills via multimedia teaching, which also facilitated their interest and ability to achieve the learning outcomes.

Key Factors in the Application of Sharestart to Enhance the Learning Attitude of Students.

Under the background of globalization and the popularity of distance learning ande-learning channels provided on the Internet, teaching methods that encourage the self-directed learning of students are becoming popular. There is an increasing number of domestic teachers joining in the practice for change. The various teaching methods that make the students acquire critical thinking skills can be summarized as learning by doing, critical thinking learning, multiple assessments, team discussion teaching, and cooperative learning. With the teachers of the universities in Shanghai as the questionnaire analysis objects, a total of 360 copies of questionnaires were distributed, and 256 valid copies were retrieved, with the retrieval rate of 71%. The research results are summarized as follows. (1) The "mental adaptation and engagement of students" is the most emphasized dimension, followed by the "professional development of teachers," "administration and parent support," and "material and teaching strategy." (2) The top five emphasized indicators, among 14, are the ordered cultivation of self-study and thinking habits, the development of the professional community for the collaborative lesson study of teachers, the support and cooperation of the president and the administration, adoption of heterogeneous grouping, and co-learning, discussion and cooperative learning. According to the results, it is expected to propose more definite practice directions for teachers intending to attempt such a teaching method, as well as provide some specific suggestions for the first movers of Sharestart.

Discussion of Students' E-book Reading Intention With the Integration of Theory of Planned Behavior and Technology Acceptance Model.

The emergence of e-books with the characteristics of easy access and reading any time anywhere is a subject of debate in academia. Topics include the use of e-books in libraries, their use in support teaching, new possibilities for reading activities, potential uses for library archives, and the motivation and intention of e-book users. Students at Guilin University of Technology participated in a survey. Of the 300 copies of the questionnaire distributed, 263 valid copies were returned, a retrieval rate of 88%. The research results show that (1) Usability and reading need are the key factors in e-book usage. Usability refers to convenient keyword searches, portability, and any time reading. E-books are considered to make searching and reading large amounts of data easier. (2) E-books are not restricted to time and space so that the overall reading quantity is increasing. Readers become accustomed to reading e-books, and the quality of their digital reading is gradually enhanced. (3) Students should complete e-book use courses offered by libraries to enhance their familiarity with e-books and their use of e-book software, thereby enhancing postgraduate student readers' e-book information literacy. The results of the research prompt suggestions to enhance the promotion of reading and e-book information to encourage student readers' e-book reading intention.

Methods and evaluations on the sterioid-induced osteoporosis mice model with the type of Kidney-Yin deficiency / 中国骨伤

<p><b>OBJECTIVE</b>To establish the steriod-induced osteoporosis model with the type of Kidney-Yin deficiency.</p><p><b>METHODS</b>Totally 45 female Kunming mice were randomly divided into normal group,model group and Liuwei Dihuang pills(Chinese character: see text)group. The model was established by intramuscular injecting of Dexamethasone. Liuwei Dihuang pills (Chinese character: see text) group was administered orally with Liuwei Dihuang pills (Chinese character: see text). The signs and symptoms of mice were observed dynamically. All the animals were sacrificed at the end of the 6th weeks. The level of ACTH, cAMP, cGMP, TSH and E2 in serum were detected to evaluate deficiency of Kidney-Yin. Morphological changes and bone density were observed to evaluate osteoporosis.</p><p><b>RESULTS</b>(1) Compared with control group, mice in model group appeared obvious Kidney-Yin deficiency symptoms, including hair dry, restlessness, excitability, hard stool, and yellow. (2) Compared with control group,the weight of mice in model group gained slower (P<0.01); the index of adrenal gland,liver and spleen decreased (P<0.01, P<0.01 ,P<0.01); the level of ACTH and TSH increased (P<0.01 ,P<0.01), the level of E2 decreased (P<0.01) and the ratio of cAMP/cGMP increased (P< 0.05). (3)Compared with control group,the bone density of lumbar vertebra and femur in model group were significantly decreased (P<0.01, P<0.05); HE staining revealed osteoporosis in model group mice. (4)However, the Liuwei Dihuang pills (Chinese character: see text) group can partly antagonize the inhibition of the HPA axis, alter the disordered sex hormone and the ratio of cAMP/cGMP, and reverse the osteoporosis partly.</p><p><b>CONCLUSION</b>the model of osteoporosis with type of Kidney-Yin deficiency could be established by Dexamethasone intramuscular injection. With less interference, it wight be a stable and reliable modeling method for integration of disease and syndrome in TCM.</p>