Label Distribution Learning by Exploiting Fuzzy Label Correlation.

Researchers have proposed to exploit label correlation to alleviate the exponential-size output space of label distribution learning (LDL). In particular, some have designed LDL methods to consider local label correlation. These methods roughly partition the training set into clusters and then exploit local label correlation on each one. Each sample belongs to one cluster and therefore has only one local label correlation. However, in real-world scenarios, the training samples may have fuzziness and belong to multiple clusters with blended local label correlations, which challenge these works. To solve this problem, we propose in LDL fuzzy label correlation (FLC)-each sample blends, with fuzzy membership, multiple local label correlations. First, we propose two types of FLCs, i.e., fuzzy membership-induced label correlation (FC) and joint fuzzy clustering and label correlation (FCC). Then, we put forward LDL-FC and LDL-FCC to exploit these two FLCs, respectively. Finally, we conduct extensive experiments to justify that LDL-FC and LDL-FCC statistically outperform state-of-the-art LDL methods.

XAI Driven Intelligent IoMT Secure Data Management Framework.

The Internet of Medical Things (IoMT) has transformed traditional healthcare systems by enabling real-time monitoring, remote diagnostics, and data-driven treatment. However, security and privacy remain significant concerns for IoMT adoption due to the sensitive nature of medical data. Therefore, we propose an integrated framework leveraging blockchain and explainable artificial intelligence (XAI) to enable secure, intelligent, and transparent management of IoMT data. First, the traceability and tamper-proof of blockchain are used to realize the secure transaction of IoMT data, transforming the secure transaction of IoMT data into a two-stage Stackelberg game. The dual-chain architecture is used to ensure the security and privacy protection of the transaction. The main-chain manages regular IoMT data transactions, while the side-chain deals with data trading activities aimed at resale. Simultaneously, the perceptual hash technology is used to realize data rights confirmation, which maximally protects the rights and interests of each participant in the transaction. Subsequently, medical time-series data is modeled using bidirectional simple recurrent units to detect anomalies and cyberthreats accurately while overcoming vanishing gradients. Lastly, an adversarial sample generation method based on local interpretable model-agnostic explanations is provided to evaluate, secure, and improve the anomaly detection model, as well as to make it more explainable and resilient to possible adversarial attacks. Simulation results are provided to illustrate the high performance of the integrated secure data management framework leveraging blockchain and XAI, compared with the benchmarks.

Label Distribution Learning by Partitioning Label Distribution Manifold.

Researchers have suggested leveraging label correlation to deal with the exponentially sized output space of label distribution learning (LDL). Among them, some have proposed to exploit local label correlation. They first partition the training set into different groups and then exploit local label correlation on each one. However, these works usually apply clustering algorithms, such as K -means, to split the training set and obtain the clustering results independent of label correlation. The structures (e.g., low rank and manifold) learned on such clusters may not efficiently capture label correlation. To solve this problem, we put forward a novel LDL method called LDL by partitioning label distribution manifold (LDL-PLDM). First, it jointly bipartitions the training set and learns the label distribution manifold to model label correlation. Second, it recurses until the reconstruction error of learning the label distribution manifold cannot be reduced. LDL-PLDM achieves label-correlation-related partition results, on which the learned label distribution manifold can better capture label correlation. We conduct extensive experiments to justify that LDL-PLDM statistically outperforms state-of-the-art LDL methods.

Explainable AI for Medical Image Analysis in Medical Cyber-Physical Systems: Enhancing Transparency and Trustworthiness of IoMT.

Medical image analysis plays a crucial role in healthcare systems of Internet of Medical Things (IoMT), aiding in the diagnosis, treatment planning, and monitoring of various diseases. With the increasing adoption of artificial intelligence (AI) techniques in medical image analysis, there is a growing need for transparency and trustworthiness in decision-making. This study explores the application of explainable AI (XAI) in the context of medical image analysis within medical cyber-physical systems (MCPS) to enhance transparency and trustworthiness. To this end, this study proposes an explainable framework that integrates machine learning and knowledge reasoning. The explainability of the model is realized when the framework evolution target feature results and reasoning results are the same and are relatively reliable. However, using these technologies also presents new challenges, including the need to ensure the security and privacy of patient data from IoMT. Therefore, attack detection is an essential aspect of MCPS security. For the MCPS model with only sensor attacks, the necessary and sufficient conditions for detecting attacks are given based on the definition of sparse observability. The corresponding attack detector and state estimator are designed by assuming that some IoMT sensors are under protection. It is expounded that the IoMT sensors under protection play an important role in improving the efficiency of attack detection and state estimation. The experimental results show that the XAI in the context of medical image analysis within MCPS improves the accuracy of lesion classification, effectively removes low-quality medical images, and realizes the explainability of recognition results. This helps doctors understand the logic of the system's decision-making and can choose whether to trust the results based on the explanation given by the framework.

Identification and validation of biomarkers for epithelial-mesenchymal transition-related cells to estimate the prognosis and immune microenvironment in primary gastric cancer by the integrated analysis of single-cell and bulk RNA sequencing data.

BACKGROUND: The epithelial-mesenchymal transition (EMT) is associated with gastric cancer (GC) progression and immune microenvironment. To better understand the heterogeneity underlying EMT, we integrated single-cell RNA-sequencing (scRNA-seq) data and bulk sequencing data from GC patients to evaluate the prognostic utility of biomarkers for EMT-related cells (ERCs), namely, cancer-associated fibroblasts (CAFs) and epithelial cells (ECs). METHODS: scRNA-seq data from primary GC tumor samples were obtained from the Gene Expression Omnibus (GEO) database to identify ERC marker genes. Bulk GC datasets from the Cancer Genome Atlas (TCGA) and GEO were used as training and validation sets, respectively. Differentially expressed markers were identified from the TCGA database. Univariate Cox, least-absolute shrinkage, and selection operator regression analyses were performed to identify EMT-related cell-prognostic genes (ERCPGs). Kaplan-Meier, Cox regression, and receiver-operating characteristic (ROC) curve analyses were adopted to evaluate the prognostic utility of the ERCPG signature. An ERCPG-based nomogram was constructed by integrating independent prognostic factors. Finally, we evaluated the correlations between the ERCPG signature and immune-cell infiltration and verified the expression of ERCPG prognostic signature genes by in vitro cellular assays. RESULTS: The ERCPG signature was comprised of seven genes (COL4A1, F2R, MMP11, CAV1, VCAN, FKBP10, and APOD). Patients were divided into high- and low-risk groups based on the ERCPG risk scores. Patients in the high-risk group showed a poor prognosis. ROC and calibration curves suggested that the ERCPG signature and nomogram had a good prognostic utility. An immune cell-infiltration analysis suggested that the abnormal expression of ERCPGs induced the formation of an unfavorable tumor immune microenvironment. In vitro cellular assays showed that ERCPGs were more abundantly expressed in GC cell lines compared to normal gastric tissue cell lines. CONCLUSIONS: We constructed and validated an ERCPG signature using scRNA-seq and bulk sequencing data from ERCs of GC patients. Our findings support the estimation of patient prognosis and tumor treatment in future clinical practice.

Image recognition of traditional Chinese medicine based on deep learning.

Chinese herbal medicine is an essential part of traditional Chinese medicine and herbalism, and has important significance in the treatment combined with modern medicine. The correct use of Chinese herbal medicine, including identification and classification, is crucial to the life safety of patients. Recently, deep learning has achieved advanced performance in image classification, and researchers have applied this technology to carry out classification work on traditional Chinese medicine and its products. Therefore, this paper uses the improved ConvNeXt network to extract features and classify traditional Chinese medicine. Its structure is to fuse ConvNeXt with ACMix network to improve the performance of ConvNeXt feature extraction. Through using data processing and data augmentation techniques, the sample size is indirectly expanded, the generalization ability is enhanced, and the feature extraction ability is improved. A traditional Chinese medicine classification model is established, and the good recognition results are achieved. Finally, the effectiveness of traditional Chinese medicine identification is verified through the established classification model, and different depth of network models are compared to improve the efficiency and accuracy of the model.

Colorimetric sensor array based on Au2Pt nanozymes for antioxidant nutrition quality evaluation in food.

Total antioxidant capacity (TAC) has become an important index to evaluate the food quality. Effective antioxidant detection has been the research hotspot of scientists. In this work, a novel three-channel colorimetric sensor array founded on Au2Pt bimetallic nanozymes for the discrimination of antioxidants in food was constructed. Benefiting from the unique bimetallic doping structure, Au2Pt nanospheres exhibited the excellent peroxidase-like activity with Km of 0.044 mM and Vmax of 19.37 × 10-8 M s-1 toward TMB. The density functional theory (DFT) calculation revealed that Pt atom in the doping system was active sites and there was no energy barrier in catalytic reaction which made Au2Pt nanospheres had excellent catalytic activity. Accordingly, a multifunctional colorimetric sensor array was constructed based on Au2Pt bimetallic nanozymes for rapid and sensitive detection of five antioxidants. Based on the different reduction ability of antioxidants, oxidized TMB could be reduced in different degrees. In the presence of H2O2, the colorimetric sensor array could generate differential colorimetric signals (fingerprints) by using TMB as the chromogenic substrate, which could be accurately discriminated through linear discriminant analysis (LDA) with a detection limit of <0.2 µM. The sensor array was able to the evaluate TAC in three actual samples (milk, green tea and orange juice). Furthermore, we prepared a rapid detection strip to meet the needs of practical application, making a positive contribution to food quality evaluation.