Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Publication year range
1.
Gen Dent ; 71(5): 18-23, 2023.
Article in English | MEDLINE | ID: mdl-37595078

ABSTRACT

Atherosclerosis is an inflammatory disease of the arteries responsible for a high rate of morbidity and mortality worldwide. The objective of this study was to associate the histopathologic and immunohistochemical aspects of tongue inflammation with aortic and coronary atherosclerosis in autopsied humans. A total of 4378 autopsy reports were analyzed, and cases were included in the study if fragments of the individual's tongue, aorta, and coronary artery were available for analysis (N = 16). Morphologic and immunohistochemical evaluations were performed for interleukin 1α (IL-1α), IL-6, tumor necrosis factor α (TNF-α), and interferon γ (IFN-γ). Findings of IL-1α in the aorta were associated with the following parameters evaluated in the tongue: IL-6 (P = 0.031), inflammation in the submucosa (P = 0.042), and spongiosis (P = 0.018). Findings of IL-6 in the tongue were associated with IL-1α (P = 0.031), IL-6 (P = 0.016), and TNF-α (P = 0.016) in the aorta. Tongue exocytosis was associated with IL-6 (P = 0.003) and IFN-γ (P = 0.003) in the aorta. Inflammation in the submucosa, spongiosis, and higher immunostaining by IL-6 on the tongue are associated with higher immunostaining by IL-1α in the aorta. In addition, increased intensity in the presence of IL-6 in the tongue is also associated with increases in IL-6 and TNF-α in the aorta. Because these cytokines contribute to the process of atherosclerosis, and infectious agents are a major cause of inflammation in the tongue, it seems likely that proper prevention and treatment of lingual infections could reduce the risk of atherosclerosis. However, further studies are needed to corroborate these findings.


Subject(s)
Atherosclerosis , Tumor Necrosis Factor-alpha , Humans , Coronary Vessels/pathology , Interleukin-6 , Autopsy , Inflammation/pathology , Interferon-gamma , Atherosclerosis/complications , Atherosclerosis/pathology , Aorta/pathology , Tongue/pathology
2.
Rev. bras. cir. plást ; 36(4): 431-436, out.-dez. 2021. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1365576

ABSTRACT

■ RESUMO Introdução: O alívio da dor após a cirurgia continua sendo um dos desafios médicos mais significativos, principalmente na cirurgia estética. A infiltração da incisão cirúrgica com anestésicos locais tem sido cada vez mais utilizada para reduzir a dor e o uso de analgésicos. No entanto, pouco se sabe sobre o efeito desta injeção na cicatrização. O objetivo é avaliar a interferência dos anestésicos locais na área de infiltrado inflamatório e cicatriz de fibrose em ratos. Métodos: Duas incisões lineares foram feitas cada uma na região dorsal de 40 ratos Wistar. A incisão esquerda foi infiltrada com doses de 1,8ml de bupivacaína, levobupivacaína, ropivacaína ou solução salina 0,9%. A incisão direita não recebeu infiltração, servindo como grupo controle. Após sete dias, amostras das incisões foram coletadas para avaliação morfométrica histológica. Resultados: Quando comparada com os grupos controle, a área de infiltrado inflamatório encontrada foi maior nos grupos bupivacaína, ropivacaína e levobupivacaína. O grupo bupivacaína apresentou um infiltrado inflamatório maior do que a levobupivacaína e a ropivacaína. A área da cicatriz fibrosa foi maior nos grupos levobupivacaína e ropivacaína. Não houve diferença entre os grupos que receberam anestésico e solução salina. Conclusão: Como não houve diferença entre os grupos de anestésico e soro fisiológico, o volume aplicado ou o trauma podem ter sido a causa das maiores áreas de infiltração e cicatriz associadas à aplicação dos anestésicos locais.


■ ABSTRACT Introduction: Pain relief after surgery remains one of the most significant medical challenges, mainly in aesthetic surgery. The infiltration of the surgical incision with local anesthetics has been increasingly used to reduce pain and other analgesic use. However, little is known about the effect of this injection on healing. The objective is to evaluate the interference of local anesthetics in the area of inflammatory infiltrate and fibrosis scar in rats. Methods: Two linear incisions each were made on the dorsal region of 40 Wistar rats. The left incision was infiltrated with doses of 1.8ml of bupivacaine, levobupivacaine, ropivacaine, or 0,9% saline solution infiltration. The right incision did not receive infiltration, serving as a control group. After seven days, samples of the incisions were collected for histological morphometric evaluation. Results: When compared with the control groups, the area of inflammatory infiltrate was found larger in the bupivacaine, ropivacaine, and levobupivacaine groups. The bupivacaine group presented a larger inflammatory infiltrate than the levobupivacaine and ropivacaine. The fibrous scar area was larger in the levobupivacaine and ropivacaine groups. There was no difference between the groups that received anesthetic and saline solution. Conclusion: As there was no difference between the anesthetics and saline solution groups, the volume applied, or the trauma may have been the cause of the larger areas of infiltrating and scar associated with local anesthetics application.

SELECTION OF CITATIONS
SEARCH DETAIL
...